Materials and methods Design Open-label, randomized trial, February 2010 to May 2011, avoiding the...
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![Page 1: Materials and methods Design Open-label, randomized trial, February 2010 to May 2011, avoiding the summer period Participants recruited from a primary.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e385503460f94b284bf/html5/thumbnails/1.jpg)
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Materials and methods
• Design• Open-label, randomized trial, February 2010 to May 2011, avoiding the
summer period
• Participants• recruited from a primary care centre in Sweden, serving a population with a
high proportion of non-European residents
• Inclusion criteria • age 15 years or above and vitamin D deficiency 25(OH)D3 less than 25
nmol /L
• Exclusion criteria• light-sensitive skin• ongoing treatment with vitamin D supplementation• sunny holidays • intake of photosensitive medicine during the study period.
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UVB
• The average starting dose was 0.36 J• increments were about 15% every second treatment session• the average maximal (final) dose was 1.20 J.• The mean cumulative dose was 9.0 J /cm2
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Results
• Significantly greater increase in 25(OH)D3 levels in the NB-UVB treated group compared with the tablet-treated group after 6 weeks of treatment (P = 0.02)
• in the NB-UVB treated group The 25(OH)D3 levels (mean ± SD) increased from 19.2 ± 6 nmol /L to 75 ± 16.8 nmol/L vs. 23.3 ±4.4 nmol /L to 60.6 ± 16.7 nmol /L in the oral vitamin D3 treated group
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Results
• No significant difference regarding PTH, calcium, albumin or HbA1c levels.
• A significant decrease in PTH
• A significant increase in calcium levels
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Limitations
• lack of compliance among the group who took vitamin D3 supplements
• high dropout number
• primarily non-European immigrants
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Conclusion
• exposure to a small dose of full body NB-UVB radiation three times a week is more efficient in raising vitamin D levels than prescription of a daily oral intake of 1600 IU vitamin D3
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Race ?Skin type?
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Suscreen?
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Winter vs summer
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NB UVB vs BB UVB?
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Diet?
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Screening?
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Deficiency?
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-Vitamin D deficiency is defined as a 25(OH)D below 20 ng/ml (50 nmol/liter)
- Vitamin D insufficiency is defined as a 25(OH)D of 21–29 ng/ml
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Daily requirement?
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Treatment
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