Welcome to the next generation

Mastersizer 3000Smarter particle sizing

Not just a new instrument a new Mastersizer First Mastersizer launched in 1988 Now more than 10,000 users worldwide Laser diffraction has become the worlds most widely used particle sizing technique Malvern Instruments is the global leader for particle sizing technology and applications understanding

Mastersizer Particle sizing has evolved

1988 1998 2011

The new Mastersizer 3000 at a glance

The new Mastersizer 3000 at a glance

State-of-the-art compact instrument design Class-leading performance 10nm to 3.5mm Rapid measurements Robust results Rapid and effective wet dispersion Efficient in-line sonication Cutting-edge dry dispersion Suitable for fragile and cohesive samples Software that lightens your workload Effortless work not guess work!

Laser Diffraction: reasons for success

Wide dynamic range From the nanometre to the millimetre size range Rapid measurements Results possible in less than a minute Repeatability Large number of particles sampled High sample throughput Hundreds of measurements can be made in a day Calibration not necessary Easily verified using standard reference materials Well established technique, covered by ISO13320 (2009) Describes general principles and expected performance

d

Transmit a laser through a dispersion of particles Angle of diffraction depends upon particle size Large particles scatter at smaller angles Small particles scatter light at wider angles

Images: Dr Kevin Powers, PERC, University of Florida

5 microns 800 nanometres

Laser diffraction how does it work?

Measurement cell Focal plane

detectors

Side scatter

detectors

Back scatter

detectors

633nm red

laser

Precision

folded optics

Mastersizer 3000 optics: red light measurements

Mastersizer 3000 optics: blue light measurements

470nm blue

light source

Side scatter

detectors

Measurement cell

Back scatter

detectors

Mastersizer 3000 : Delivers performance

Widest measurement range 10nm - 3.5mm measurement range Excellent sub-micron resolution Powerful 20mW blue solid state light source Fast measurement times Rapid system initialisation and measurement cycle Sampling, measurement, cleaning in

Size / Pm0.01 0.1 1 10 100 1000 10000

F

r

e

q

u

e

n

c

y

(

%

)

0

2

4

6

8

10

Icing Sugar

Castor Sugar

Granulated Sugar

Mastersizer 3000: Wide dynamic range

Particle Size / Pm0.01 0.1 1 10

V

o

l

u

m

e

(

%

)

0

10

20

30

40

50

60

30nm

46nm

100nm

220nm

500nm

700nm

1300nm

2000nm

3000nm

5000nm

9000nm

Mastersizer 3000: Sub-micron resolution

Mastersizer 3000: measurement robustness

Dv50 RSD (fine): 0.34% Dv50 RSD (coarse): 0.7%Size / Pm0.1 1 10 100 1000

V

o

l

u

m

e

(

%

)

0

1

2

3

4

5

Feed

Fines

Measurement Number

0 10 20 30 40 50 60S

i

z

e

/

P

m

1

10

100

Dv10 Dv50 Dv90

Alternating between fine and coarse samples

Mastersizer 3000: Lightens your workload

Fast results and method development Real-time optimization of each measurement Flexible, user-independent operation Easily switched dispersion units with auto locking cells Automatic initialisation for robust measurements Software that delivers your data, your way Edit-in-place report designer Free up bench space Compact footprint and dispersion accessories Top class support Built-in intelligence - Malvern experts on-demand

Software: Measurement Manager

Measurement Manager: Observe

View measurement parameters and particle size distribution Instant feedback of results

Measurement Manager: Interact

Full control of all dispersion parameters at your fingertips

Real-time control over your method development

Change sample documentation on the fly

Rolling trend plotting and statistics Rapid method optimization in line with ISO 13320 guidance

Measurement Manager: Optimize

Software: viewing your results

Rapid result review

Software: simple and flexible data reporting

Simple measurement reporting

Confidential. Malvern Instruments 2011

Software: reviewing your results and methods

Accessible data

Confidential. Malvern Instruments 2011

Software: expert advice for better results

Wet or dry: a solution for every application

Wet sample dispersion Hydro range Powerful and rapid sample dispersion A range of sample volumes to suit your application Dry sample dispersion Aero range Completely new, state of the art technology Flexibility to disperse cohesive and fragile powders

Mastersizer: Hydro wet dispersion units

All dispersion accessories: Achieve excellent dispersion with powerful centrifugal pump and

stirrer Fast dispersion of cohesive samples with in-line sonication Chemically compatible internally as standard Full software control over the sample dispersion Integral tank light for viewing the dispersant and sample

Mastersizer Hydro - Accessories

Hydro MV Medium sample volume - 120ml Fully automated cleaning Hydro LV Large sample volume - 600ml Fully automated cleaning Hydro EV Exchangeable sample volume

250ml / 600ml / 1000ml Easy sample recovery

Hydro MV and Hydro LV: how they work

Hydro unit measurement cell

Automatically locked into measurement position System recognises cell type Windows can be quickly removed without needing special tools Jacketed heating/cooling for rapid temperature stabilisation Chemically compatible seals

Hydro EV: sampling performance

Copper powder - density 8.92 g/cm3 Stir speed titration stable >2500 rpm

stir speed / rpm

500 1000 1500 2000 2500 3000 3500 4000

s

i

z

e

/

P

m

0

20

40

60

80

100

120

140

160

180

Dv10

Dv50

Dv90

stir speed / rpm

500 1000 1500 2000 2500 3000 3500 4000

o

b

s

c

u

r

a

t

i

o

n

(

%

)

-10

-5

0

5

10

15

20

obscurationDv10

Dv50

Dv90

In-line sonication : rapid and efficient dispersion

measurement no.

0 5 10 15 20 25 30

s

i

z

e

/

P

m

30

40

50

60

70

80

90

100

Dv10

Dv50

Dv90

HYDRO MV HYDRO LVHYDRO EV

Hydro unit reproducibility

15 20 25 300 5 1010

Benefits of dry dispersion

Fundamentally new design state-of-the art knowledge Fast measurement times Excellent sampling of polydisperse materials Flexible dispersion power - apply the appropriate dispersion energy Environmental and safety no solvent disposal

Wide size range 0.1 Pm to 3500 Pm Precise pressure control 0.1 to 4.0 bar Modular venturi disperser Standard suitable for most powders Options for extremely cohesive or abrasive Modular sample tray design Adjustable sample hopper Full software control of sample feed and dispersion

Aero S Dry Powder Disperser

Aero S: modular venturi for flexibility

Modular Easy Changeover Plug-and play Automatically recognized Standard Venturi Right angle design Suitable for most types of sample HE Venturi Elbow design (cf. Scirocco) High energy for very cohesive samples

Aero S: optimum sample feed

Hopper and tray assembly Hopper vibrates with the tray Height can be adjusted A basket can be fitted into the hopper if required. Configuration of the hopper and tray is auto-detected

Automatically locked into measurement position System recognises cell type Windows can be quickly removed for cleaning without needing any

tool Vacuum connection is on the optical bench Sheath air flow is filtered

Aero S: measurement cell

Size / Pm10 100 1000

F

r

e

q

u

e

n

c

y

(

%

)

0

2

4

6

8

10

4 bar

3 bar

2 bar

1 bar

0.5 bar

Aero S: wide dynamic range and sampling

Coffee - polydisperse, >3mm, sticky due to oils

Aero S: wide dynamic range

Size / Pm10 100 1000

F

r

e

q

u

e

n

c

y

(

%

)

0

2

4

6

8

10

12

Expresso

Smooth

Filter

Coffee: polydisperse samples up to 3.5mm

Aero S: fragile samples

Sucralose is a typical fragile material Challenge to disperse samples without breaking primary particles Need enough energy but not too much Aero S standard venturi is ideal for fragile materials

Presure / bar

0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0

S

i

z

e

/

P

m

0

100

200

300

400

500

600

Dv10

Dv50

Dv90

Dv10

Dv50

Dv90

Stable dispersion below 1.0 barSucralose: Aero S Standard Venturi

Presure / bar

0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0

S

i

z

e

/

P

m

0

100

200

300

400

500

600

Dv10

Dv50

Dv90

Dv10

Dv50

Dv90

No stable region down to 0.1 barSucralose: High Energy Venturi

Measurement Number

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

S

i

z

e

/

P

m

0

2

4

6

8

10

12

14

Dv10

Dv50

Dv90

Size / Pm0.01 0.1 1 10 100 1000F

r

e

q

u

e

n

c

y

(

%

)

0

1

2

3

4

5

6

Cohesive sample: Aero S standard venturi

Size / Pm 10 100 1000

Size / Pm0.01 0.1 1 10 100 1000

V

o

l

u

m

e

(

%

)

0

1

2

3

4

5

6

2.13%

6.33%

9.41%

14.08%

17.42%

21.92%

37.64%

Aero S: robust performance

Obscuration (%)

0 5 10 15 20 25 30 35 40

S

i

z

e

/

P

m

0

10

20

30

40

50

60

Dv10

Dv50

Dv90

Cement stable over a wide obscuration range Dv10: 2.4%, Dv50: 0.5%, Dv90: 1.0%

Mastersizer 3000: R&D Environment

High performance Wide particle size range Excellent sub-micron resolution Fully flexible system Range of dispersion accessories to suit your sample Easy changeover of dispersion accessories Build custom reports in a few mouse clicks Your data, your way Easy to use Does not require expert operator In-built intelligence and expertise

Mastersizer 3000: QC Environment

Boost productivity and throughput Fast measurement times Fully automated measurement and cleaning Easy to use Does not require expert operator In-built intelligence and expertise Robust results Lockdown your methods with SOPs Validatable performance

Mastersizer 3000 - Pharmaceuticals

Highest performance Flexibility combined with ease-of use One platform right across the development cycle Easy transfer of methods from R&D to QC Aero S offers excellent dry

dispersion performance for fragile

materials such as actives Full IQ/OQ/PQ validation available CFR21 part 11 compliance

Mastersizer 3000 - Summary

High performance Wide size range Fast measurements Robust results Flexible Range of wet and dry dispersion units Easy changeover, auto-locking cells Full manual control and SOP modes Easy to use From novice to expert Malvern expertise inside More Information : www.malvern.com/MS3000

Questions or Feedback?