MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood...
Transcript of MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood...
![Page 1: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/1.jpg)
A Rahman A Jamal MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN, DPNS, ANS,
UKM Medical Molecular Biology Institute (UMBI)
Universiti Kebangsaan Malaysia
![Page 2: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/2.jpg)
Penyelidikan berkualiti memerlukan sampel berkualiti
BRCA1/BRCA2 dalam kanser
payudara familial
Her2 +ve dan penggunaan
herceptin
![Page 3: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/3.jpg)
Whole Genome Sequencing ke atas 295 tisu kanser gaster: Klasifikasi baru
TCGA. Nature. 513:2014
![Page 4: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/4.jpg)
Inovasi: Penemuan ColoPREDICThasil penyelidikan dari Biobank
Satu panel 19-gen untuk menentukanprognosis pesakitkanser kolorektal
Nombor Paten: PI2014702296
Panel gen telah divalidasi menggunakankohort pesakit kanser kolorektal USA
![Page 5: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/5.jpg)
BIOBANK
Satu koleksi besar sampel tisu serta data biologi dan perubatan
yang dikumpulkan untuk tujuan penyelidikan
![Page 6: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/6.jpg)
Lonjakan paradigmapengumpulan tisu dan spesimen
Koleksi spesimen patologi
• Tisu atas slaid
• Formalin-fixed paraffin embededed
BIOBANK sebagai
infrastruktur penyelidikan
• Pelbagai jenis sampel
![Page 7: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/7.jpg)
Generasi baru -80oC freezer
NHS National Biosample Centre, Milton Keynes United Kingdom
![Page 8: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/8.jpg)
Biobank: Jenis sampel yang disimpan
Whole blood
Mono-nuclear
cellsPlasma Serum
RBC clot Urine Hair Nails
Stools Saliva DNA RNA
![Page 9: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/9.jpg)
TUJUAN DAN PERANAN UTAMA
Koleksi biospesimen
berkualiti
Penyelidikan berkualiti
![Page 10: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/10.jpg)
BIOBANK di serata dunia
![Page 11: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/11.jpg)
Biobanks in Europe
![Page 12: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/12.jpg)
Malaysia pun BOLEH?
Biobank PPUKM-
UMBI
![Page 13: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/13.jpg)
Biobank Cohort: Terbesar di Asia Tenggara
• Biobank Utama• 2 Biobank Satelit
(PPUKM & MTDC)
![Page 14: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/14.jpg)
Pemetaan peserta Cohort menggunakan GIS
Kordinat untuk 106,527 peserta 44 % Malays (•), 33% Chinese (•),
15% Indians (•), 8% others (•)
Menggunakan Aplikasi Geographical Information System (GIS), Arch GIS 9.0
Potensi kajian interaksigen-persekitaran dll.
![Page 15: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/15.jpg)
MS ISO 15189:2007: AkreditasiMakmal Bioanalitikal Cohort
![Page 16: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/16.jpg)
BIG data = BIG Paper: IF 9.7
![Page 17: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/17.jpg)
POTENSI PESAKIT PPUKM SEBAGAI SUMBER PENYELIDIKAN
382,086 pesakit luar
35,837 pesakit dalam
7,858 pesakit dalam surgeri
14,099 pesakit luar psikiatri
Data dari Jabatan Farmasi PPUKM 2014
![Page 18: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/18.jpg)
RIBUAN SAMPEL PESAKIT PPUKM TIDAK DIKUMPUL
>2000 pembedahan tumor otak sejak 1997
• Peluang keemasan untuk membangunkan koleksi terbesar tumour otak
~150 tisu glioma
dikumpul dan disimpan
• Projek penyelidikan glioma
• Memakan masa 3 tahun (2010-2013)
![Page 19: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/19.jpg)
Pesakit psikiatri: Potensi tinggi untuk penyelidikan
3000 kes bipolar &
schizophrenia
• Pesakit susulan
<50 spesimen terkumpul
• Projek validasi varian kes bipolar
• Sudah >2 tahun
![Page 20: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/20.jpg)
7 sebab jadi begini
Ini bukan penyelidikan saya
Ini bukan skop kerja saya
Apa yang saya dapat?
Tak ada masa untuk ambil informed consent
Kenapa harus saya bantu?
Kenapa perlu tolong UMBI?
Kalau saya beri sampel, nanti orang lain yang dapat guna untuk penyelidikan
![Page 21: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/21.jpg)
HARUS KITA INGAT
UKM adalah universiti
penyelidikan
HCTM adalah hospital pengajar
Penyelidikan memerlukan
sampel
Kelebihan penyelidikan
dengan sampel yang sudah lengkap
![Page 22: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/22.jpg)
BIOBANK PPUKM-UMBIPertumbuhan pesat• Kapasiti• Kompetensi• Kualiti• Jaringan penyelidikan
2003 MULA!!!• Kertas Kerja
Biobank• Jawatankuasa
PPUKM-UMBI
• Diluluskan• Pengumpulan
sampeldimulakan
• Jabatan Surgeri:Kanser Payudara& Rektum
• Penyimpanan(-80C) & tisu
sahaja
• Kapasiti kecil tangkiLN (-190 C)
2005
2006
2016• Kapasiti besar
tangki LN (-190)• Pengumpulan
sampel daripadapelbagai penyakit
![Page 23: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/23.jpg)
Sampel dari >30 jenis penyakitDISEASE DISEASE
1 NORMAL SAMPLES (CONTROLS) 18 GASTRITIS2 BETA THALASSEMIA 19 IGM DEFICIENCY3 ACUTE LEUKEMIAS 20 PARKINSON’S DISEASE4 GENETIC RARE DISEASES 21 BIPOLAR DISORDERS5 LIVER CANCER 22 EPILEPSY6 BREAST CANCER 23 MYELOPOLIFERATIVE NEOPLASIA7 OBSTRUCTIVE LUNG DISEASE 24 CERVICAL CANCER8 BRAIN TUMOR 25 PLACENTA PRAEVIA9 CORONARY ARTERY DISEASE 26 HEMOPHILIA10 FRAGILE X 27 PANCREATIC CANCER11 LUNG CANCER 28 CHILDHOOD OBESITY12 CYSTIC FIBRIOSIS 29 GASTRIC CANCER13 HUNTINGTON'S DISEASE 30 HERNIA14 OVARIAN CANCER 31 SLE15 BLADDER CANCER 32 GOUT16 HIRSCHSPRUNG'S DISEASE 33 PENDRED SYNDROME17 ENDOMETRIUM CANCER 34 SEPSIS
![Page 24: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/24.jpg)
DARI MULA HINGGA KINI
Keperluan sampel untuk
projek penyelidikan
Permintaan dari penyelidik
Penyimpanan strategik untuk
penyelidikan masa depan
![Page 25: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/25.jpg)
FASILITI BIOBANK PPUKM-UMBI
-80C (12) -20C (1) 4C (1) Cryocyl (10) Tangki cecair
nitrogen(12) Tangki penyimpanan
sampel (9)
![Page 26: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/26.jpg)
KOMPONEN UTAMA BIOBANK PPUKM-UMBI
PesakitPlatform analisis
InsfrastrukturBiobank
Spesimenbiologi
dan data
Isu etikadan undang-
undangAplikasi
Diagnosis kanser
atau bukankanser
Keizinanpesakit
Komunitietika
Spesimendarah & pecahan
DNA & RNA
Kanser tisu
Data laporanhistopatologi,
sejarahkeluarga, rawatan,
susulan, etc
Molecular BiologyMass SpectrometryMicroscopyFlow CytometryUltrastructure analysis
Penyimpanan spesimendi dalam -800C dan -
1960C
Pemprosesan
Penyimpanan data Biocomputing,
Bioinformatik danVisualisasi
Personalisedmedicine
Biomarker research
Target to drug
discovery
Basic life science
research
Public health
![Page 27: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/27.jpg)
APA YANG DISIMPAN?
Tisu Biopsi Darah
(plasma, serum, seldarah merahdan seldarah putih)
Tisu kanserdan tisunormal
DNA
Data peribadidenganmematuhiperaturan-peraturanperlindungandata
DiluluskanolehJawatankuasaetika
![Page 28: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/28.jpg)
JUMLAH SAMPEL KANSER
TERKUMPUL 2004-2015
0 100 200 300 400 500 600 700
Kanser Pankreas
Kanser Paru-Paru
Kanser Gastrik
Leukimia Mieloid Akut (AML)
Kanser Pundi Kencing
Kanser Servik
Radang Usus
Kanser Ovari
Kanser Hati
Kanser Endometrium
Kanser Tiroid
Kanser Otak
Leukimia Limfosit Akut (ALL)
Kanser Kolorektal
Kanser Payudara
1
2
5
8
15
50
58
66
69
105
163
163
210
507
638
![Page 29: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/29.jpg)
JUMLAH PENYAKIT BUKAN
KANSER
0 50 100 150 200 250 300 350 400 450 500
Sistik Fibrosis
Arteri Koronari
Osteogenesis
Kemurungan
Bipolar/Gangguan Mood
SLE
Epilepsi
Fragile X
Aterosklerosis
Talasemia
5
8
18
19
29
68
128
140
140
464
![Page 30: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/30.jpg)
PENYELIDIKAN YANG BOLEH
DILAKUKAN
SpesimenBiorepositori
Analisis Saintifik
Genomik
Transkriptomik
Epigenomik
Proteomik
Metabolomik
Diagnosis
Rawatan/ UjianDiagnostik
![Page 31: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/31.jpg)
CABARAN
Sistem C-Hets yang kurang dikemaskini
Sukar melakukan pengambilan sampel bagi keskecemasan dan kes pada hujung minggu.
Sampel yang diperolehi kurang berkualiti
Cabaran untuk mendapat kerjasama daripadapegawai perubatan
Cabaran untuk mendapat kerjasama daripadakakitangan hospital
![Page 32: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/32.jpg)
PERANAN PESAKIT DAN WARGA PPUKM/HCTM
Kesedaran peranan Biobank
Lobi dan kempen
Anggap sampel amat
berharga
Penyelidikan memberi
manfaat besar
![Page 33: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/33.jpg)
Pesanan untuk para doktor
Hargai sampel pesakit untuk
tujuan penyelidikan
Bantu mendapatkan
‘informed consent’
![Page 34: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/34.jpg)
Aktiviti utama BIOBANK: Semua dengan SOPs
Keizinan bermaklumat
Pengumpulan &
Pengangkutan
Proses & Simpan
Dokumentasi & Maklumat
Klinikal
Kawalan kualiti
Pembekalan sampel & Analisa
![Page 35: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/35.jpg)
BEBERAPA ISU PENTING
![Page 36: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/36.jpg)
Konsep Colder is Better
-20oC • DNA
-80oC• RNA,
Serum & plasma
-196oC• RNA,
serum, plasma, cells
Waspada akan enzim degradatif pada suhu rendah
![Page 37: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/37.jpg)
Faktor yang boleh menjejaskan kualiti samples
Time to separate cells from
plasma/serum
Tissue hypoxia from arterial
clamping
Temperature for transportation
Medication and anaesthesia
regime
Length of time at room temperature
before storage
Time to fixate and type of fixative
![Page 38: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/38.jpg)
Biobank Cohort: Penghantaran & pemprosesan dalam masa 24 jam
![Page 39: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/39.jpg)
Tisu segar diperlukan untukpenyelidikan ‘omik’ berkualiti
Tisu akan lemas dalam fixative
Sel mula mati apabila tumor dibedah – hypoxia menyebabkan degradasi RNA dan protein
Formalin merosakkan protein, DNA dan RNA
Tisu segar yang TERBAIK
Formalin-fixed paraffin-embedded
(FFPE)
![Page 40: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/40.jpg)
Isu penting
ConsentPrivacy and
data protection
Legal & Technical
Re-identification
Ownership, benefits,
rights
Access to resources
Representation and bias
Governance Standardisation
![Page 41: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/41.jpg)
SIAPA PEMILIK SPESIMEN?
Pesakit atau PendermaTisu/Spesimen Mempunyai hak untuk
menarik diri sertamemohon untuktisu/spesimendikeluarkan dariBIOBANK
Ketua Institusi sebagaiPENJAGA (Custodian)
X
![Page 42: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/42.jpg)
KOLABORASI PENYELIDIKAN
Kolaborasi denganpenyelidik dari:
Jabatan Perubatan
Jabatan Patologi
Jabatan Surgeri
Jabatan Psikiatri
Jabatan O&G
Jabatan Pediatrik
Jabatan KesihatanMasyarakat
Fakulti SainsKesihatan
![Page 43: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/43.jpg)
KOLABORASI PENYELIDIKAN GENOMIK-JABATAN SURGERI DAN PATOLOGI
![Page 44: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/44.jpg)
MESEJ UNTUK DIBAWA PULANG
Penyelidikan berkualiti
memerlukan spesimen berkualiti
BIOBANK PPUKM-UMBI sebagai infrastruktur
penyelidikan penting
Perlu kesedarantentang pentingnya
menyimpanbiospesimen
(its like GOLD!)
Jom jadikan Biobank PPUKM-UMBI yang
terbaik di Asia!
![Page 45: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/45.jpg)
Thank you
![Page 46: MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore), PJN ......Jenis sampel yang disimpan Whole blood Mono-nuclear cells Plasma Serum RBC clot Urine Hair Nails Stools Saliva DNA RNA TUJUAN](https://reader033.fdocuments.in/reader033/viewer/2022053108/607a35675344763f7f618c83/html5/thumbnails/46.jpg)
PENGHARGAAN
Kakitangan Biobank PPUKM-UMBI
Kakitangan Biobank Cohort
Semua pakar dan penyelidik yang menyumbang
Semua kakitangan sokongan yang membantu/menyumbang
Kumpulan KIK
Dr. Nor Azian Abd Murad dan rakan-rakan felo