MBS-6

How did it come about?

• Charlotte’s virus• Jisel, Chula, and Clostridium botulinum• Transmission of virus• Specialized transduction to

Mo’s cleavage plateSpecialized Transduction. Digital image. Microbiology - MCB 2010. Teresa G. Fischer, 2010. Web. 24 Apr. 2012. <http://faculty.irsc.edu/FACULTY/TFischer/micro%20resources.htm>.

The story of Patient 0

The New Gene

• Keyboard habitat• Easily contracted• New gene: blocks release

of Acetylcholine at neuromuscular junctions• Paralysis-victims often

found using Facebook

Acetylcholine. Digital image. Pharmacology. 9 Mar. 2012. Web. 24 Apr. 2012. <http://pharmacology-notes-free.blogspot.com/2012/03/acetylcholine.html>.

Signs and Symptoms

• Upper respiratory complications– Congestion– Coughing– Sneezing

• Muscle and joint aches– Focused around the neck and shoulder area

• Fever• Carpal tunnel• Fatigue

Public Health Risk/Prevention

• Shorten social network site exposure• Only add/accept people you know– Stranger danger

• Wash hands frequently• Take walks outdoors– At least 20mins

Morbidity versus Mortality32,122 Infections

97 Deaths

0.3% of those infected are expected to die from MBS-6

99.7% of those infected are expected to make a full recovery

At Risk PopulationsCollege Educated Women in California

Number of Deaths by Education Level

9

42

24

58

0

10

20

30

40

50

60

70

# of deaths

Education Level

Number of Deaths

no response

some high school

high school grad

some college

college grad

At Risk Populationsnumber of deaths by sex

female77%

male23%

femalemale

Women were almost 3

times more likely to die

from MBS-6!!

At Risk PopulationsNumber of Deaths

80%

2%

1%

2%

3%

1%

2%

1%

1%

1%

3%

1%

2%

CaliforniaColorado`EnglandFloridaHawaiiMarylandMexicoMichiganNew JerseyPakistanTexasWashingtonUnreported

80% of Those

Who Died from

MBS-6 Lived

in

California !!!!

MBS-6 A global disease

Countries affected:United States, UK, Pakistan, Mexico, New Zealand, Australia

MBS-6 Deaths per Day

MBS-6 R0

•R0 = Basic reproduction number

•R0 = (βΝ)/Υ• R0 = (Contact rate x Total Population) / Average infection

period

•Initial estimate: R0 < 3

•Actual: R0 > 5

•R0 > 1 is considered an epidemic

• Vaccination–Herd immunity

• Inactivation of toxic producing cells–Blocking hemmaglutinin and neuraminadase

Possible cures and vaccines?

• Anticholinergenic agent• Reversible agents–Nicotine–caffeine

Immediate response