MCQ_Oncology-Critical Point Chemo 22-7-55
description
Transcript of MCQ_Oncology-Critical Point Chemo 22-7-55
Medication
2BLEOMYCIN
3CYCLOPHOSPHAMIDE (Endoxan )
4CYTARABINE (Ara-c ), Alexan)
5DACTINOMYCIN (ACTINOMYCIN)
6DOCETAXEL (Taxotere)
7DOXORUBICIN (Adriamycin)
85 FU, FLUOROURACIL
9IDARUBICIN
10L-ASPARAGINASE (Leunase)
11MTX, METHOTREXATE
12OXALIPLATIN (Eloxatin, Oxalip, Oxitan)
13PACLITAXEL (Intaxel, Taxol)
14VINBLASTINE
15VINCRISTINE
BLEOMYCIN
Anaphylaxis
V/S 15
CBC
CXR Pulmonary function tests 1
Renal function tests 400 units
SBP 120 / ,RR > 20 / , T > 38.5 C
ANC < 1500 cells/mm3
BUN ,Creatinine
Slow IV push > 10 , IV infusion 10-60
2-3
( pulmonary fibrosis)
CYCLOPHOSPHAMIDE (Endoxan )
CBC ,Platelet
Renal function tests
Acute haemorrhagic cystitis
ANC < 1500 cells / mm3
platelet count < 100,000 / mm3
UA , BUN, Creatinine
Slow IV push 20-30 , IV infusion 1-24 hrs
1.5-2 gm / m2 2 haemorrhagic cystitis
CYTARABINE (Ara-c ), Alexan)
CBC ,Platelet
Renal function test
Liver function tests
Cerebellar toxicity
Conjunctivitis
ANC 2.5
BUN, Creatinine
IV infusion only 1 hr
prophylactic G-CSF
> 38.5 c
DOXORUBICIN (Adriamycin)
Extravasation
CBC, Platelet
Cardiotoxicity
( )
ANC 60 , , CHF, 450 mg/m2, ejection fraction 30-40 %
4-12
2-4
()
Echo
5 FU, FLUOROURACIL
CBC ,Platelet
renal function tests
Liver function tests
ANC 10-15
( )
1 2
, , ( 3 - 10 )
L-ASPARAGINASE (Leunase)
Anaphylaxis
CBC
V/S 15 X 4
Pancreatitis ( Enz. Amylase 3 )
Renal function test
Prothrombin time
Allergic reaction ( , , )
ANC < 1500 cells / mm3
SBP < 90 mmHg , HR < 60 120 / , RR > 20 / , T > 38.5 C
Enz. Amylase ( 44-128 IU/L)
BUN, Creatinine
Prothrombin time (10-13 )
IM , slow IV push , IV infusion 30 - 60
Hypersensitivity reaction intradermal test dose dose asparaginase test dose dose 1 (Test dose 0.1 ml of a dilute 20 unit/ml solution )
MTX, METHOTREXATE
CBC
Liver function tests
Renal function tests
ANC 1 , IV infusion - 4 hrs
High dose ( > 1 gm / m2 ) Hydration Alkalinization
dose > 500 mg /m2 Leucovorin (Rescue dose)
Preservative 1 mg/ml (max 2 mg/ml) IT
OXALIPLATIN (Eloxatin, Oxalip, Oxitan)
CBC
Liver function tests
Renal function tests
signs of neuropathy
respiratory effects
ANC 38.5 C
IV infusion only 2-3 hrs
Premedication
Carboplatin , Cisplatin Paclitaxel
infusion set ( Non PVC tube)
VINBLASTINE
Extravasation
CBC
Renal function test
( )
ANC