Me international-consensus-criteria
39
This is an Accepted Article that has been peer-reviewed and approved for publication in the Journal of Internal Medicine, but has yet to undergo copy-editing and proof correction. Please cite this article as an “Accepted Article”; doi: 10.1111/j.1365- 2796.2011.02428.x Accepted Date : 15-Jul-2011 Article type : Review !"#$%&' )*'+,-#$./"+$&0&12 3*0+4*#0&.*#$ 5.*1+*161 54&0+4&# !"#$% ' ()""#*+%",- "#$ %"$ &'%()%* )+,-./0,1*2 34.-5-4.-40$ 674+,89-1$ :;%;$ %747.7 ')"./"0% 1 2)3 4% 5)34%$ :<.$ =17.#/5 <. )+,-./0,1*2 34.-5-4.-40$ %7>?71@$ A:$ %747.7 6%337 8 9% '%0":%0"$ "#$ (B#2 #-5710C-40 ,D (B@E/,>,?@ 74. "-./+/4-$ 61/F- G4/9-1E/0@ ,D :18EE->E$ H/CC84/07E &,84.70/,4$ :18EE->E$ :->?/8C; ;)3$7 < 6:0=),$ "#2 #-5710C-40 ,D "-./+/4- $G4/9-1E/0@ ,D "/7C/ "/>>-1 I+B,,> ,D "-./+/4- 74. "/7C/ 6-0-174E ADD7/1E "-./+7> %-40-1$ "/7C/$ &J$ GIA </"4/3 !"/4%"0$>$ (B#2 #-5710C-40 ,D "-./+/4-$ G4/9-1E/0@ ,D A>K-107$ <.C,40,4$ A:$ %747.7 ?%""7 '0*$+%::$ "A$ "#$ &'%(70B2 H,4,171@ %,4E8>0740 D,1 LHI 70 (-0-1K,1,8?BM%7CK1/.?-$ J,N-E0,D0$ I8DD,>O$ G4/0-. P/4?.,C; 9/3 5*)03%,$ "::I$ "(H$ &A&(H"$ &A&Q<"2 =,>. %,7E0 (8K>/+ H-7>0B G4/0$ I,80B5,10$ R8--4E>74.2 H-7>0B I+/-4+-E 74. "-./+/4-$ :,4. G4/9-1E/0@$ ',K/47$ R8--4E>74.$ A8E017>/7 @( A%*%" A/B:%,$ "'A%($ &'A%($ &'%()%*$ A:I"2 &7+8>0@ ,D H-7>0B I+/-4+-E$ "+"7E0-1 G4/9-1E/0@ 74. I0; S,E-5BTE H-7>0B+71- H7C/>0,4$ H7C/>0,4$ QL$ %747.7; ;0C%: 5D%0C+*$ "A$ ":$ :%B/1$ &'%($ &'%(%H$ #%H2 34.-5-4.-40$ #81B7C$ G4/0-. P/4?.,C E/,)=#34 F)::03C,$ "LU"$ ":$ :I$ "'%I$ J'%(2 H,N/+O H-7>0B 74. "-./+7> %-401-$ H,N/+O$ L-N U-7>74.; 8#$034) !)*%=)3$ "I$ "#2 &70/?8- %,4E8>070/,4 %>/4/+$ I7>0 J7O- '-?/,47> "-./+7> %-40-1V 7.F84+0 D7+8>0@ W 340-147> "-./+/4-$ &7C/>@ (17+0/+-$ G4/9-1E/0@ ,D G07B$ I7>0 J7O- %/0@$ GX$ GIA; !)"G)") !)#=C)"*%3H@#,*"+%0=$ "#2 "<M%&I %-40-1$ QE>, G4/9-1E/0@ H,E5/07> H&$ L,1N7@; 9)204 5 !%::$ "#$ &AA(2 #-5710C-40 ,D (7-./701/+E$ I070- G4/9-1E/0@ ,D L-N Y,1O$ :8DD7>,$ LY; ;0$/:%**) ()":/H5*%::)$ "#$ (B#2 34.-5-4.-40$ (79/7$ 307>@ I/+3 (+0)$ "#2 H71K,1ZG%JA "-./+7> %-40-1$ G4/9-1E/0@ ,D %7>/D,14/7$ J,E A4?->-E2 <6 "-. '-E-71+B$ J,C/07$ %A$ GIA @#,*03 9)"")C+$ "A$ "#$ &&I<"; )'%(3$ '%I3*$ &'IH&3 :/,> 3 )H,4*2 J302%",0*7 /K 80=%"0$>- 80=%"0$>- 1"%:)34 9)%+7#3 I/$ "#$ (B#2 (7/4 %>/4/+$ P,4@74? G4/9-1E/0@ H,E5/07>$ #7-F-,4$ P,1-7 9/3 8%B0,$ "#2 #,497>- I5-+/7>/E0 "-./+7> %-401-$ #,497>-$ 6/+0,1/7$ A8E017>/7 @:)3 E 80C+*$ (B#2 #-50E ,1 A4-E0B-E/,>,?@$ L-81,K/,>,?@ 74. A470,C@$G4/9-1E/0@ ,D G07B$ I7>0 J7O- %/0@$ G07B$ GIA; 5/37) ')",+)::H<")40,G0>- (B#2 H-7>0B I+/-4+-E 74. "-./+/4-$ :,4. G4/9-1E/0@$ ',K/47$ R8--4E>74.$ A8E017>/7; 1,=)%: '%3)$ "#2 #-5710; "-./+/47 L8+>-71$ %>/4/+7 J7E %,4.-E$ I740/7?,$ %B/>- I#47 @ '0>/20*,$ (B#2 [B/00-C,1- (-0-1E,4 34E0/080-$ G4/9-1E/0@ ,D L-97.7$ '-4,$ L6 GIA 6#30+0,) '0B)$ "#$ (B#2 "/N7 L7/O7 %>/4/+$ X,@7C7$ S7574 '/4") '#"/2,>)$ "#$ (B#2 A; P/1+B-4E0-/4 34E0/080- ,D "/+1,K/,>,?@ 74. 6/1,>,?@$ '/?7 I017./4E G4/9-1E/0@$ '/?7$ J709/7$ ')"*03 8 A)::$ (B#2 #-5710C-40 ,D :/,+B-C/E01@ \ :7E/+ "-./+7> I+/-4+-E$ [7EB/4?0,4 I070- G4/9-1E/0@$ (,10>74.$ Q'$ GIA 5*)$0 5*%2%3,$ "A2 #-5710C-40 ,D I5,10E I+/-4+-E$ G4/9-1E/0@ ,D 0B- (7+/D/+$ I0,+O0,4$ %A GIA;
Transcript of Me international-consensus-criteria
This is an Accepted Article that has been peer-reviewed and approved for publication in the Journal of Internal Medicine, but has yet to undergo copy-editing and proof correction. Please cite this article as an “Accepted Article”; doi: 10.1111/j.1365-2796.2011.02428.x
Accepted Date : 15-Jul-2011 Article type : Review
!"#$%&'()*'+,-#$./"+$&0&12((3*0+4*#0&.*#$(5.*1+*161(54&0+4&#(
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
1"%:)34&
9)%+7#3&I/$!"#$!(B#2!(7/4!%>/4/+$!P,4@74?!G4/9-1E/0@!H,E5/07>$!#7-F-,4$!P,1-7!9/3&8%B0,$!"#2!#,497>-!I5-+/7>/E0!"-./+7>!%-401-$!#,497>-$!6/+0,1/7$!A8E017>/7!@:)3&E&80C+*$!(B#2!#-50E!,1!A4-E0B-E/,>,?@$!L-81,K/,>,?@!74.!A470,C@$G4/9-1E/0@!,D!G07B$!I7>0!J7O-!%/0@$!G07B$!GIA;!!!5/37)&')",+)::H<")40,G0>-&(B#2!H-7>0B! I+/-4+-E! 74.!"-./+/4-$! :,4.!G4/9-1E/0@$! ',K/47$!R8--4E>74.$!A8E017>/7;!1,=)%:&'%3)$!"#2!#-5710;!"-./+/47!L8+>-71$!%>/4/+7!J7E!%,4.-E$!I740/7?,$!%B/>-!I#47&@&'0>/20*,$!(B#2
!E#3303C&?0*:%V!"<V!340>;!%,4E-4E8E!%1/0-1/7!&
&
@G,*")$*!
!!!!XB-! >7K->!]+B1,4/+! D70/[email protected],C-^!)%&I*!B7E!5-1E/E0-.!D,1!C74@!@-71E!K-+78E-!,D! >7+O!,D!
O4,N>-.?-! ,D! 0B-! -0/,>,?/+7>! 7?-40E! 74.! ,D! 0B-! ./E-7E-! 51,+-EE;! ! 34! 9/-N! ,D! C,1-! 1-+-40!
1-E-71+B! 74.! +>/4/+7>! -_5-1/-4+-! 0B70! E01,4?>@! 5,/40! 0,! N/.-E51-7.! /4D>7CC70/,4! 74.!
C8>0/E@E0-C/+! 4-81,570B,>,?@$! /0! /E! C,1-! 7551,51/70-! 74.! +,11-+0! 0,! 8E-! 0B-! 0-1C! ]C@7>?/+!
-4+-5B7>,C@->/0/E^)"<*! K-+78E-! /0! /4./+70-E! 74! 84.-1>@/4?! 570B,5B@E/,>,?@;! ! 30! /E! 7>E,!
+,4E/E0-40! N/0B! 0B-! 4-81,>,?/+7>! +>7EE/D/+70/,4! ,D! "<! /4! 0B-! [,1>.! H-7>0B! Q1?74/`70/,4aE!
340-1470/,47>!%>7EE/D/+70/,4!,D!#/E-7E-E!)3%#!=bc;c*;!!%,4E-d8-40>@$!74!340-1470/,47>!%,4E-4E8E!
(74->! +,4E/E0/4?! ,D! +>/4/+/74E$! 1-E-71+B-1E$! 0-7+B/4?! D7+8>0@! 74.! 74! /4.-5-4.-40! 570/-40!
7.9,+70-! N7E! D,1C-.! N/0B! 0B-! 5815,E-! ,D! .-9->,5/4?! +1/0-1/7! K7E-.! ,4! +811-40! O4,N>-.?-;!!
XB/10--4! +,8401/-E! 74.! 7!N/.-! 174?-! ,D! E5-+/7>0/-E!N-1-! 1-51-E-40-.;! ! %,>>-+0/9->@$!C-CK-1E!
B79-!7551,_/C70->@!eff!@-71E!,D!K,0B!+>/4/+7>!74.!0-7+B/4?!-_5-1/-4+-$!780B,1-.!B84.1-.E!,D!
5--1! 1-9/-N-.! 58K>/+70/,4E$! ./7?4,E-.! ,1! 01-70-.! 7551,_/C70->@! gf$fff! "<! 570/-40E$! 74.!
E-9-17>! C-CK-1E! +,780B,1-.! 51-9/,8E! +1/0-1/7;! ! XB-! -_5-10/E-! 74.! -_5-1/-4+-! ,D! 0B-! 574->!
C-CK-1E! 7E! N->>! 7E! (8K"-.! 74.! ,0B-1! C-./+7>! E,81+-E! N-1-! 80/>/`-.! /4! 7! 51,?1-EE/,4! ,D!
E8??-E0/,4EM.17D0EM1-9/-NEM1-9/E/,4E;! XB-! 780B,1E$! D1--! ,D! 74@! E5,4E,1/4?! ,1?74/`70/,4$!
7+B/-9-.!hffi!+,4E-4E8E!0B1,8?B!7!#->5B/!0@5-!51,+-EE;!!!
!!!!XB-! E+,5-!,D! 0B/E!575-1! /E! >/C/0-.! 0,! +1/0-1/7!,D!"<!74.! 0B-/1! 755>/+70/,4;! !A++,1./4?>@$! 0B-!
+1/0-1/7!1-D>-+0!0B-!+,C5>-_!E@C50,C70,>,?@;!!Q5-170/,47>!4,0-E!-4B74+-!+>71/0@!74.!E5-+/D/+/0@!
K@!51,9/./4?!?8/.74+-!/4!0B-!-_51-EE/,4!74.!/40-151-070/,4!,D!E@C50,CE;!!%>/4/+7>!74.!1-E-71+B!
755>/+70/,4! ?8/.->/4-E! 51,C,0-! ,50/C7>! 1-+,?4/0/,4! ,D! "<! K@! 51/C71@! 5B@E/+/74E! 74.! ,0B-1!
B-7>0B! +71-! 51,9/.-1E$! /C51,9-! +,4E/E0-4+@! ,D! ./7?4,E-E! /4! 7.8>0! 74.! 57-./701/+! 570/-40E!
/40-1470/,47>>@$!74.!D7+/>/070-!+>-71-1!/.-40/D/+70/,4!,D!570/-40E!D,1!1-E-71+B!E08./-E;!
&
13*"/4#$*0/3&
& "@7>?/+! -4+-5B7>,C@->/0/E! )"<*$! 7>E,! 1-D-11-.! 0,! /4! 0B-! >/0-17081-! 7E! +B1,4/+! D70/?8-!
[email protected],C-!)%&I*$! /E!7!+,C5>-_!./E-7E-! /49,>9/4?!51,D,84.!.@E1-?8>70/,4!,D!0B-!+-4017>!4-19,8E!
E@E0-C!)%LI*!jhZck!74.!/CC84-!E@E0-C!jeZlk$!.@ED84+0/,4!,D!+->>8>71!-4-1?@!C-07K,>/EC!74.!/,4!
0174E5,10! jbZhhk$! 74.! +71./,97E+8>71! 7K4,1C7>/0/-E! jhmZhek;! ! XB-! 84.-1>@/4?! 570B,5B@E/,>,?@!
51,.8+-E!C-7E817K>-!7K4,1C7>/0/-E!/4!5B@E/+7>!74.!+,?4/0/9-!D84+0/,4!74.!51,9/.-E!7!K7E/E!D,1!
84.-1E074./4?!0B-!E@C50,C,>,?@;! !XB8E$!0B-!.-9->,5C-40!,D! 340-1470/,47>!%,4E-4E8E!%1/0-1/7!
0B70! /4+,15,170-! +811-40! O4,N>-.?-! EB,8>.! 7.974+-! 0B-! 84.-1E074./4?! ,D! "<! K@! B-7>0B!
517+0/0/,4-1E$!74.!K-4-D/0!K,0B!0B-!5B@E/+/74!74.!570/-40!/4!0B-!+>/4/+7>!E-00/4?!7E!N->>!7E!+>/4/+7>!
1-E-71+B-1E;!!
&&&&?+%&D"/G:%=&B0*+&G"/)4:7&03$:#,02%&$"0*%"0)&jhg$!hnk!/E!0B70!0B-@!.,!4,0!E->-+0!B,C,?-4-,8E!
E-0E!,D!570/-40E;!!XB-!%-40-1E!D,1!#/E-7E-!%,401,>!51-97>-4+-!-E0/C70-E!/4+1-7E-.!0-4D,>.!D1,C!
f;mei!8E/4?!0B-!&8O8.7!+1/0-1/7!jhok!0,!m;gei!8E/4?!0B-!'--9-E!-C5/1/+7>!+1/0-1/7!jhnk;!!S7E,4!-0!
7>;! jhlk! E8??-E0! 0B-1-! 71-! D>7NE! /4! '--9-Ea! C-0B,.,>,?@! K-+78E-! /0! /E! 5,EE/K>-! 0,! C--0! 0B-!
-C5/1/+7>! +1/0-1/7! D,1!"<!N/0B,80!B79/4?! 74@!5B@E/+7>! E@C50,CE!74.! /0!.,-E!4,0!./E+1/C/470-!
"<M%&I!570/-40E!D1,C!0B,E-!N/0B!"7F,1!#-51-EE/9-!#/E,1.-1;!!(70/-40!E-0E!0B70!/4+>8.-!5-,5>-!
NB,!.,!4,0!B79-! 0B-!./E-7E-! >-7.! 0,!K/7E-.! 1-E-71+B! D/4./4?E$! /47551,51/70-! 01-70C-40E$! 74.!
N7E0-!E+71+-!1-E-71+B!D84.E!jhbk;!
!!!!I,C-! E@C50,CE! ,D! 0B-! &8O8.7! +1/0-1/7! ,9-1>75! N/0B! .-51-EE/,4! NB-1-7E! 0B-! %747./74!
%,4E-4E8E!%1/0-1/7! jmfk!./DD-1-40/70-!"<!570/-40E! D1,C! 0B,E-!NB,!71-!.-51-EE-.!74.! /.-40/D@!
570/-40E!NB,!71-!C,1-!5B@E/+7>>@!.-K/>/070-.!74.!B79-!?1-70-1!5B@E/+7>!74.!+,?4/0/9-!D84+0/,47>!
/C57/1C-40E!jmhk;!!!
!
13*%"3)*0/3):&(/3,%3,#,&("0*%"0)&&
&&&XB-!%747./74!%,4E-4E8E!%1/0-1/7!N-1-!8E-.!7E!7!E0710/4?!5,/40$!K80!E/?4/D/+740!+B74?-E!N-1-!
C7.-;!!XB-!E/_ZC,40B!N7/0/4?!5-1/,.!K-D,1-!./7?4,E/E!/E!4,!>,4?-1!1-d8/1-.;!!L,!,0B-1!./E-7E-!
+1/0-1/7!1-d8/1-!0B70!./7?4,E-E!K-!N/0BB->.!840/>!7D0-1!0B-!570/-40!B7E!E8DD-1-.!N/0B!0B-!7DD>/+0/,4!
D,1! E/_! C,40BE;! ! L,0N/0BE074./4?! 5-1/,.E! ,D! +>/4/+7>! /49-E0/?70/,4! N/>>! 971@! 74.! C7@! K-!
51,>,4?-.$! ./7?4,E/E! EB,8>.! K-!C7.-!NB-4! 0B-! +>/4/+/74! /E! E70/ED/-.! 0B70! 0B-! 570/-40! B7E!"<!
170B-1!0B74!B79/4?!0B-!./7?4,E/E!1-E01/+0-.!K@!7!E5-+/D/-.!0/C-!D7+0,1;!!<71>@!./7?4,E-E!C7@!->/+/0!
4-N!/4E/?B0E! /40,!0B-!-71>@!E07?-E!,D!570B,?-4-E/E2!51,C50!01-70C-40!C7@!>-EE-4!0B-!E-9-1/0@!
74.!/C57+0;!!
!!!!GE/4?! ]D70/?8-^! 7E! 7! 47C-!,D! 7! ./E-7E-! ?/9-E! /0! -_+>8E/9-! -C5B7E/E! 74.! B7E! K--4! 0B-!C,E0!
+,4D8E/4?!74.!C/E8E-.!+1/0-1/,4;!!L,!,0B-1!D70/?8/4?!./E-7E-!B7E!]+B1,4/+!D70/?8-^!7007+B-.!0,!
/0E! 47C-! W! -;?;! +74+-1M+B1,4/+! D70/?8-$! C8>0/5>-! E+>-1,E/EM+B1,4/+! D70/?8-! Z! -_+-50! "<M%&I;!
&70/?8-!/4!,0B-1!+,4./0/,4E! /E!8E87>>@!51,5,10/,47>!0,!-DD,10!,1!.8170/,4!N/0B!7!d8/+O!1-+,9-1@$!
74.!N/>>!1-+81!0,!0B-!E7C-!-_0-40!N/0B!0B-!E7C-!-DD,10!,1!.8170/,4!0B70!E7C-!,1!4-_0!.7@;!!XB-!
570B,>,?/+7>!>,N!0B1-EB,>.!,D!D70/?7K/>/0@!,D!"<!.-E+1/K-.!/4!0B-!D,>>,N/4?!+1/0-1/7!,D0-4!,++81E!
N/0B! C/4/C7>! 5B@E/+7>! ,1! C-407>! -_-10/,4$! 74.! N/0B! 1-.8+-.! 7K/>/0@! 0,! 84.-107O-! 0B-! E7C-!
7+0/9/0@!N/0B/4!0B-!E7C-!,1!E-9-17>!.7@E;!
!!!!XB-! 340-1470/,47>! %,4E-4E8E! %1/0-1/7! )X7K>-! h*! /.-40/D@! 0B-! 84/d8-! 74.! ./E0/4+0/9-!
+B717+0-1/E0/+! 5700-14E! ,D! E@C50,C! +>8E0-1E! ,D!"<;! ! XB-! K1,7.! E5-+018C! ,D! E@C50,CE! 7>-10E!
C-./+7>!517+0/0/,4-1E!0,!71-7E!,D!570B,>,?@!74.!C7@!/.-40/D@!+1/0/+7>!E@C50,CE!C,1-!7++8170->@!
jhlZmfk;! !Q5-170/,47>!4,0-E! D,>>,N/4?!-7+B! +1/0-1/,4!51,9/.-! ?8/.74+-! /4! E@C50,C!-_51-EE/,4!
74.!+,40-_087>!/40-151-070/,4;!! !XB/E!N/>>!7EE/E0!0B-!51/C71@!+>/4/+/74!/4!/.-40/D@/4?!74.!01-70/4?!
"<!570/-40E!/4!0B-!51/C71@!+71-!E-00/4?;!!
(Please insert Table 1 here.)
&
("0*%"0)&@"%&5#DD/"*%4&G7&E%,%)"$+&
!!!!!%1/0-1/7>! E@C50,CE!71-!E855,10-.!K@!7!E08.@!,D!C,1-! 0B74!m$gff!570/-40E!0B70!.-0-1C/4-.!
NB/+B!E@C50,CE!B7.!0B-!?1-70-E0!-DD/+7+@!0,! /.-40/D@!"<!570/-40E!jmmk;!349-E0/?70/,4E!,D!?-4-!
-_51-EE/,4! jmcZmok! 74.! E018+081-! D810B-1! E855,10! 0B-! +1/0-1/7! 70! 7! C,>-+8>71! >-9->! /4+>8./4?!
74,C7>/-E!,D! /4+1-7E-.!,_/.70/9-!E01-EE! je$!mlk$!7>0-1-.! /CC84-!74.!7.1-4-1?/+!E/?47>>/4?!jmb$!
cfk$!74.!7>0-1-.!,-E01,?-4!1-+-50,1!-_51-EE/,4!jchk;!!34!7../0/,4$!-9/.-4+-!E855,10/4?!7!?-4-0/+!
51-./E5,E/0/,4! 0,! "<! 5,/40E! 0,! C,./D/+70/,4E! /4! E-1,0,4/4! 0174E5,10-1! ?-4-E! jcm$! cck$! 0B-!
?>8+,+,10/+,/.! 1-+-50,1! ?-4-! jcek$! 7E! N->>! 7E! HJA! +>7EE! 33! /49,>9-C-40! jcgk;! ! XB-! 5,0-40/7>!
+,CK/470,1/7>! -DD-+0E! ,D! 0B-E-! C,./D/+70/,4E! B79-! 1-+-/9-.! >/C/0-.! 700-40/,4! jcn$! cok;! I,C-!
-71>@! K1,7.! K7E-.! E08./-E! EB,N! 7! >7+O! ,D! ,KF-+0/9-! D/4./4?E! E8+B! 7E! 4,! 7EE,+/70/,4!N/0B! HJA!
?-4,0@5-!jclk;! !A!E08.@!,D!570/-40E! D1,C!7!0N/4!1-?/E01@!E8??-E0-.!0B70!-49/1,4C-407>!D7+0,1E!
C7@!,80N-/?B!74@!?-4-0/+!51-./E5,E/0/,4!/4!K1,7.!K7E-.!570/-40!5,58>70/,4E!jcbk;!!
!!!!!G4.-1>@/4?!51,K>-CE!,D! /4+,4E/E0-40! D/4./4?E! /4! 1-E-71+B! E08./-E! B79-! K--4! /.-40/D/-.! jef$!
ehk! 74.! /4+>8.-! 7! 4--.! D,1! E08./-E! 0,! K-! K7E-.! ,4! >71?-1! E7C5>-! E/`-E! N/0B! 7! C,1-! +>-71>@!
.-D/4-.! 5B-4,0@5-2! /4! 5710/+8>71! ,4-! 0B70! 1-+,?4/`-E! 0B-! >/O->@! -_/E0-4+-! ,D! E/?4/D/+740!
E8K?1,85E!N/0B/4!0B-!570/-40!5,58>70/,4;!!!34!7!E08.@!,D!0B-!'--9-E!-C5/1/+7>!+1/0-1/7!jhnk$!S7E,4!
-0!7>!jhlk!1-5,10-.!0B70!0B/10@Z-/?B0!5-1+-40!)cli*!,D!570/-40E!./7?4,E-.!N/0B!"7F,1!#-51-EE/9-!
#/E,1.-1!N-1-!C/E+>7EE/D/-.!7E!B79/4?!%&I!74.!,4>@!0-4!5-1+-40!)hfi*!,D!570/-40E! /.-40/D/-.!7E!
B79/4?! %&I! 7+087>>@! B7.! "<;! ! A++,1./4?>@$! 0B-! 51/C71@! ?,7>! ,D! 0B/E! +,4E-4E8E! 1-5,10! /E! 0,!
-E07K>/EB! 7! C,1-! E->-+0/9-! E-0! ,D! +>/4/+7>! +1/0-1/7! 0B70! N,8>.! /.-40/D@! 570/-40E! NB,! B79-!
4-81,/CC84-!-_B78E0/,4!N/0B!7!570B,>,?/+7>!>,NZ0B1-EB,>.!,D!D70/?7K/>/0@!74.!E@C50,C!D>71-!/4!
1-E5,4E-!0,!-_-10/,4;! ! !XB/E!N/>>!-47K>-! >/O-!570/-40E!0,!K-!./7?4,E-.!74.!-41,>>-.!/4!1-E-71+B!
E08./-E!/40-1470/,47>>@!84.-1!7!+7E-!.-D/4/0/,4!0B70!/E!7++-507K>-!0,!5B@E/+/74E!74.!1-E-71+B-1E!
71,84.!0B-!N,1>.;!
@L (,E0Z<_-10/,47>!L-81,/CC84-!<_B78E0/,4!)(<L<!!5-4 Z-*!!!!
!!!]"7>7/E-!Z!7!97?8-!D-->/4?!,D!./E+,CD,10!,1! D70/?8-^!jemk! /E!74! /47++8170-!74.! /47.-d870-!
N,1.!D,1!0B-!570B,>,?/+7>!>,NZ0B1-EB,>.!D70/?7K/>/0@!74.!5,E0Z-_-10/,47>!E@C50,C!D>71-;!!(7/4!
74.!D70/?8-!71-!+18+/7>!K/,7>71C!E/?47>E!0B70!/4E018+0!570/-40E!0,!C,./D@!NB70!0B-@!71-!.,/4?!
/4! ,1.-1! 0,! 51,0-+0! 0B-! K,.@! 74.! 51-9-40! D810B-1! .7C7?-;! ! (,E0Z-_-10/,47>! 4-81,/CC84-!
-_B78E0/,4! /E! 5710! ,D! 0B-! K,.@aE! ?>,K7>! 51,0-+0/,4! 1-E5,4E-! 74.! /E! 7EE,+/70-.! N/0B!
.@ED84+0/,4! /4! 0B-! 1-?8>70,1@! K7>74+-! N/0B/4! 74.! K-0N--4! 0B-! 4-19,8E$! /CC84-! 74.!
-4.,+1/4-! E@E0-CE$! 74.! +->>8>71! C-07K,>/EC! 74.! /,4! 0174E5,10! jecZeok;! XB-! 4,1C7>!
7+0/9/0@M1-E0! +@+>-$!NB/+B! /49,>9-E! 5-1D,1C/4?! 74! 7+0/9/0@$! K-+,C/4?! D70/?8-.$! 74.! 07O/4?! 7!
1-E0!NB-1-K@!-4-1?@!/E!1-E0,1-.$!K-+,C-E!.@ED84+0/,47>;!!
!!!!L8C-1,8E!575-1E!.,+8C-40!7K4,1C7>!K/,>,?/+7>!1-E5,4E-E!0,!-_-10/,4$!E8+B!7E!>,EE!,D!0B-!
/49/?,170/4?! -DD-+0E! ,D! -_-1+/E-! jmfk$! .-+1-7E-.!57/4! 0B1-EB,>.! jelZgfk$! .-+1-7E-.! +-1-K17>!
,_@?-4! 74.! K>,,.! 9,>8C-MD>,N! jghZgek$! .-+1-7E-.! C7_/C8C! B-710! 170-! jggk$! /C57/1-.!
,_@?-4! .->/9-1@! 0,! C8E+>-E! jgnk$! ->-970-.! >-9->E! ,D! 4/01/+! ,_/.-! C-07K,>/0-E! jgok$! 74.!
N,1E-4/4?! ,D! ,0B-1! E@C50,CE! jglk;! ! (70/-40E! 1-7+B! 0B-! 747-1,K/+! 0B1-EB,>.! 74.!C7_/C7>!
-_-1+/E-! 70! 7!C8+B! >,N-1! ,_@?-4! +,4E8C50/,4! >-9->! jgbk;! ! '-5,10-.! 51,>,4?-.! -DD-+0E! ,D!
-_-10/,4!/4+>8.-!->-970-.!E-4E,1@!E/?47>>/4?!0,!0B-!K17/4!jnfk!0B70!/E!/40-151-0-.!7E!57/4!74.!
D70/?8-!jnhk$!->-970-.!+@0,O/4-!7+0/9/0@!jnmk$!.->7@!/4!E@C50,C!7+0/970/,4!jnck!74.!7!1-+,9-1@!
5-1/,.!,D!70!>-7E0!el!B,81E!jglk;!!
L-81,/C7?/4?! E08./-E! 1-5,10! /11-9-1E/K>-! 584+0870-! >-E/,4E! jnnk$! 74! 7551,_/C70-! hfi!
1-.8+0/,4! /4! ?17@! C700-1! 9,>8C-! jno$! nlk$! B@5,5-1D8E/,4! jnbZoek! 74.! K17/4! E0-C!
B@5,C-07K,>/EC! jhk;! ! <>-970-.! >-9->E! ,D! >70-17>! 9-401/+8>71! >7+070-! 71-! +,4E/E0-40! N/0B!
.-+1-7E-.!+,10/+7>!K>,,.!D>,N$!C/0,+B,4.1/7>!.@ED84+0/,4!74.!,_/.70/9-!E01-EE!jogk;!!!'-E-71+B!
E8??-E0E!0B70!.@E1-?8>70/,4!,D!0B-!%LI!74.!780,4,C/+!4-19,8E!E@E0-C!7>0-1E!51,+-EE/4?!,D!
57/4! 74.! E-4E,1@! /4580! jel$! nh$! on$! ook;! ! (70/-40Ea! 5-1+-50/,4! 0B70! E/C5>-! C-407>! 07EOE!
1-d8/1-! E8KE0740/7>! -DD,10! /E! E855,10-.! K@! K17/4! E+74! E08./-E! 0B70! /4./+70-! ?1-70-1! E,81+-!
7+0/9/0@! 74.! C,1-! 1-?/,4E! ,D! 0B-! K17/4! 71-! 80/>/`-.! NB-4! 51,+-EE/4?! 78./0,1@! 74.! E570/7>!
+,?4/0/9-!/4D,1C70/,4!jolZlfk;!!(,,1!700-40/,47>!+757+/0@!74.!N,1O/4?!C-C,1@!71-!51,C/4-40!
./E7K>/4?!E@C50,CE!jmf$!ol$!lhk;!!!
!
(L 1==#3%&1=D)0"=%3*,&&
!!!!",E0!570/-40E!B79-!74!7+80-! /4D-+0/,8E!,4E-0!N/0B! D>8Z>/O-!74.M,1! 1-E5/170,1@!E@C50,CE;!!!
A! N/.-! 174?-! ,D! /4D-+0/,8E! 7?-40E! B79-! K--4! 1-5,10-.! /4! E8KE-0E! ,D! 570/-40E! /4+>8./4?!
p-4,01,5/+!C81/4-!>-8O-C/7!9/18EZ1->70-.!9/18E!)p"'6*!jlmk!74.!,0B-1!C81/4-!>-8O-C/7!9/18E!
)"J6*Z1->70-.!9/18E-E!jlck$!-40-1,9/18E!jleZlnk$!<5E0-/4!:711!9/18E!jlok$!B8C74!B-15-E!9/18E!n!
74.! o! jllZbfk$! %B>7C@./7! jbhk$! +@0,C-?7>,9/18E! jbmk$! 5719,9/18E! :hb! jbck! 74.! %,_/->>7!
K814-00/!jlok;!!%B1,4/+!-40-1,9/18E!/4D-+0/,4!,D!0B-!E0,C7+B!74.!7>0-1-.!>-9->E!,D!#!J7+0/+!7+/.!
51,.8+/4?!K7+0-1/7!/4!0B-!?7E01,/40-E0/47>!017+0!B79-!K--4!/49-E0/?70-.!jlg$!bek;!!!(,EE/K>@!0B-!
/4/0/7>!/4D-+0/,4!.7C7?-E!5710!,D!0B-!%LI!74.!/CC84-!E@E0-C!+78E/4?!51,D,84.!.-1-?8>70/,4!
74.!7K4,1C7>!1-E5,4E-E!0,!/4D-+0/,4E!jek;!!!(8K>/+70/,4E!.-E+1/K-!.-+1-7E-.!470817>!O/>>-1!+->>!
E/?47>>/4?! 74.! D84+0/,4$! 7K4,1C7>! ?1,N0B! D7+0,1! 51,D/>-E$! .-+1-7E-.! 4-801,5B/>! 1-E5/170,1@!
K81E0E!74.!XBh$!N/0B!7!EB/D0!0,N71.E!7!XBm!51,D/>-!jeZl$!bg$!bnk;!!%B1,4/+!/CC84-!7+0/970/,4!
jmok$!/4+1-7E-E!/4!/4D>7CC70,1@!+@0,O/4-E$!51,Z/4D>7CC70,1@!7>>->-E!!jeZl$!boZbbk$!+B-C,O/4-E!
74.!X!>@C5B,+@0-E$!74.!.@E1-?8>70/,4!,D!0B-!740/9/17>!1/K,4-8+>-7E-!J!)'L7E-!J*!570BN7@!jne$!
hffZhfck!C7@!5>7@!7!1,>-!/4!+78E/4?!D>8Z>/O-!E@C50,CE$!NB/+B!7K-11740>@!D>71-!/4!1-E5,4E-!0,!
-_-10/,4!jg$!bgk;!!!!
!
9L M3%"C7&A"/4#$*0/3N?")3,D/"*&1=D)0"=%3*,&
!!!!XB-! +,4E/E0-40! +>/4/+7>! 5/+081-!,D! 51,D,84.!-4-1?@! /C57/1C-40! E8??-E0E!.@E1-?8>70/,4!,D!
0B-!C/0,+B,4.1/7!74.!+->>8>71!-4-1?@!C-07K,>/EC!74.!/,4!0174E5,10$!74.!+B744->,570B@!jbZ
hh$!hfc$!hfek;!!A!K/,+B-C/+7>!5,E/0/9-!D--.K7+O!+@+>-!+7>>-.!0B-!qLQMQLQQZ!+@+>-a!C7@!5>7@!7!
1,>-! /4!C7/407/4/4?! 0B-! +B1,4/+! 47081-! ,D!"<$! 0B-! 51-E-4+-! ,D! ,_/.70/9-! E01-EE! jhfgZhfok$!
/4D>7CC70,1@!+@0,O/4-!->-970/,4!jboZbbk!74.!C/0,+B,4.1/7>!.@ED84+0/,4!jhflZhhhk$!74.!1-E8>0!
/4!1-.8+-.!K>,,.!D>,N!74.!97E+8>,570B@!jhfb$!hhfk;!!!!!!!
!!!!&/4./4?E! ,D& ]EC7>>! B-710^! N/0B! EC7>>! >-D0! 9-401/+8>71! +B7CK-1! 74.! 5,,1! +71./7+!
5-1D,1C74+-! /4! 570/-40! E8KE-0E! jhhm$! hhck! E855,10! 51-9/,8E! 1-5,10E! ,D! +71./7+! 74.! >-D0!
9-401/+8>71! .@ED84+0/,4! jhheZhhnk$! NB/+B! 51-./E5,E-! 0,! ,10B,E070/+! /40,>-174+-! jhe$! hhok;!!
J,N! K>,,.! 51-EE81-! 74.! -_7??-170-.! ./8147>! 971/70/,4! C7@! K-! .8-! 0,! 7K4,1C7>! K>,,.!
51-EE81-! 1-?8>70/,4! jhhlk;! ! A>0-1-.! +,401,>! 74.! 1-.8+-.! +,10/E,>! 51,.8+0/,4! .81/4?! 74.!
D,>>,N/4?! -_-1+/E-! C7@! K-! /49,>9-.;! ! Q10B,E070/+! /40,>-174+-! /E! 7EE,+/70-.! N/0B! D84+0/,47>!
/C57/1C-40! 74.! E@C50,C! E-9-1/0@! jhhbk;! !"-7E817K>-! 97E+8>71! 7K4,1C7>/0/-E! E8??-E0! 0B70!
0B-!K17/4!/E!4,0!1-+-/9/4?!E8DD/+/-40!+/1+8>70/4?!K>,,.!9,>8C-!/4!74!851/?B0!5,E/0/,4!jhm$!hhok$!
NB/+B! /E! /40-4E/D/-.! NB-4! E074./4?! /4! ,4-! 5>7+-! E8+B! 7E! 7! ?1,+-1@! E0,1-! +B-+OZ,80! >/4-;!!
I/?4/D/+740! 1-.8+0/,4! /4! B-710! 170-! 971/7K/>/0@! .81/4?! E>--5! /E! 7EE,+/70-.! N/0B! 5,,1! E>--5!
d87>/0@!74.!E8??-E0E!7!5-197E/9-!E070-!,D!4,+08147>!E@C570B-0/+!B@5-19/?/>74+-!jhmfk;
!
@DD:0$)*0/3&/K&("0*%"0)&
!!!#/7?4,E0/+! +1/0-1/7! E-19-! 0N,! 4-+-EE71@! K80! ./9-1?-40! D84+0/,4E! W! 0B-! D/1E0! /E! ./7?4,E/4?!
/4./9/.87>E!/4!7!+>/4/+7>!E-00/4?!74.!0B-!E-+,4.!/E!/.-40/D@/4?!570/-40!E-0E!D,1!1-E-71+B!E08./-E;!!!
&
@L (:030$):&@DD:0$)*0/3&&!
OL <%3%"):&(/3,04%")*0/3,!!!!
)L "#$#%&'(#! )*#$*#%! +,&-$.&! /01+$#%! -2$$#%(+! 2%#! /.(3%1#($! N/0B! 0B,E-! -_5-+0-.!
D1,C!.@ED84+0/,4!,D!74!84.-1>@/4?!+78E7>!E@E0-C;!!!!
GL 4,&-$.&+! '($#%2/$!5,(2&'/200,!N/0B/4!7! E07K>-! +>8E0-1&K-+78E-! 0B-@! EB71-! 0B-! E7C-!
.--5!+78E7>! 1,,0E;!(70/-40Ea! +,40-_087>!,KE-1970/,4E!71-!-EE-40/7>! /4!.-0-1C/4/4?! 0B-!
-_51-EE/,4!,D!/40-17+0/,4!,D!E@C50,C!5700-14E!74.!E-9-1/0@!,D!0B-/1!/C57+0;!!
$L 4,&-$.&! +#6#%'$,! '&-2/$! C8E0! 1-E8>0! /4! 7! gfi! ,1! ?1-70-1! 1-.8+0/,4! ,D! 7! 570/-40aE!
D"%=/"G04!7+0/9/0@!>-9->!D,1!7!./7?4,E/E!,D!"<;!!'0:4V!7551,_/C70->@!gfi!1-.8+0/,4!/4!
7+0/9/0@$!=/4%")*%P!C,E0>@! B,8E-K,84.$! ,%2%"%P!C,E0>@! K-.K,84.$! 74.!2%"7& ,%2%"%P!
K-.K,84.!74.!.-5-4.-40!,4!B->5!D,1!5B@E/+7>!D84+0/,4E;!
4L 4,&-$.&! +#6#%'$,! *'#%2%/*,! EB,8>.! K-! .-0-1C/4-.! 5-1/,./+7>>@! 0,! B->5! ,1/-40! 74.!
C,4/0,1!01-70C-40;&!
%L 7%'$#%'20!+183%.1-+9!!(,E0Z-_-10/,47>!4-81,/CC84-!-_B78E0/,4!/E!0B-!B7>>C71O!D-7081-;!!
30! C7@! K-! B->5D8>! 0,! E8K?1,85! 7++,1./4?! 0,! NB/+B! ,D! 0B-! ,0B-1! ./7?4,E0/+! +1/0-1/7>!
5700-14E! K-E0! 1-51-E-40! 7! 570/-40aE! +>8E0-1! ,D! C,E0! E-9-1-! E@C50,CEV! 4-81,>,?/+7>$!
/CC84-$! -4-1?@! C-07K,>/ECM0174E5,10$! ,1! -+>-+0/+! )E@C50,CE! N/.->@! ./E01/K80-.!
7C,4?!E8K?1,85E*;!!
KL 4#-2%2$#!-%'&2%,!+,&-$.&+!:%.&!+#/.(52%,!+,&-$.&+!2(5!233%262$.%+;!#/E0/4?8/EB!
51/C71@! E@C50,C!+,C5>-_-E! D,1C-.!K@! 7!./E-7E-!51,+-EE! D1,C! E-+,4.71@!-DD-+0E!,D!
+,5/4?!N/0B! 0B-! ./E-7E-$! E8+B! 7E! 74_/-0@! 7K,80! D/474+-E;! !#-0-1C/4-! 0B-! -DD-+0E! 74.!
K81.-4! ,D! 7??17970,1E! 74.! E01-EE! -4B74+-1E! E8+B! 7E! D7E0! 57+-.! -49/1,4C-40E! 74.!
-_5,E81-!0,!0,_/4E;!
CL "#$#%&'(#!$.$20!'00(#++!81%5#(!8,!2++#++'(3!+,&-$.&!+#6#%'$,<!'($#%2/$'.(!2(5!.6#%200!
'&-2/$;!!%,4E/.-1!7>>!7E5-+0E!,D!0B-!570/-40aE!>/D-!W!5B@E/+7>$!,++8570/,47>$!-.8+70/,47>$!
E,+/7>!74.!5-1E,47>!7+0/9/0/-E!,D!.7/>@!>/9/4?;!!(70/-40E!NB,!51/,1/0/`-!0B-/1!7+0/9/0/-E!C7@!
K-!7K>-! 0,!.,!,4-! /C5,10740! 7+0/9/0@!K@!->/C/470/4?!,1! E-9-1->@! 1-.8+/4?! 7+0/9/0/-E! /4!
,0B-1!7E5-+0E!,D!0B-/1!>/D-;!
+L =*#! >($#%(2$'.(20! 4,&-$.&! 4/20#! EB,8>.! 4,0! K-! 5710! ,D! 0B-! /4/0/7>! +>/4/+7>! /40-19/-N!
K-+78E-! /0! C7@! ./E081K! 0B-! N-/?B0/4?! 74.! E/?4/D/+74+-! ,D! 1-E8>0E! ,K07/4-.! D,1! 74!
/4./9/.87>!570/-40;!
GL %B/>.1-4! +744,0! K-! -_5-+0-.! 0,! F8.?-! 51-Z/>>4-EE! D84+0/,4! N/0B! +811-40! D84+0/,4;!
AEE-EE!/C57+0!K@!+,C571/4?!B,KK/-E$!-.8+70/,47>$!E,+/7>!74.!E5,10!7+0/9/0/-E!0B-!+B/>.!
5710/+/570-.!/4!K-D,1-!/>>4-EE!N/0B!51-E-40!7+0/9/0@!>-9->;!
$L %B/>.1-4!C7@!755-71! /11/07K>-!NB-4!0B-@!71-!7EO-.!0,!.,!E,C-0B/4?!NB-4!0B-@!D-->!
-_B78E0-.;! ! Q4! 0B-! ,0B-1! B74.$! 0B-@! 71-! ,D0-4! 7K>-! 0,! 7++,CC,.70-! D70/?8-! K@!
1-E0/4?$!NB/+B!C7@!K-!/47551,51/70->@!/40-151-0-.!7E!K-/4?!>7`@;!
4L 4/*..0! ?*.8'29! Y,84?! 570/-40E! E5-4.! C,E0! ,D! 0B-/1! ,80Z,DZE+B,,>! B,81E! 1-E0/4?!
NB-1-7E!+B/>.1-4!N/0B!E+B,,>!5B,K/7!N/>>!K-!E,+/7>/`/4?!74.!5710/+/570/4?!/4!7+0/9/0/-E;!!
H,N-9-1$! /0! /E! 5,EE/K>-! 0B70! E+B,,>! 5B,K/7! C7@! K-+,C-! 7! E-+,4.71@! E@C50,C!
K-+78E-!,D!K8>>@/4?!,1!7+7.-C/+!./DD/+8>0/-E!.8-!0,!B79/4?!"<;!
%L @2$1%20!7.1%+#9! %B/>.1-4!+74!K-!9-1@! E-9-1->@!7DD>/+0-.!K80! 0B,E-!NB,E-! E@C50,CE!
71-! ,D! C/>.! 0,! C,.-170-! E-9-1/0@! ?-4-17>>@! 71-! C,1-! >/O->@! 0,! B79-! 0B-C! ?,! /40,!
1-C/EE/,4!0B74!7.8>0E;!!(1,?4,E/E!+744,0!K-!51-./+0-.!N/0B!+-107/40@;!
&
!L&E%,%)"$+&@DD:0$)*0/3&&&
!!!!!!!!!A! +>/4/+7>! ./7?4,E/E! C8E0! K-! +,4D/1C-.! K-D,1-! 7! 570/-40! +74! 51,9/.-! 8E-D8>! ?-4-17>!
O4,N>-.?-! 7K,80! 0B-! ./E-7E-;! XB-! .707! ,K07/4-.! D1,C! 570/-40E! 7>>,NE! +,401,>>-.! 74.!
C-74/4?D8>!,KE-1970/,4E!74.!E8??-E0E!B@5,0B-E-E!0,!K-!0-E0-.!74.!+,4D/1C-.!,1!1-D80-.;!!
&
OL <%3%"):&(/3,04%")*0/3,&
)L ?2$'#($+!+*.105!&##$!$*#!:100!/%'$#%'2!D,1!-5/.-C/,>,?/+7>!E08./-E;!3D!E5-+/D/+!E8K?1,85E!
,1!70@5/+7>!"<!71-!/4+>8.-.!/4!7!1-E-71+B!E08.@$!0B70!EB,8>.!K-!+>-71>@!/4./+70-.;!&
GL 4-#/':'/'$,9!:-+78E-!+1/0/+7>! E@C50,CE!71-! +,C58>E,1@$! /0! -4E81-E!51,5-1! E->-+0/,4!,D!
570/-40E;! ! P-@! ,5-170/,47>! ?8/.->/4-E! -4B74+-! +>71/0@! 74.! E5-+/D/+/0@;! ! '74O/4?! 0B-!
B/-171+B@!,D!0B-!C,E0!01,8K>-E,C-!E@C50,CE!C7@!K-!B->5D8>!/4!E,C-!E08./-E;&
$L A#0'28'0'$,9&I@C50,CE!C8E0!4,0!K-!9/-N-.!7E!7!4,C/47>! +B-+O>/E0;! ! XB-! 340-1470/,47>!
%,4E-4E8E! %1/0-1/7! D,+8E! ,4! E@C50,C! 5700-14E$! NB/+B! /4+1-7E-! 1->/7K/>/0@;! XB-!
13*%"3)*0/3):&57=D*/=&5$):%&-4E81-E!+,4E/E0-4+@!/4!0B-!N7@!d8-E0/,4E!71-!7EO-.!74.!
D810B-1! /4+1-7E-E! 1->/7K/>/0@! ,D! .707! +,>>-+0-.! /4! ./DD-1-40! >,+70/,4E;! & ! (70/-40E! EB,8>.!
+,C5>-0-!0B-!340-1470/,47>!I@C50,C!I+7>-&D"0/"&*/&%3*%"03C&)&"%,%)"$+&,*#47;&
&
QL RD*0/3):&(/3,04%")*0/3,&
%>7EE/D@/4?!570/-40E!K@!E8K?1,85E!0,!-47K>-!+,C571/E,4!,D!570/-40E!N/0B/4!0B-!./7?4,E/E!,D!
"<!C7@!K-!B->5D8>!/4!E,C-!E08./-E;!!&
)L B(+#$9!7+80-!/4D-+0/,8E!,1!?17.87>!
GL B(+#$!+#6#%'$,!C7@!K-!7!?,,.!51-./+0,1!,D!E-9-1/0@!/4!0B-!+B1,4/+!5B7E-;!
$L 4,&-$.&!+#6#%'$,9!C/>.$!C,.-170-$!E-9-1-$!9-1@!E-9-1-!!!
4L 7%'$#%'20!+183%.1-+9!4-81,>,?/+7>$!/CC84-$!-4-1?@!C-07K,>/ECM0174E5,10$!,1!-+>-+0/+!!
&&&&&&&&&&&&&&&&"#$$!%&'('%)&!)**&'%)+',(!-,.!/01*+,1!/$2$.'+0!)(3!%.'+$.')&!/456.,4*/78!
!
(/3$:#,0/3,&
!XB-! 340-1470/,47>! %,4E-4E8E! %1/0-1/7! 51,9/.-! 7! D17C-N,1O! D,1! 0B-! ./7?4,E/E! ,D! "<! 0B70! /E!
+,4E/E0-40! N/0B! 0B-! 5700-14E! ,D! 570B,5B@E/,>,?/+7>! .@ED84+0/,4! -C-1?/4?! D1,C! 58K>/EB-.!
1-E-71+B!D/4./4?E!74.!+>/4/+7>!-_5-1/-4+-;!!I@C50,C!5700-14E!/40-17+0!.@47C/+7>>@!K-+78E-!0B-@!
71-!+78E7>>@!+,44-+0-.;!!XB/E!B7E!K--4!D,1C7>>@!7..1-EE-.!K@!E,C-!/49-E0/?70,1E!NB,!B79-!8E-.!
N->>Z-E07K>/EB-.! C8>0/971/70-! E070/E0/+7>! 0-+B4/d8-E$! E8+B! 7E! +,CC,4! D7+0,1! ,1! 51/4+/57>!
+,C5,4-40!747>@E-E!0,!/.-40/D@!E@C50,C!+,4E018+0E!jhmh$!hmmk;!!Q0B-1E!B79-!-_0-4.-.!0B-!8E-!
,D!E8+B!C-0B,.E!0,!?8/.-!0B-!747>@E/E!,D!?-4-!-_51-EE/,4!51,D/>-E!jmlk!74.!0,!.->/4-70-!570/-40!
E8KZ?1,85E! jhmck;! %,4E/E0-40! N/0B! 0B/E! 7551,7+B$! 0B-! 574->! /E! .-9->,5/4?! 74! 340-1470/,47>!
%,4E-4E8E! I@C50,C! I+7>-! )3%II*! 0B70!N/>>! K8/>.! ,4! 0B-E-! 84.-1>@/4?! /40-17+0/,4E;! H,N-9-1! 7!
4-+-EE71@! D/1E0! E0-5! /4! -E07K>/EB/4?! 7! d8740/070/9-! E+,1-! D,1! 74@! ./7?4,E0/+! /4E018C-40! /E! 0B-!
E5-+/D/+70/,4! ,D! C-7E817K>-! D7+0,1E! 0B70! 71-! C,E0! 1->-9740! 0,! 0B-! />>4-EE;! ! <E07K>/EB/4?! E8+B!
+1/0-1/7! N7E! 0B-! 51/C71@! ,KF-+0/9-! ,D! 0B/E! N,1O! 74.! N-! K->/-9-! 0B-! 340-1470/,47>! %,4E-4E8E!
%1/0-1/7!N/>>!B->5!+>71/D@!0B-!84/d8-!E/?47081-!,D!"<;!!!
!!!!!30!/E!/C5,10740!0,!4,0-!0B70!0B-!+811-40!-C5B7E/E!C8E0!51/C71/>@!1-C7/4!7!+>/4/+7>!7EE-EEC-40$!
N/0B! E->-+0/,4! ,D! 1-E-71+B! E8KF-+0E! +,C/4?! >70-1;! &,1! 0B/E! 1-7E,4! 0B-! 574->! /E! .-9->,5/4?!
(B@E/+/74Ea! =8/.->/4-E$! NB/+B! N/>>! /4+>8.-! ./7?4,E0/+! 51,0,+,>! K7E-.! ,4! 0B-! 340-1470/,47>!
%,4E-4E8E! %1/0-1/7! 74.! 01-70C-40! ?8/.->/4-E! 0B70! 1-D>-+0! +811-40! O4,N>-.?-;! 34./9/.87>E!
C--0/4?! 0B-! 340-1470/,47>! %,4E-4E8E! %1/0-1/7! B79-! C@7>?/+! -4+-5B7>,C@->/0/E! 74.! EB,8>.! K-!
1-C,9-.! D1,C! 0B-! '--9-E! -C5/1/+7>! +1/0-1/7! 74.! 0B-!L70/,47>! 34E0/080-! D,1! %>/4/+7>! <_+->>-4+-!
)L3%<*!+1/0-1/7!D,1!+B1,4/+!D70/[email protected],C-;!!XB-E-!?8/.->/4-E!71-!.-E/?4-.!E5-+/D/+7>>@!D,1!8E-!
K@!0B-!51/C71@!+71-!5B@E/+/74!/4!0B-!B,5-!,D!/C51,9/4?!175/.!./7?4,E/E!74.!01-70C-40!K@!D/1E0Z
>/4-!C-./+7>! +71-!51,9/.-1E;! ! XB/E!C7@! 1-E8>0! /4! 0B-!.-9->,5C-40!,D! 74!7../0/,47>! EB,10! D,1C!
9-1E/,4! 0B70!N,8>.! K8/>.! ,4! 0B-! 1->70/,4EB/5E! >/4O/4?! E@C50,CE! 0,! D,1C8>70-! 74! 7KK1-9/70-.!
E+1--4/4?!51,0,+,>;!!&,1!0B-!D/1E0!0/C-!+>/4/+7>$!57-./701/+!74.!1-E-71+B!755>/+70/,4E!71-!51,9/.-.$!
NB/+B!N/>>!7.974+-!0B-!84.-1E074./4?!,D!C@7>?/+!-4+-5B7>,C@->/0/E!74.!-4B74+-!+,4E/E0-4+@!,D!
./7?4,E-E! /40-1470/,47>>@;! ! XB-! +,C58>E,1@! +1/0/+7>! +1/0-1/7! 7>>,N! +,C5717K>-! .707! 0,! K-!
+,>>-+0-.! /4!971/,8E! >,+70/,4E!74.!C7@!7EE/E0! /4!.-9->,5/4?!+,4E/E0-40!K/,C71O-1E!74.! D810B-1!
/4E/?B0E!/40,!0B-!C-+B74/EC!74.!-0/,>,?@!,D!C@7>?/+!-4+-5B7>,C@->/0/E;!
&
6MS&TRE95P&C@7>?/+!-4+-5B7>,C@->/0/E$!+B1,4/+!D70/[email protected],C-$!+1/0-1/7$!.-D/4/0/,4$!./7?4,E/E;!
U#3403C&
XB/E!%,4E-4E8E!575-1!/E!D1--!,D!E5,4E,1EB/5;!!!A>>!780B,1E!+,401/K80-.!0B-/1!0/C-!74.!-_5-10/E-!
,4!7!9,>840--1!K7E/E!74.!4,!,4-!1-+-/9-.!74@!57@C-40E!,1!B,4,171/8CE;!
(/3K:0$*&/K&13*%"%,*&5*)*%=%3*L&!
A>>!780B,1E!B79-!./E+>,E-.!5,0-40/7>!+,4D>/+0E!,D!/40-1-E0!74.!7>>!C-CK-1E!.-+>71-!0B70!0B-@!B79-!
4,!+,C5-0/4?!/40-1-E0E;!!
@$>3/B:%4C%=%3*,&
XB-!574->!N,8>.!>/O-!0,!?170-D8>>@!7+O4,N>-.?-!0B-!5710/+/570/,4!74.!E855,10!,D!0B-!570/-40E!
74.!0B-/1!D7C/>/-E!/4!0B-!1-E-71+B!.-E+1/K-.!B-1-/4!74.!85,4!NB/+B!0B-E-!?8/.->/4-E!71-!K7E-.;!
&
@#*+/"&(/3*"0G#*0/3,!
(/%40*/",&H&$/3$%D*0/3-&4")K*03C&/K&D)D%"&)34&"%20,0/3,P&&:;";!%71180B-1E$!";3;!974!.-!I74.-;!
!
130*0):&,#CC%,*0/3,&)34&,#G,%V#%3*&$"0*0$):&"%20%B,P&&P;J;!#-!"-/1>-/1$!L;=;!P>/C7E$!=;!:1,.-1/+O$!
X;!"/0+B->>$!#;!I07/4-E$!A;%;(;!(,N>-E$!L;!I5-/?B0$!';!67>>/4?E$!!J;!:70-C74$!:;!:78C?710-4Z
A8E01B-/C$!#;I;!:->>$!L;!%71>,ZI0->>7$!S;!%B/7$!!A;!#7117?B$!#;!S,$!#;!J-N/E$!A;';!J/?B0$!I;!"71EB7>>Z
=17./EK/O$!!3;!"-47$!S;A;!"/O,9/0E$!P;!"/N7$!";!"81,9EO7$!";J;!(7>>$!I;!I0-9-4E;!
!
U03):&)DD"/2):&)34&$/3,%3,#,P&&XB-1-!N7E!hffi!+,4E-4E8E!K@!0B-!780B,1E!,4!0B-!D/47>!
+,4E-4E8E!575-1;&&:;!";!%71180B-1E$!";!3;!974!.-!I74.-$!P;J;!#-!"-/1>-/1$!L;=;!P>/C7E$!=;!
:1,.-1/+O$!X;!"/0+B->>$!#;!I07/4-E!$!A;%;(;!(,N>-E$!!L;!I5-/?B0$!!';!67>>/4?E$!J;!:70-C74$!:;!
:78C?710-4ZA8E01B-/C$!#;I;!:->>$!L;!%71>,ZI0->>7$!S;!%B/7$!!A;!#7117?B$!#;!S,$!#;!J-N/E$!A;';!J/?B0$!
I;!"71EB7>>Z=17./EK/O$!3;!"-47$!S;A;!"/O,9/0E$!P;!"/N7$!";!"81,9EO7$!";J;!(7>>$!I;!I0-9-4E;!
!
(/3,%3,#,&(//"403)*/"P!!";!974!.-!I74.-!
!
!E%K%"%3$%,&
h; X/1->>/!G$!%B/-1/+B-00/!&$!X79/,!"$!I/C,4->>/!%$!:/74+B/4!=$!U74+,!($!&-1>/4!=;!:17/4!5,E/01,4!
-C/EE/,4!0,C,?175B@!)(<X*!/4!+B1,4/+!D70/[email protected],C-V!51->/C/471@!.707;!!91$.!:!;$3!
hbbl2!OWXV!geIZlI;!!j("3#V!bobfelck!!
m; %,,O!#:$!J74?-!=$!#-J8+7!S$!L70->E,4!:H;!!'->70/,4EB/5!,D!K17/4!"'3!7K4,1C7>/0/-E!74.!
5B@E/+7>!D84+0/,47>!E0708E!/4!+B1,4/+!D70/[email protected],C-;!!<(+!:!=$4.,/%'!!mffh2!OWYV!hZn;!
j("3#V!hhcmlnobk
c; %B-4!'$!J/74?!&p$!",1/@7!S$!Y7C7O7N!S$!I8C/4,!H$!P74.7!X$!Takahashi T;!!%B1,4/+!D70/?8-!
[email protected],C-!74.!0B-!+-4017>!4-19,8E!E@E0-C;!!:!<(+!;$3!>$/!mffl2!Z[P!lnoZoe;!!j("3#V!
hllchlolk
e; :1,.-1/+O!=$!&8/0-!S$!P1-/0`!A$!6-14,4!I#$!P>/C7E!L$!&>-0+B-1!"A;!!A!D,1C7>!747>@E/E!,D!
+@0,O/4-!4-0N,1OE!/4!+B1,4/+!D70/[email protected],C-;!?.)'(!?$@)2!<114(!!mfhf2!Q\P!hmfbZho;!!
j("3#V!mfeeoegck;
g; J,18EE,!J$!"/OB7@>,97!I[$!%75->>/!<$!&-1171/!#$!L?,4?7!=P$!'/+-980/!=;!!3CC84,>,?/+7>!
7E5-+0E!,D!+B1,4/+!D70/[email protected],C-;!!94+,'114(!>$2!!mffb2!]P!mloZbh;!j("3#V!hllfhengk
n; &>-0+B-1!"A$!U-4?!p'$!"7B-1!P$!-0!7>;!:/,C71O-1E!/4!+B1,4/+!D70/[email protected],C-V!<97>870/,4!
,D!470817>!O/>>-1!+->>!D84+0/,4!74.!./5-50@>!5-50/.7E-!36;!!AB,#!C=D!!mfhf2!XV!-hflho;!!j("3#V!
mfgmflcok!
o; "/B7@>,97!3$!#-'8@0-1!"$!'8CC-4E!SJ$!:7EC74E!<$!"7-E!";!!#-+1-7E-.!-_51-EE/,4!,D!%#nb!
/4!+B1,4/+!D70/[email protected],C-!/4!1->70/,4!0,!/4D>7CC70,1@!C71O-1EV!-9/.-4+-!D,1!7!E-9-1-!
./E,1.-1!/4!0B-!-71>@!7+0/970/,4!,D!X!>@C5B,+@0-E!74.!470817>!O/>>-1!+->>E;!!=$4.,!D(3,%.'(,&!
B$++!!mffo2!Q]P!eooZlc;!!j("3#Vhonbcbook
l; P>/C7E!L=$!I7>970,!&'$!",1?74!'$!&>-0+B-1!"A;!3CC84,>,?/+!!7K4,1C7>/0/-E!/4!+B1,4/+!
D70/[email protected],C-;!!:!E&'(!;'%.,5',&!hbbf2!Q]P!hefcZhf;!!j("3#V!mhnnflek!
b; "@B/>>!I$!:,,0B!L<$!"+J71-4ZH,N71.!S;!!%B1,4/+!D70/[email protected],C-!74.!C/0,+B,4.1/7>!
.@ED84+0/,4;!!<(+!:!E&'(!!DF*!;$3!!mffb2!QP!hZhn;!!j("3#V!hbecnlmok
hf; (/-+`-4/O!I'$!L-8E07.0!S;!!"/0,+B,4.1/7>!.@ED84+0/,4!74.!C,>-+8>71!570BN7@E!,D!./E-7E-;!!
DF*!;,&!A)+@,&!mffo2!]ZP!leZbm;!!j("3#V!homcbcofk
hh; :-B74!["$!",1-!3A$!:-B74!(Q;!!"/0,+B,4.1/7>!7K4,1C7>/0/-E!/4!0B-!5,E09/17>!D70/?8-!
[email protected],C-;!!9%+)!=$4.,*)+@,&!hbbh2!]ZP!nhZg;!!j("3#V!hobmlngk
hm; I01--0-4!#H$!XB,C7E!#$!:->>!#I;!!XB-!1,>-E!,D!,10B,E070/+!B@5,0-4E/,4$!,10B,E070/+!
07+B@+71./7!74.!E8K4,1C7>!-1@0B1,+@0-!9,>8C-!/4!0B-!570B,?-4-E/E!,D!0B-!+B1,4/+!D70/?8-!
[email protected],C-;!!91!:!;$3!mfff2!ZQWP!hZl;!j("3#V!hfbhfcnnk
hc; (-+O-1C74!A$!J7"74+7!SS$!#7B>!PA$!%B-C/0/?740/!'$!R81-/EB/!:$!L70->E,4!:H;!!AK4,1C7>!
/C5-.74+-!+71./,?175B@!51-./+0E!E@C50,C!E-9-1/0@!/4!%B1,4/+!&70/[email protected],C-;!!91!:!
;$3!#%'!!mffc2!ZQ[P!ggZnf;!j("3#V!hmbmfecgk!!!!!!
he; H,>>/4?EN,10B!P=$!S,4-E!#<$!X7@>,1!'$!:>7C/1-!A"$!L-N0,4!SJ;!!3C57/1-.!+71./,97E+8>71!
1-E5,4E-!0,!E074./4?!/4!+B1,4/+!D70/[email protected],C-;!!D4.!:!E&'(!<(2$/+!mfhf2!\WP!nflZhg;!
j("3#V!mfeboenhk
hg; IB715-!"%$!A1+B71.!J%$!:747097>7!S<$!-0!7>;!!A!1-5,10!Z!+B1,4/+!D70/[email protected],C-V!!?8/.->/4-E!
D,1!1-E-71+B;!!:!>!#,%!;$3!hbbh2!]\P!hhlZmh;!j("3#V!hbbblhck
hn; '--9-E![%$![7?4-1!#$!L/E-4K78C!'$!-0!7>;!!%B1,4/+!D70/[email protected],C-!W!7!+>/4/+7>>@!
-C5/1/+7>!7551,7+B!0,!/0E!.-D/4/0/,4!74.!E08.@;!!?;E!;$3!mffg2!ZP!hb;!j("3#V!hncgnholk
ho;!!&8O8.7!P$!I0178E!I<$!H/+O/-!3$!IB715-!"%$!#,KK/4E!S=$!P,C71,DD!A$!74.!0B-!340-1470/,47>!
%B1,4/+!&70/[email protected],C-!I08.@!=1,85;!!%B1,4/+!&70/[email protected],C-V!7!+,C51-B-4E/9-!
7551,7+B!0,!/0E!.-D/4/0/,4!74.!E08.@;!!9((!<(+$.(!;$3!hbbe2!OQOP!bgcZgb;!j("3#V!obolommk
hl; S7E,4!!JA$!L7F71!L$!(,10-1!L$!'-B!%;!!<97>870/4?!0B-!%-40-1E!D,1!#/E-7E-!%,401,>aE!-C5/1/+7>!
+B1,4/+!D70/[email protected],C-!+7E-!.-D/4/0/,4;!!:!G'/)5'&!A,&!#+43'$/!!mffb2!QWP!bhZhff;!!
.,/Vhf;hhooMhfeemfocflcmgbbg!!A++-EE-.!,4!hfMfmMmfhh!70!!!
B005VMM.5E;E7?-58K;+,CM+,40-40MmfMm;0,+!!!
hb; S7E,4!!JA$!%B,/!";!!#/C-4E/,4E!74.!7EE-EEC-40!,D!D70/?8-;!!34V![70747K-!Y$!<9-4?71.!:$!
L70->E,4!:H$!S7E,4!JA$!P8170E84-!H$!-.E;!!H)+'64$!#%'$(%$!I41)(!I$)&+@;!!X,O@,V!I51/4?-12!
mfflV!hZhn;!!
mf; %71180B-1E!:"$!S7/4!AP$!#-!"-/1>-/1!PJ$!-0!7>;!!"@7>?/+!<4+-5B7>,C@->/0/EM%B1,4/+!&70/?8-!
[email protected],C-V!!%>/4/+7>![,1O/4?!%7E-!#-D/4/0/,4$!#/7?4,E0/+!74.!X1-70C-40!(1,0,+,>E;!!:!EH#!!
mffc2!OO^O_P!oZhhn;!!A++-EE-.!,4!mfMfcMmfhh!70!
B005VMMNNN;C-DC7+0/,4;+,CM/C7?-EME0,1/-EM"-./+7>M"<Z%&IZ%,4E-4E8EZ#,+8C-40;5.D!!
mh; S7E,4!JA$!X,11-EZH71./4?!I'$!S81?-4E!A$!H->?-1E,4!S;!!%,C571/4?!0B-!&8O8.7!-0!7>;!%1/0-1/7!
74.!0B-!%747./74!%7E-!#-D/4/0/,4!D,1!%B1,4/+!&70/[email protected],C-;!!:!EH#!!mffe2!OQP!coZgm;!
A++-EE-.!,4!hfMfmMmfhh!70!!B005VMMNNN;+D/.EZ+7K;,1?M+DEZ
/4D,1CM%&I;+7E-;.-DMF7E,4;-07>fe;5.D!!!!!
mm; #-!:-+O-1!($!"+=1-?,1!L$!#-!"-/1>-/1!P;!!A!.-D/4/0/,4!WK7E-.!747>@E/E!,D!E@C50,CE!/4!7!
>71?-!+,B,10!,D!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-;!!:!<(+$.(!;$3!mffh2!QXWP!mceZef;!
j("3#V!hhggghmlk
mc; ',N-!PI$!',N-!PS;!!I@C50,C!5700-14E!,D!+B/>.1-4!74.!7.,>-E+-40E!N/0B!+B1,4/+!D70/?8-!
[email protected],C-;!!34V!I/4?B!LL$!Q>>-4./+O!XH!\!I/4?B!AL$!-.E;!<(+$.(!A$./*$%+'2$!E@'&3!
93,&$/%$(%$!;$(+)&!I$)&+@7!!Q_D,1.V!<>E-9/-1!I+/-4+-!J0.2!mffm2!^2/:&Q_P!cbgZemh;
me; P78EB/O!L$!&-71!#$!'/+B71.E!I%$!-0!7>;!!=-4-!-_51-EE/,4!/4!5-1/5B-17>!K>,,.!C,4,48+>-71!
+->>E!D1,C!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-;!:!E&'(!A)+@,&!!mffg2!X]P!lmnZlcm;!j("3#V!
hnfebmlek
mg; P-11!S'$!:81O-!:$!(-00@!'$!-0!7>;!!I-9-4!?-4,C/+!E8K0@5-E!,D!+B1,4/+!D70/?8-!
[email protected],C-MC@7>?/+!-4+-5B7>,C@->/0/E2!7!.-07/>-.!747>@E/E!,D!?-4-!4-0N,1O!74.!+>/4/+7>!
5B-4,0@5-E;!!:!E&'(!A)+@,&!mffl2![OP!ocfZocb;!j("3#V!hlfgofolk
mn; P-11!S'$!(-00@!'$!:81O-!:$!=,8?B!S$!&-71!#$!I/4+>7/1!J3$!-0!7>;!!=-4-!-_51-EE/,4!E8K0@5-E!/4!
570/-40E!N/0B!+B1,4/+!D70/[email protected],C-MC@7>?/+!-4+-5B7>,C@->/0/E;!!:!<(-$%+!G'/!mffl2!O`YP!
hhohZle;!j("3#V!hlenmhnek
mo; AE5>-1!AJ$!:,>EB/4!%$!6-14,4!I#$!:1,.-1/+O!=;!!<9/.-4+-!,D!34D>7CC70,1@!3CC84-!I/?47>>/4?!
/4!%B1,4/+!&70/[email protected],C-V!A!(/>,0!I08.@!,D!=-4-!<_51-EE/,4!/4!(-1/5B-17>!:>,,.;!?$@)2!
?.)'(!H4(%+!!mffl2!\P!ee;!.,/Vhf;hhlnMhoeeZbflhZeZee;!!j("3#V!hllmmheck
ml; :1,.-1/+O!=$!%17..,+O!'%$![B/E0>-1!X$!X7@>,1!'$!P>/C7E!L$!G4?-1!<';!3.-40/D@/4?!/>>4-EE!
5717C-0-1E!/4!D70/?8/[email protected],C-E!8E/4?!+>7EE/+7>!51,F-+0/,4!C-0B,.E;!A@).1)%,6$(,1'%/!
mffn2!YV!efoZhb;!!j("3#V!hnnhfbghk!
mb; J/?B0!A'$![B/0-!AX$!H8?B-4!'[$!J/?B0!P%;!!",.-170-!-_-1+/E-!/4+1-7E-E!-_51-EE/,4!D,1!
E-4E,1@$!7.1-4-1?/+$!74.!/CC84-!?-4-E!/4!+B1,4/+!D70/[email protected],C-!570/-40E!K80!4,0!/4!
4,1C7>!E8KF-+0E;!!:!A)'(!mffb2!OWP!hfbbZhhm;!j("3#V!hbneoebek!
cf; J/?B0!A'$!:70-C74!J$!S,!#$!H8?B-4!'[$!674B7/0EC7!XA$![B/0-!AX$!J/?B0!P%;!!=-4-!
-_51-EE/,4!7>0-170/,4E!70!K7E->/4-!74.!D,>>,N/4?!C,.-170-!-_-1+/E-!/4!570/-40E!N/0B!%B1,4/+!
&70/[email protected],C-$!74.!&/K1,C@7>?/[email protected],C-;!!:!<(+$.(!;$3!!mfhh!"7@!mn;!.,/V!
hf;hhhhMF;hcngZmobn;mfhh;fmefg;_;!j<58K!7B-7.!,D!51/40k!!!!j("3#V!mhnhglfok
ch; =1r4E!H$!L/>EE,4!"$!#7B>C74Z[1/?B0!P$!<9-4?s1.!:;!'-.8+-.!>-9->E!,D!,-E01,?-4!1-+-50,1!
K-07!C'LA!/4!IN-./EB!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-;!:!E&'(!A)+@,&!!mffo2![WV!hbgZ
l;!j("3#V!hnochgbmk
cm; L71/07!"$!L/EB/?7C/!L$!L71/07!L$!Y7C7?80/!P$!QO7.,!L$![70747K-!Y$!P8170E84-!H;!
AEE,+/70/,4!K-0N--4!E-1,0,4/4!0174E5,10-1!?-4-!5,>@C,15B/EC!74.!+B1,4/+!D70/?8-!
[email protected],C-;!!?',%@$1!?',*@0/!>$/!E,114(!!mffc2!ZOOV!mneZn;!j("3#V!hegbmeflk
cc; &7>O-4K-1?!6'$!=81K7_74/!:"$!G4?-1!<'$!'7F--974!"I;!&84+0/,47>!?-4,C/+E!,D!E-1,0,4/4!
1-+-50,1!mA!)HX'mA*V!/40-17+0/,4!,D!5,>@C,15B/EC$!C-0B@>70/,4$!-_51-EE/,4!74.!./E-7E-!
7EE,+/70/,4;!!=$4.,1,&$%4&).!;$3!mfhh2!OZV!nnZon;!j("3#V!mfbehgghk!!
ce; '7F--974!"I$!IC/0B!AP$!#/C8>-E+8!3$!G4?-1!<'$!6-14,4!I#$!H-/C!%$!'--9-E![%;!
=>8+,+,10/+,/.!1-+-50,1!5,>@C,15B/ECE!74.!B75>,0@5-E!7EE,+/70-.!N/0B!+B1,4/+!D70/?8-!
[email protected],C-7!J$($/!?.)'(!?$@)2!mffo2![P!hnoZon;!j("3#V!hnoefheck
cg; %71>,ZI0->>7!L$!:,``/4/!I$!#-!I/>9-E01/!A$!IK71E/!3$!(/``,+B-1,!%$!J,18EE,!J$!"710/4-00/!"$!
%8++/7!";!",>-+8>71!E08.@!,D!1-+-50,1!D,1!7.974+-.!?>@+70/,4!-4.51,.8+0!?-4-!51,C,0-1!
74.!/.-40/D/+70/,4!,D!E5-+/D/+!HJA!B75>,0@5-E!5,EE/K>@!/49,>9-.!/4!+B1,4/+!D70/[email protected],C-;!
<(+!:!<114(,*)+@,&!A@).1)%,&!mffb2!QQV!oegZge;!j("3#V!hblmmfbhk
cn; =,-10`->!:L$!(-447+B/4!%$!.-!I,8`7!%,->B,!J$!=81K7_74/!:$!"7>,4-@!<"$!S,4-E!S&;!
%,CK/470/,4E!,D!E/4?>-!48+>-,0/.-!5,>@C,15B/ECE!/4!4-81,-4.,+1/4-!-DD-+0,1!74.!1-+-50,1!
?-4-E!51-./+0!+B1,4/+!D70/[email protected],C-;!A@).1)%,6$(,1'%/!!mffn2!oV!eogZlc;!!j("3#V!
hnnhfbgok!
co; &7>O-4K-1?!6'$!=81K7_74/!:"$!G4?-1!<'$!'7F--974!"I;!&84+0/,47>!?-4,C/+E!,D!E-1,0,4/4!
1-+-50,1!mA!)HX'mA*V!/40-17+0/,4!,D!5,>@C,15B/EC$!C-0B@>70/,4$!-_51-EE/,4!74.!./E-7E-!
7EE,+/70/,4;!=$4.,1,&$%4&).!;$3!!mfhh2!OZV!nnZon;!j("3#V!mfbehgghk
cl; G4.-1B/>>!SA$!"7B7>/4?7C!"$!(-7OC74!"$![-EE->@!I;!J7+O!,D!7EE,+/70/,4!K-0N--4!HJA!
?-4,0@5-!74.!+B1,4/+!D70/[email protected],C-;!D4.!:!<114(,6$($+!!mffh2!Q]V!emgZl;!j("3#V!
hhemmemfk
cb; I8>>/974!(&$!<9-4?s1.!:$!S7+OE!A$!(-.-1E-4!LJ;!XN/4!747>@E-E!,D!+B1,4/+!D70/?8-!/4!7!IN-./EB!
470/,47>!E7C5>-;!A/0%@,&!;$3!!mffg2!ZXV!hcmoZcn;!!j("3#V!hnhnlhggk
ef; J74.C71OZHt@9/O!H$!'-/4-10E-4!P6$!J,?-!SH$!P1/E0-4E-4!6L$!#8C-78_!6$!&,EEs!I#$!
:t11-E-4Z#7>-!AJ$!<.971.E-4!H;!XB-!?-4-0/+E!74.!-5/?-4-0/+E!,D!D70/?8-;!A;!>!mfhf2!QV!egnZ
ng;!j("3#V!mfngnnmlk
eh; "7B-1!P$!P>/C7E!L=$!&>-0+B-1!"A;!3CC84,>,?@;!34V!S7E,4!JA$!&-44->>!(A$!X7@>,1!''$!-.E;!
H74.K,,O!,D!%B1,4/+!&70/?8-E;!!H,K,O-4$!L-N!S-1E-@!\!%747.7V!S,B4![/>-@!\!I,4E2!mffcV!
hmeZhgh;
em; #,1>74.aE!3>>8E0170-.!"-./+7>!#/+0/,471@;!!mb0B!<./0/,4;!!(B/>7.->5B/7V![;:;!I784.-1E!
%,C574@2!mfffV!hfeb;
ec; S7E,4!JA$!H->?-1E,4!S$!X,11-EZH71./4?!I'$!%711/+,!A[!X7@>,1!'';!!671/7K/>/0@!/4!./7?4,E0/+!
+1/0-1/7!D,1!+B1,4/+!D70/[email protected],C-!C7@!1-E8>0!/4!E8KE0740/7>!./DD-1-4+-E!/4!5700-14E!,D!
E@C50,CE!74.!./E7K/>/0@;!!D2)&!I$)&+@!A.,-!!mffc2!Q[P!cZmm;!j("3#V!hmnmbbhbk
ee; !S7E,4!JA$!X7@>,1!''$!P-44-.@!%J$!-0!7>;!!!A!D7+0,1!747>@E/E!,D!+B1,4/+!D70/?8-!E@C50,CE!/4!7!
+,CC84/0@ZK7E-.!E7C5>-;!!#,%!A/0%@')+.0!A/0%@')+.!D*'3$1',&!mffm2!ZYP!hlcZlb;!!j("3#V!
hmfmomegk
eg; #,NE-00!<=$!'7CE7@!A"$!"+%7104-@!'A$!:->>!<S;!!"@7>?/+!<4+-5B7>,C@->/0/E!W!A!5-1E/E0-40!
-40-1,9/17>!/4D-+0/,4u!!A,/+6.)3!;$3!:!hbbf2![[P!gmnZcf;!j("3#V!mhofbnmk
en; J>,@.!A'$!H/+O/-!3$!:,8?B0,4!%&$!I5-4+-1!Q$![7O-D/->.!#;!!(1-97>-4+-!,D!+B1,4/+!D70/?8-!
[email protected],C-!/4!74!A8E017>/74!5,58>70/,4;!!;$3!:!94/+!hbbf2!OXZP!gmmZml;!j("3#V!mmcceoek
eo; L/FE!S$!"--8E!"$!"+=1-?,1!L'$!"--8E-4!'$!.-!I+B800-1!=$!974!H,,D!<$!#-!"-/1>-/1!P;!!
%B1,4/+!&70/[email protected],C-V!<_-1+/E-!(-1D,1C74+-!'->70-.!0,!3CC84-!#@ED84+0/,4;!!;$3!#%'!
#*,.+/!DF$.%!!mffg2!ZYP!hneoZge;!!j("3#V!hnmnfbnmk
el; "--8E!"$!',8EE->!LA$!X18/F-4!I$!L/FE!S;!!'-.8+-.!51-EE81-!57/4!0B1-EB,>.E!/4!1-E5,4E-!0,!
-_-1+/E-!/4!+B1,4/+!D70/[email protected],C-!K80!4,0!/4!+B1,4/+!>,N!K7+O!57/4V!74!-_5-1/C-407>!
E08.@;!!:!>$@)5'&!;$3!mfhf2!\QP!lleZbf;!!j("3#V!mflolfghk
eb; 674!Q,E0-1N/F+O!S$!L/FE!S$!"--8E!"$!J-D-9-1!3$!H8@K1-+B0E!J$!J7CK1-+B0!J$!(78>!J;!(7/4!
/4B/K/0/,4!74.!5,E0-_-10/,47>!C7>7/E-!/4!C@7>?/+!-4+-5B7>,C@->/0/EM+B1,4/+!D70/?8-!
[email protected],C-2!74!-_5-1/C-407>!E08.@;!!:!<(+$.(!;$3!mfhf2!Q[]P!mngZol;!j("3#V!mfehmcoek
gf; [B/0-E/.-!A$!H74E-4!I$!%B78.B81/!A;!!<_-1+/E-!>,N-1E!57/4!0B1-EB,>.!/4!+B1,4/+!D70/?8-!
[email protected],C-;!!A)'(!mffe2!OW`P!eboZbb;!!j("3#V!hghgoohhk
gh; Y,EB/8+B/!P$!&71O7E!3$!L70->E,4!:H;!!(70/-40E!N/0B!+B1,4/+!D70/[email protected],C-!B79-!1-.8+-.!
7KE,>80-!+,10/+7>!K>,,.!D>,N;!!E&'(!A@0/',&!H4(%+!<1)6'(6!mffn2!Q[P!lcZn;!j("3#V!hnebegbok
gm; =,>.E0-/4!SA;!!E@.,('%!H)+'64$!#0(3.,1$K!L@$!B'15'%!I0*,+@$/'/7!!:/4?B7C50,C$!L-N!Y,1OV!
H7N,10B!"-./+7>!(1-EE2!hbbcVhb$!hhn;
gc; I01--0-4!#H;!!',>-!,D!/C57/1-.!>,N-1Z>/CK!9-4,8E!/44-1970/,4!/4!0B-!570B,?-4-E/E!,D!0B-!
+B1,4/+!D70/[email protected],C-;!!!91!:!;$3!#%'!mffh2!ZQOP!hncZno;!!j("3#V!hhmnbobfk
ge; L-71@!(S$!',K-10E!A#$!J-79/4E!L$!H711/E,4!"&$!%1,>>!S%$!I-_EC/0B!S';!!(1-D1,407>!+,10-_!
,_@?-470/,4!.81/4?!/4+1-C-407>!-_-1+/E-!/4!+B1,4/+!D70/[email protected],C-;!!E&'(!A@0/',&!H4(%+!
<1)6!mffl2!Q]P&cneZom;!!j("3#V!hlnohobck
gg; 674L-EE!S"$!I4->>!%'$!#-C5E-@![J$!I017@-1!#'$!I0-9-4E!I';!!I8K+>7EE/D@/4?!+B1,4/+!D70/?8-!
[email protected],C-!8E/4?!-_-1+/E-!0-E0/4?;!!;$3!#%'!#*,.+/!DF$.%!mffc2!ZXP!bflZhc;!j("3#V!hmolcfcok
gn; #-!:-+O-1!($!',-@O-4E!S$!'[email protected]!"$!"+=1-?,1!L$!#-!"-/1>-/1!P;!!<_-1+/E-!+757+/0@!/4!
+B1,4/+!D70/[email protected],C-;!!9.%@!<(+$.(!;$3!mfff2!OYWP!cmofZo;!!j("3#V!hhfllflbk
go; I8v1-`!A$!=8/>>7Cw!<$!',/?!X$!-0!7>;!L/01/+!,_/.-!C-07K,>/0-!51,.8+0/,4!.81/4?!-_-1+/E-!/4!
+B1,4/+!D70/[email protected],C-V!7!+7E-Z+,401,>!E08.@;!:!M,1$(/!I$)&+@!"B).%@1+8!mfhf2!O`P!
hfocZo;!j("3#V!mfenbbnhk
gl; 674L-EE!S"$!I0-9-4E!I'$!:70-C74!J$!I0/>-E!XJ$!I4->>!%';!!(,E0-_-10/,47>!C7>7/E-!/4!N,C-4!
N/0B!+B1,4/+!D70/[email protected],C-;!:!M,1$(N/!I$)&+@!"B).%@1+8!mfhf2!O`P!mcbZmee;!j("3#V!
mffbgbfbk
gb; 6-1C-8>-4!'%[$!P81O!'"$!6/EE-1!&%$!I>8/0-1![$!I+B,>0-!H';!!(70/-40E!N/0B!+B1,4/+!D70/?8-!
[email protected],C-!5-1D,1C-.!N,1E-!0B74!+,401,>E!/4!7!+,401,>>-.!1-5-70-.!-_-1+/E-!E08.@!.-E5/0-!7!
4,1C7>!,_/.70/9-!5B,E5B,1@>70/,4!+757+/0@;!!J Transl Med!!mfhf2!]P!bc;!.,/Vhf;hhlnMheobZ
glonZlZbc;!j("3#V!mfbcohhnk
nf; #-C/017+O!"A$!%1,DD,1.!JS;!!<9/.-4+-!D,1!74.!570B,5B@E/,>,?/+!/C5>/+70/,4!,D!
B@5,0B7>7C/+Z5/08/[email protected]>!7_/E!.@E1-?8>70/,4!/4!D/K1,C@7>?/7!74.!+B1,4/+!D70/?8-!
[email protected],C-;!!9((!=O!9%)3!#%'!hbbl2!]\WP!nleZbo;!j("3#V!bnmbmbgk
nh; J/?B0!A'$![B/0-!AX$!H8?B-4!'[$!J/?B0!P%;!!",.-170-!-_-1+/E-!/4+1-7E-E!-_51-EE/,4!D,1!
E-4E,1@$!7.1-4-1?/+!74.!/CC84-!?-4-E!/4!+B1,4/+!D70/[email protected],C-!570/-40E!K80!4,0!/4!
4,1C7>!E8KF-+0E;!!:!A)'(!mffb2!OWP!hfbbZhhm;!!j("3#V!hbneoebek
nm; [B/0-!AX$!J/?B0!A'$!H8?B-4!'[$!:70-C74!J$!"710/4E!X:$!H/>>!H'$!J/?B0!P%;!I-9-1/0@!,D!
E@C50,C!D>71-!7D0-1!C,.-170-!-_-1+/E-!/E!>/4O-.!0,!+@0,O/4-!7+0/9/0@!/4!+B1,4/+!D70/?8-!
[email protected],C-;!!A/0%@,*@0/',&!mfhf2!\YP!nhgZme;!j("3#V!mfmcfgffk
nc; Y,EB/8+B/!P$!%,,O!#:$!QB7EB/!P$!P8C74,!H$!P8K,O/!X$!Y7C7C,0,!Y$!L70->E,4!:H;!!A!1-7>Z
0/C-!7EE-EEC-40!,D!0B-!-DD-+0!,D!-_-1+/E-!/4!+B1,4/+!D70/[email protected],C-;!!A@0/',&!?$@)2!mffo2!
`QP!bncZl;!j("3#V!honggllok
ne; I4->>!%&$!674L-EE!S"$!I07@-1!#&$!I0-9-4E!I';!!<_-1+/E-!+757+/0@!74.!/CC84-!D84+0/,4!/4!
C7>-!74.!D-C7>-!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-!)%&I*;!!<(!P'2,!mffg2!O`P!cloZbf;!!
j("3#V!hgobnmfmk
ng; I+B80`-1!I<$!A4?->!X<$!J/8!X$!-0!7>;!#/E0/4+0!%-1-K1,E5/47>!&>8/.!(1,0-,C-E!#/DD-1-40/70-!
(,E0ZX1-70C-40!J@C-!#/E-7E-!D1,C!%B1,4/+!&70/[email protected],C-;!!AB,#!C=D!mfhh2![P!-homlo;!
j("3#V!mhclcleck!!!
nn; J74?-!=$![74?!I$!#-J8+7!S$!L70->E,4!:H;!!L-81,/C7?/4?!/4!+B1,4/+!D70/[email protected],C-;!!91!:!
;$3!hbbl2!OWXP!gfIZgcI;!j("3#V!bobfelmk
no; .-!J74?-!&($!P7>OC74!SI$!:>-/F-4K-1?!=$!H7?,,10!($!974!.-1!"--1!S[$!X,4/!3;!=17@!C700-1!
9,>8C-!1-.8+0/,4!/4!0B-!+B1,4/+!D70/[email protected],C-;!!=$4.,'1)6$!mffg2!Q[P!oooZlh;!j("3#V!
hgbggelok
nl; QO7.7!X$!X747O7!"$!P8170E84-!H$![70747K-!Y$!I7.70,!L;!!"-+B74/ECE!84.-1>@/4?!D70/?8-V!
A!9,_->ZK7E-.!C,15B,C-01/+!E08.@!,D!+B1,4/+!D70/[email protected],C-;!!?;E!=$4.,&!mffe2!\P!he;!
j("3#V!hgenhlhok
nb; Y,EB/8+B/!P$!&17O7E!S$!L70->E,4!:;!!(70/-40E!N/0B!+B1,4/+!D70/[email protected],C-!B79-!1-.8+-.!
7KE,>80-!K>,,.!D>,N;!!E&'(!A@0/',&!H4(%+!<1)6!mffn2!Q[P!lcZn;!j("3#V!hnebegbok
of; %,E07!#%$!X744,+O!%$!:1,E0,DD!S;!!:17/4E0-C!5-1D8E/,4!/E!/C57/1-.!/4!+B1,4/+!D70/?8-!
[email protected],C-;!Q<;!hbbg2!]]P!onoZoc;!j("3#V!lgemmnhk
oh; "-47!3$!6/>>748-97Z"-@-1!S;!!I08.@!,D!%-1-K17>!(-1D8E/,4!K@!L-81,I(<%X!/4!(70/-40E!N/0B!
%B1,4/+!&70/[email protected],C-;[email protected]!:"$!=,>.E0-/4!S$!J-9/4-!($!-.E;!!L@$!E&'('%)&!)(3!
#%'$(+'-'%!?)/'/!,-!;0)&6'%!D(%$*@)&,10$&'+'/R!E@.,('%!H)+'64$!#0(3.,1$7!!Q007N7$!Q4071/,!\!
Q?.-4EK81?$!L-N!Y,1O!I070-V!XB-!L/?B0/4?7>-!'-E-71+B!&,84.70/,42!hbbmV!ecmZl;
om; =,>.K-1?!"S$!"-47!3$!#71+,810!S;!!L-81,I(<%X!D/4./4?E!/4!+B/>.1-4!N/0B!+B1,4/+!D70/?8-!
[email protected],C-;!!:!!EH#!hbbo2!ZP!nhZn;!!A++-EE-.!,4!mmMfcMmfhh!70!!!
B005VMMK8K>;7+;8OM71+B/9-MF,8147>EMF+DEM9fc4fhbo;B0Cxg4-81,E5-+0!
oc; 3+B/E-!"$!I7>/0!3$!AKK-@!I$!%B84?!#=$!=17@!:$!P/1EB!S%$!&1--.C74!";!!AEE-EEC-40!,D!1-?/,47>!
+-1-K17>!5-1D8E/,4!K@!X+ZH"(AQ!I(<%X!/4!%B1,4/+!&70/[email protected],C-;!!=4%&!;$3!E,114(!
hbbg2!OZP!onoZom;!j("3#V!hebhleck
oe; :/EN7>!:$!P84N71!($!L70->E,4!:H;!!%-1-K17>!K>,,.!D>,N!/E!1-.8+-.!/4!+B1,4/+!D70/?8-!
[email protected],C-!7E!7EE-EE-.!K@!710-1/7>!E5/4!>7K->/4?;!!!:!=$4.,&!#%'!!mffh2!ZWOa!bZhh;!j("3#V!
mhhnogfnk
og; "70B-N!IS$!"7,!p$!P--?74!PA$!-0!7>;!!6-401/+8>71!+-1-K1,E5/47>!D>8/.!>7+070-!/E!/4+1-7E-.!/4!
+B1,4/+!D70/[email protected],C-!+,C571-.!N/0B!?-4-17>/`-.!74_/-0@!./E,1.-1V!74!/4!9/9,!c;f!X!)d*H!
"'I!/C7?/4?!E08.@;!!=;>!?',1$3!mffb2!QQP!mghZl;!!j("3#V!hlbemfnek
on; "--8E!"$!L/FE!S$!H8@K1-+B0E!I$!X18/F-4!I;!!<9/.-4+-!D,1!?-4-17>/`-.!B@5-17>?-E/7!/4!+B1,4/+!
D70/[email protected],C-V!+7E-!+,401,>!E08.@;!E&'(!>@$41)+,&!mfhf2!Q`P!cbcZcbl;!j("3#V!mffoohmck!!!
oo; I/-C/,4,N!6$!&74?!Y$!%7>7K1-E-!J$!I7B?7>!6$!Y8-!=H;!!A>0-1-.!+-4017>!4-19,8E!E@E0-C!E/?47>!
.81/4?!C,0,1!5-1D,1C74+-!/4!+B1,4/+!D70/[email protected],C-;!!E&'(!=$4.,*@0/',&!mffe2!OOXP!
mcomZlh;!j("3#V!hgcghclfk
ol; J74?-!=$!I0-DD4-1!S$!%,,O!#:$!-0!7>;!!QKF-+0/9-!-9/.-4+-!,D!+,?4/0/9-!+,C5>7/40E!/4!+B1,4/+!
D70/[email protected],C-V!A!:QJ#!D"'3!E08.@!,D!9-1K7>!N,1O/4?!C-C,1@;!!=$4.,'1)6$!mffg2!Q[P!
ghcZe;!j("3#V!hgbfocflk
ob; &>,1ZH-41@!($!J/4.!S%$!P,>-E!US;!!<<=!E,81+-!747>@E/E!,D!+B1,4/+!D70/[email protected],C-;!A/0%@')+.0!
>$/!mfhf2!O]OP!hggZng;!j("3#V!mfffneoek
lf; %,,O!#:$!Qa%,44,1!(S$!J74?-!=$!I0-DD-4-1!S;!!&84+0/,47>!4-81,/C7?/4?!+,11->70-E!,D!C-407>!
D70/?8-!/4.8+-.!K@!+,?4/0/,4!7C,4?!D70/[email protected],C-!570/-40E!74.!+,401,>E;!!=$4.,'1)6$!
mffo2!Z[P&hflZmm;!j("3#V!hoeflbock
lh; "/+B/->E!6$!%>[email protected]!'$!&/E+B>-1!:;!!A00-40/,4!74.!9-1K7>!>-714/4?!/4!570/-40E!N/0B!+B1,4/+!
D70/[email protected],C-;!!:!<(+!=$4.,*/0%@,&!#,%!hbbl2!\P!egnZnn;!!j("3#V!boegmcgk
lm; J,CK71./!6%$!'8E+-00/!&[$!#7E!=857!S$!-0!7>;!!#-0-+0/,4!,D!74!/4D-+0/,8E!1-01,9/18E$!p"'6$!
/4!K>,,.!+->>E!,D!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-;!!#%'$(%$!mffb2!ZQ[P!glgZb;!j("3#V!
hblhgomck
lc; J,!I%$!(1/58`,97!L$!J/!:$!P,C71,DD!AJ$!H84?!=%$![74?!'$!A>0-1!HS;!!#-0-+0/,4!,D!"J6Z1->70-.!
9/18E!?-4-!E-d8-4+-E!/4!K>,,.!,D!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-!74.!B-7>0B@!K>,,.!
.,4,1E;!!A.,%!=)+&!9%)3!#%'!S#9!mfhf2!OWYP!hgloeZb;!j("3#V!mfoblfeok
le; %B/7!S$!%B/7!A$!6,->>-1!"$!J--!X$!%B74?!';!!A+80-!-40-1,9/18E!/4D-+0/,4!D,>>,N-.!K@!C@7>?/7!
-4+-5B7>,C@->/0/EM+B1,4/+!D70/[email protected],C-!74.!9/17>!5-1E/E0-4+-;!:!E&'(!A)+@,&!mfhf2![ZP!
hncZl;!j("3#V!hblmlbflk
lg; %B/7!S$!%B/7!A;!!%B1,4/+!D70/[email protected],C-!/E!7EE,+/70-.!N/0B!+B1,4/+!-40-1,9/18E!/4D-+0/,4!,D!
0B-!E0,C7+B;!!J Clin Pathol !mffl2![OP!ecZl;!j("3#V!holomclck
ln; %B/7!SP;!!XB-!1,>-!,D!-40-1,9/18E!/4!+B1,4/+!D70/[email protected],C-;!!:!E&'(!A)+@,&!mffg2!X]P!hhmnZ
cm;!j("3#V!hnmgefbok
lo; U74?!!J$!=,8?B!S$!%B1/E0C7E!#$!-0!7>;!!!"/+1,K/7>!/4D-+0/,4E!/4!-/?B0!?-4,C/+!E8K0@5-E!,D!
+B1,4/+!D70/[email protected],C-!C@7>?/+!-4+-5B7>,C@->/0/E;!!:!E&'(!A)+@,&!mfhf2![ZP!hgnZne;!
j("3#V!hbbggggek
ll; AK>7EB/!#6$!<7E0C74!H:$!QN-4!%:;!!&1-d8-40!HH6Zn!740/K,.@!!74.!HH6Zn!1-7+0/970/,4!!/4!
C8>0/5>-!E+>-1,E/E!)"I*!74.!+B1,4/+!D70/[email protected],C-!)%&I*!570/-40E;!!:!E&'(!P'.,&!mfff2!O[P!
hobZbh;!j("3#V!hfoclhcok
lb; %B75-4O,!I$!P18C/47!A$!P,`/-1-97!I$!L,17!U$!I8>074,97!A$!6/OE47!J$!"81,9EO7!";!!A+0/970/,4!
,D!B8C74!B-15-E9/18E-E!n!74.!o!/4!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-;!!:!E&'(!P'.,&!!
mffn2!ZY&5#DD:&OV!IeoZIgh;!!j("3#V!homoncnbk!!
bf; L/+,>E,4!=J$!=74!'$!H7/E-1!S;!!"8>0/5>-!+,Z/4D-+0/,4E!)"@+,5>7EC7$!%B>7C@./7$!B8C74!
B-15-E!9/18EZn*!/4!K>,,.!,D!+B1,4/+!D70/[email protected],C-!570/-40EV!7EE,+/70/,4!N/0B!E/?4E!74.!
E@C50,CE;!!9A;<#!mffc2!OOOP!ggoZnn;!j("3#V!hmllogfok
bh; %B/7!SP$!%B/7!JY;!!%B1,4/+!%B>7C@./7!54-8C,4/7!/4D-+0/,4V!7!01-707K>-!+78E-!,D!+B1,4/+!
D70/[email protected],C-;!E&'(!<(-$%+!G'/!hbbb2!Q`P!egmZc;!j("3#V!hfeonongk
bm; :-d7F!IH$!J-14-1!A"$!&/0`?-17>.!S#;!!3CC84,7EE7@!N/0B!+@0,C-?7>,9/18E!-71>@!740/?-4E!
D1,C!?-4-!51,.8+0E!(gm!74.!%"!m!)GJee!74.!GJ!go*!.-0-+0E!7+0/9-!/4D-+0/,4!/4!570/-40E!
N/0B!+B1,4/+!D70/[email protected],C-;!!:!E&'(!A)+@,&!mffl2![OP!nmcZn;!!j("3#V!hlfconnfk!
bc; P-11!S'$!%844/DD-!6I$!P->>-B-1!($!:-14E0-/4!'"$!:18+-!3L;!!I8++-EED8>!/40179-4,8E!
/CC84,?>,K8>/4!0B-175@!/4!c!+7E-E!,D!5719,9/18E!:hbZ7EE,+/70-.!+B1,4/+!D70/[email protected],C-;!!
E&'(!<(-$%+!G'/!!mffc2!Z[P!-hffZn;!j("3#V!hmohgcmnk
be; IB--.@!S1$!'/+B71.E!<H$![-00-4B7>>!'<H$!-0!7>;!!34+1-7E-.!#Z>7+0/+!7+/.!/40-E0/47>!K7+0-1/7!/4!
570/-40E!N/0B!%B1,4/+!&70/[email protected],C-;!!<(!P'2,!mffb2!QZP!nmhZl;!j("3#V!hbgnocblk
bg; :1-48!<[$!I07/4-E!#'$!:7EO810!QP$!AEB0,4!PS$!'7C,E!I:$!%B1/E0@!'"$!"71EB7>>Z=17./E4/O!
I";!!3CC84-!74.!B-C,1B-,>,?/+7>!+B74?-E!/4!+B1,4/+!D70/[email protected],C-;!!:!L.)(/&!;$3!
mfhf2!]P!h;!j("3#V!mffnemnnk!!
bn; P>/C7E!L=$!P,4-18!AQ;!!%B1,4/+!D70/[email protected],C-V!/4D>7CC70/,4$!/CC84-!D84+0/,4$!74.!
4-81,-4.,+1/4-!/40-17+0/,4E;!!E4..!>@$41)+,&!>$*!mffo2!`P!elcZo;!j("3#V!hlhoonfmk
bo; &>-0+B-1!"A$!U-4?!p'$!:714-E!U$!J-9/E!I$!P>/C7E!L=;!!(>7EC7!+@0,O/4-E!/4!N,C-4!N/0B!
+B1,4/+!D70/[email protected],C-;!!:!L.)(/&!;$3!mffb2!YP!bn;!!j("3#V!hbbfbgclk
bl; %7C-1,4!:$!H/1E+BK-1?!#J$!',E-4K-1?ZH7EE74!Y$!AK>7EB/!#$!J>,@.!A';!!I-18C!+@0,O/4-!>-9->E!
/4!5,E0/4D-+0/9-!D70/[email protected],C-;!E&'(!<(-$%+!G'/!mfhf2!XWP!molZb;!j("3#V!mffcecelk
bb; %71>,ZI0->>7!L$!:7.8>>/!%$!#-!I/9-E01/!A$!-0!7>;!!XB-!D/1E0!E08.@!,D!+@0,O/4-!?-4,C/+!
5,>@C,15B/ECE!/4!%&IV!(,E/0/9-!7EE,+/70/,4!,D!XL&Zlgo!74.!3&L?7CC7!loe!171-!7>>->-E7!E&'(!
DF*!>@$41)+,&!mffn2!Q\P!hobZlm;!j("3#V!hnonmhggk
hff; #-!"-/1>-/1!P$!:/EK7>!%$!%7C5/4-!3$!#-!:-+O-1!($!I7>-B`7.7!X$!#-C-001-!<$!J-K>-8!:;!!A!co!
O#7!mZgA!K/4./4?!51,0-/4!7E!7!5,0-40/7>!K/,+B-C/+7>!C71O-1!D,1!+B1,4/+!D70/[email protected],C-;!!
91!:!;$3!mfff2!OW]&^Q_P!bbZhfg;!j("3#V!hhhmncmhk!!
hfh; I8.,>4/O!'S$!J,CK71./7!6$!(-0-1E,4!#J$!-0!7>;!!:/,+B-C/+7>!-9/.-4+-!D,1!7!4,9->!>,N!
C,>-+8>71!N-/?B0!mZgAZ.-5-4.-40!'L7E-!J!/4!+B1,4/+!D70/[email protected],C-;!!:!<(+$.-$.,(!
E0+,T'($!>$/!hbbo2!OYP!cooZlg;!j("3#V!bmeccnbk
hfm; L/FE!S$!&1yC,40!";!!34017+->>8>71!/CC84-!.@ED84+0/,4!/4!C@7>?/+!-4+-5B7>,C@->/0/EM+B1,4/+!
D70/[email protected],C-V!E070-!,D!0B-!710!74.!0B-175-80/+!/C5>/+70/,4E;!!DF*$.+!C*'(!L@$.!L).6$+/!
mffl2!OQP!mlhZb;!!j("3#V!hlmnbcclk
hfc; L/FE!S$!#-!"-/1>-/1!P$!"--8E!"$!"+=1-?,1!L1$!<4?>-K/-44-!(;!!%B1,4/+!D70/[email protected],C-V!
/4017+->>8>71!/CC84-!.-1-?8>70/,4E!7E!7!5,EE/K>-!-0/,>,?@!D,1!7K4,1C7>!-_-1+/E-!1-E5,4E-;!!
;$3!I0*,+@$/$/!mffe2![QP!ogbZng;!!j("3#V!hgflmhfmk
hfe; [,4?!'$!J,57E+B8O!=$!UB8!=$!-0!7>;!!IO->-07>!C8E+>-!C-07K,>/EC!/4!0B-!+B1,4/+!D70/?8-!
[email protected],C-;!!34!9/9,!7EE-EEC-40!K@!ch(!48+>-71!C7?4-0/+!1-E,474+-!E5-+01,E+,5@;!!E@$/+!!
hbbm2!OWQP!hohnZmm; [("3#V!heeneolk
hfg; S7CC-E!Y$!I0-/4K-1?!S=$!"7CK1/4/!Q$!:1y?-,4!&$!#->>/78_!I;!!!%B1,4/+!D70/[email protected],C-V!
7EE-EEC-40!,D!/4+1-7E-.!,_/.70/9-!E01-EE!74.!7>0-1-.!C8E+>-!-_+/07K/>/0@!/4!1-E5,4E-!0,!
/4+1-C-407>!-_-1+/E-;!!:!<(+$.(!;$3!!mffg2!QXYP!mbbZchf;!j("3#V!hgohgnlok
hfn; "/N7!P$!&8F/07!";!!&>8+0870/,4!,D!E-18C!9/07C/4!<!)7>5B70,+,5B-1,>*!+,4+-40170/,4E!.81/4?!
-_7+-1K70/,4!74.!1-C/EE/,4!5B7E-E!/4!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-;!!I$).+!
P$//$&/!mfhf2!QXP!chbZmc;!j("3#V!mfnonlehk
hfo; '/+B71.E!'I$![74?!J$!S->/4-O!H;!!<1@0B,+@0-!,_/.70/9-!.7C7?-!/4!+B1,4/+!D70/[email protected],C-;!!
9.%@!;$3!>$/!mffo2!Z]^O_P!beZl;!j("3#V!hohoechk
hfl; (7>>!"J$!I700-1>--!S#;!<>-970-.!4/01/+!,_/.-M5-1,_@4/01/0-!C-+B74/EC!D,1!0B-!+,CC,4!
-0/,>,?@!,D!C8>0/5>-!+B-C/+7>!E-4E/0/9/0@$!+B1,4/+!D70/[email protected],C-$!74.!5,E00178C70/+!
E01-EE!./E,1.-1;!!9((!=O!9%)3!#%'!mffh2!`ZZP!cmcZb;!!j("3#V!hmffffcck
hfb; P8185!'P$!P8185!(A;!!H@5,0B7>7C/+!./?,_/4$!+-1-K17>!+B-C/+7>!.,C/474+-!74.!C@7>?/+!
-4+-5B7>,C@->/0/E;!!<(+!:!=$4.,/%'!mffc2!OOZP!nlcZofh;!j("3#V!hmoegnmok
hhf; (7>>!"J;!DF*&)'('(6!US($F*&)'($3!<&&($//$/VK!!G'/$)/$!A).)3'61!-,.!E@.,('%!H)+'64$!
#0(3.,1$R!;4&+'*&$!E@$1'%)&!#$(/'+'2'+0R!H'5.,10)&6')R!A,/+WL.)41)+'%!#+.$//!G'/,.3$.R!J4&-!
M).!#0(3.,1$!)(3!C+@$./7!!:/?B7C0,4$!LYV!H711/4?0,4!(71O!)H7N,10B*!(1-EE$!mffo;
hhh; %B78.B81/!A$![70E,4![I$!(-714!S$!:-B74!(Q;!!XB-!E@C50,CE!,D!+B1,4/+!D70/[email protected],C-!
71-!1->70-.!0,!7K4,1C7>!/,4!+B744->!D84+0/,4;!!;$3!I0*,+@$/$/!mfff2!X\P!gbZnc;!!j("3#V!
hfobfomgk
hhm; "/N7!P$!&8F/07!";!!%71./7+!D84+0/,4!D>8+0870-E!.81/4?!-_7+-1K70/,4!74.!1-C/EE/,4!/4!@,84?!
7.8>0E!N/0B!+B1,4/+!D70/[email protected],C-!74.!]EC7>>!B-710^;!!:!E).3',&!!mffb2!X\P!mbZcg;!j("3#V!
hbncmghok
hhc; "/N7!P$!&8F/07!";!IC7>>[email protected],C-!/4!570/-40E!N/0B!+B1,4/+!D70/[email protected],C-;!E&'(!
E).3',&!mffl2!ZOP!cmlZcc;!!j("3#V!hlncngcfk
hhe; (-+O-1C74!A$!J7"74+7!SS$!R81-/EB/!:$!#7B>!PA$!=,>D-00/!'$!Y7C7C,0,!Y$!L70->E,4!:H;!!
:71,1-+-50,1!1-D>-_!74.!/40-?170/9-!E01-EE!1-E5,4E-E!/4!+B1,4/+!D70/[email protected],C-;!!
A/0%@,/,1!;$3!mffc2
hhg; (-+O-1C74!A$!J7"74+7!SS$!#7B>!PA$!%B-C/0/?740/!'$!R81-/EB/!:$!L70->E,4!:H;!!AK4,1C7>!
/C5-.74+-!+71./,?175B@!51-./+0E!E@C50,C!E-9-1/0@!/4!+B1,4/+!D70/[email protected],C-;!!91!:!
;$3!#%'!mffc2!ZQ[P!ggZnf;!j("3#V!hmbmfecgk
hhn; J-14-1!A"$!J7N1/-!%$!#N,1O/4!HI;!!'-5-0/0/9->@!4-?70/9-!+B74?/4?!X!N79-E!70!meZB!
->-+01,+71./,?175B/+!C,4/0,1E!/4!570/-40E!N/0B!0B-!+B1,4/+!D70/[email protected],C-;!!J-D0!
9-401/+8>71!.@ED84+0/,4!/4!7!+,B,10;!!E@$/+!hbbc2!OW\P&hehoZmh;!j("3#V!lmmmoblk!
hho; ',N-!(%$!%7>O/4E!H;!!L-817>>@!C-./70-.!B@5,0-4E/,4!74.!+B1,4/+!D70/[email protected],C-;!!91!:!
;$3!hbbl2!OWXP!hgIZmhI;!j("3#V!bobfeook!
hhl; L-N0,4!SJ$!IB-0B!A$!IB/4!S$!(7/1C74!S$![/>0,4!P$!:810!SA$!S,4-E!#<;!!J,N-1!7CK8>70,1@!K>,,.!
51-EE81-!/4!+B1,4/+!D70/[email protected],C-;!!A/0%@,/,1!;$3!!mffb2!YOP!cnhZg;!j("3#V!hbmbocfbk
hhb; %,E0/?74!A$!<>>/,00!%$!"+#,47>.!%$!L-N0,4!SJ;!!Q10B,E070/+!E@C50,CE!51-./+0!D84+0/,47>!
+757+/0@!/4!+B1,4/+!D70/[email protected],C-V!/C5>/+70/,4E!D,1!C747?-C-40;!!Q:;!mfhf2!OWZP!glbZ
bg;!j("3#V!mfgcenggk!
hmf; :810,4!A'$!'7BC74!P$!P7.,07!Y$!J>,@.!A$!6,>>C-1Z%,447!G;!'-.8+-.!B-710!170-!971/7K/>/0@!
51-./+0E!5,,1!E>--5!d87>/0@!/4!+7E-Z+,401,>!E08.@!,D!+B1,4/+!D70/[email protected],C-;!DF*!?.)'(!>$/!
mfhf2!QW\P!ohZl;!j("3#V!mfgfmllnk
hmh; L/E-4K78C!'$!'-@-E!"$!"7N>-!A%$!'--9-E![%;!&7+0,1!747>@E/E!,D!84-_5>7/4-.!E-9-1-!
D70/?8-!74.!/40-11->70-.!E@C50,CEV!,9-1>75!N/0B!+1/0-1/7!D,1!+B1,4/+!D70/[email protected],C-;!91!:!
D*'3$1',&!hbbl2!O\]P!omZo;!!j("3#V!bnncefnk
hmm; (1/-K-!I$!&7OB,81@![P$!H-44/4?E-4!(;!&84+0/,47>!/4+757+/0@!74.!5B@E/+7>!74.!5E@+B,>,?/+7>!
E@C50,CEV!B,N!0B-@!/40-1+,44-+0!/4!+B1,4/+!D70/[email protected],C-;!A/0%@,*)+@,&,60!mffl2!\OP!
ccbZeg;!j("3#V!hlongbgbk
hmc; %71C->!J$!<D1,4/!I$
(#""%3*&@#*+/"&@44"%,,%,&
9"L&()""#*+%",P!enfo!:>-4B-/C!I0;$!674+,89-1$!:%$!!6nJ!cAc$!%747.7;!!K+71180Bz0->8E;4-0!!!
',L& 2)3& 4%& 5)34%P! hgh! A1K,81! '/.?-! %/1+>-! L[$! %7>?71@$! A:! Xc=! c6b$! %747.7;!!
C974.-EzEB7N;+7!!
9"L&9%&'%0":%0"P!#-5710C-40!,D!(B@E/,>,?@$!61/F-!G4/9-1E/0@!,D!:18EE->E$!H/CC84/07E!!!&,84.70/,4$!:18EE->E$!hhmf$!:->?/8C;[email protected] 9"L&6:0=),P!#-5710C-40!,D!"-./+/4-$!G4/9-1E/0@!,D!"/7C/$!hmfh!L[!hn!I0;$!"/7C/$! &J!cchmg$!
GIA;!!4O.,+hmcz7,>;+,C!!
9"L&!"/4%"0$>P!#/9/E/,4!,D!(8>C,471@!"-./+/4-$!#-5710C-40!,D!"-./+/4-$!G4/9-1E/0@!,D!A>K-107$!!
["%!m<e;eh
9"L&!)#=C)"*%3H@#,*"+%0=P!"<M%&I!%-40-1$!QE>,!G4/9-1E/0@!H,E5/07>!H&$!([email protected]>-4$!LZfeme!QE>,$!L,1N7@;!!8_K7K7z,8EZBD;4,!! 9"L&!%::P!!oo!I,80B!"7/4!I01--0$!J@.,49/>>-!LY!hefbl$!LY$!GIA;!.EK->>C.z@7B,,;+,C!!! 9"L&()":/H5*%::)P!"-4,++B/,!hf$!3Zmohff$!(79/7$!307>@;!!4/+O/+Ez>/K-1,;/0!!!
9"L&(+0)P!H71K,1ZG%JA!"-./+7>!%-40-1$!G4/9-1E/0@!,D!%7>/D,14/7$!J,E!A4?->-E$!%A!bffme2!<6!"-.!
'-E-71+B$!mgccm!L71K,44-!A9-;!xhof$!J,C/07$!%A!bfoho$!GIA;!!-9C-.zEK+?>,K7>;4-0!!!
9"L&9)"")C+P!!qX717K-7?a$!H/>>!,D!X717$!X717$!%,!"-70B$!31->74.!2!!%B-C/+7>!\!<49/1,4C-407>!
I+/-4+-!#-5710C-40$!G4/9-1E/0@!,D!J/C-1/+O$!J/C-1/+O$!31->74.;&&&.7170717z-/1+,C;4-0!
9"L&I/P!(7/4!%>/4/+$!P,4@74?!G4/9-1E/0@!H,E5/07>$!#7-F-,4$!P,1-7;!!574.F,z57174;+,C!!!!
9"L&8%B0,P!%&I!#/E+,9-1@$!#,497>-!I5-+/7>/E0!"-./+7>!%-401-$!I8/0-!l$!bf!"/0+B7C!',7.$!!
#,497>-$!6/+0,1/7!chhh$!A8E017>/7;!.5>-N/Ez+DE./E+,9-1@;,+;78!!!
9"L&80C+*P!!#-50E;!,D!A4-E0B-E/,>,?@$!L-81,K/,>,?@!74.!A470,C@$!c%!eee!IQ"$!G4/9-1E/0@!,D!
G07B$!cfL!hbff<$!I7>0!J7O-!%/0@$!G07B!lehcm$!GIA;!!7>74;>/?B0zBE+;807B;-.8!
9"L&')",+)::H<")40,30>P!&7+8>0@!,D!H-7>0B!I+/-4+-E!74.!"-./+/4-$!:,4.!G4/9-1E/0@$!',K/47$!!!R8--4E>74.!emmb$!A8E017>/7;!!EC71EB7>zK,4.;-.8;78!! 9"L&'%3)P!#-5710;!"-./+/47!L8+>-71$!%>/4/+7!J7E!%,4.-E$!I740/7?,$!%B/>-;!!/C-47C.z?C7/>;+,C!!
9"L&'0>/20*,P
9"L&A)::P!#-50;!,D!:/,+B-C/E01@!74.!:7E/+!"-./+7>!I+/-4+-E$
A#32%50#++!.:!2!-2$'#($L+!%#/.6#%,!$'&#!:%.&!%#25'(3!:.%!R!*.1%<! '$!)'00!$2I#!&1/*!0.(3#%!$.!%#/.6#%!
:%.&!3%./#%,!+*.--'(3!:.%!R!*.1%!2(5!#6#(!0.(3#%!':!%#-#2$#5!$*#!(#F$!52,!S!':!280#;!!=*.+#!)*.!%#+$!
8#:.%#! 2(! 2/$'6'$,! .%! *26#! 25T1+$#5! $*#'%! 2/$'6'$,! 0#6#0! $.! $*#'%! 0'&'$#5! #(#%3,! &2,! *26#! +*.%$#%!
%#/.6#%,!-#%'.5+!$*2(!$*.+#!)*.!5.!(.$!-2/#!$*#'%!2/$'6'$'#+!25#E12$#0,;!>&-2/$9!#;3;!G(!.1$+$2(5'(3!
2$*0#$#!/.105!*26#!2!NOP!%#51/$'.(!'(!*'+U*#%!-%#H'00(#++!2/$'6'$,!0#6#0!2(5!'+!+$'00!&.%#!2/$'6#!$*2(!2!
+#5#($2%,!-#%+.(;!!!
!L&;%#"/:/C0$):&1=D)0"=%3*,&&
&&&&@*&:%),*&R3%&57=D*/=&K"/=&*+"%%&/K&*+%&K/::/B03C&K/#"&,7=D*/=&$)*%C/"0%,&!OL&;%#"/$/C30*02%&1=D)0"=%3*,!
)L 90KK0$#:*7& D"/$%,,03C& 03K/"=)*0/3P& ,:/B%4& *+/#C+*-& 0=D)0"%4& $/3$%3*")*0/3& #;3;! /.(:1+'.(<!
5'+.%'#($2$'.(<!/.3('$'6#!.6#%0.25<!5'::'/10$,!)'$*!&2I'(3!5#/'+'.(+-&+0.)#5!+-##/*<!2/E1'%#5!
.%!#F#%$'.(20!5,+0#F'2&&
GL 5+/"*H*%"=&=%=/"7&:/,,P&#;3L&5'::'/10$,!%#&#&8#%'(3!)*2$!.(#!)2($#5!$.!+2,<!)*2$!.(#!)2+!
+2,'(3<!%#$%'#6'(3!).%5+<!%#/200'(3!'(:.%&2$'.(-!-..%!).%I'(3!&#&.%,&&
QL&A)03&!)L b%)4)$+%,P&#;3;!/*%.('/<!3#(#%20'V#5!*#252/*#+!.:$#(!'(6.06#!2/*'(3!.:!$*#!#,#+<!8#*'(5!$*#!
#,#+! .%! 82/I! .:! $*#! *#25! $*2$!&2,! 8#! 2++./'2$#5!)'$*! /#%6'/20! &1+/0#! $#(+'.(W!&'3%2'(#W!
$#(+'.(!*#252/*#+&&!GL 50C30K0$)3*&D)03&$)3&G%&%cD%"0%3$%4&03&=#,$:%,-&=#,$:%H*%34/3&.#3$*0/3,-&./03*,-&)G4/=%3&/"&
$+%,*L& & 1*& 0,&3/3H03K:)==)*/"7& 03&3)*#"%&)34&/K*%3&=0C")*%,L&#;3;!3#(#%20'V#5!*,-#%203#+'2-&
)'5#+-%#25!-2'(!M&2,!&##$!:'8%.&,203'2!/%'$#%'2Q<!&,.:2+/'20!.%!%25'2$'(3!-2'(!!ZL&&5:%%D&90,*#"G)3$%!
)L 90,*#"G%4&,:%%D&D)**%"3,9!#;3;!'(+.&('2<!-%.0.(3#5!+0##-!'(/015'(3!(2-+<!+0##-'(3!&.+$!.:!$*#!
52,!2(5!8#'(3!2)2I#!&.+$!.:! $*#!('3*$<! :%#E1#($!2)2I#('(3+<!2)2I'(3!&1/*!#2%0'#%! $*2(!
8#:.%#!'00(#++!.(+#$<!6'6'5!5%#2&+U('3*$&2%#+!GL J3"%K"%,+%4&,:%%DP&#;3;!2)2I#(!:##0'(3!#F*21+$#5!%#32%50#++!.:!51%2$'.(!.:!+0##-<!52,H$'&#!
+0##-'(#++&!
\L &;%#"/,%3,/"7-&A%"$%D*#):&)34&'/*/"&90,*#"G)3$%,!)L ;%#"/,%3,/"7& )34& D%"$%D*#):P& #;3L& '(28'0'$,! $.! :./1+! 6'+'.(<! +#(+'$'6'$,! $.! 0'3*$<! (.'+#<!
6'8%2$'.(<!.5.1%<!$2+$#!2(5!$.1/*W!'&-2'%#5!5#-$*!-#%/#-$'.(!GL '/*/"P!#;3;!&1+/0#!)#2I(#++<!$)'$/*'(3<!-..%!/..%5'(2$'.(<!:##0'(3!1(+$#25,!.(!:##$<!2$2F'2&
@.$#+9! @#1%./.3('$'6#! '&-2'%&#($+<! %#-.%$#5! .%! .8+#%6#5<! 8#/.&#!&.%#! -%.(.1(/#5!)'$*! :2$'31#;!
B6#%0.25! -*#(.&#(2! &2,! 8#! #6'5#($! )*#(! $).! $2+I+! 2%#! -#%:.%! +'&10$2(#.1+0,;! G8(.%&20!
%#2/$'.(! $.! 0'3*$! H! :01/$12$'.(! .%! %#51/#5! 2//.&&.52$'.(! %#+-.(+#+! .:! $*#! -1-'0+!)'$*! %#$#($'.(! .:!
%#2/$'.(;&40##-!5'+$1%82(/#+! 2%#! $,-'/200,! #F-%#++#5!8,! -%.0.(3#5! +0##-<! +.&#$'&#+! #F$%#&#<! '(! $*#!
2/1$#! -*2+#! 2(5!.:$#(! #6.06#! '($.!&2%I#5! +0##-! %#6#%+20! '(! $*#! /*%.('/! +$23#;! !D.$.%! 5'+$1%82(/#+!
&2,!(.$!8#!#6'5#($!'(!&'05!.%!&.5#%2$#!/2+#+!81$!28(.%&20!$2(5#&!32'$!2(5!-.+'$'6#!A.&8#%3!$#+$!
&2,!8#!.8+#%6#5!'(!+#6#%#!/2+#+;!&
(L&1==#3%-&<),*"/H03*%,*03):&d&<%30*/#"03)"7&1=D)0"=%3*,&
&&&&&@*&:%),*&R3%&57=D*/=&K"/=&*+"%%&/K&*+%&K/::/B03C&K02%&,7=D*/=&$)*%C/"0%,&&
OL U:#H:0>%&,7=D*/=,&=)7&G%&"%$#""%3*&/"&$+"/30$&)34&*7D0$)::7&)$*02)*%&/"&B/",%3&B0*+&%c%"*0/3L&
#;3;! +.%#! $*%.2$<! +'(1+'$'+<! /#%6'/20! 2(5U.%! 2F'002%,! 0,&-*! (.5#+!&2,! #(02%3#! .%! 8#! $#(5#%! .(!
-20-'$2$'.(&
QL 5#,$%D*0G0:0*7&*/&20"):&03K%$*0/3,&B0*+&D"/:/3C%4&"%$/2%"7&D%"0/4,&ZL <),*"/H03*%,*03):&*")$*P&#;3;&(21+#2<!285.&'(20!-2'(<!80.2$'(3<!'%%'$280#!8.)#0!+,(5%.&#&
\L <%30*/#"03)"7P&%LCL&1%'(2%,!1%3#(/,!.%!:%#E1#(/,<!(./$1%'2&XL 5%3,0*020*0%,&$.!:..5<!'/2$'.(+<!.5.1%+!.%!/*#&'/20+&
@.$#+9!4.%#! $*%.2$<! $#(5#%! 0,&-*!(.5#+<!2(5! :01H0'I#! +,&-$.&+!.86'.1+0,!2%#!(.$! +-#/':'/! $.!DK!81$!
$*#'%!2/$'62$'.(!'(!%#2/$'.(!$.!#F#%$'.(!'+!28(.%&20;&=*#!$*%.2$!&2,!:##0!+.%#<!5%,!2(5!+/%2$/*,;!!J21/'20!
'(T#/$'.(!2(5!/%'&+.(!/%#+/#($+!&2,!8#!+##(!'(!$*#!$.(+'002%!:.++2#<!)*'/*!2%#!2(!'(5'/2$'.(!.:!'&&1(#!
2/$'62$'.(;&&&&!
9L&M3%"C7&A"/4#$*0/3N?")3,D/"*)*0/3&1=D)0"=%3*,P&@*&:%),*&R3%&57=D*/=&
OL ()"40/2),$#:)"P&#;3;! '(28'0'$,! $.! $.0#%2$#!2(!1-%'3*$!-.+'$'.(! H!.%$*.+$2$'/! '($.0#%2(/#<!(#1%200,!'2$#5!*,-.$#(+'.(<!-.+$1%20!.%$*.+$2$'/!$2/*,/2%5'2!+,(5%.&#-&-20-'$2$'.(+!)'$*!.%!)'$*.1$!
/2%5'2/!2%%*,$*&'2+<!0'3*$H*#25#5(#++U5'VV'(#++!QL E%,D0")*/"7P&#;3;!2'%!*1(3#%<!028.1%#5!8%#2$*'(3<!:2$'31#!.:!/*#+$!)200!&1+/0#+&!ZL 8/,,& /K& *+%"=/,*)*0$& ,*)G0:0*7P&#;3;! +18(.%&20! 8.5,! $#&-#%2$1%#<!&2%I#5!5'1%(20! :01/$12$'.(+W!
+)#2$'(3! #-'+.5#+<! %#/1%%#($! :##0'(3+! .:! :#6#%'+*(#++! )'$*! .%! )'$*.1$! 0.)! 3%25#! :#6#%<! /.05!
#F$%#&'$'#+!&
\L 13*/:%")3$%&/K&%c*"%=%,&/K&*%=D%")*#"%&&
@.$#+9! B%$*.+$2$'/! '($.0#%2(/#! &2,! 8#! 5#02,#5! 8,! +#6#%20! &'(1$#+;! ?2$'#($+! )*.! *26#! .%$*.+$2$'/!
'($.0#%2(/#!&2,! #F*'8'$!&.$$0'(3! .:! #F$%#&'$'#+<! #F$%#&#! -200.%! .%! A2,(215L+! ?*#(.&#(.(;! ! >(! $*#!
/*%.('/!-*2+#<!&..(+!.:!:'(3#%!(2'0+!&2,!%#/#5#;!
A)%40)*"0$&(/3,04%")*0/3,&&&&
4,&-$.&+!&2,! -%.3%#++!&.%#! +0.)0,! '(! /*'05%#(! $*2(! '(! $##(23#%+! .%! 2510$+;! ! >(! 255'$'.(! $.! -.+$H
#F#%$'.(20! (#1%.'&&1(#! #F*21+$'.(<! $*#! &.+$! -%.&'(#($! +,&-$.&+! $#(5! $.! 8#! (#1%.0.3'/209!
*#252/*#+<!/.3('$'6#!'&-2'%&#($+<!2(5!+0##-!5'+$1%82(/#+;!
OL b%)4)$+%,P&5%2%"%&/"&$+"/30$&+%)4)$+%,&)"%&/K*%3&4%G0:0*)*03CL&'0C")03%&=)7&G%&)$$/=D)30%4&G7&
)&")D04&4"/D&03&*%=D%")*#"%-&,+)>03C-&2/=0*03C-&40)""+/%)&)34&,%2%"%&B%)>3%,,L&
QL ;%#"/$/C30*02%& 1=D)0"=%3*,P& & 90KK0$#:*7& K/$#,03C& %7%,& )34& "%)403C& )"%& $/==/3L& & (+0:4"%3&=)7&
G%$/=%& 47,:%c0$-& B+0$+& =)7& /3:7& G%& %204%3*& B+%3& K)*0C#%4L& & 5:/B& D"/$%,,03C& /K& 03K/"=)*0/3&
=)>%,& 0*&40KK0$#:*&*/&K/::/B&)#40*/"7&03,*"#$*0/3,&/"&*)>%&3/*%,L&@::&$/C30*02%& 0=D)0"=%3*,&B/",%3&
B0*+&D+7,0$):&/"&=%3*):&%c%"*0/3L&&S/#3C&D%/D:%&B0::&3/*&G%&)G:%&*/&=)03*)03&)&K#::&,$+//:&D"/C")=L!ZL A)03&=)7&,%%=&%"")*0$&)34&=0C")*%&V#0$>:7L&&I/03*&+7D%"H=/G0:0*7&0,&$/==/3L&
@.$#+9! ! J01/$12$'.(! 2(5! +#6#%'$,! *'#%2%/*,! .:! (1&#%.1+! -%.&'(#($! +,&-$.&+! $#(5! $.! 62%,! &.%#!
%2-'50,!2(5!5%2&2$'/200,!$*2(!'(!2510$+;&&&!
(:),,0K0$)*0/3&
eeee&'7):C0$&M3$%D+):/=7%:0*0,&&&
eeee&@*7D0$):&'7):C0$&M3$%D+):/=7%:0*0,P&=%%*,&$"0*%"0)&K/"&D/,*H%c%"*0/3):&3%#"/0==#3%&%c+)#,*0/3&
G#*&+),&*B/&/"&:%,,&*+)3&"%V#0"%4&/K&*+%&"%=)0303C&$"0*%"0):&,7=D*/=,L&&A)03&/"&,:%%D&40,*#"G)3$%&=)7&
G%&)G,%3*&03&")"%&$),%,L!
Mc$:#,0/3,P& & G+! '(! 200! 5'23(.+#+<! #F/01+'.(! .:! 20$#%(2$#! #F-02(2$.%,! 5'23(.+#+! '+! 2/*'#6#5! 8,! $*#!
-2$'#($L+!*'+$.%,<!-*,+'/20!#F2&'(2$'.(<!2(5!028.%2$.%,U8'.&2%I#%!$#+$'(3!2+!'(5'/2$#5;!!>$! '+!-.++'80#!
$.!*26#!&.%#! $*2(!.(#!5'+#2+#!81$! '$! '+! '&-.%$2($! $*2$!#2/*!.(#! '+! '5#($':'#5!2(5!$%#2$#5;! !A"0=)"7&
D,7$+0)*"0$&40,/"4%",-&,/=)*/K/"=&40,/"4%"&)34&,#G,*)3$%&)G#,%&)"%&%c$:#4%4L& &A)%40)*"0$P& f-%'&2%,L&
+/*..0!-*.8'2;!!!
(/H=/"G04& M3*0*0%,P& U0G"/=7):C0)-& '7/K),$0):& A)03& 5734"/=%-& ?%=D/"/=)340G#:)"& I/03*& 5734"/=%-&
1""0*)G:%& !/B%:& 5734"/=%-& 13*%",*0*0):& (7,*0*0,-& E)73)#4g,& A+%3/=%3/3-& A"/:)D,%4& '0*"):& F):2%-&
'0C")03%,-& @::%"C0%,-& '#:*0D:%& (+%=0$):& 5%3,0*020*0%,-& b),+0=/*/g,& ?+7"/040*0,-& 50$$)& 5734"/=%-&
E%)$*02%& 9%D"%,,0/3L& D'3%2'(#! 2(5! '%%'$280#! 8.)#0! +,(5%.&#! &2,! -%#/#5#! DK! 81$! $*#(! 8#/.&#!
2++./'2$#5!)'$*!'$;!!J'8%.&,203'2!.6#%02-+;!
!
