MSDS & MOA(Material Safety data sheet &

METHOD OF ANALYSIS)

Presented by: Chintan Shah

WHAT IS Material Safety Data Sheet? If there are hazardous chemicals in

your workplace, you need to know about the material safety data sheet, commonly known as the MSDS. This important document reveals the hazards of the chemicals you work with and describes the precautions you need to take to keep safe and healthy.

The MSDS can be a real lifesaver. That’s why you need to know as much as possible about how to use it.

MSDS

• How to use the MSDS to protect yourself and others from chemical hazards?

• Recognize the importance of the MSDS

• Locate essential safety and health information

• What is MOA?

Right to Know – OSHA’s (Occupational safety and health administration) Hazard

Communication Standard—also known as the “right-to-know” law—is based on the idea that you have a right to know about hazardous chemicals you use on the job and a need to know how to work safely with those chemicals.

– Right-to-know information is communicated in a number of ways, including the MSDS, container labels, warning signs.

– The MSDS is the key to all this information because the information found on labels, on signs, and in training is typically based on the information found in the MSDS. There is an MSDS for each hazardous chemical in the workplace

Who play role?– Chemical manufacturers

• Should determine hazards of chemical products and provide MSDS for each product

• Should label each container

– Employers• Should make MSDS available to all employees and train them

accordingly to prevent any injury / illness• Should identify and label hazardous material containers and

have written hazard communication program

– Employees• Should read MSDS and understand how to work safely with

the chemical• Should read the labels on chemical containers before using

chemicals

What MSDS say?The MSDS tells you:

What chemicals are contained in a product;What hazards you could face when you use that product;What precautions you need to take to keep safe; andWhat to do in the event of a spill or exposure involving a hazardous chemical.

MSDS Formats

– There is no any standard format for MSDSs. Chemical manufacturers can decide how required information is arranged in the document.

– That means MSDSs may have a different number of pages, different section titles, or even different number of sections.

– Back in 1985 OSHA established the format of 8 sections as a voluntary guide to assist chemical manufacturers in organizing MSDS information.

– Recently, however, OSHA has recommended a different format designed some years back by the American National Standards Institute, also known as ANSI. The ANSI MSDS has 16 sections and is more organized and comprehensive than the 8-section format. OSHA recommends the ANSI format because it makes it easier to find information.

– Regardless of format, however, the same basic safety and health information is provided in all MSDSs.

– The MSDS always contains the manufacturer’s name, address, and phone number so you can contact the manufacturer if you have questions about the chemical.

– It also provides an 24-hour emergency number where you can ask questions about chemical spills or exposures.

– The name of the chemical will also be listed. Sometimes this will be a specific chemical name such as “acetone” or “sulfuric acid.” Some manufacturers may use the brand name of the chemical. Sometimes manufacturers give chemical products a product number. These names and numbers will help you match the MSDS with the container label to make sure you have the right MSDS.

– The date of the MSDS will also be listed. This is important because you don’t want to use an old, out-of-date MSDS. The manufacturer may have changed the formula for the product or new safety information about a chemical might have recently become available.

Exposure Limits

– PEL (Permissible Exposure Limit)– 8 hr

– STEL (Short-Term Exposure Limit)– 15 min

– TLV (Threshold Limit Value) –same as PEL

Physical Properties – Boiling point and melting

point– Vapor pressure and

evaporation rate– Vapor density – Solubility in water and

specific gravity– How chemical looks and

smells under normal conditions

Health Hazards – Routes of entry– Health effects and

symptoms of exposure (Acute & chronic)

– Effect on existing medical conditions

– Target organs

Fire and Explosion Data

– Flashpoint– Flammability limits– Hazardous

combustion products

Safe Handling Precautions Storage Recommendations Dispensing requirements

– Such as proper grounding and bonding of containers and the use of spark proof tools around the chemical.

– The MSDS might also recommend the type of pump to use when dispensing the chemical or the materials the pump or dispensing hoses should be made of

Spills and Leaks – Evacuation and

isolation of area– Evaluation by

trained responders– Cleanup

Key Points to Remember – The MSDS is the foundation of chemical safety– MSDSs must be accessible at all times– Always read the MSDS before working with a

chemical– Ask a supervisor if you still have questions

about hazards or precautions

Method of Analysis (MOA)• MOA is part of analytical techniques those are used to determine

the concentration of a chemical compound or chemical element in given product.

• There are a wide variety of techniques used for analysis e.g.– Liquid-Liquid extraction– Solid Phase extraction– Protein Precipitation– Chromatography– Titration– Bioanalysis

Solid Phase Extraction

• Solid-phase extraction (SPE) is a separation process by which compounds that are dissolved or suspended in a liquid mixture are separated from other compounds in the mixture according to their physical and chemical properties.

• Solid phase extraction can be used to isolate analytes of interest from a wide variety of matrices, including urine, blood, water, beverages, soil, and animal tissue.

Solid Phase extraction

SPE is an extraction process whereby an aqueous sample is filtered through a thin bed of silica sorbent particles, the analytes of interest are removed from the liquid matrix, and concentrated onto the sorbent. Once concentrated, the analytes are removed by an eluting solvent.

Stationary phase

Mobile phase

Liquid-liquid extraction• Liquid–liquid extraction also known as solvent extraction is a method

to separate compounds based on their relative solubility in two different immiscible liquids, usually water and an organic solvent. It is an extraction of a substance from one liquid into another liquid phase.

• If a chemist has to extract anisole from a mixture of water and 5% acetic acid using ether, then the anisole will enter the organic phase.

• The two phases would then be separated.• The acetic acid can then be removed from the organic phase by shaking

the organic extract with sodium bicarbonate. The acetic acid reacts with the sodium bicarbonate to form sodium acetate, carbon dioxide, and water.