FILE COPY

ecor U.S. DEPARTMENT OF

HEALTH. EDUCATION. ANO W ELFARE May 28, 1968

Vol. XX, No. 11 NATIONAL INSTITUTES OF HEALTH

PUBLIC H EA LTH SERVICE

Dr. G. B. Mider Moving To New Post at NLM As Special Assistant

By Jone Stafford The most accessible person at

NIH has been Dr. G. Burroughs Mider, Director of Laboratories and Clinics.

If you needed or wanted to see him about a problem, whether you

Dr. G. Burroughs Mider- recipient of DHEW Distinguished Service Aword­o lso honored by being selected to give the Jomes Ewing Lecture.

are a scientist or an administrative assistant or a science writer in an information office, you could sec him, and usually within a very short time of asking for an ap­pointment.

If you wonder how such an im­portant and busy pet·son found time for all the big and little people, the answer is very simple: He "moved papers" fast, he made decisions

(See DR. MIDER, l'aD• S)

Dr. Stuart M. Sessoms Retires From Fed. Govt.

Dr. Stuart M. Sessoms, Deputy Dfrecto1· of the National Institutes of Health since 1962, is retiring from the Federal Government after 25 yeari of service to assume new duties at Duke University effective Aug. 1.

Dr. Sessoms will serve there as director of the Duke Hospital, pro­fessor of medicine and associate dean for clinical sciences at the School of Medicine.

Dr. Sessoms came to NIH in 1953 as a staff member of the National Cancer Institute. From 1955 to 1957 he was assistant director of the Clinical Center , and assistant director of the ~CI prior to his appointment in 1958 as chief of the Cancer Chemotherapy National Service Center.

Deputy Director Since '62

He continued to be responsible for the cancer chemotherapy pro­gram from 1958 to 1962. It was during this period that Dr. Sessoms was appointed NCI associate direc­tor (1960), and associate director for collaborative research (1961) with responsibility for NCI's new Virology Research Resources Branch. He was appointed NIH Deputy Director on August 1, 1962.

During his career at NIH, Dr. Sessoms was the 1·ecipient of two Meritorious Service Awards. The first, in 1964, was in recognition of his accomplishments as chief of the Cancer Chemotherapy National

(See DR. SESSOMS, Paue ,J

Fifteen Employees of NIH Being Honored Today at Annual Awards Ceremony Here

Fifteen NIH employees are being given special recognition at the annual Awa1·ds Ceremony today (May 28) at 2 p. m. in the Clinical Center auditorium.

The Superiot· Service Award is being presented to 13 employees and Robert J. Eisel, National Cancer ' Institute medical technician, is re- the international marshalling of ceiving a $1500 cash award for a data to guide the treatment of can­Specia l Act or Service, Dental Di- cer." rector George A. Nevitt, Bureau Dr. Hans L. Falk associate sci­of Heal~h ~anpower! is receiving entific director for Carcinogenesis, the Mentono_us Serv1~e Medal. NCI , " ... for his highly signifi-

The ~up~rio~ Service awardees cant contributions to the develop-and the1~ citations are: ment of a na tional program on ex-

Dr. Sidney J. Cutlet·, head of perimental carcinogenesis." End Results Section, Biometry Dr. Robert A. Manaker head, Branch, NCI, " .. . for pioneering /See AWARDS, Page 8)'

Fundamental and Applied NH I Research Aids in Synthesis of Thyroid Hormone

Fundamental and applied resea1·ch by National Institutes of Health scientists on thyrocalcitonin-a thyroid hormone recently discovered in several animal species--has:

• Provided the first chemical definition of the hormone's structure that has just led to synthesis of the hormone by S,viss researchers ;

• Provided a sensitive method of measuring the normally minute amounts of hormone ci rculating in the blood;

• Established through the assay method the hormone's physiologi­cal impo1·tancc in bone and mineral metabolism; and

• Demonstrated that the purified hormone, administ.crt'd to patients suffering from high blood calcium levels and bone demineralization, produces rapid and beneficial re­sults.

These findings, of far-reaching scientific and medical importance and the subject of intensive re­search efforts by many research teams in this country and abroad, were presented May 21 at the ht-

ternational Symposium on Protein nnd Polypeptide Hormones, Liege, Belgium, by Dr. John T. Potts, Jr., of the National Heart Jnstitute's Laboratory of Molecular Diseases.

Dt·. Potts, head of the Labora­tory's Section on Polypeptide Hor­mones, and his coworkers, Drs. Hugh D. Niall, Henry T. Keut­mann, H. Bryan Brewer, J r., Leon­ard J. Deftos, and Michael R. Lee, have also 1·epo1-ted these findings in the April and May issues of the Proceedin{JH of lhe National Academy of Science~.

Previous reseurch in this country and Canada had found a substance that lowers blood calcium levels,

(See SYNTJ/ESIS, Pa(Jr 5)

Shown here is the omino ocid sequonco of thyrocalcitonin. The 32 omino ocid components of the mole cule are arranged in o single polypeptide choin with o loop at one e nd. Particularly interesting molecular sites include tyrosine (o mino ocid 12 ), the point ot which radioactive iodine wos ottoched to tho molecule for rodioimmuno-ossoy studies; ond methionine (omino acid 25), whose exte nsive alte rotion does not offect the molecule's hormonal activity.­Photos by Ralph Fernandez.

Page 2 May 28, 1968 THE NIB RECORD

ecord Published biweekly at Bethesda, Md., by the Publications and Reports Branch, Office of Information, for the information of employees of the National Institutes of Health, principal research agency of the Depart­ment of Health, Education, and Welfare, and circulated by request t o interested writers and to investigators in the field of biomedical and r elated research. The content is reprintable without permission. Pictures are available on request.

The NIH Record reserves the right to make corrections, changes or dele­tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare. NIH Record Office .. . Bldg. 16, Rm. 212. Phone: 49-62125

Editor ...... . .. .. .. .... ... .......... ... .. ..... .. ... .. .... . .. . .. Fronces W. Davis Assistont Editor .. ....... ... ... . .... . . .. .. .. Foy Leviero

Staff Correspondents

Tony Anastasi, DRS; Bari Attis, NIN DB; Lloyd Blevins, NICHD; George Bragaw, NHI; Katie Broberg, NTAMD; Robert Callahan and Doris Ilchefl', BHM; Dale Carter, DRMP; Elsie Fahrenthold, CC; Sue Hannon, NIDR; Walter Jacob, OAM; Sheila Jacobs, NCI; Elizabeth Y. J ames, DEHS ; Betty Kuster, DCRT; Hugh J. Lee, DRG; Art Mc­Intire, N IMH; Martha Mader, NIAID; Robert Mehnert, NLM; Faye Peterson, DBS; Wanda Warddeli, NIGMS; Beverly Wan·an, DRFR.

NEWS from PERSONNEL

VIETNAM VETERANS The Civi l Service Commission is­

sued r egulations recently to im­plement a new program for the appointment of returning Vietnam veterans to positions in the Fed­eral service under a special non­competitive transitional appoint­ment.

Progra m Authori:ted

These appointments, authorized by Executive Order 11397 signed on Feb. 9, 1968, permit returning veterans to be employed in the Federal service and, at the same time, continue their education or training in an approved course of study.

The program, designed to in­crease incentives to improve edu­cation and employment skills, is only one of a three part Govern­ment plan to increase assistance to Vietnam veterans.

lnformotion Points Set Up

It includes establishment of in­formation points in many cities where returning veterans can get assistance and advice about Fed­eral job opportunities.

Also, special attention will be given to their applications in order to speed up the rating process so that they can be considered for employment as soon as possible.

At each of the information points the CSC has posted counselling specialists. In addition, the CSC is furnishing interviewers at the U.S. Veterans Assistance Centers being established by the Veterans Ad­ministration.

The transitional appointment is

Excess Property Display Moves to New Building

The Property Utilization excess property display area has moved to the Danae Building, 12725 Twin­brook Parkway, Rockville.

In announcing the move, James B. Davis, chief of the Supply Man­agement Branch, stressed the im­portance of NIH pe1·sonnel using the excess property display as a source of supply before purchasing new equipment.

A shuttle service provides five round trips daily to the area ware­house. NIH employees have been asked to ca II Ext. 68251 for the shuttle service schedule.

Government Code of Ethics

Any person in Government service should:

Put loyalty to the highest moral principles and to coun­try above loyalty to persons, party, or Government depart­ment.

considered one of the most impor­tant components of this program. To be eligible for such an appoint­ment, the veteran must agree to enroll in an approved course of study. Further, he must:

Requirements Listed

• Have served on active military duty on or after August 5, 1964;

• Have less than one year of ed­ucation beyond high school; and

• Meet all of the requirements for the job.

Appointments of this nature may be made to any position, GS-5 and below or the equivalent under other F,ederal pay plans. Both the em­ployment and the education may

Military Chaplains Attend CC Program To Broaden Hospital Pastoral Skills

Four militory chaplains, on duty at othe r hospita ls, discuss postorol problems with CC Chaplain, Robert Robey (second from rightl. Left to right ore: Chap­lains 0. Roy Fit:<gerold, Floyd Heckord, Dovid Polhemus, Chaplain Robey, and Father John Brennon.-Photo by Ra lph Fe rna nde:<.

Four Washington area military chaplains recently completed a Clini­cal Center training program which included seminars and consultations with patients and staff members. The program was under the direction of Clinical Center Chaplain, Rob­ert Robey.

This training is part of a year­long r11·ogram which enables ex­perienced chaplains to earn certifi­cation in the Association for Clini­cal Pastoral Education.

Goin Fresh Perspective

Chaplains John Brennan, Floyd Heckard, and David Polhemus rep, resented 'Walter Reed Army Hos­pital. Chaplain 0 . Ray Fitzgerald came from the National Naval Medical Center. Each has had at least 12 years of service as a pro­fessional military chaplain.

By working and talking with pa­tients and staff members in a hos­pital other than their own, the chaplains agreed that they were able to gain a fresh perspective on their roles as members of a hospital team.

At the Clinical Center, tlhe chap­lains were assigned to fewer pa­tients than they would normally have had in t heir respective hos­pitals. This left them more time for consultation with medical and paramedical personnel, and for analysis of their study group ac­tivities.

According to the chaplains, the numbe1· of CC staff members in proportion to patients was greater than in most hospitals. Also, pa­tients treated here had a greater variety of illnesses. Roth factors, they thought, helped them to broaden the pastoral skills they would need as part of a hospital team.

While their pace at the Clinical

be either full or pa1·t time and may lead to permanent employment.

After at least one year of satis­factory service, a transitional ap­pointee will be converted to career or career-conditional status provid­ing he has successfully complet ed the agreed upon course of study.

Center may have been more leis­urely, their daily schedules were more demanding.

The chaplains spent 4 hours, be­ginning a t 7 :45 a.m., with patients in their own hospitals. Then they worked at the Clinical Center from noon until '8 :30 p.m.

Soon after the military chap­lains departed, a group of semi­narians arrived at the Clinical Center to begin the regular pas­toral training program.

Dr. Tester to Serve on NIGMS Behav. Sciences Training Comm.

Dr. John R. Teste1·, ecologist and associate professor, Department of Ecology and Behavioral Biology, College of Biological Sciences, Uni­versity of Minnesota, has been ap­pointed to the Behavioral Sciences Training Committee of the Nation­al Institute of General Medical Sciences.

Dr. Richa rd C. Greu lich, NIDR's Di­rector of Intramural Research (cen­te r), presents cosh owords to Joel D. Rosenthal (left), biologist , for a sug­gestion which saves time, effort, and funds in order ing and storing ca rbon dioxide tonks, o nd Jomes Ingram (right), supervisory b io logicol lo boro­tory technician, for devising a more efficient system for distribut ion of o nimol food.-Photo by Ed H11bbord.

TIIE NIH RECORD

DR. MIDER (Contin,;cd from Pago 1)

fast, he reviewed the endless stream of reports fast.

Now Dr. Mider is moving to the National Library of Medicine. To many people at NIH, Dr. Mider himself has seemed a walking med­ical library, and one needing no computer to retrieve the vast fund of information stored in his mind.

Duties Defined But since NLM has 1,500,000

books, journals, theses, films, mi­crofilms and pamphlets with com­puters, and even satellites to in­crease the computer service, one wonders about what Dr. Mider will do.

Officially, he will be a Special Assistant to Dr. Martin M. Cum­mings, the Director. Unofficially, he may be known as the Library of Medicine's physician or medical specialist.

The Library has on its staff many specialists: information system spe­cialists, chemists, pharmacologists, historians, and so on. But few med­ical people, aside from Dr. Cum­mings himself.

Is Well Known Because Dr. Mider is known, both

by reputation and to a large extent personally, in every government agency and institution conducting or administering medical research in t his country and abroad, he will be able to augment Dr. Cummings' activities in making the Library both better known and more re­sponsive to the needs of the medi­cal research community and to the medical profession through medical schools and the larger community hospitals.

Another one of his concerns at the library will be the review for possible publication of various original papers deposited in the li­brary.

Dr. Midel· first came to NTH as a research fellow at the National Cancer Institute in 1939. In 1941, when that fellowship was terminat­ing, Dr. Carl Voegtlin, Director of NCI, suggested that Dr. Mider apply for a Comm ission in the PIIS.

Re joins NIH in '52 Subsequently Dr. L. R. Thomp­

son, Director of NIH, called Dr. Mider into his office and told him he could not meet the }Jhysical standards for a Commission and advised him to leave NIH because there was no fut ure in the organi­zation unless one was an officer. Dr. Mider went to Cornell.

It was not until 1952 that Dr. Mider came back to NIH as asso­ciate director in charge of research at the NCI. The growth, or rather, the evolution of the National Can­cer Institute from a small institu­tion of scientists concerned with bi­ology in a rather narrow sense to

May 28, 1968

WOMEN AT NIH

Novice Dentist's Vacation Visit to NIH Sparks Interest in Electron Microscopy

By Hiloh Thomas At NIH a slim, youthful, soft-spoken Dane, who speaks English like

a native, is an international authority on the fine structure of dental tissues.

The expert on that subject is Dr. Mar ie U . Nylen, National Institute of Dental Research, a widely known electron m icroscopist and the author of numerous papers on the development and structure of enamel and dentin.

She has also w1·itten papers on the process of calcification as it

Dr. Nylen finds the ti me to troin young scientists in e lectron microscopy.

occurs in such diverse places as invertebi-ate al1imals, in dental calculus, and in aortas and tendons.

Dr. Nylen was the first to dem­onstrate the atomic characteristics of a biological substance when she photographed the crystal latt ice of enamel. She showed how these m i­nute crystals grow and what the relationships are between them and thei r organic matrix.

T n addition to activities in a number of scientific organizations,

a world-renowned institution giving leadership in every phase of cancer research followed.

From the NCI Dr. Mider moved to the position of Director of Labo­ratories and Clinics, NIH, where the r>rocess of growth and evolution was already under way.

Much of Dr. Mider's professional career has been spent in teaching and in administration. Unlike many scientists, he likes administrative work. He also likes writing and editing, and is expert at botih.

Dr. Nylen has served as an ad­visory editor to the Jom"lwl of Denuil Research. She is also a Fellow of the American College of Dentists.

Today, Dr. Nylen administers t!he Laboratory of Histology and Pathology and studies such prob­lems as the e ffect of the antibiotic, tetracycline, on tooth structures.

She is also in charge of trajning young scientists in electron m icro­scopy, a much-needed skill in mod­ern biomedical resea1·ch .

Is Badminton Champion

In addition, she manages a home and three children, and in addition to Uint, the attractive doctor is a champion in her favorite sport-­badminton. At one time she was badminton champion of both the District of Columbia and New England.

Twice, she won the All England Singles Championship, and she was fourtime winner of the women's doubles championship in Denmark.

Dr. Nylen grew up with three brothers. As a you11gster she dreamed of becoming a physician. Her ambitions were fostered by her father, a law professor, who brought up his daughter with the maxim that marriage was not equivalent to ea·rning a livelih.ood.

During t he war years the young student switched her ambitions of

Page 3

Banner Year Predicted By Officials for NIH' s '68 Savings Bond Drive

As the Record went to press first reports were coming in on the 1968 Savings Bond Drive. About 500 Institute and Division keymen be­gan the drive with a person-to­person canvass of NIH's 12,000 em­ployees.

Some campaign officials are pre­dicting that this will be a record year for }Jayroll deduction in the Bond drive.

Advontoges Cited Dr. G. Donald Whedon, NIAMD

Director and Chairman of the 1968 Bond Drive, emphasiied that the pul·chase of Savings Bonds by pay­roll deduction represents good busi­ness sense and offers many advan­tages.

"The system is automatic, con­venient, and the interest rate was raised recently. It is the only sav­ings-interest income which is not subject to Suite as well as Federal tax," Dr. Whedon explained.

Canvassers throughout NIH are being provided with Bond pam­JJhlets that show how investoTS may use their Savings Bonds upon re­tirement and obtain specia l interest advantages.

The pamphlets also point out how a fund for educating the chil­dren can be established with Bonds, and how the compounding of inter­est over a long term can lead to substantial savings.

becoming a doctor, to that of den­tistry; the change in plans some­what accelerated her education.

Dr. Nylen graduated from the Royal College of Dentistry, in Co­penhagen. Soon after she became

(Seo /lff. NY /,EN. Page 4)

Birdwatching is one of his hob­bies, and he and Mrs. Mider can frequently be seen in the early morning walking along the tow1iath of the C. and 0. canal above Penni­field Lock watching for the many varieties of birds that can be seen in that vicinity during spring and fall migrations.

Dr. Mider is a member of many scientific societies and a recipient of the Distinguished Service Award of the Department of Health, Edu­cation, and Welfare.

Wilbur J. Cohen tokes the ooth of office as DHEW Secretory at tht. White House on Moy 16. Vice President Hubert H. Humphrey administers the oath, while Mrs. Cohen holds the family Bible. Included in the swearing-in ceremony were President Lyndon B. Johnson, and Secretary ond Mrs. Cohen's three sons (I. to r.l: Stuart, Bruce, and Christophe r. Lote r, a ceremony ond reception hon­oring Secretary Cohen were held in the DHEW auditorium. The program at the ceremony wos piped to the DHEW cofete rio, the Social Security Building in Baltimore, ond Wilson Holl (Building 1 l.-Photo by Jerry Hecht.

Page 4

Dr. Di Chiro Elected to Membership in AANS

Dr. Giovanni Di Chiro, head of the Section on Neuroradiology, Medical Neurology Branch, Na­tional Institute of Neur ological Dis­eases and Blindness, has been elected to associate membership in the American Association of Neu­rological Surgeons at its annua l meeting held in Chicago in April.

Associate members of the AANS "constitute the leaders in t he fields of neurological sciences" acco1·ding to the secretary of t he organiza­tion, which was founded in 1931 as the Harvey Cushing Society.

Reseorch Inte rest Noted Dr. Di Chil'o has been with

NINDB since 1958, His research interest encompasses both basic and diagnostic uses of x-rays and radioar.tive isotopes in the neuro­logical sciences.

He has contributed to the devel­opment and improvement of sev­eral techniques fo1· studying and visualizing the brain and spinal cord.

Dental Research Careers Illustrated in New Film

A film to illustrate the various fields of research in dental science, is being produced under the aus­pices of the American Dental As­sociation and supported by the Na­tional Institute of Dental Research. It is planned for autumn release.

The film points out how such in­terrelated fields as microbiology, biophysics, biochemistry, and simi­lar subjects, are all represented in dental research.

The motion picture, produced by Wexler Film Productions in Los Angeles, will be shown to high school and college freshmen who are primarily science majors.

Cameramen shoot scenes ot a De ntal Institute loborotory for o f ilm illus­trating how many fields of science ore re presented in dentol reseorch.

May :!8, 1968

NCI Study Finds Enzyme Abnormality in Chronic Mye/ogenous leukemia Patients

National Cancer Institute investigators have reported that patients witJh chronic myelogenous leukemia, even those in remission, have ab­normally low levels of pyrimidine deoxyribosyltransferase.

DR. NYLEN (Contittued from, Page 3)

an instr uctor there in operative dentistry.

She set aside most of her earn­ings for a trip to the United States, with Washington as her destina­tion. A friend who lived there offered her free lodging.

While staying with that friend in t he s ummer of 1949, she tele­phoned one of her former profes­sors who was a v isiting scientist at N IH. He invited her to inspect the NIH dental laboratories, then in Building 4.

Pioneer Influe nces Corecr She was introduced to Dr. David

R. Scott, a pioneer in electron mi­croscopy, who, with Dr. Ralph W. G. Wyckoff of the N,a tional Insti­tute of Arthritis and Metabolic Diseases, was doing research in that field.

Dr. Nylen was fascinated with this n(;w technique-and restless after her summer vacat ion. She spent the rest of that year as a g uest worker at ~IDR studying and learning about the electron micl'Oscope.

At t hat time the glass knife and present methods of making thin slices had not been invented. Dr. Nylen spent weary hours sharpen­ing steel knives and trying to make sections only 1/10,000 mm thick.

Awarded Fe llowship Impressed with her performance

and capabilities, NIDR gave her a postdoctoral fellowsh ip for the following year. Because she did not have a permanent visa, Dr. Nylen returned to Copenhagen in 1051. ffiie was appointed assistant professor in the Depa1-t;ment of Oral Diagnosis at the Royal Den­tal College. She also helped to set up an electron microscopy research program at the college.

In 1!)55 she returned penna­nently to NTH at the invitation of NIDR.

The following January she met Aage Nylen, and in 6 months they were married. Mr. Nylen was born in Norwa y. During World War IT he escaped to Sweden where he served with Norwegian forces. In 1951 he settled in the United States as a photog1·apher and rcpo-rtcr for a Brooklyn newspaper. At present he is an executive in the hotel business in Washington.

The Nylens liv·e near Chevy Chase Circle with Ingrid, 10; Erik, 8; and Thomas, a tow-headed two­year-old charmer. Dr. Nylen says she is fortunate in having very healthy chlldren and a reliable housekeeper. Because of these two

The enzyme pyrimidine deoxyri­bosyltransferase, which catalyzes the synthesis of deoxythymidine and deoxyuridine, normally is more t han five times as active in granu­Locytes as in other white cells.

Low levels of th,e enzyme in pa­tients with acute and chronic mye­logenous and lymphocytic leuke­mias are due in part to the de­creased number of normal granu­locytes in these patients.

The investigators, Dr. R. Gallo, Dr. S. Perry and C. Davis, assayed the white blood cells of 14 patients ,vith ch ronic myelogenous leukemia (CML) in remission and found that 16 of 17 samples showed be­low-normal transferase activity. By contrast, control samples from )4 normal volunteers had normal transferase levels.

Abnormolity Explained

The abnormality in the CML p a­tients was not due to chemother­apy since values in eight patients not 1·eceiving therapy did not dif­fer from results with patients on therapy. By contrast, four patients with acute myelocytic leukemia in remission had normal enzyme lev­els.

Transferase deficiency is appar­ently characteristic of CML granu­locytes even though the cells are morphologically mature, tJhe dif­ferential count is normal, and pa­tients are in remission.

The investigators believe that this enzyme deficiency may suggest a chemical alteration in these cells at the level of gene expression.

It is hoped that the finding may have diagnostic usefulness in chronic myelogenous leukcmia.---a d isease in which blood changes may occur years before significan t symptoms appear.

factors, she rarely misses a day's work.

The press of duties has forced Dr. Nylen to put aside her hobbies of bridge and badminton. She says, "Today, photographing the children and reading are my chief diver­sions. As for vacations, we take the children to Europe to see their g1·andparents as often as we can."

Family Is Multilingual Dr . Nylen's eyes twinkled when

she was asked if the children spoke Danish or Norwegian. ''We speak both languages at home," she said, "and I know they understand a lot, but so far nothing induces them to speak anything but English. Nev­ertheless, everybody speaks Eng­lish in Scandinavia; so they get along very well when we travel."

If they are at all like their par­ents, they will, indeed, get along very well anywhere.

THE Nill RECORD

DR. SESSOMS (Contimied from Pa,ge 1)

Service Center. His second MSA, presented in

1006, was in recognition of his "outstanding ability and achieve­ments in t he development, opera­tion and staffing" of t he new re­g ional medical programs. In recom­mending Dr. Sessoms for the award, Dr. James A. Shannon, NIH Director , specifically noted Dr. Ses­soms' substantial contributions to the legislative process resulting in Public Law 89-239, the Heart Dis­ease, Cancer and Stroke Amend­ments of 1965.

A native of North Carolina, Dr . Sessoms received his M.D. degree

Upon retirement from NIH, Dr. Stuart M. Sessoms will ossume new odminis­trotive ond teaching duties ot Duke Unive rsity on Aug. 1.

from the Medical College of Vir­ginia in 1946. He did graduate work at Johns Hopkins School of Medicine and received additional trnining at the Memorial Center for Cancer and Allied Diseases in New York prior to joining NIH.

Dr. Sessoms is a Diplomate of the American Board of Internal Medicine, a Fellow of the New York Academy of Sciences, and a member of the Association of Mili­tary Surgeons and the American Hospital Association.

Drs. Bradley and Vaughn Named to NIAID Board

Two new members have been ap­pointed to 4-year terms on the Na­tional Institute of Allergy and In­fectious Diseases Board of Scientif­ic Counselors.

S. Gaylen Bradley, Ph.D., Pro­fessor of Microbiology at the Uni­versity of Minnesota, and John H. Vaughn, M.D., Professor of Medi­cine in the University of Rochester School of Medicine and Dentistry, will join the Board on July 1.

Among Dr. Vaughn's research interests are allergy and immuno­logical phenomena in internal med­ici',ie. Professor Bradley's speciali­ties include actinomycetes, micro­bial genetics, morphogenesis, and physiology.

THE NIB RECORD

SYNTHESIS (Continued from Page 1)

identified t his as t hyrocalc.itonin, and it s origin as tlhe thyroid gland, and strongly suggested that this was another important thyroid hormone t hat acts in concert with t he parathyroid hormone to regu­late blood calcium and prevent bone demineralization.

Evidence Provided

T he NHI scientists' studies pro­vided evidence that thyrocalcitonin is a hormone and is continually re­leased into the bloodstream in small amounts to perform a normal physiological role, t hat of control­ling the rate of bone demineraliza­tion and thereby helping- to regu­late blood calcium levels.

The NHI scientists previously had isolated the hormone in pure form from partially purified ex­tracts of pig thyroid, increased its potency 50,000 times, and subjected it to stringent tests which estab­lished its purity.

Molecule Structure Defined

These isolat ion studies next led Dr. Potts and his coworkers to a defin ition of the structure of the thyrocalcit onin molecule, a peptide containing 32 amino acids, the se­quence of which was determined by several biochemical methods.

The identical results from t hese methods s howed the 32 amino acids are arranged in a single polypep­tide chain with a loop at one end.

Ultimate proof that the correct structure has been obtained and practical application of the knowl­edge of hormonal structure re­quires laboratory synthesis of the

Or. Potts (right) exomines a strip chart emanoting from an Automotic Record­ing Rad ioactivity Detector with Dr. Leonard J. De ftas (center) and Dr. Michoe l R. Lee, a visiting scientist from Oxford University, Englond. Ors. Deftas ond Lee have focused the ir ef­forts toward the de velopment of the new rodioimmunoassay technique .

hormone. This has been accom­plished.

Within t he past 2 weeks, Dr. St. Guttman a nd coworkers at Sandoz Ltd., a pharmaceutical company in Basel, Switzerland, achieved com­plete synthesis of highly act ive

May 28, 1968

,,. ~~,· .'-~ ,·

" Fingerprints" of various peptide frogme nts of thyrocalcitanin are shown being discussed by Dr. He nry T. Keutmann of NHl's Laboratory of Molecular Dis­eases (center), Dr. John T. Patts, Jr., head of the Laboratory's Section on Polypeptide Hormones (left), and Lynn "Skip" Collahan, Laboratory te ch­nician. The fragments, seen as spots on the filte r pape r, were stoined to rende r them visible following their separotion by electrophoresis. The spots are then cut out and washed with solvents ta remove the frog men ts for further process­ing by several techniques rece ntly deve loped by Dr. Keutmann to digest the fragments into the ir component amino ocids. These are then individuolly anolyzed by Mr. Callahan in the machine directly behind him, the Automatic Amino Acid Analyzer.

thryocalcitonin, by using as t heir "blueprints" the structural infor­mation supplied by Dr. Potts' group.

Scientists of two othez· pharma­ceutical firms, Ciba Pharmaceutical Company in Switzerland, and Led­erle Laboratories in the United States, have also announced con­siderable success in its synthesis.

Assoy Technique Deve loped

Development by the NH! scien­tists of a sensitive radioimmuno­assay technique for determining small, physiological amounts of the hormone in blood has opened the door to evaluation of thryocal­citonin's importance in normal bone and mineral metabolism and its role in various disease states.

With this technique, the NHI scientists were able to detect, for the first time in any normal ani­mal, the minute quantities of thyro­calcitonin continuously secreted into the blood of intact rabbits, and to measure the rapidly increas­ing amounts of hormone released in response to infusions of a cal­cium solution.

Studies Suggest Value

'l'ests with the assay in human patients have shown t hat a cert ain form of thyroid cancer produces excessive quantities of thyrocalcito­nin, a finding that may explain many of the symptoms of this dis­order, the NHI scientists believe.

These studies have strengthened the probabil ity, currently under st udy by a number of clinics, t hat thyrocalcitonin has value in treat­ing patients suffering from cert ain diseases characterized by softening and weakening of the bones, as well as in combatting high blood cal-

Bess Dawson, on NHI chemist, exam­ines a thin-layer plote contoining several peptide fragments of thyrocal­citanin that have been made visible with special stains. Miss Dawson ond Dr. H. Bryon Brewer, Jr. hove done most of the Lobarotary's work involv­ing this particular technique, thin- laye r chromatography, which hos proved ve ry useful for separoting the peptide fragments.

cium levels. The blood assay should prove useful in monitoring blood levels of the hormone during such therapeutic use.

In one NH l patient, afflicted with widespread cancer of the pa1·athy­roid glands and extensive destruc­t ion of bone (uncontrollable by con­ventional therapy), blood calcium has been maintained at normal levels for a period of 5 months, and bone lesions healed, by only intermittent treatment with small amounts of the highly purified hor­mone preparation supplied by Ar­mour Pharmaceutical Company.

This and othe:r clinical studies were performed by the NHI Lab­oratory of Clinical Endocrinology, headed by Dr. Frederic C. Bartter.

Page 5

Lighting System Survey Pinpoints Inadequacies

A survey of the ultraviolet light­ing systems in NIH laboratories has been completed by the Biologi­cal Control Section, Envirnnmental Services Branch, Division of Re­search Services.

Of the 283 lights surveyed, r e­sults showed t hat in some older buildings, up to 50 percent of the UV lights needed t o be replaced due to inadequat e intensity or be­cause the lights were completely burned out.

In one of the newer buildings, occupied less than one year, 70 per­cent of the UV lights were inade­quate.

Because of t he principle involved in utilizing UV lighting for germi­cidal purposes, certain maintenance procedures are essential in order to insure the proper functioning of lights at maximum efficiency.

Caution in Cleoning Urged

The ESB recommends that tubes be wiped clean with a soft cloth moistened with isopropyl alcohol at each 2-week interval, and more fre­quently in dusty ar eas.

(Caulio1,: The UV lights must be turned off for cleaning purposes to prevent exposure to personnel and to prevent a fire hazard.)

New UV light tubes should be installed when the old tubes fall below 70 percent of their original intensity.

ESB has started a program for checking t he intensity of ultra­violet lights at 6-month intervals. However, regular checks by Insti­tute personnel are encouraged.

Anyone desiring additional in­formation about UV light installa­tions should contact the Environ­mental Services Branch, Ext. 64995.

Dr. Hugh D. Niall, NHI , examines the product of one step in the seque ntial degradation of thyrocalcitonin, while Rosemary Ronan purifies onother am­ino acid that hos just bee n cleaved from its parent molecule. Dr. Niall, a visiting scientist from Monash Univer­sity, Melbourne, Austrolia, odapted the sequential degradation (Edman) procedure for use in these studies to determine the omino acid sequence of thyrocalcitonin.

Page 6

Blood Bank at CC Receives 219 Units of Blood in April

The Clinical Center Blood Bank reports that 219 units of blood were received from NI H donors in April. During the same period, CC patients re­ceived 1,812 units of blood.

Four NIH staff members have joined t he "Gallon Donor Club." They are : CI if ton Brown, OD; John W. Samen, DRS; Evelyn H. Wall, N CI; and Betty D. Kuster, DCRT. In addition, Donald B. Spencer, NIMH, r eached the gallon donor mark.

AWARDS (Co,,tinu('d from Pape J)

liiicr obiol.ogy Section, Viral Biology Branch, NCI, " . .. for h is out­st:mdin~~ program management c'.lpabil ities and for his develop­ment of scientific concepts and im­portant new prccedures for defini­tive studies on the virus etiology and control of leukemia in man."

Othe r Citations Noted

Leland D. May, assistant chief (Bud~ct), Financial Management Dra;:ch, Office of the Di ,.ector, " in recog nition of h is leader­s!1ip ro' e in t he planning and exe­c~1tion of sensitive and responsive budget ma nagement at the NIH."

Gernld F. Meyer, administrative officer, Etiology, NCI, " .. . for sustained excellence in integrating modern administrative practices wit h ever-changing needs of a large, complex research pr ogram on cancer causation."

Dr. ,John B. Moloney, Viral Leu­kemia and Lymphoma Branch, NCI, " ... for his outstanding contribu­tions towards understanding com­parative mechanisms of viral car­cinogenesis in animals and the ap­plication of this information to cancer in man."

Dr. Ph ilip Honored

Dr. Cornelius B. Philip, head, Medical Entcmology and Acarology Section, National Institute of Al­lergy and Infectious Diseases' Rocky Mountain Laboratory," ... in recognition of his international scientific stature, significant rec­ord of achievement, and Tecent contributions on the problem of epidemic typhus in domestic ani­mals."

Samuel M. Poiley, head, Mam­malian Ge11etics and Animal Pro­duction Section, NCI, " ... for skillful management in the devel­opment and procurement of experi­mental animals f.o1· cancer re­search, and for improving the hea.lth of laboratory animals throughout the world."

Dr. Arnold W. Pratt, Ditector of the Division of Computer Research and Technology, " ... his forceful and imaginative leadership has created a far-sighted and innova-

May 28, 1968

Grants Management Officers Evaluate Their Role at Three-Day Conference

The first Grants Management Seminar sponsored by the NIH Ad­visory Committee for Extramural Management Procedures recently held a 3-day series of lectures and discussions at Airlie Conference Center, War-renton, Va.

The seminar, under the auspices of the NIH Committee on Staff Training Extramural Programs, brought 26 grants management offi­cers and specialists from NIH (in­cluding the National Library of Medicine), and the National Insti-

tute of Mental Health. Acc ording t o Dr. Thomas

Bowery, associate director for Op­erations, Division of Research Facilities and Resources, who acted as seminar moderator, the purpose of t he meeting was to discuss:

(1) The proper role of the grants management office1· in an organ iza­tion administered by scientists; (2) the function of the grant s manage­ment officer at vadous levels within the department; (3) the f unction of grants administrators in relation to their university counterparts .

Participants in o rece nt Gronts Monagement Seminar at Airlie Confe rence Center, from left, ore: Row 1 J George Porrish, N IAMD; Anna Marie Pe rrell, DEHS; Robert Ginsburg, NIDR; Leo Buscher and Jock Coleman, NCI; Dr. Thomas Bowery, DRFR; Steven Bernard, NHI; Gregory Lewis, NIAMD; Ber­nard Dvockin, DRFR; John Spoin, NLM. Row 2J Virginia Lehr, NIAID; Mor­guerite Pusey, NLM; Richard Hopkins, N ICHD; Ernestine Taylor, NHI; Ke n­neth Anderson and Robert Dickenson, DRFR; He len Schroeder, NIGMS; Linden Neff, NIAMD; Nicholas Moriorty, DRG; Jacob Se idenberg, FMB-OD. Row 3) Guerry Smith, DRG; Donald Townsend and Eleanor Offutt, NIMH; Dr. Robert Gibbs, OD- NIH; Robe rt Poul, NIGMS; Irving Nash, NINDB; Donald Clark, NICHD; James Quirk, NIAID. Jone Knopp, DRG, was not present for the photo.

tive program of computer research, development and applications in support of biomedical science."

Dr. Marvin A. Schneiderman, as­sociate chief, Biometry Branch, NCI, " . . . for his significant con­tributions to clinical trial design and to the improvement of biosta­tistical applications to cancer re­search."

Dr. Earl R Stadtman, chief of the Laboratory of Biochemistry, National Heart I nstitute, " .. . for his pioneering work in biochemis­tt·y which has led to fundamental contributions toward the under­standing of metabolic regulation."

Di·. Ludwig von Sallman, chief of Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, " ... in recog11ition of his major contributions to knowledge of the control of intra­ocular pressure, the pathogenesis of cata1,acts, and to many aspects of clinical ophthalmology."

Dr. Herbert H. Weissbach, deputy chief, Laboratory of Clinical Bio­chemistry, NHI, " ... for contri­butions to the understanding of

vitamin-Bit coenzyme biosynthesis and its physiologic implications a nd for exce llent research in many a1·eas of biological chemistry."

Mr. Eisel's cash award for a Special Act 01· Serv ice is being pr e­sented for his crucial role in the invention and development of con­t inuous llow, closed centrifuge sys­t em to allow the removal of se­lected elements from human blood and to 1,et urn the remainde1· di­rectly back to the donor.

Importance of Work Cited

He recognized and pursued the solution to the final, critical tech­nical problem which, until that point, had prevented the complex centrifuge system from being clini­cally useful.

Dr. Nevitt, a commissioned officer, is receiving his medal " ... in rec­ognition of more than 2 decades of superior public service in further­ing the advancement of dental health in !Jhe United States and for his valuable assistance in sup­port of dental progress in other countries."

TRE NIR RECORD

Dr. John G. Hayward, OIR Administrator, Dies

Dr . J ohn G. Hayward, a health science administrator in the Office of International Research, died May 13. He was 50 years old.

At the time of his death, Dr. Hayward was a staff mernber of the U.S. Secretariat of the U .S.­Japan Cooperative Medical Science Program, and was responsible for the coordination of research activ­ity for the Parasitic Diseases (schistosomiasis and filariasis) and Tuberculosis Panels.

Bockground Described

Dr. Hayward, born in Irvington, N.J ., received the DVM deg1·ee from Texas A & M University in 1941.

He worked for the USDA Bureau of Animal Industry for 2 years and then served in the U.S. Army Vet­erinary Corps from 1943 to 1945.

D1·. Hayward engaged in private practice in Russellville, Ark. from 194-5 to 1959. During these years he became extremely interested in parasit ic diseases, and conducted an internal and external parasitic control program for city and county public health agencies.

He also developed numerous vet­erinary surgical techniques such as corneal t ransplants f or animals, pelvic repair, and "buttonhole sur­gery."

Traveled Exte nsively

Leaving private practice, Dr. Hayward served as a veterinary advisor to the Administration foT International Development, Depart­ment of State, for 5 years. He trav­eled extensively in the Caribbean area and in Africa, establishing national disease research labora­tories and disease control programs and conducting nutritional studies.

In November 1965, Dr. Hayward joined NIH as a Research Grants Associate.

Dr. Hayward is survived by his widow, Betty, and two sons, John G., Jr. and Stephen.

Dr. Hayward coordinated research ac­tivity for the parasitic diseases ond tuberculosis panels, U.S.-Japan Coop­erative Medical Science Program.

THE NIH RECORD May 28, 1968

18 Kalamazoo College Sophs Take Part In Studies at CC as Normal Volunteers

Normal Volunteers Steve Anker (left) ond Rod Kropf listen as Dr. Robert S. Gordon, NIAMD clinical director, explains controls of t he Metabolic Cham­be r.-Photos by Ralph Fcrnandex.

By Gail Hodgkiss Kal,mwzno College Volunteer

Eigl1teen Kalamazoo College sophomores are among t he 45 normal volunteers currently undergoing research stud ies at the Clinical Center.

These students are participating in the Kalamazoo College Career and Service Program, under which third quarter sophomores arc given the opportunity to work on jobs related to t heir major fields of study.

Not all the students in the cur­r ent group are science or psychol­ogy majors. Rod Krapf, a history major, and Steve Anker, a n eco­nomics major, are particularly pleased to he working in an area whicb is new to them.

Study Expla ined

Rod commented, " I've learned a lot of things here t hat I couldn't have learned any place else."

Both boys are on a rice diet for a study under the direction of D1·. Robert S . Gordon, Jr., clinical di­rector of the National l nstitute of Arthritis a nd Metabolic Diseases.

While visiting East Pakistan, Dr. Gordon particularly observed the d isease, cholera, among t he na­tive people. Because these people subsist on a diet consisting mainly of rice, which is low in potassium, Dr. Gordon decided to study t he effects of a low potassium diet upon healthy individuals.

Simulates Be ngali Climate

After 4 to 6 weeks on this diet, the boys will be placed for an hour and a half per day in a metabolic chamber at 110 degrees and 60 per­cent humidity, a simulation of the Bengali climate. Sweat from the forehead will be collected, and the amount of potassium in it checked.

Dr. Gordon is especially proud of the fact that of the four volunteers on his study, three of them are doing their "career assignments" under his direction.

Rod is helping to compile data from charts, and St eve is working with electronic equipment. Of his experience here, Steve said, "It's

Kalamaxoo College Normal Volunteer, Gai l Hodgkiss, rushes to meet a dead­line while on he r Career Assignment in the CC Information Office.

exciting to be working with the real top pioneers of research."

Mary Goodwin, a French major at Kalamazoo College, is partici­pating in fever studies under the direction of Dr. Sheldon M. Wolff, clinical director of the National In­stitute of Allergy and I nfectious Diseases.

T he purpose of her particular study is to determine the normal body's ability to remove particles of a fever-inducing drug from the blood. A sample of the volunteer's blood is checked originally to pro­vide a base line.

Then a fever is induced periodi­cally to which the volunteer s bui ld up a resistance. Later, the volun­t eers are rechecked to see how well their bodies a re removing particles from the blood.

Mar y a lso will soon be on a study to help investigate different ways of administering flu vaccine. She will be given flu serum either by nose drops or by injection.

For 3 weeks afterwards, she will have 5 cc's of saline solution intro­duced in her nose which she will expel into a paper cup for analysis in the laboratory.

Mary is working with Dr. Rob­ert L. DuPont, J r ., of the Labora­t ory of Clinical Science, National Institute of Mental Health, for her career assignment.

Assists in Mental Study

She is helping to compile ratings of psychotic patients in therapeutic wards. The behavior of these pa­tients is rated weekly by their nurses and doctors. These ratings are now being collected and graphed in order to locate trends of behavior or states of mind.

Studies will then be done to try to find the causes of each new trend. For example, a per iod of de­pression may follow the assign­ment of a new doctor on the wa rd.

Mary is especially excit ed about the people she has ha d the oppor­tunit y to meet here. " One of the things that impresses me most about NIH is the friendliness of nearly everyone," she decla r ed.

Volunteer Service Stressed

Delbert Nye, administrator of the Normal Volunteer Patient Pro­gram at the Clinical Center, stressed the importance of volun­teer participation. "Much of the re­search done here at NTH could not go on without the normal volun­teers," he said.

In order to study the effects of disease on the body, it is first nec­essary to establish a nor mal, or control, base line with which t o compare the effects of disease.

"Two basic qualities are essen­tial in a normal volunteer,'' Mr. Nye continued. " The first is, of course, a willingness to volunteer since t he studies are performed only with the volunteer's written consent given after a careful ex­planation of each project.

Integrity Aids Research

"The second is a basic in tegrity. It would be easy to cheat on some of the t ests , particularly the meta­bolic diet studies, and this of course would make any results valueless."

Mr. Nye is particularly pleased with the Kalamazoo group of vol­unteers. He called them "A whole­some, healthy group of young peo­ple."

The Normal Volunteer Program has been in existence nearly as long as the Clinical Center. Begun in 1954, the progr am has included over 3500 volunteers, and is now averaging about 400 per year.

These healthy people are ac­cepted through a sponsoring organ­ization such as Kalamazoo and other colleges, churches, and civic groups.

"What do you know, rice for lunch again!" comment Steve A nke r (left) and Rod Krapf, CC Normal Voluntee rs participating in a rice sludy.

Steve Anker wires a chassis which will prese nt a digital d ispla y of heart rates of as many a s four patients simultane­ous ly.

Another Normal Volunteer, Mary Goodwin, watches Dr. Sheld on M. W olff, NIAID, check he r fever by elec­tric thermometer.

Rod Krapf checks graph which pro­vides a record of pat ient's blood flow for an indicaction of heat output of the f ingers.

Page 8

Influences on Standards Described at Conference Sponsored by NICHD

A confer ence on Studies of the Acquisition and Development of Values was held at the Pan Ameri­can Health Organization Building in Washington, D.C., May 15-17.

This conference, sponsored by the National Institute of Child Health and Human Development, pre­sented 1·esearch material concerned with determining moral values, ethical st andards, and character formation.

Sherman Opens Conference The conference opened with an

introduction by Dr. John F. Sher­man, NIH Associate Dh:ector for Extramural Programs.

The major address was given by Dr. John G. Stoessinger, acting di­rector, Political Affairs Division of the United Nations Secretariat's Department of Political and Secu­rity Council Affairs. D,·. Stoessin­ger presented an historical review of society's concern for value sys­tems.

More than 50 eminent scientists from the fields of theology, ethics, sociology, philosophy, psychology, anthropology, psychiatry, and hu­man development attended.

Influencing Principles Discussed

T he conferees described the prin­ciples which influence the develop­ment of values and that identify the scientific teachings which con­tribute to an understanding of t hese values.

Conference speakers included: Dr. Richard F lacks, University of

Chicago; Dr. Lawrence Kohlberg, Harvard University; Dr. Urie Bronfenbrenne-r, Cornell Univer­sity; Dr. Francis Hsu, Northwest­ern University; Dr. Robert J. Lif­ton, Yale University School of Medicine, and Dr. Abraham Edel, City College of New York.

Guerry R. Smith Retires After 40 Yrs. in Govt.

Guerry R. Smith, chief of the Grants 'Management B-ranch, Divi­sion of Research Grants, retired iast month after 40 years in Fed­eral Government. For the past 5 years he has been with DRG.

Mr. Smith started his career in 1927 with the Government Printing Office.

Since that time he has held ad­ministrative positions with a num­ber of Federal agencies including the Departments of Agriculture, State, and Commerce.

A trained lawyer, Mr. Smith earned two degrees from George Washington University- a B.A. in 1935, and an LLB in 1938.

His retirement plans include gar­dening, sailing, and traveling.

May 28, 1968

Dr. Margaret Kelly Dies, With NCI for 28 Years

Dr. Margaret Kelly, pharmacol­ogist at the National Cancer Insti­tute, died of cancer on May 5 in the Clinical Center. She was the wife and collaborator of Dr. Roger W. O'Gara, a pathologist at NOi. Dr. Kelly used her maiden name t hroughout her career.

Dr. Kelly joined the Institute in 1940 as a medical technician in the Laboratory of Pathology. She was a senior investigator in the Labora­tory of Chemical Pharmacology at the time of her death. P,rior to her

Dr. Margaret Kelly's research inte rests include d the phormocology of drugs used in cancer che motherapy.

NCI appointment, she worked for a group of pathologists in the Washington area, and later, for the Walter Reed Army Medical School.

Her research interests included the pharmacology of drugs used in cancer chemotherapy, carcinogene­sis, and chemical protection against radiation and a lkylating agents.

Dr. Kelly's studies with labora­tory animals showed that sulfhy­dryl compounds may protect against toxicity from x-inadiation and alkylating agents by a distri­bution pattern which causes more of a protective compound to accu­mulate in the sensitive tissues than in the tumor.

She also demonstrated that new­born mice are as sensitive to chemi­cal carcinogens as they are to viral carcinogens.

Bree ding Colonies Established

In recent years, Dr. Kelly estab­lished one of the first rhesus mon­key breeding colonies in this area for the study of carcinogenicity in primates.

She used these animals to pro­duce the first consistently r epro­ducible primate tumor, a liver tu­mor induced by diethylnitrosamine. Recently these induced liver tumors produced an alpha fetoprotein simi­lar to that produced by human hepatomas. Dr. Kelly succeeded in growing this tumor in tissue cul­ture.

In collaboration with Dr. Michael Walker, a neurosurgeon, she devel­oped techniques for adapting this

Drs. Fraley and Paulson Share Award for Essay On Laboratory Research

Drs. Elwin E. Fraley and David F. Paulson of the Sm·gery Branch, National Cancer Institute, recently shared first prize of $500 in t he American Urological Association's annual essay contest for laboratory research.

The NCI scientists were honored for their mo'l"phological and bio­chemical studies of virus (SV40) transformed pros ta tic tissue.

In collaboration with Dr. Alan Rabson of the Pathologic Anatomy Branch, NCI, Drs. Fraley and Paul­son prepared tissue cultures from prostatic cells of newborn ham­sters. The tissue cultures w ere then transformed with the SV 40 virus and injected into adult male ham­sters.

Research Result Cited

The result of their 1·csearch was the development of prnstatic tu­mors in the hamsters which re­semble human carcinoma of the prostate.

Dr. Fraley is a senior investiga­tor in the Surgery Branch. A na­tive of Pennsylvania, he received his M.D. degree (cum laude) from the Harvard Medical School in 1961.

He served his internship and r esidency in surgery and residency in urology at Massachusetts Gen­eral Hospital. He was on the staff of that hospital until he joined NCI.

In 1967 he received first prize in the American Urological Associa­tion contest for clinical 1·esearch.

Dr. Paulson was born in Wash­ington, D.C. and received his M.D. iegree from Duke University School of Medicine in 1964. He is a third year clinical associate in the Sur­gery Branch.

tumor to grow within the monkey brain as a quasi-metastatic type of cerebral neoplasm. This research gave scientists a prototype primary liver tumor for chemotherapeutic experiments. It also provided a prototype metastatic brain tumor for chemotherapeutic and pharma­cologic experiments.

Dr. Kelly was born in 1906 in Minneapolis, Minn. She attended the University of Minnesota from 1923 to 1927. While working at the National Cancer Institute she con­tinued her studies at George Wash­ington University. She r eceived the B.S. degree in chemistry in 1941, tho M.S. degree in biochemistry in 1945, and the Ph.D. in pharmacol­ogy in 1951.

It was D-r. O'Gara's request that any tributes should be in the form of contributions addressed to the Anna Fuller Fund, administered by Dr. W. U. Gardner of Yale Uni­versity Medical School, or the American Cancer Society.

THE NIH RECORD

Dr. Cantarow Elected Vice-Pres., Association For Cancer Research

Dr. Abraham Cantarow, National Cancer Institute, has been elected vice president (president-elect) of the American Association for Can­cer Research.

Dr. Cantarow is research plan­ning officer in the Program Analy­sis and Formulation B1·anch, NCI.

He is a well-known teacher and investigator in both medicine and biochemistry. An autho1·ity in the field of calcium metabolism and chemical carcinogenesis, he is t he author and coauthor of more than 188 scientific articles and textbooks.

A graduate of Tufts College, he received the M.D. degree from Jefferson Medical College.

Dr. Cantarow began his career in research in 1924 as a resident chemist at Jefferson Medical Col­lege Hospital. He held several po­sitions there until 1966 when he joined NCI as associate chief of Program Planning, Awards Re­view and Technical Administration Branch, Extramural Activities.

Dr. Abrohom Cantorow is on authority in the f ield of calcium metabolism and chemical carcinogenesis.

Dr. Cantarow, who is active in a number of scientific organizations, was a member of the Chemother­apy Study Section at NIH from 1960 to 1964. Since 1947 he has been a consultant in Biochemistry in the U.S. Navy's Bureau of Medi­cine and Surgery.

Dr. Huebner Presents 1968 Ricketts Lecture

Dr. Robert J. Huebner, chief of the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, presented the Howard Taylor Ricketts Lecture for 1968 at the University of Chi­cago on May 22. His subject was "Cancer as an Infectious Disease."

Dr. Huebner is a member of the American Association for Cancer Research which encourages the presentation and discussion of new, significant observations and prob­lems in cancer.