Mealshape, a clinically-proven carb blocker
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Transcript of Mealshape, a clinically-proven carb blocker
Two growing worldwide pandemics :
overweight and diabetes
Dialpha focus on prevention for populations at risk of developing
“diabesity” and related diseases
Source: World Health Organization
387
592
2014 2035
Diabetes(million)
Source: International Diabetes Federation
2014 2030
Overweight adults (billion; BMI ≥ 25)
1.9
3.3
2
Put carbs in check with MealShape®
The next generation starch blocker
• MealShape® is an innovative starch blocker that instantly blocks carb
absorption by more than 20%.
• By inhibiting enzymatic digestion of dietary starch, MealShape® helps
prevent glycemic spikes and sugar crashes, thus aiding the body to reduce
the conversion of excess sugar into fat.
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Human clinical data
MealShape® significantly decreased postprandial glycemia by 21% in men and women without stimulating insulin secretion
Placebo-controlled, randomized
crossover, double-blind trial
Conducted in France
18 healthy subjects
Published in BMC Alternative &
Complementary Medicine*
(*p<0.05)
0
200
400
600
800
1000
Placebo MealShape 1g
- 21.2%
AUC 0-60 min
Blood sugar levels following a standard meal
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0
5
10
15
20
25
30
35
40
45
50
0 30 60 90 120
Delta glycemia (mg/dL)
Time (min)
Placebo
MealShape 1g
*
*Beejmohun et al. BMC Complementary & Alternative Medicines 2014 (http://www.biomedcentral.com/1472-6882/14/351)
*
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Preclinical data / body weight
MealShape® taken on the long term is beneficial for weight management
24
28
32
36
40
44
0 7 14 21 28 35 42 49 56 63 70 77 84
Body weight (g)
Time (day)
Control group
MealShape 50 mg/kg bw
Body weight evolution in normal mice
STT STT STT
STT : starch tolerance test
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Preclinical data / blood glucose
MealShape® effect on blood glucose level increases on the long term
Postmeal blood glucose evolution in normal mice
(*p<0.05; **p<0.01; ***p<0.001)
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Proof of concept on bread
A significant efficacy demonstrated on a cooked food matrix
CONTROL 0.5% 1% 2%
Incorporation of MealShape® in a french baguette
(*p<0.05; **p<0.01; ***p<0.001)
-30%*
*****
0
20
40
60
80
100
Controlbread
BreadMealShape
0,5%
BreadMealShape
1%
BreadMealShape
2%
Glycemia (%)
Evolution of bread Glycemic index in rats
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How does it work ?
Inhibition of alpha-amylase
Delays the digestion & the absorption of carbohydrates
Alpha-amylase
Long chain carbohydrates Simple sugars
MealShape®
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MealShape® helps the body to reduce the conversion of excess sugar into fat
First uses of sugars:
As energy (cells)
Stored in the liver
Excess converted
into fat
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The first and only cinnamon extract
working as a carb blocker
Raw material: Ceylon cinnamon
Safety guaranteed: only traces of coumarin
compared with Cassia species
More efficient than Cassia species on the
inhibition of starch digestion
Cinnamomum zeylanicum
MealShape®
Water-ethanol extract
Patented
Standardized at min 40% polyphenols
FDA GRAS status + Non Novel food in the EU
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Various applications
Dietary supplements
1 g or 2 x 500 mg / day
To take before meal
Starchy food
0.5% of carbohydrates
Functional beverages
Pet food
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In brief…
Reduce your blood sugar level
by more than 20% after a meal,
as of the first intake
Overall glycemia
Weight management
Cholestrol control
Oxidative stress
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In brief… MealShape® is:
INNOVATIVE First starch-blocker extracted from cinnamon
EFFICIENT 1 g provides 20% reduction of blood sugar level after a meal (clinical data)
Unique cinnamon extract with an acute effect on glycemia
SAFE Low level of coumarin
QUALITATIVE Made by contract manufacturers with GMP certifications
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www.dialpha.com
Dialpha SAS
Parc Agropolis 2 ▪ Batiment 6 ▪ 2196 boulevard de la Lironde ▪ 34980 Montferrier sur Lez ▪ France
Tel: +33 4 67 40 44 19 ▪ [email protected]