Master of Clinical Toxicology - Ain Shams...
Transcript of Master of Clinical Toxicology - Ain Shams...
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Master of Clinical Toxicology السموم األكلينيكيةفى املاجستريدرجة
Program Code: FT610
Program Guide and Logbook
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C a n d i d a t e C u r r i c u l u m v i t a e
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Experience
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Education
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Training
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Filled by post graduate authorities
Date of Registration
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TABLE OF CONTENTS: Page
I – Welcome
II - Mission Statement
III – Academic advisor and affiliated departments and Hospitals
IV – Program specifications
1 - Basic Information
2 - Professional Information
3 – Academic standards
4 – Curriculum structure and contents
5 - Program courses.
6. Program admission requirements
7. Regulation for progression and program completion
8. Appendix: course specifications
Pharmacology course specification
Ethics of medical aspects course specification
Internal medicine course specification
Medical Responsibilities and Malpractice in Clinical Toxicology course
specification
General toxicology course specification
Systemic toxicology course specification
Intensive care of poisoned patients course specification
Treatment of Drug Dependence and Practical Program of
Analytical Toxicology course specification
Elective courses
Medical statistics course specification
Computer course specification
Immunology course specification
V - General information
VI – Your log book
1 – Introduction
2 – Supervisors
3 - Tables for training records
4 – Log book preview
VII - Head of department approval for the exam entry
Detachable forms:
VIII – Thesis follow up
IX - Evaluation forms
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I – Welcome Statement:
The Department of Forensic Medicine and Clinical Toxicology welcomes you to
the Master of Science in Clinical Toxicology. As a department, we are committed
to medical student education and continuously strive to improve your educational
experience.
This handbook presents information guide and logbook activity of the Master of
Science in Clinical Toxicology, Faculty of Medicine, Ain Shams University.
II - Mission Statement:
The mission of the Faculty of Medicine, Ain Shams University is “The
preparation of a competent graduate, who is able to compete on both national
and regional levels, capable of lifelong learning, training and tutoring, while
adhering to the codes of practice of medical health services and ethics. The
college as well, seeks continuous development of programs and courses. It also
enhances expansion of applied scientific research and health programs for
community services and environmental development. Moreover, through
providing distinguished academic and research cadres of teaching staff,
supporting the administrative system and sustainability of own resources, the
college is able to achieve goals and objectives”.
The mission of this degree is to graduate a clinical toxicologist who recognize
the basics, types, mechanisms and varied toxic effects in clinical toxicology.
Furthermore, enough skilled in interpreting diagnostic tools and in management
methods, enough talented to distinguish poisoning from different disease entities,
competent in operating toxicological disasters and developing preventive measures
to protect the community in an ethical way using the current and advanced
guidelines.
III – Senior Supervisor and Affilated Departments and Hospitals
Senior Supervisor
Prof.
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E-mail:
Affiliated Departments and Hospitals
Poison Control Center, Ain Shams University Hospitals
Other Hospitals
IV – Program Specifications
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A- Basic Information
Program title: Master of Science in Clinical Toxicology
Program type: Single
Faculty: Ain Shams University – Faculty of medicine
Department: Forensic Medicine and Clinical Toxicology Department
Assistant coordinator: Write the name
Coordinator: Write the name
Last date of program approval:
2 - Professional Information
1. Program aims:
1. Provide learning experiences that promote a broad understanding of the role of
medical toxicology as it relates to other medical disciplines.
2. Develop measurable objectives to assess the progression of the specialist in the
two-year training program.
3. Integrate the sciences applicable to medical toxicology with clinical
experiences in a progressive manner.
4. Provide the specialist in medical toxicology with progressive patient care
responsibilities, commencing with general medical skills and progressing to
complete care of patients in need of toxicological care.
5. Provide training that will enable the specialist in medical toxicology to rapidly
evaluate, initiate treatment, and provide appropriate therapy, and disposition of the
patient.
6. Provide the opportunity to develop the teaching skills of specialists in
emergency medicine in regard to toxicological emergencies.
7. Provide the opportunity to develop the skills necessary for problem solving in
the practice of medical toxicology.
8. Provide the opportunity to develop professional leadership and management
skills.
9. Provide the opportunity to conduct research in medical toxicology.
10. Provide the opportunity to learn to practice clinical toxicology in an ethical
fashion.
2. Intended learning outcomes (ILOs):
1- Knowledge and understanding (K):
By the end of this program the candidate will be able to:
a.1 Demonstrate knowledge in principles of therapeutics; pharmacokinetics,
pharmacodynamics and their application to toxicology, adverse drug reaction and
interactions, principle of drug abuse, drug dependence, drug withdrawal and
tolerance and a practical classification of poisoning
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a.2 Demonstrate knowledge in the mechanism of toxicity and usual toxic dose of
common poisons
a.3 Discriminate types of poisoning with the knowledge of the different
toxidromes.
a.4 Identify the need for different methods of decontamination and the benefits
and risks of each method.
a.5 Demonstrate knowledge of mechanisms of action ant indications for the
commonly used antidotes
a.6 Recognize and advise patients and their families regarding the general
epidemiology and prevention of poisonings and more specifically inappropriate use
of medications dangerous interactions between medications risks of polypharmacy
and excessive over the counter medications use.
a.7 Demonstrate knowledge in medical, legal, psychiatric and social aspects
of toxicology
a.8 Recognize patient's rights to confidentiality and neutrality in the face of
authorities involvement whilst fulfilling social and legal obligations as per the
medical ethics code and the local regulations.
2- Intellectual skills (IS):
By the end of the program, the candidate will be able to:
b.1. Specify and solve medical dilemmas and complexities.
b.2. Make conclusions and be able to conduct scientific discussion.
b.3. Differentiate different clinical presentations and recognize their emergency
nature.
b.4. Prioritize and tailor the management according to different therapeutic
guidelines to individual situations
b.5. Predict toxicological hazards within a community according to research
studies and cumulated statistics
b.6. Interpret results of investigations for proper diagnosis
3- Professional and practical skills (PS):
By the end of the program, the candidate will be able to:
c.1. Take a focused medical history with proper analysis and conclusions.
c.2. Examine properly and systematically to identify different toxidromes.
c.3. Perform and modify analytical procedures according to given clinical data.
c.4. Interpret toxicological results to reach an accurate diagnosis and design a
treatment plan in reference to therapeutic guidelines and protocols.
c.5. Interpret general medical investigations and use their findings in diagnosis and
therapy.
c.6. Put a diagnosis and differential diagnosis of different cases.
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c.7. Write a treatment prescription for a given medical problem within a
multidisciplinary management plan if needed.
c.8. Identify patients needing hospitalization and emergency intervention.
c.9. Identifying patients in need for higher specialization.
c.10. Master the different emergency and routine procedures necessary in the
clinical Toxicology specialty.
4- General and transferable skills (GS):
By the end of this program the candidate will be able to:
d.1. Gain communication skills with workers, nurses, juniors, professors, peers,
patients and their care givers.
d.2. Gain communication skills in operating a specialized center for poisoning
treatment and in operating toxicological disasters in cooperation with local
authorities and media
d.3. Master computer skills in research, data base filing and preparation of
presentation.
d.4. Use computer efficiently in solving medical problems.
d.5. Work in team.
d.6. Acquire managerial skills.
3. Academic standards: (Benchmarks)
Programs preparing Board of Medical Toxicology and Diplome d'etudes
superieures de toxicology clinique
4. Curriculum structure and contents:
4 a- Program duration: two years (4 semesters)
4b- Program structure:
اناهح
انكىد انقزراخ انذراسيحانساعاخ
انعرذج
دورج أساسياخ انثحث انعهي يرطهثاخ انكهيح
اندزء األول
FT6101 1 عهى األدويــح
FT6102 1 أخالقياخ يارسح انه انطثيـــــح
FT6103 1 انثاطح انعايح
FT6104 1 انسؤنيح انطثيح نحاالخ انرسى و أخطاء األطثاء
FT6105 2 انسىو انعايح
6 انزسانح
اندزء انثاي
FT6106 6 عهى انسىو انخاصح
FT6107 6 انزعايح انزكزج نحاالخ انرسى
عالج األديا
يقزر عه و ذطثيق نهرحانيم انسيحFT6108 5
االحصاء انطث يخرار انطانة واحذ ي تي: االخرياريح انقزراخ E6009 1
10
E6047 اسرخذاو انكثيىذز
E6015 عهى اناعح
6 كزاسح األشطح
36 اندىع
5. Program courses:
a. Compulsory
Code Course title No. of hours
L C F SDL
FT6101 Pharmacology course specification
FT6102 Ethics of medical aspects course
specification
FT6103 Internal medicine course specification
FT6104 Medical Responsibilities and Malpractice
in Clinical Toxicology course specification
FT6105 General toxicology course specification
FT6106 Systemic toxicology course specification
FT6107 Intensive care of poisoned patients course
specification
FT6108
Treatment of Drug Dependence and
Practical Program of Analytical
Toxicology course specification
L: Lecture, C: Clinical, F: field and SDL: Self directed learning
b. Elective
Code Course title No. of hours
L C F SDL
E6009 Medical statistics course specification
E6047 Computer course specification
E6015 Immunology course specification
5.1- Program: Master of Science in Clinical Toxicology (FT610) : Semester 1
a. Compulsory = 6 CH
6. Program admission requirements:
-( : يشرزط نقيذ انطانة نهحصىل عه درخح اناخسريز:6) انادج
أ ك زاصال ػه دسخح انثكانسط ف انطة اندشازح ي إزذ خايؼاخ خسح يصش انؼشتح -1
أ ػه دسخح يؼادنح
أ ك لذ أيض عح انرذسة )االيراص( -2
يافمح خح انؼم. -3
(1عرالن األخضج اعرفاء انغرذاخ انطهتح ف انهسك )ذغذذ انشعو يصاسف انرذسة ا -4
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0انرفشؽ نهذساعح نذج فصه دساع لثم دخل ايرسا اندضء انثا -5
-اناخغرش األساق انرانح :ح مذو طانة اإلنرساق نذسخ ( :1يهحق )
-5ج انالد أيغرخشج سع. شاد -4شادج اإليراص. -3 0شادج انثكانسط -2 0طهة إنرساق -1
صس فذغشافح 6ػذد -7 0يافمح خح انؼم ػه انرغدم انرفشؽ انطهب -6 0انلف ي انردذ
0تانغثح نهافذ مذو انطانة يافمح انغفاسج سذد خح ذسم انفماخ كا مذو شادج صسح -8 0خذذج7. Regulation for progression and program completion
رى انرغدم نهاخغرش يشج ازذج ف انغح ذثذأ ي أل ن زر أخش أغغطظ ػه أ ذثذأ (: 8يادج )
دص لثل ذغدم اناب انؼذ انافذ ف انفرشج ي أل 0انذساعح ف شش أكرتش ي كم ػاو
اندضء األل إال تؼذ إمضاء فرشج انذساعح فثشزر أخش دغثش ػه أال غر نى تذخل إيرسا
.انطهتح
ذصع انذساعح ف كم ػاو خايؼ ػه فصه دساع يذج كم يا خغح ػشش اعثػا . ثذا (: 9يادج )
االل ف أل أكرتش ثذا انثا ف يصف فثشاش. يغ ذظى فصم دساع صف يكثف نذج عرح اعاتغ .
نهفصم انذساع لثم اعثػ ي تذار ػه االلم تؼذ إعرفاء انششط زغة انمشساخ رى انرغدم
عاػاخ يؼرذج. دص نهطانة ذؼذم 6انغدهح. الثغ أ ضذ انؼةء انذساع ف انفصم انازذ ػ
غساب خالل عر انمشساخ خالل اعثػ ي تذاح انفصم انذساع )تانسزف ا االضافح(. كا دص ن اال
اعاتغ ي ازذ انمشاسخ د ازرغات ساعثا ف.
: يذج انذساعح نهسصل ػه دسخح انذتهو أ اناخغرش أستؼح ػشش ششا )أستؼح ( 11انادج )
فصل دساعح( ػه خضئ دراص فا انطانة تشايدا ذذسثا يركايال طثما نهغاػاخ انؼرذج انضسح
ال غر ن تذخل اإليرسا لثم األشطح انثاب انشاتغ غرف خالنا انطهب يح ف كرة يراتؼح ت
0إعرفاء ثالثح أستاع انطهب يح ف كم خضء ي انثشايح
دراص تؼذا انطانة ازذ يذج انذساعح ف انذتهو اناخغرش اندضء األل فصم دساع ( :12انادج )
ال شرشط انداذ ف تانكايم نإلرمال نهذساعح ف اندضء انثا. اندضء انثا رطهة ذفشؽ انطانة إيرساا
.تأزذ انغرشفاخ أ انشاكض انؼرذج ي انكهح نذج فصه دساع نهرذسة
ؼذ مو انذاسط نذسخح اناخغرش ترغدم يضع انشعانح ػه شكم تسث ظش أ ػه ت( : 13يادج )
ػه األلم ػه ي انرغدم إعرفاء فصم دساع ازذ ػه األلم دص أ الش سعانرح تؼذ عرح شس
أ ك لذ در ف يمشساخ اندضء األل تانكايم لثم دخل إيرسا اندضء انثا ال خصص نا
0خ دسخا
دم انشعانح يرطهثاخ انكهح لثم مو داسط اناخغرش تإعرفاء يرطهثاخ اندايؼح لثم ذغ( : 14يادج )
يرطهثاخ اندايؼح انسصل ػه شادج انرفم ف انهغح اإلدهضح .دخل إيرسا اندضء انثا
دسخح ػه األلم( يرطهثاخ انكهح زضس دساخ يؼرذج ي ندح انذساعاخ انؼها 450تدع )
ء انطث أ تإخراص إخرثاساخ خاصح ذسذدا انهدح. اإلزصا ياح انثسث انؼهتانكهح ف يدال
دص نهساصه ػه دسخح انذتهو إعركال دسخح اناخغرش ترغدم سعانح اناخغرش خالل (: 15يادج )
أستغ عاخ ي انسصل ػه دسخح انذتهو سصم ػه انذسخح تؼذ إعرفاء يرطهثاخ اندايؼح انكهح
يالشح انشعانح تداذ.
انغاػاخ انؼرذج نذساعح انذتهو اناخغرش ثالث عاػح يؼرذج ػه األلم خصص يا (: 16يادج )
ذشم عد عاػاخ ػه األلم نهدضء األل ثا ػششج عاػح ػه يراتؼح األشطح عد عاػاخ نكرة
ضاف إنا عد عاػاخ نهشعانح ف اناخغرش. األلم نهدضء انثا
يذج انمذ نذسخح اناخغرش أستغ عاخ. (:22يادج )
دسخح نهدضء األل. 300دسخح يا 1200يدع دسخاخ االيرسا انائ نهاخغرش (: 24يادج )
دسخح نهاخغرش. 300ه انرشاك تا اص صضاف انا انؼذل انف
ؼمذ إيرسا انذس انثا ف أتشم ؼمذ إيرسا انذس األل ف أكرتش فثش ي كم ػاو (: 25يادج )
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يا ي كم ػاو.
% ي انذسخح 60ك انداذ ف كم يادج ي انذتهو انؼان اناخغرش تؼذ انسصل ػه (: 26يادج )
ك انداذ ف ياد انذكرسا % 50ػه ا ال ذمم دسخح انرسشش ػ انكهح نكم ندا انادج يدرؼح
ك انشف كم ػه زذج.انرسشش انؼه االكه % ي دسخح60تؼذ انسصل ػه
(: فىى زانىىح إعىىرفار يىىذج انمىىذ كىى نطانىىة انذساعىىاخ انؼهىىا إػىىادج انرغىىدم يىىشج أخىىش ال ؼرىىذ 29)يااادج
تانداذ ف اندضء األل أ انشعانح دة إػادذا.
Assessment Schedule and Weighing of Assessments
Item Mark
Po
ints
GP
A s
core
انط
انح
انح
ة
Stu
den
t
sta
te
During
semester
End of
semester Total
First semester (If present) 100 300 400
Second semester 100 100
Third semester 100 100
Fourth
semester
Final exam
Written
900 900
Oral
Practical
/Clinical
Total 300 1200 1500
عه انىخه انراني: يهحىظح: ذعادل درخاخ انطانة طثقا نهقاط
قاط 4 : % فأكثز 90 -1 A
قاط 3663 : % 90% حر أقم ي 85ي -2 A-
قاط 3633 : %85% حر أقم ي 80ي - 3 B+
قاط 3600 : %80% حر أقم ي 35ي - 4 B
قاط 2663 : %35% حر أقم ي 30ي - 5 B-
قاط 2633 : %30% حر أقم ي 65ي - 6 C+
قاط 2600 : %65% حر أقم ي 62ي -3 C
قاط 1663 : %62% حر أقم ي 60ي - 8 C-
F صفز : %60أقم ي - 9
( ػهى أعىاط يدىع زاصىم ضىشب مىاط كىم يمىشس يضىشتا فى ػىذد GPAرى زغاب انؼذل انفصه )
عاػاذ انؼرذج يمغيا ػه انغاػاخ انؼرذج نهمشساخ انر دسعىا انطانىة فى انفصىم انذساعى. كىا ىرى
نرىى زصىىم ػهىىا ( ػهىى أعىىاط يدىىع زاصىىم ضىىشب انمىىاط اCGPAانؼىىذل انرشاكىى نهطانىىة ) زغىىاب
انطانة ف كم يمشس يضشتا ف ػذد عاػاذ انؼرذج يمغيا ػه يدع انغاػاخ انؼرذج انكهح.
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ىرى اإلػىادج فى أ انىذكرسا اناخغىرش فى انىذتهو أمىشساخ انف زانىح انشعىب فى يىادج أ يدػىح يى
سصم ػه ف أل إػادج فمظ أيا إرا ذكىشس سعىب رى زغاب انرمذش انفؼه انز انادج أ اندػح فمظ.
ماط ا 1.67% فمظ )ا60فسغة ن ػذ انداذ ذمذش -
C.)
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C O U R S E S S P E C I F I C A T I O N S
P h a r m a c o l o g y c o u r s e s p e c i f i c a t i o n s University: Ain Shams Faculty: of Medicine
Course specifications
Program on which the course is given: Master of Science in Clinical Toxicology
(FT610)
Major or minor element of programs: Minor
Department offering the program: Department of Forensic Medicine and clinical
Toxicology
Department offering the course: Department of Pharmacology
Academic level: First year
Date of Specification Approval:
A- Basic Information
Title: Pharmacology Code: FT6101
Credit Hours: 1 Lectures: 8 h Tutorials:
Clinical: 16 h: Total contact: 24 h
Coordinator:
B - Professional Information
1- Course Aims:
The aim of the course is to assure that the students obtain a thorough
comprehension of the basic pharmacological principles
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding
By the end of the course the candidate will be able to:
a1. Describe the basic pharmacokinetics of drugs and recognize the bioavailability
and biotransformation of drugs
a2. Describe and explain pharmacodynamic concepts of drug-receptor interaction
to accurately predict drug responses at all levels of biological organization.
a3. Demonstrate the basic mechanisms of drug interactions.
a4. Discuss therapeutic indications and side effects of drugs
b- Intellectual skills
By the end of the course the candidate will be able to:
b1. Interpret pharmacological data such as drug levels in the context of
optimizing drug therapy.
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b2. Apply pharmacological principles in the therapeutic management of
poisoned patients.
b3. Predict the biotransformation and efficacy of metabolites and the
significance of their analysis.
b4. Calculate the area under the curve to estimate the drug concentrations
c- Professional skills
By the end of the course the candidate will be able to:
c1- be familiar with the interpretations of drug levels on the basis of absorption,
metabolism and elimination and kinetics
d- General and transferable skills
By the end of the course the candidate will be able to:
d.1. Use database to collect material needed for research.
d.2. Gather and organize material on new drugs from various sources
(including library, electronic and online resources).
d.3. Understand the importance of continuing medical education.
3- Course content:
Topics No. of hours
L T C/P SDL
General Pharmacology
Pharmacokinetics 1 1 1
Pharmacodynamics 1 1 1
Mechanism of action of drugs 1 1 1
Routes of drug administration and
Factors modifying drug action
1 1 1
Pharmacological bases of drug
interactions
1 1 1
Adverse drug reactions 1 1 1
Receptor pharmacology 1 1 1
Pharmacogenetic 1 1 1
L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed
learning
. 4 - Student Assessment Methods
4.1 written exam the form of Short essays to assess knowledge and MCQs to
assess knowledge and intellectual skills
Weighing of assessment
4.1 written exam 20
Total 20
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5 -- List of References
5.1- Course Notes (paper and / or electronic)
5.2- Essential Books (Text Books)
5.3- Recommended Books
5.4- Periodicals, Web Sites, etc
E t h i c s o f M e d i c a l P r a c t i c e c o u r s e s p e c i f i c a t i o n
University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology (FT610)
Major or minor element of programs Major
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Forensic Medicine and
Clinical Toxicology
Academic level First year
Date of Specification Approval
A - B A S I C I N F O R M A T I O N
Title Ethics of Medical
Practice Code FT6102
Credit Hours 1 Lectures: 8 h Tutorials: 8 h
Clinical: 8 h Total contact: 24 h
Coordinator
Professional Information
1-Course Aims
The aim of the course is to assure that the students obtain a thorough
comprehension of the basic ethical principles in toxicology practice and in
emergency medicine
2- Intended Learning Outcomes (ILOs)
a- Knowledge and understanding:
By the end of the course the candidate will be able to:
c1. Recognize the ethical principles of emergency medicine practice and the
challenges to apply them.
c2. Recognize the ethics rules governing medical practice and issued by the
Egyptian Medical Syndicate.
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c3. To list different types and limitations of consent in clinical toxicology.
c4. Recognize the medicolegal importance of informed consent and its
limitations.
c5. Describe the confidentiality, fairness and the respect of privacy and dignity
of acutely intoxicated patients and their limitations.
c6. Know how to make full documentations for toxicological patients presented
in emergency room, in-patient unit, intensive care unit and out-patient units.
c7. Describe procedure and limitations to restrain the patients at ICU.
c8. Know the patient rights referring to human rights and lawful legalizations.
2/3 credit hour for knowledge.
b- Intellectual skills
By the end of the course the candidate will be able to:
b1-Correlate between actions done towards acute intoxicated patients and
malpractice could be done in emergency room, in-patient unit and ICU.
b2- Analyze information given by phone to reach proper decision towards a patient
telephone.
b3- Practice of Emergency and Critical care Medicine in cost conscious manner
b4- Recognize causes of ethical concern in Emergency and critical care
b5- Recognize ethical principles in medical interventions and procedures e.g.
Mechanical Ventilation
This will be achieved by problem oriented sessions.
c- Professional skills
By the end of the course the candidate will be able to:
c1. Demonstrate the procedure and formalities to restrain a patient in ICU.
c2. Write full documentation as regard medical charts; follow up charts for
different intoxicated patients in ER, in-patient unit, out-patient and ICU.
c3. Write a valid consent in different situations and consent needed for discharge a
patient against medical advice.
c4. Write medico-legal reports of acute intoxicated patient.
1/3 credit hour for practical.
d- General and transferable skills
By the end of the course the candidate will be able to:
d1- Maintain honesty and integrity in all interactions with teachers, colleagues and
others with whom physicians must interact in their professional lives.
d2- Recognize the scope and limits of their role as students as well as the necessity
to seek and apply collaboration with other workers.
d3- Be responsible towards work.
18
III. COURSE CONTENTS:
3- Course content:
Topics No of hours
L T C/P SDL
Medical Ethics 1 Credit Hour
1) Concept of medical ethics 1
2) Ethical principles 2 2 1
3) Ethical principles and limitations in
critical and critical care.
2 2 1
4) Procedures posing special concern in
breaking the ethical principles in emergency
and clinical toxicology practice
1 2
2
5) Rules governing medical ethics in
Egypt
1 1 2
6) Ethical rules in use of drugs and
research
1 1 2
Total 8 8 8
L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed
learning.
4- Student Assessment Methods
4.1 Short essays to assess knowledge
4.2 MCQs to assess knowledge and intellectual skills
4.3 Practical/ Clinical exam to assess professional skills and general skills
4.3 Oral exam to assess intellectual, professional and general skills
Weighing of assessments 1 Written examination: 30
2 Practical examination 20
3 Oral examination 10
Total 60
5 -- List of References
5.1- Course Notes (paper and / or electronic)
5.2- Essential Books (Text Books)
5.3- Recommended Books
5.4- Periodicals, Web Sites, etc
Internal Medicine course specification University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Major
19
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Internal Medicine
Academic level First Year
Date of Specification Approval
B- Basic Information
Title Internal Medicine Code FT6103
Credit Hours 1 Lectures: 8 h Tutorials:
Clinical: 16 h Total contact: 24 h
Coordinator
C- Professional Information
1- Course Aims
1. Acquire an appropriate background of internal medicine diseases that may
simulate toxicological presentations.
2. Identify and manage medical complications in the context of poisoning
3. Acquire competent practice in general medical examination and develop
skills in differentiating diseases by proper integration of assembled clinical data.
4. Develop the skills to predict and manage possible signs of ominous
system failure and diseases of organs targeted by poisons.
5. Acquire the talent and experience of rapid management of medical
emergencies.
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding (K):
By the end of the course the candidate will be able to:
a1. Identify and describe general systemic medical illnesses using the medical
knowledge.
a2. Recognize the elements of evaluation and approach to the patient to
perform proper systemic examination
a3. Identify differentiating clinical points in differentiating metabolic,
structural and toxicological presentations as coma, convulsions, shock, respiratory
failure
a4. Describe the basic investigation tools, their limitations in confirming and
differentiating medical from toxicological illnesses.
a5. Identify differential diagnosis of systemic signs and presentations that
simulate poisoning.
a6. Recognize the medical complications and evolution of general systemic
diseases and follow up guidelines designed in protocols of treatment
20
a7. Identify the therapeutic guidelines and protocols of management of
medical diseases that may concomitantly present in poisoning patient.
a8. Be acquainted with the emergency medical procedures and medications,
their limitations, complications and efficacy in different clinical situations.
b- Intellectual skills (IS):
By the end of the course the candidate will be able to:
b.1. Reach clinical diagnosis based on a proper history and general medical
examination to help delineation of toxicological from medical diseases.
b.2. Correlate clinical presentations to pathophysiology of the disease process
b.3. Envisage the evolution of diseases based on the course and detected
prognostic criteria
b.4. Correlate clinical and laboratory findings that differentiate medical and
toxicological illnesses.
b.5. Depict dangerous signs that endanger patient life and correlate them to
medical or toxicological pathology.
b.6. Design rapid and emergency plan of treatment depending on the detailed
presented clinical and laboratory data, especially in critical presentations.
b.7. Design multidisciplinary treatment plan in poisoned patient suffering
medical complication.
c- Professional skills (PS):
By the end of the course the candidate will be able to:
c.1. Perform clinical examination especially to the cardiovascular, respiratory,
renal, neurological, and gastrointestinal systems.
c.2. Acquire the skills and perform the procedures necessary for the
evaluation, differentiation, and care of patients with shock and or respiratory
failure
c.3. Acquire the skills to differentiate metabolic, toxicological and structural
brain lesions in cases presenting with coma, convulsions and agitation or altered
behavior
c.4. Acquire the skills necessary for the evaluation, differentiation, and care of
patients with renal, hepatic failure as toxic versus viral fulminant hepatitis, prerenal
versus organic renal failure
c.5. be familiar with the interpretations of imaging: e.g., Plain radiography,
ultrasound, Computed Tomography (CT), Magnetic Resonance Imaging (MRI),
etc.
21
2- General and transferable skills (GS):
By the end of the course the candidate will be able to:
d.4. Maintain honesty and integrity in all interactions with teachers, colleagues
and others with whom clinical toxicologist must interact in their professional lives.
d.5. Recognize the limits of their role as toxicologist as well as the necessity to
seek and collaborate with other workers.
d.6. Use database to collect material needed for research.
d.7. Gather and organize material from various sources (including library,
electronic and online resources).
d.8. Understand the importance of continuing professional development.
d.9. Demonstrate ethical medical practice and envisage honesty, fairness and
respect to the patient and families / friends.
d.10. Work cooperatively and show respect for other opinions.
3- Course content
Topics No of hours
L T C/P SDL
Internal Medicine 1 Credit Hour
1) General Clinical Examination 2
2) Neurological diseases:
Cerebrovascular accidents,
Meningoencephalitis, Acute confusional states,
coma, peripheral neuropathy, paralytic states,
2 2 1
3) Cardiovascular Diseases: Shock and
heart failure, hypertension, coronary artery
heart diseases, myocarditis, arrhythmias.
1.5 2 1
4) Respiratory diseases: Acute
bronchospastic conditions, Pneumonitis,
Pulmonary edema, pneumothorax, respiratory
failure,
1.5 2
1
5) Metabolic diseases: Diabetes Mellitus 0.5 0.5 1
6) Gastroenterology: Investigations of
liver disease, acid peptic diseases, hepatitis,
liver cell failure,
1 0.5 1
7) Renal diseases: Glomerulonephritis,
renal failure and ESRD
0.5 0.5 0.5
8) Hematological diseases: Anemia,
neutropenia, DVT, pulmonary
thromboembolism.
1 0.5 0.5
Total 8 8 8
22
L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed
learning.
4- Student Assessment Methods
4.1 Short essays to assess knowledge
4.2 MCQs to assess knowledge and intellectual skills
4.3 Practical/ Clinical exam to assess professional skills and general skills
4.3 Oral exam to assess intellectual, professional and general skills
Weighing of assessments 1 Written examination: 30 marks
2 Practical examination ----
3 Oral examination -----
4 Clinical examination 15 marks
Total 45 marks
5- List of References
1- Harrison's textbook of Internal Medicine
2- Oxford Handbook of Clinical Medicine Hope et al
3- Cecil Textbook of Medicine
Medical Responsibilities and Malpractice in Clinical Toxicology course specification
University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Major
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Forensic Medicine and
Clinical Toxicology
Academic level First Year
Date of Specification Approval
Basic Information
Title Medical
Malpractice and
responsibilities
Code FT6104
Credit Hours 1 Lectures: 8 h Tutorials: 10 h
Clinical: 6 h Total contact: 24 h
23
Coordinator
Professional Information
1 Course Aims
- Acquire an appropriate background of basics of standards of care in medicine
disease actionable in toxicology.
- Identify and manage medical complications in the context of poisoning
malpractice
- Recognize the inappropriate procedures, drugs, antidotes and other supportive
management
- Acquire the talent and experience of rapid accurate management of medical
emergencies.
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding (K):
By the end of the course the candidate will be able to:
a1. Determine malpractice points in reference to therapeutic guidelines and
protocols that could be done for acute intoxicated patients in emergency room, in-
patient unit, ICU, out-patient unit and laboratory.
a2. Know how to write medico-legal report in acute intoxicated patients.
a3. Enumerate the medico-legal responsibilities towards answering a patient
telephone asking a medical advice.
a4. Recognize different forms of negligence in acutely intoxicated patient.
a5. Recognize the medico-legal aspects of transfer and referral
a6. Recognize negligence in providing efforts of diagnosis and management in
toxicology practice
a7. Requirements for Negligence to be Actionable
b- Intellectual skills (IS):
By the end of the course the candidate will be able to:
b1. Acquire the skill to avoid malpractice claim in all activities of toxicology
practice.
b2. Express wisdom to negate the elements of a claim.
b3. Express skill to depict inappropriate management and solve it.
b4. Avoid breach of duty by sticking to therapeutic guidelines and protocols that
consider basic standards of care.
b5. Depict dangerous signs that endanger patient life and correlate them to
medical or toxicological pathology.
c- Professional skills (PS):
By the end of the course the candidate will be able to:
24
c.1. Acquire Communication skills to harmonize patient toxicologist
interrelation.
c.2. Acquire communication skills with health care providers to achieve the
c.3. goal to cure the patient without commission a breach of duty.
c.4. Arrange teaching sessions aiming at avoiding inappropriate management
from the part of physicians (non toxicologist) and other health care providers
d- General and transferable skills (GS):
By the end of the course the candidate will be able to:
d.1. Maintain honesty and integrity in all interactions with patients.
d.2. Assume responsibility towards the patient related to the toxicologist by a
duty
d.3. Work cooperatively and show respect for other opinions.
3- Course content:
Topics No of hours
L C/P C/P SDL
Medical Responsibilities and Malpractice in
Clinical Toxicology
1 Credit Hour
Ideal and basics standards of Care 1 1
Types of malpractice 1 1
Deviation from standards of care by ignorance 2 2 1
Deviation from standards of care by negligence 2 2 1
Elements of negligence claim 1 1
Factors enhancing claim 1
The most common causes of claims and health
care providers
1
Malpractice versus assault 1
Types of informed consent and contribution of
patient in negligence
1
Case studies of common malpractice 4
Total Contact hours = 24 8 10 6
Total Credit hours = 1
4- Student Assessment Methods
4.1 Short essays to assess knowledge
4.2 MCQs to assess knowledge and intellectual skills
4.3 Practical/ Clinical exam to assess professional skills and general skills
4.3 Oral exam to assess intellectual, professional and general skills
25
Weighing of assessments 1 Written examination: 30 marks
2 Practical examination 20
3 Oral examination 10
4 Clinical examination 15 marks
Total 75 marks
5- List of References
5.1- Course Notes (paper and / or electronic)
5.2- Essential Books (Text Books)
5.3- Recommended Books
5.4- Periodicals, Web Sites, etc
General Toxicology course specification University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Major
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Forensic Medicine and
Clinical Toxicology
Academic level First Year
Date of Specification Approval
A- Basic Information
Title General toxicology Code FT6105
Credit Hours 2 Lectures: 21 h Tutorials:
Practical: 18 h Total contact: 39 h
Coordinator
B - Professional Information
1- Course Aims:
a) To be competent in the clinical evaluation of acute intoxicated patients and
identify those who need life saving procedures.
b) Share in the general management of an acutely intoxicated patient mainly
perform the elimination procedure
b) Diagnose and state the proper management of complications due to acute
intoxication
26
c) To apply background knowledge of the basic toxicology sciences in explaining
special toxicological systemic insults and atypical pictures in extremes of age ,
pregnancy and diseases.
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding
By the end of the course the candidate will be able to:
a1. Describes the pathophysiology, toxic causes, clinical picture and
diagnosis of complications of poisoning (respiratory, neurological, cardiovascular
and metabolic)
a2. Describe, in details, the steps of the general management of acutely
intoxicated patients.
a3. Discuss how the different body systems respond to poisoning
a4. Describes the atypical pictures acute poisoning due to pregnancy,
extremes of age and multiple overdoses.
b- Intellectual skills
By the end of the course the candidate will be able to:
b1. Interpret and diagnose critical life threatening complications of acute
intoxications and identify conditions needing immediate intervention.
b2. Decide promptly the required management procedure and clearly design
the proper pathway of care of and acutely intoxicated patient.
b3. Relate the atypical clinical pictures to special conditions as extremes of
age and pregnancy.
c- Professional skills
By the end of the course the candidate will be able to:
c1. Perform full and informative general and systemic clinical examination of
an intoxicated patient.
c2. Choose the proper required investigational procedure for the general
evaluation of the patient condition
c3. Undergo efficiently all procedures used for detoxification and elimination of
poisoning
d- General and transferable skills
By the end of the course the candidate will be able to:
d1 –Present cases and discusses clinical data with peers.
d2 – Self education and collect data from the net and other sources
d3 – Communicate properly with patients, peers and seniors ……….
d4 – Work, within a team, in preparing research articles.
27
3- Course content
Topic No. of hours
L C/P C/P SDL
General clinical examination of poisoning
cases and role of the lab.
2 2 4
Toxidromes 1 1 2
Management of acute poisoning
1
Detoxification (Gastric lavage, emesis,
catharsis)
1 2
Elimination procedures (Diuresis, dialysis and
others)
1 2
Toxic causes, diagnosis of specific clinical
complications:
Neurological complications of poisoning and
Management
Coma , Seizures, tremors, fasciculations 2 1
Agitation, Hallucinations and delusions and
Behavioral changes
1 1 1
Encephalopathy, Cranial nerve toxicity -
Peripheral neuropathy
1
Cardiovascular complications
Hypotension, Shock – Hypertensive crises 1
Myocarditis, Myocardial, and peripheral
ischemia
1
Respiratory complications
Respiratory failure - Pneumonitis – ARDS 1
Pulmonary edema (Cardiogenic and non-
cardiogenic)and Acute bronchospastic
conditions
1
Acid Base and Electrolytes imbalance 1 1
Topics No. of hours
L C/P C/P SDL
Poisoning at extreme of ages, pregnancy and
in diseases
1 1
Nephrotoxicity 1
Hepatotoxicity 1
28
Toxicity of hematological system 1
Immunotoxicity 1
Antidotes 1
4 - Student Assessment Methods
4.1 - Essay written … to assess a1, a2, a3 a4
4.2 - Practical exam to assess b5…….……….
4.3 - Clinical exam and check list application to assess c1, c2, c3, c4 and d3
4.4 - MCQ exam to assess a1, a2, a3, a4, c1, c2, c3, c4
4.4 - Research article presentation to assess d1, d2, d4.
Weighing of assessments 1 Written examination: 70 marks
2 Practical examination 20
3 Oral examination 10
Total 90 marks
5- List of References
1. Ellenhorn's Medical Toxicology
2. Dreisbach's handbook of poisoning
SYSTEMIC TOXICOLOGY course specification Course specifications
University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical Toxicology
(FT610)
Major or minor element of programs Major
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Forensic Medicine and
Clinical Toxicology
Academic level (2nd
Year)
Date of Specification Approval 18 -10- 2009
A- Basic Information
Title Special toxicology. Code FT6106
Credit Hours 6 Lectures: 60 h Tutorials: h
Clinical and Practical: 65h
Total contact hours : 125 h
Coordinator
B - Professional Information
29
1- Course Aims:
a) To be competent in the clinical evaluation and provide immediate and correct
general and specific emergency management of an acutely intoxicated patient
b) To identify and manage properly all complications due to acute intoxication
c) To apply background knowledge of the basic toxicology sciences in conducting
managerial and professional skill in hospital emergency and outpatient clinics and
provide optimal health services to acute , chronic,occupational and environmetal
intoxications.
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding
By the end of the course the candidate will be able to: a1 Discuss the pathophysiology of common acute intoxications with drugs and
chemicals
a2 Describe acute clinical picture and complications of common drugs and
chemical acute intoxications.
a3 – Outlines the required investigational procedures that help in diagnosis of acute
and chronic intoxications.
a4 –Discusses the details of management of the acute intoxicated patient.
b- Intellectual skills
By the end of the course the candidate will be able to:
b1- Interpret and diagnose acute intoxications, and identify conditions needing
immediate intervention.
b2 – Decide promptly the required management procedure and clearly design the
proper pathway of care of acute of intoxications.
b3 – Show competency in solving problems revolving around acute intoxications
with referral to medical ethics and medico-legal responsibilities
b4- Apply basic toxicological sciences in the prevention of acute intoxicated cases.
b5 – Formulate questions on research points that require evidence based research.
c- Professional skills
By the end of the course the candidate will be able to:
c1- Perform full and informative general and systemic clinical examination of an
intoxicated patient.
c2 - Choose the proper required investigational procedure that helps in diagnosis
and interpret correctly.
c3 - Undergo efficiently all procedures used for detoxification and elimination of
poisoning
c4 - Show competency in applying protocols for specific and antidotal
management of acute intoxicated cases.
30
d- General and transferable skills
By the end of the course the candidate will be able to:
d1 –Present cases and discusses clinical data with peers.
d2 – Self education and collect data from the net and other sources
d3 – Communicate properly with patients, peers and seniors ……….
d4 – Work within a team in preparing research articles
3- Course content:
Topics No. of hours
L C/P C/P SDL
Over the Counter drugs
Acetaminophen 1 1 1
Salicylates 1 1 1
Non Steroidal Anti-Inflammatory Drugs 1 1
Vitamins antioxidants and body builders 1 1
Anorexigenic drugs, Obesity Drugs 1 1
Cephalosporins and Penicillins 1 1
Macrolides Quinolones Aminoglycosides 1
Antituberculous drugs 1
Central Nervous System Drugs
Antidepressants 1 1 2
Neuroleptics 1 1
Lithium 1 1
Sedatives hypnotics (Benzodiazepines,
Barbiturates, Meprobamate, Zopiclone,
zolpidem, Melatonin receptor, bromides, plant
origin sedatives.)
1 1 1
Anxiolytics Others (Buspirone…) 1/2 1
Muscle relaxants Others 1/2 1
Antiepileptics 1 1
Respiratory Drugs
Theophylline and Xanthines 1 1 1
Beta2-adrenergic receptor agonist 1
Cardiovascular Drugs
Digitalis preparations 1 1 1
Beta blockers 1 1 1
Diuretics 1
31
Calcium Channel Blockers 1 1 1
Antiarrhytmics 1 1
Antihypertensives 1 1
Nitrates 1 1
Drugs of Abuse(acute intoxication)
Opiates and opioids 1 1 1
Cannabis 1 1 1
Alcohol 1 1 1
Amphetamines 1 1
Cocaine 1 1
Metals and salts
Lead 1
Mercury 1
Arsenic 1
Iron 1 1 1
Corrosives (Acids, Alkalis, chlorine) 3 1 2
Chemicals
Toxic Gases (Carbon monoxide, cyanide,
chlorine, hydrogen sulfide…)
4 1 2
Toxic Alcohols and Glycols 1
Rodenticides (Phosphides, anticoagulants,
Boron, Carbamates)
1 1 1
Insecticides (Organophosphates,
Organochlorines, Carbamates, Pyrethroids,
Others)
1 2 2
Herbicides (Paraquat, diquat, atrazine) 1
Dioxins 1
Petroleum distillates and hydrocarbons 1 1 1
Detergents, Dyes, food colors and preservatives 1
Food Poisoning (Bacterial, viral, chemical,
endogenous…)
1 1 1
Botulism 1 1 1
Ciguatera, Paralytic shellfish. Scombroid 1 1 1 *
Food allergy versus poisoning 1 *
Animal Envenomation
Scorpion 1 1 1
32
Snakes 1 1 1
Spider Bees and wasps and Marine 1
Toxic Plants
Mushrooms 0.5
Mycotoxins, Houseplant 0.5
Atropine, Hyoscine (atropa belladonna &
related plants) Other hallucinogenic
psychoactive plants (Nutmeg, khat, supari,
valerian.)
1
Operating Toxicological Disaster 1
Chemical Warfare (including biological
warfare of toxicological importance)
1
Radiation toxicity 1 1
L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning
4 - Student Assessment Methods
4.1Essay written … to assess a1, a2, a3 a4
4.2Practical exam to assess b5
4.3Clinical exam and check list application to assess c1, c2, c3, c4 and d3
4.4 MCQ exam to assess a1, a2, a3, a4, b1, b2, b3, b4, b5
4.4 research article presentation to assess b6, d1, d2, d4.
Weighing of assessments 1 Written examination: 170 marks
2 Practical examination 40
3 Oral examination 50
4 Clinical examination 40
Total 300 marks
5 - List of References
5.1- Course Notes (paper and / or electronic)
…Provided by staff members
5.2- Essential Books (Text Books)
Handbook of medical toxicology,Peter Viccellio,Little ,Brown and company
5.3- Recommended Books
Goldfrank Toxicologic emergencies,
Haddad
Ellenhorn's Medical Toxicology
5.4- Periodicals, Web Sites, etc
33
Intensive Care of Poisoned Patients course specification Course specifications
University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Major
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Forensic Medicine and
Clinical Toxicology
Academic level (2nd
Year)
Date of Specification Approval 18 -10- 2009
A- Basic Information
Title Intensive care of poisoning patient Code FT6107
Credit Hours 6 Lectures: 60 h Tutorials: h
Clinical and Practical: 62h
Total contact hours : 122 h
Coordinator
B - Professional Information
1- Course Aims:
1) To be competent in the emergency clinical evaluation and management of
an acutely intoxicated patient. acutely ill patient suffering acute intoxications
immediate and correct general and specific emergency management of
2) To identify and manage acute systemic disturbances and failure and
properly manage all complications due to acute intoxication
3) To express skills and competence in dealing with resuscitative measures
as antidotes administration, oxygenation, monitoring, and mechanical ventilation
adjustments suitable for acutely intoxicated patient based on the recognized clinical
toxic effects of poisons.
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding
By the end of the course the candidate will be able to: a1. Describe the resuscitative measures and critical care modalities in patients
with acute or chronic intoxications complicated with system failure.
a2. Explain the usual evolution of poisoning. Depict the prognostic signs and
interpret their significance using the investigative tools and toxicology laboratory
results.
34
a3. Understand the basis of the critical care antidotes and drugs, equipment
and their functioning, use indications, values, complications and limitations
according to type of poisons.
a4. Comprehend the preset parameters of mechanical ventilation, adjustments,
meaning of monitoring value for all types of intoxication, stage of the disease and
circumstances.
a5. Realize the monitoring value of electrocardiographic changes, significance
in different intoxication and emergency management.
a6. Understand the basis of elimination and detoxification procedures, their
potential values and risks and their indications.
a7. Understand the basis and indications of hemodialysis and recommend
specific prescriptions for every poison and other circumstances.
a8. Understand the basis of other procedures helping the eliminations of poison
as peritoneal dialysis, hemofiltration and hemoperfusion.
a9. Outline the required emergency investigational procedures that help in
diagnosis of acute and chronic intoxications.
a10. Discuss the details of management of the acute intoxicated patient.
b- Intellectual skills
By the end of the course the candidate will be able to:
b1. Provide skills to diagnose acute intoxications and their vital complications
on emergency basis interpret the clinical data and select immediate intervention.
b2. Interpret the monitoring values and significance of clinical changes for rapid
and immediate therapeutic intervention using antidotes, drugs or resuscitative
equipment.
b3. Modify the therapeutic modalities of equipment according to the values and
calculations of clinical and machine data.
b4. Express competence in interpreting arterial blood gas, other laboratory
parameters of significance and monitoring values of cardiac monitor,
electrocardiography, imaging, ventilation, central venous pressure, response of
antidotes and elimination procedures.
b5. Evaluate the patient clinical condition by selecting the proper modality.
b6. Decide promptly the required management procedure and clearly design the
proper pathway of care of acute of intoxications.
b7. Show competency in solving problems related to critical care tools used in
the management of the intoxicated patient. Recognize troubleshooting of every
equipment and express competence in dealing and correcting it
b8. Understand the value of documentation and cumulative critical care
observation for subsequent decision making concerning the management of acute
intoxications
b9. Formulate questions on research points that require evidence based research.
35
b10. Apply basic toxicological sciences in the prevention of acute intoxicated
cases.
c- Professional skills
By the end of the course the candidate will be able to:
c1. Perform full and informative general and systemic clinical examination of
an intoxicated patient.
c2. Select the investigational approach on emergency basis for clarification of
the detailed diagnosis, severity and possible systemic affection.
c3. Choose the required intervention and procedure, and express competence
in performing them, including elimination procedures as emesis, gastric lavage,
assuring airway and endotracheal intubation, AMBU resuscitation and mechanical
ventilation, assessment of central venous pressure, humidification of airway,
oxygenation, nebulizer, use of special modality ventilation, using cardiac
monitoring for starting or terminating antidotes or drugs or for other decision
making therapeutic modality, defibrillation and other minor and major procedures
c4. Undergo efficiently all procedures used for detoxification and elimination
of poisoning
c5. Demonstrate skill in applying protocols for specific and antidotal
management of acute intoxicated cases.
c6. Demonstrate skill in emergency management of acute life threatening
conditions as arrest, treatment of shock, seizures, respiratory failure
d- General and transferable skills
By the end of the course the candidate will be able to:
d1. Communicate with colleagues and seniors for the sake of a more accurate
diagnosis and effective treatment
d2. Present cases and discuss clinical data with peers.
d3. Practice emergency medicine with referral to medical ethics and medico-
legal responsibilities
d4. Self education and collect data from the net and other sources
d5. Work within a team in preparing research articles
3- Course content
Topics No. of hours
L T C/P SDL
I- General
Criteria for ICU admission of poisoned
patient
1
1
2
4
36
1
1
1
1
3
3
37
II- Respiratory 1- Airway management
2- Pulmonary edema
3- Adult respiratory distress syndrome
4- Respiratory failure
5- Oxygen therapy
6- Mechanical ventilation
III- Cardiovascular 1- Shock and cardiac arrest
2- Acute myocardial infarction
3- Heart failure
4- Common arrhythmias and conduction
disturbance
5- Pulmonary embolism
6- Hypertensive crisis
7- Training in Basic Life Support (BLS),
and Advance Life Support (ALS)
8- ECG interpretation
IV- Neurology
1- Coma, differential diagnosis of
metabolic, structural versus toxic coma.
2- Seizures, agitation, delirium and
confusional states: Causes and management in
Toxicology
3- Cerebrovascular disease
4- Post anoxic brain damage
5- Meningitis and encephalitis
6- Brain death.
V- Renal
Renal failure
VI- Endocrine
1. Diabetic Ketoacidosis
2. Hyperglycemic Hypersomolar
nonketotic Syndrome
3. Diabetes insipidus
4. SIADH
4
1
1
1
1
1
1
2
3
3
2
1
1
1
1
2
1
1
1
1
4
1
2
1
1
4
4
4
4
3
2
4
3
3
3
3
4
2
38
VII- Metabolic & Nutritional 1- Fluid, electrolyte and acid-base disorders
2- Nutritional requirements, monitoring of
nutrition.
3- Enteral and parenteral nutrition
VIII- Haematological 1- Disseminated intravascular coagulation
2- Haemolytic syndromes
3- Acute anaemia
4- Blood component therapy
IX- Infections 1- Severe infection due to aerobic and
anaerobic bacteria, viruses, and fungal
2- Nosocomial infection
3- Aantimicrobial therapy
X- Gastro-intestinal 1- Pancreatitis
2- Acute and chronic liver failure
3- Prevention and treatment of acute G.I.
Bleeding
XI- Common ICU procedures
1. Central venous line and measurement of
CVP
2. Chest tubes
3. Cricothyrotomy and tracheostomy
4. Gastric lavage
1
1
2
1
2
1
2
1
1
1
1
1
1
2
1
1
1
1
TOTAL Contact Hours = 122 hours 60 24 38
TOTAL Credit Hours = 6 hours 4 0.75 1.25
L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed
learning
39
4 - Student Assessment Methods
4.1Essay written … to assess a1 – a10
4.2Practical exam to assess b1 – b7
4.3Clinical exam and check list application to assess c1 – c6 and d1 - d3
4.4 MCQ exam to assess a1 - a10, b1 - b7
4.4 Research article presentation to assess b8-9, d1, d2, d4.
Weighing of assessments 1 Written examination: 180 marks
2 Practical examination 20
3 Oral examination 20
4 Clinical examination 50
Total 270 marks
5 - List of References
5.1- Course Notes (paper and / or electronic)
…Provided by staff members
5.2- Essential Books (Text Books)
Handbook of medical toxicology, Peter Viccellio, Little ,Brown and company
5.3- Recommended Books
Goldfrank Toxicologic emergencies,
Clinical Toxicology of commercial products
Haddad,
The ICU Book, by Paul L. Marino
Clinical Electrocardiography by Ary L. Goldberger
5.4- Periodicals, Web Sites, etc
1. www.americanheart.org
2. http://toxnet.nlm.nih.gov/
A cluster of databases on toxicology, hazardous chemicals and related areas.
3. http://www.uic.edu/com/er/toxikon
Discussions, classes and reviews sponsored by The University of Illinois at
Chicago.
4. http://www.ansci.cornell.edu/plants/index.html
Database of photos, botanical information, and health information on poisonous
plants. Contains links to other related sites
5. http://www.hypertox.com/
Hunter Area Toxicology Service’s modules on approximately 25 common toxic
drugs and environmental agents, including information on pharmacology,
toxicology, and treatment.
6. http://www.aapcc.org/
40
AAPCC is a nationwide organization of poison centers and interested individuals.
7. http://pharminfo.com/phrmlink.html
Very extensive menu of links to data on pharmaceuticals, biotechnology, and
pharmaceutical companies.
8. http://www.ace.orst.edu/info/extoxnet/
Provides a variety of information about pesticides.
9. http://www.foodsafety.gov/~mow/intro.html
This is a site from the US FDA?s Center for Food Safety and Applied Nutrition.
Useful information on mushroom toxidromes.
10. http://www.floridaplants.com/mpois.htm
Information on poisonous plants and mushrooms from around the world.
11. http://www.acep.org/
This site contains the latest news, updates and guidelines for emergency
physicians.
12. http://www.clinicalpharmacology.com/
Search engine for commonly prescribed drugs with; dosages, indications,
interactions, pharmacokinetics, costs and more.
13. http://www.streetdrugs.org/
This is a comprehensive collection of drugs of abuse, although the information is
somewhat basic it is very comprehensive.
14. http://www.martindalecenter.com/Pharmacy.html
Access to Martindale's pharmacy center for drug information.
15. http://www.ecglibrary.com/
ECG library
Treatment of Drug Dependence and Practical Program of Analytical Toxicology course specification
Course specification
University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Major
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Forensic Medicine and
Clinical Toxicology
Academic level Second Year
Date of Specification Approval
41
Treatment of Drug Dependence
Basic Information
Title Drug Dependence Code FT6108
Credit Hours: 2.6
Lectures: 24 h Tutorials: h
Clinical and Practical: 30 h
Total contact hours: 54 h
Coordinator
B- Professional Information
1- Course Aims
1. Acquire an appropriate background of drug dependence and methods of
diagnosis using clinical methods, challenge tests and analytical techniques.
2. Identify and manage medical complications of drug dependence including
overdose
3. Acquire competency in detecting drugs of abuse using analytical tools
4. Acquire skills in detoxification maneuvers using internationally approved
techniques and in ethical way
5. Practice in general medical examination and develop skills in
differentiating diseases by proper integration of assembled clinical data.
6. Develop the skills to predict and manage possible signs of ominous
system failure and diseases of organs targeted by poisons.
7. Acquire the talent and experience of rapid management of medical
emergencies.
2- Intended Learning Outcomes (ILOs):
a- Knowledge and understanding (K):
By the end of the course the candidate will be able to:
a1. Recognize the drugs used in dependence and drugs in current use.
a2. Describe the pathophysiological changes of drugs of dependence
including central neurotransmitter changes.
a3. Describe the complications of every drug abuse.
a4. Explain the clinical picture of overdose by drugs of abuse and their
complications.
a5. Elucidate the clinical picture of chronic use for every drug and their
complications.
a6. Understand the mechanisms employed for different detoxification
procedures.
42
a7. Specify the rules, including ethical regulations, governing the different
methods of detoxification procedures in different parts of the world.
a8. Recognize the value, dangers and limitations of detoxification in every
drug, multi-drug use, patient's clinical status, chronicity and intensity of addiction.
a9. Describe the role of toxicological analysis in the follow up of ex-addicts
b1- Intellectual skills (IS):
Drug Dependence
By the end of the course the candidate will be able to:
b1- Depict the clinical and pathological changes of drug abusers and clarify
them and their correlation.
b2- Acquire a prudent approach to get history and examine patients requesting
treatment.
b3- Apply the rules of ethics to avoid malpractice.
b4- Manifest intellectual conduct and attitude to encourage the patient to submit to
requirements of the examination and subsequently to treatment.
b5- Expresses skills in dealing with patients on follow up and patients hiding their
relapse.
b6- Express skills in diagnosis of multi drug abuse in modified clinical picture.
b7- Design a detailed toxicological analysis and treatment protocol based on
patient's particular factors.
d- Professional and practical skills (PS):
Drug Dependence
By the end of the course the candidate will be able to:
a1. Competently carry out clinical examination to accomplish accurate and
detailed diagnosis of drug abuse with its medical complications.
a2. Request investigations and challenge tests pertinent to the clinical data
and preliminary diagnosis.
a3. Perform decontamination procedures in a safe and appropriate technique
according to the standards of care.
a4. Effectively perform procedures and therapeutic actions in accordance of
emerging complications of drug of abuse as special devices oxygenation, special
mode ventilation, arrhythmia correction
d- General and transferable skills (GS):
By the end of the course the candidate will be able to:
d.1. Retrieve the methods and experience through internet contact with other
analytical toxicology centers
43
d.2. Communicate the experience of your results and gain on the other hand
that of other centers
d.3. Achieve the best results through discussion and communication with
colleagues and superiors
d.4. Demonstrate respect, honesty and confidentiality for the patient under
your care and persons for which screening are performed.
d.5. Acquire communication skills with prosecutor, police officers and other
family members or work managers requesting the toxicological test.
3- Course content:
Topics No of hours
L C/P C/P SDL
Mechanisms and theory of drug abuse: receptor
toxicology
2
General basics of drug abuse 2 1
Opiates, narcotics and tramadol 2 2 2
Benzodiazepines and sedatives hypnotics
(Zopiclone, barbiturates, meprobamate and
myorelaxants)
2 2 2
Alcohol abuse 1 1 1
Central stimulants: Cocaine, amphetamine,
designer drugs, sympathomimetic and others
2 1 1
Cannabis 2 1 2
Other drugs of abuse: Research spirit 1 1 1
General examination of dependent patient in
overdose and other dependence emergencies
2 2 2
Tailoring analytical toxicology for diagnosis
and shaping profile of drug abuse
2 1
Detoxification procedures 4 2 4
Monitoring ex drug abuser 2 1
Total 24 15 15
L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed
learning.
44
4- Student Assessment Methods
4.1 Short essays to assess knowledge
4.2 MCQs to assess knowledge and intellectual skills
4.3 Oral exam to assess intellectual, professional and general skills
Weighing of assessments
1 Written and MCQ examination: 80 marks
2 Oral examination 20 marks
Total 100 marks
5- List of References
1- Clarke's analysis of drugs and poisons
2- Goldfrank clinical toxicology
Practical Program of Analytical Toxicology course specification
1- Basic Information
Title Analytical
Toxicology Code FT6108
Credit Hours 2.4 Lectures: 22 h Tutorials: h
Clinical and Practical: 30 h
Total contact hours : 52 h
Coordinator
B- Professional Information
1- Course Aims
1- To acquire knowledge of Principles and theories of different analytical
procedures.
2- Acquire an appropriate background of Toxicological sampling, and sample
preservation
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding (K):
By the end of the course the candidate will be able to:
a.1 Assimilate the principles of toxicological sampling
a.2 Recognize the preparation steps of samples before analysis
a.3 Assimilate the kinetic and dynamic of different poisons and rules governing
their biotransformation, redistribution and elimination
45
a.4 Understand the principles and theories of each technique used in toxicological
analysis
a.5 Describe the steps of each method of analysis
a.6 Comprehend the mechanism of sample extraction methods
a.7 Recognize the reliability, reproducibility, specificity and sensitivity of each
methodology.
a.8 Understand the basic requirements for each methodology, technique and
procedure.
a.9 Recognize indications, medico-legal implications and cost of each method of
analysis.
d- Intellectual skills (IS):
By the end of the course, the candidate will be able to:
b.1. Reject a sample not valid for toxicological analysis
b.2. Prioritize analytical methods according to the requirement and situation as
emergency, medico-legal or therapeutic; as for the most economic, rapid reliable or
sensitive.
b.3. Preferentially select the plan and sequence of toxicological analysis
according to the given clinical data
b.4. Modify steps according to the required poison to be analyzed, chemicals
availability and cost
b.5. Expect a certain method and selected body fluid for analysis according the
general rules of biotransformation of a given poison with a specific structure.
b.6. Review the literature and references to reach suitable method of
toxicological analysis according to the available resources
b.7. Design a toxicological analysis for an unknown poison of potential
hazards to the community using the basics of research
b.8. Comprehend the values and limitations of poisoning markers
b.9. Comprehend the problems and difficulties of delay, misinterpretation or
ignoring an important step of toxicological analysis
b.10. Accurately interpret results of toxicological analysis according to the used
methods, situation and other factors as timing, body fluid and based on the
toxicological information given by the patient and physician.
b.11. Comprehend the medico-legal aspects and limitations of each result.
46
d- Professional and practical skills (PS):
By the end of the course the candidate will be able to:
c.1. Describe and perform simple color tests that may rule out certain
diagnostic possibilities
c.2. Correctly and appropriately report and interpret the results after
confirming the analysis to comply with international standards of toxicological
analysis.
d- General and transferable skills (GS):
By the end of the course the candidate will be able to:
d.6. Retrieve the methods and experience through internet contact with other
analytical toxicology centers
d.7. Communicate the experience of your results and gain on the other hand
that of other centers
d.8. Achieve the best results through discussion and communication with
colleagues and superiors
d.9. Demonstrate respect, honesty and confidentiality for the patient under
your care and persons for which screening are performed.
d.10. Acquire communication skills with prosecutor, police officers and other
family members or work managers requesting the toxicological test.
3- Course content
Topics No of hours
L C/P C/P SDL
Toxicological sampling 2 1
Medico-legal implications in treatment of drug
of abuse and analytical toxicology
1 1
Principles and theories of different analytical
procedures
3 1
Extraction procedures: Principle, methods,
Practical
3 1 3
Color tests 1 1 1
Spectrophotometry in analytical toxicology,
Practical
2 1 1
Thin layer chromatography: Techniques and
procedures for different drug and poison
groups, Practical
3 2 4
Gas chromatography: Description of theory and
Technique, Uses and different methods,
Practical
2 2 2
47
High Performance liquid Chromatography:
Description of theory and Technique, Uses and
different methods, Practical
2 2 2
Immunoassays: Theory, advantages and
limitations, Practical
2 2 2
Other analytical methods : Description of
technique, Atomic absorption, Conway cell,
distillation procedures,
1 1
Total: 22 13 17
4- Student Assessment Methods
4.1 Written and MCQs to assess knowledge and intellectual skills
4.2 Oral exam to assess intellectual, professional and general skills
4.3 Practical exam to assess professional skills
Weighing of assessments
1 Written and MCQ examination: 80 marks
2 Oral examination 20 marks
3 Practical examination 50 marks
Total 150 marks
5- List of References
Clarke's analysis of drugs and poisons
Elective courses Medical statistics course specification University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Minor
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Community, Environmental and
Occupational Medicine
Academic level
Date of Specification Approval
A- Basic Information
Title: Medical statistics course Code: E7024
Credit Hours: 1 hour Lecture: 0.65 /w. Total: 10
48
Practical: 0.6/2w. Total: 10
A credit hour = one hour lecture or practical weekly for 15 weeks
Coordinator
Community, Environmental and Occupational Medicine Department
B - Professional Information
Course Aim:
To enable the doctorate candidate to plan, conduct, analyze and interpret the results
of a research in his specific field. This course unit introduces the application of
statistical ideas and methodology to medical research.
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding
By the end of the course the candidate will be able to:
a1 - Define medical statistics and identify uses and importance of medical statistics
in medical research
a2 – Define:
Types of variables.
Descriptive statistics.
Presentation and summarization of data.
Measures of central tendency and scatter.
Principles of probability and probability distributions.
Concepts of inferential statistics: confidence interval and hypothesis testing.
Different tests of statistical significance.
Difference between parametric and nonparametric tests of significance.
Correlation and regression
Concept of statistical modeling using multivariable and multivariate
statistical methods.
Combining evidence from different studies and meta-analysis
Importance and methods of sampling and how to determinate the suitable
sample size.
Different types of research methodology:
Observational and intervention studies and the different statistical issues
related to the design, conduct, analysis and interpretation of the results of
each study type.
Ethical aspects of medical research including those specifically applied to
clinical trials.
b- Intellectual skills
By the end of the course the candidate will be able to:
49
b1 - Interpret correctly the results of statistical analyses and critically evaluate the
use of statistics in the medical literature.
b2 - Integrate and evaluate information from a variety of sources.
c- Professional skills
By the end of the course the candidate will be able to:
c1- Select appropriate study designs to address questions of medical relevance
c2 - Select and apply appropriate statistical methods for analyzing data typically
encountered in medical applications.
c3- Use selected software packages for statistical analysis and data management.
d- General and transferable skills
By the end of the course the candidate will be able to:
d1 - Work effectively in a group from different backgrounds.
d2 - Respects the role of staff and co-staff members regardless of degree or
occupation.
d3 - Communicate effectively with professional statisticians and the wider medical
community, including the ability to present results of statistical analyses through
written and oral presentations
d4 - Use of computer data bases and other computer skills.
d5 - Handle data appropriately and analyze them through: decision processes,
objective criteria, problem definition, project design and evaluation, risk
management, teamwork and coordination.
d6 - Learn independently with open-mindedness and critical enquiry.
3- Course content:
Topics
T C/P
Introduction to medical statistics and its uses x X
Types of variables and Descriptive statistics x X
Graphic presentation of data x X
Introduction to probability theory and rules x X
Sample and population: sampling distribution of mean and proportion x X
Confidence interval of a mean and a proportion x X
Confidence interval of a difference between two mean /proportion x X
Testing a hypothesis about population mean/proportion x X
Testing a hypothesis about the difference between two
means/proportion
x X
Comparing between more than two means-Introduction to factorial
analysis
x X
Cross-tabulation and introduction to categorical data analysis x X
Simple correlation and simple regression x X
50
Introduction to multivariable and multivariate analysis x X
Study designs: observational studies x X
Study designs: Intervention studies: clinical trials x X
Study designs: Experimental animal studies x X
Study designs: Bias and Confounding x X
Ethical issues in medical research x X
Sample size estimation for continuous and binary outcome measures. x X
Meta-analysis and publication bias. x X
T: Tutorial and C/P: Clinical or Practical and SDL: Self directed learning
4 - Student Assessment Methods
4-1 Written exam to assess knowledge and understanding and will concentrate on
problem solving questions
4-2 Weighing of assessment
Written exam 100
Total 100
5 - List of References
5.1- Course Notes (paper and / or electronic)
Student Notes on Medical Statistics and Research Methods. Prof. Mohsen Abdel
Hamid and Dr Moustafa El Houssinie. Department of Community, Environmental
and Occupational Medicine.
5.2- Essential Books (Text Books)
Statistics in Clinical Practice. avid Coggon. BMJ Books. 2nd
edition 2003
5.3- Recommended Books
Handbook of Epidemiology. Springer 2005
5.4- Periodicals, Web Sites, etc
www.brettscaife.net/statistics/introstat/
onlinestatbook.com/rvls/
www. Epidemiolog.net
http://www.shef.ac.uk/
Computer Science Course Specification: University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Minor
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Department of Forensic Medicine and
Clinical Toxicology
51
Academic level
Date of Specification Approval A- Basic Information
Title: Computer Science Code: E6047b Credit Hours: Lecture: 1 h/w (15 h) Total: 15 actual hours Coordinator
A- Professional Information
1 – Overall Aims of Course:
By the end of the course, the student should become aware of computer science
principles and tools, how to do a presentation, how to use internet in
communication and getting knowledge and updated sciences.
2– Intended Learning Outcomes of Course (ILOs):
a. Knowledge and Understanding:
By the end of the course, the candidate should be able to:
a1- Know computer components
a2- Understand principles of computer
a3- Know commonly used softwares
b. Intellectual Skills:
By the end of the course, the candidate should be able to:
b1- How to get maximum from computer facilities
b2-How to use internet to get knowledge
b3-How to do a presentation with the help of computer
c. Professional and Practical Skills
By the end of the course, the candidate should be able to:
c1- Use of computer in an optimum way
c2- Use Microsoft office properly
c3- Use of internet
d. General and Transferable Skills
By the end of the course, the candidate should be able to:
d1- Communicate with collegues through the net.
d2- Communicate with staff through computer
d3- Interchange data with collegues and staff
3. Contents :
Topic No. of hours /week
lectures practical Tutorial
Information Technology 2
Windows 2
Microsoft Office (word, excel, access,
power point)
8
Internet 3
52
4 - Student Assessment Methods
4.1 written to assess knowledge
Weighing of Assessments:
Final Examination (written): 50 marks
Total 50 marks
5 -- List of References
5.1- Course Notes (paper and / or electronic)
Lecture notes
5.2- Essential Books (Text Books)
5.3- Recommended Books
5.4- Periodicals, Web Sites, etc
Basic Immunology course specification University Ain Shams Faculty of Medicine
Program on which the course is given Master of Science in Clinical
Toxicology
Major or minor element of programs Minor
Department offering the program Department of Forensic Medicine and
Clinical Toxicology
Department offering the course Clinical pathology department
Academic level
Date of Specification Approval
A- Basic Information
Title: Basic Immunology course Code: E6015
Credit Hours: 1 hour Lecture: 15 Total: 15
Coordinator
Head of immunology unit clinical pathology dept.
B - Professional Information
1- Course Aims:
The aims of the course are to provide postgraduate students with an advanced
academic and laboratory research training in modern cellular and molecular
immunology, with emphasis on the interface between the basic and clinical aspects
of the subject.
By the end of the course the candidate will be able to:
a) Have a good understanding of the molecular and cellular mechanisms
involved in the development and regulation of the immune response.
b) Understand the way in which the immune system can be manipulated in
the treatment of disease, in particular transplantation and cancer.
53
c) Understand the ways in which defects in the immune system can lead to
disease such as allergy and auto-immunity.
d) Understand the basis of major immunological laboratory investigations
and their clinical use.
2- Intended Learning Outcomes (ILOs) from the Course:
a- Knowledge and understanding
By the end of the course the candidate will be able to:
a1. Identify major mechanisms involved in the immune response.
a2. Recognize how the immune system can 'go wrong' to cause disease.
a3. Recognize how the immune system can be manipulated to prevent or treat
disease learning'
a4. Know the latest research techniques and approaches, including molecular and
cellular immunology and data handling, data storage and manipulation.
b- Intellectual skills
By the end of the course the candidate will be able to:
b1 - Analyze & solve immunological problems.
b2 - Integrate and evaluate information from a variety of sources
c- Professional skills
By the end of the course the candidate will be able to:
c1- Analyse experimental results and determine their strength and validity
c2 - Prepare research reports
c3 - Give research presentations Use the scientific literature effectively
c4- Use computational tools and packages
d- General and transferable skills
By the end of the course the candidate will be able to:
d1 - Work effectively in a group during preparation of seminars.
d2- Respects the role of staff and co-staff members regardless of degree or
occupation.
d3 - Communicate effectively through oral computer processing and written
reports.
d4 - Use of computer data bases and other computer skills.
d5 - Handle data Appropriately and analyze them through: decision processes,
objective criteria, problem definition, project design and evaluation, risk
management, teamwork and coordination.
d6 - Learn independently with open-mindedness and critical enquiry.
3- Course content:
Topics
No. of hours
L T C
/P
S
D
54
L
A. Anatomy and
cellular elements of
the immune system
Anatomy of the immune system
Cells of myelomonocytic
lineage, NK cells and non-specific
defence
Ontogeny, structure, phenotype,
function and activation
Organisation of the lymphoid
system
Primary and secondary
lymphoid organs
Lymphocyte migration
Mucosal and other
compartments of the lymphoid system
Complement
structure, function, control in
defence and in disease
Complement and Fc
receptors, adhesion molecules
Deficiencies
1
1
B. Immune and
inflammatory
mechanisms
Natural or innate immune
response
Antigens and antigen processing
and presentation
Antigens: types, structures,
processing and presentation
Macrophage & Dendritic Cell
Function
APC Regulation of the Immune
Response
Major Histocompatibility
Complexes:
structure, function and
regulation
T Lymphocytes and cell mediated
immunity
Ontogeny, phenotype,
subpopulations
T cell receptors: structure,
function and antigen binding
Receptor/ligand interactions and
1
1
1
1
1
55
cell activation
T cell mediated immune
responses - participating cells
T cell subsets
Regulatory T cells and memory
cells
Effector functions
B Lymphocytes and humoral
immunity
B cell receptors; structure,
function and antigen binding
Immunogenetics:
polymorphisms, generation of diversity
and rearranging gene families
Immunoglobulins: structure,
function and antigen binding
Idiotype networks: inhibition
and stimulation
Effector functions
Cytokines, chemokines and
immunomodulators
Cytokines and Chemokines:
origin, structure, effect, site(s) of action
receptors, metabolism, and
regulation
The acute phase response and
inflammation
Inflammatory mediators
(e.g. leukotrienes, prostaglandins and
platelet-activating factor): origin,
structure, effect, site(s) of action
(receptor), metabolism and regulation
1
1
3. Cellular
interactions and
immunomodulation
1. Cellular activation and regulation: for
each cell type, understand mechanisms of
activation and suppression of function
(e.g. T cell:B cell interactions via
CD28:CD80/86)..
3. Immune cell trafficking; adhesion
molecules, chemokines
1
56
4.
Immunoregulation
Immunoregulation
Tolerance: clonal selection,
suppression and antigen paralysis
Oral tolerance
Cell-cell interactions; help and
suppression
1
5. Immune response
mediated tissue
damage
Hypersensitivity mechanisms
IgE-mediated; acute and late phase
reactions
IgA-,IgG and IgM-mediated:
opsonization, complement fixation,
antibody dependent, cell-mediated
cytotoxicity, stimulation and blocking
Immune complex mediated:
physicochemical properties and clearance
Cell-mediated: participating cells,
effector mechanisms and granuloma
formation
Immune Mechanisms of
Autoimmunity and Autoimmune
Disease What is autoimmunity?
Factors [breakdown of functional T
cell anergy, genetics, infection, exposure
to normally hidden antigens, new
epitopes] which give rise to autoimmune
disorders
Mechanisms of tissue damage in
autoimmunity
1
1
6-Autoimune
Diseases:
Laboratory diagnosis of autoimmune
(connective tissue) diseases
Clinical relevance of autoantibodies,
diagnostic specificity and sensitivity for
autoimmune disorders
SLE
Diagnosis of rheumatoid arthritis
and seronegative arthropathies
1
57
Differential diagnosis of rheumatic
diseases
Rare Rheumatic Disorders: diagnosis
Systemic vasculitis including
Cryoglobulinaemia
7-
Immunomodulatory
therapy
Scientific basis of immunosuppressive
and immunomodulatory therapy Drugs
Antibodies
Recombinan molecules
Others
1
L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed
learning
4 - Student Assessment Methods
4.1written exam to assess knowledge and understanding
Weighing of assessment
4.1 written exam 50
Total 50
58
Your log book
1- Introduction
The aim of this book is to give you a guide to the expectations for each item. It will
be a guide for both you and your teachers to what you should be seeing and doing.
It will give you a list of the important topics that you should think about and should
be covered in:
1. Clinical or practical sessions
2. Tutorials
3. Self-directed learning (SDL)
For each item there is also a list of
1. Clinical conditions or Practical sessions to be seen or attended
2. Practical procedures to be seen and done
Remember
This document is only a guide. It is not an exhaustive list. It is not just a
checklist to score points. It is a guide to encourage you to read and learn more. This
book is for your benefit. It will form a record of your clinical training and
experience.
2 - Supervisors
Nominated Staff members for each unit and activity to sign the logbook items
3–Tables for Training Records
The candidate will record the details and date of each activity, and the authorized
staff member signature.
Candidates are required to fulfill 75% of the listed activities in order to be eligible
for the exam entry. The minimum number required for each activity = 75% (it is
listed for each activity). You are free to attend more and record your extra
attendance.
59
W E E K L Y D E P A R T M E N T P L A N
LECTU
RE
WARD
)يزور
انذرسي
وانىاب(
GRAND
ROUND
)يزور
( االساذذج
SEMI
NAR
TOXICOLO
GY LAB
CASE
PRESENTATI
ON
Saturday 8 – 9
11 - 12
9 – 11 12 - 14 14 -15
Sunday 8 – 9
11 - 12
9 – 11
12-15
Monday 8 – 9
11 - 12
9 – 11 12 -
14
14 - 15
Tuesday 8 – 9
11 - 12
9 – 11 12 - 14
14-15
Wednesd
ay
8 – 9
11 - 12
9 – 11 12 -
14
14 - 15
Thursday 8 – 9
11 - 12
9 – 11
12 - 15
Department Seminar attendance
(NB. Minimum number required is 15)
No Date Place Topics Supervisor
signature
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
60
Case Presentation (Special topics are compulsory)
(NB. Minimum number required is 24)
The following case studies are obligatory: Organophosphates, Hydrocarbon,
Corrosives, Scorpion envenomation, snake envenomation, food poisoning,
Opiates overdose, other drug of abuse, and coma of undetermined cause.
No Date Place Topics Supervisor
signature
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
61
Thesis attendance
(NB. Minimum number required is attending 10)
No Date Place Name of the thesis Supervisor
signature
1
2
3
4
5
6
7
8
9
10
62
On the Job Training (24 hours attendance in the Poison Control Center)
(NB. Minimum number required is 30)
No Total Number & / New poisons seen Date Supervisor
signature
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
63
Analytical Toxicology attendance
(Minimum number required for each Lab procedure is 10)
1. Colorimetric analysis (min 5)
No Number & Types of analysis Date Supervisor
signature
1
2
3
4
5
2. Thin Layer Chromatography (min 5)
No Number & Types of cases Date Supervisor
signature
1
2
3
4
5
3. Immunoassay technique
(Minimum number is 10)
No Number of cases Date Supervisor signature
1
2
3
4
5
6
7
8
9
10
64
Airway Management
(NB. Minimum number required is 10)
No Date Type of Management / Poison Supervisor
1
2
3
4
5
6
7
8
9
10
Attendance of Mechanical Ventilation Setting and Follow up and discussion for a
Minimum number of 10 cases
No Toxic cause Date Supervisor
signature
1
2
3
4
5
6
7
8
9
10
Gastric Lavage Procedure
(Minimum number is 10)
No Type of poisons Date Supervisor
signature
1
2
3
4
5
6
7
65
8
9
10
Antidotal Management and Follow Up
(NB. Minimum number required is 20)
No Date Antidote / Poison Supervisor
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Malpractice – Inappropriate Management Case Study
(NB. Minimum number required is 5)
No Date Type of Management / Poison Supervisor
1
2
3
4
5
66
P R A C T I C A L S K I L L S ( A G R E E M E N T S C A L E )
Requirements
Candidates are required to fulfill 75% of the listed activities in order to be eligible
for the exam entry. The minimum number required for each activity = 75%. You
are free to attend more and record your extra attendance.
a-Poor b- Satisfactory c- Excellent
A. Clinical Procedures and Evaluation
Each of the following procedure should be observed, then assisted then performed
independently
Item
No
Ob
serv
ed
Dat
e an
d s
ign
Ass
iste
d
Dat
e an
d s
ign
Do
ne
ind
epen
den
tly
(A,
B,
C)
Dat
e an
d s
ign
Coma examination
1
2
3
4
5
Control of Toxic seizures
1
2
3
4
5
Intubation
1
2
3
4
5
Challenge tests
(Antidotes)
(5x3)
1
2
3
4
5
Basic general 1
67
neurological examination
(5x3)
2
3
4
5
Respiratory assessment
(imaging, ABG)
1
2
3
4
5
Management and
evaluation of Shock
(5x3)
1
2
3
4
5
TPN prescription
1
2
3
4
5
Management and
evaluation of agitation,
confusion and delirium
(5x3)
1
2
3
4
5
Gastric lavage
1
2
3
4
5
Central Vein
Catheterisation
1
2
3
4
5
Arrhythmia evaluation 1
68
and management
(including DC Shock)
2
3
4
5
Performing and
interpreting abnormal
ECG of toxic etiology
1
2
3
4
5
B. Analytical Procedures
Item
No
Ob
serv
ed
Dat
e an
d s
ign
Ass
iste
d
Dat
e an
d s
ign
Do
ne
ind
epen
den
tly
(A,
B,
C)
Dat
e an
d s
ign
Thin Layer
Chromatography
1
2
3
4
5
Colorimetric analysis
1
2
3
4
5
Immunoassay
(5x3)
1
2
3
4
5
69
5 - Log book preview
The candidate logbook will be reviewed and patients seen/ skills performed
summarized by diagnosis groups during the semester evaluation and at the end of
the course in the table below. This reflects the number of activity done by
category. (According to each degree) The results of this review will be totaled in
the summary chart below.
Semester 1st 2
nd 3
rd 4
th total
Activity
Department Seminar attendance (15)
Case Presentation (Special topics are compulsory)
(24)
Thesis attendance (10)
On the Job Training (24 hours attendance in the
Poison Control Center) (30)
Analytical Toxicology attendance (10)
Colorimetric analysis ( 5)
Thin Layer Chromatography) (5)
Immunoassay technique (10)
Airway Management (10)
Attendance of Mechanical Ventilation Setting and
Follow up and discussion (10)
Gastric Lavage Procedure (10)
Antidotal Management and Follow Up (20)
Malpractice – Inappropriate Management Case Study
(5)
Clinical Procedures and Evaluation
Coma examination(5)
Control of Toxic seizures(5)
Intubation(5)
Challenge tests (Antidotes)(5x3)
Basic general neurological examination (5x3)
Respiratory assessment(imaging, ABG) (5)
Management and evaluation of Shock (5x3)
TPN prescription(5)
Management and evaluation of agitation, confusion
and delirium (5x3)
Gastric lavage(5)
70
Central Vein Catheterisation(5)
Arrhythmia evaluation and management (including
DC Shock) (5)
Performing and interpreting abnormal ECG of toxic
etiology (5)
Analytical Procedures
Thin Layer Chromatography (5)
Colorimetric analysis (5)
Immunoassay (5x3)
Supervisor signature
VII - Head Of Department Approval For The Exam Entry
__________________________________________________________________
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71
VIII – Thesis Follow up
انرقزيز انصف انسىي نعاو / انراريخ/
ع انطانة /
انقيذ نذرخح ) ياخسيرز (
تقسى /
ذقزيز انسادج االساذذج انشزفي
تذأ خع انادج انعهيح و كراتح انقذيح
طع شىطا يحذوداق
أوشك عه اإلرهاء
إره ي اندع
تذأ اندزء انعه
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحهيم
تذأ ياقشح انرائح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحزيز
تذأ خعح انهائيح يع انشزفانزا
قطع شىطا يحذودا
أوشك عه اإلرهاء
إرهد ذايا
إسرزار قيذ انطانة رأي انسادج انشزفي
يذ انقيذ
شطة قيذ انطانة
عى ذى ذشكيم ندح اناقشح ال
اريخ انرشكيم ذ
/ /
يذ / شطة انقيذ
وكيم انكهيح ذىقيع انسادج انشزفي
72
73
انرقزيز انصف انسىي نعاو / انراريخ/
ع انطانة /
انقيذ نذرخح ) ياخسيرز (
تقسى /
ذقزيز انسادج االساذذج انشزفي
تذأ خع انادج انعهيح و كراتح انقذيح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي اندع
تذأ اندزء انعه
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحهيم
تذأ ياقشح انرائح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحزيز
تذأ انزاخعح انهائيح يع انشزف
قطع شىطا يحذودا
أوشك عه اإلرهاء
إرهد ذايا
إسرزار قيذ انطانة رأي انسادج انشزفي
يذ انقيذ
طة قيذ انطانة ش
عى ذى ذشكيم ندح اناقشح ال
ذاريخ انرشكيم
/ /
يذ / شطة انقيذ
وكيم انكهيح ذىقيع انسادج انشزفي
74
75
انرقزيز انصف انسىي نعاو / انراريخ/
ع انطانة /
انقيذ نذرخح ) ياخسيرز (
تقسى /
ذقزيز انسادج االساذذج انشزفي
تذأ خع انادج انعهيح و كراتح انقذيح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي اندع
تذأ اندزء انعه
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحهيم
تذأ ياقشح انرائح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحزيز
تذأ انزاخعح انهائيح يع انشزف
ا يحذوداقطع شىط
أوشك عه اإلرهاء
إرهد ذايا
إسرزار قيذ انطانة رأي انسادج انشزفي
يذ انقيذ
شطة قيذ انطانة
عى ذى ذشكيم ندح اناقشح ال
ذاريخ انرشكيم
/ /
يذ / شطة انقيذ
وكيم انكهيح ذىقيع انسادج انشزفي
76
77
انرقزيز انصف انسىي نعاو / انراريخ/
ع انطانة /
انقيذ نذرخح ) ياخسيرز (
تقسى /
ز انسادج االساذذج انشزفيذقزي
تذأ خع انادج انعهيح و كراتح انقذيح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي اندع
تذأ اندزء انعه
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحهيم
تذأ ياقشح انرائح
شىطا يحذودا قطع
أوشك عه اإلرهاء
إره ي انرحزيز
تذأ انزاخعح انهائيح يع انشزف
قطع شىطا يحذودا
أوشك عه اإلرهاء
إرهد ذايا
إسرزار قيذ انطانة رأي انسادج انشزفي
يذ انقيذ
شطة قيذ انطانة
عى ذى ذشكيم ندح اناقشح ال
ذاريخ انرشكيم
/ /
يذ / شطة انقيذ
وكيم انكهيح ذىقيع انسادج انشزفي
78
79
نعاو / انراريخ/ انرقزيز انصف انسىي
ع انطانة /
انقيذ نذرخح ) ياخسيرز (
تقسى /
ذقزيز انسادج االساذذج انشزفي
تذأ خع انادج انعهيح و كراتح انقذيح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي اندع
تذأ انعهاندزء
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحهيم
تذأ ياقشح انرائح
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحزيز
تذأ انزاخعح انهائيح يع انشزف
قطع شىطا يحذودا
أوشك عه اإلرهاء
رهد ذاياإ
إسرزار قيذ انطانة رأي انسادج انشزفي
يذ انقيذ
شطة قيذ انطانة
عى ذى ذشكيم ندح اناقشح ال
ذاريخ انرشكيم
/ /
يذ / شطة انقيذ
وكيم انكهيح ىقيع انسادج انشزفيذ
80
81
انرقزيز انصف انسىي نعاو / انراريخ/
ع انطانة /
انقيذ نذرخح ) ياخسيرز (
تقسى /
ذقزيز انسادج االساذذج انشزفي
تذأ عهيح و كراتح انقذيحخع انادج ان
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي اندع
تذأ اندزء انعه
قطع شىطا يحذودا
أوشك عه اإلرهاء
إره ي انرحهيم
تذأ ياقشح انرائح
قطع شىطا يحذودا
أوشك عه اإلرهاء
ه ي انرحزيزإر
تذأ انزاخعح انهائيح يع انشزف
قطع شىطا يحذودا
أوشك عه اإلرهاء
إرهد ذايا
إسرزار قيذ انطانة رأي انسادج انشزفي
يذ انقيذ
شطة قيذ انطانة
عى ذى ذشكيم ندح اناقشح ال
ذاريخ انرشكيم
/ /
يذ / شطة انقيذ
وكيم انكهيح ذىقيع انسادج انشزفي
82
83
VIII – Evaluation Forms
To be completed at -------------------------------------
Candidate
Supervisor
Location
Aim of training
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Agreed educational objectives and timescale in which objectives should be
achieved.
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Candidate
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Supervisor
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Date of next meeting
Signed by candidate
Signed by Supervisor
Date
84
85
VIII – Evaluation Forms
To be completed at -------------------------------------
Candidate
Supervisor
Location
Aim of training
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Agreed educational objectives and timescale in which objectives should be
achieved.
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Candidate
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Supervisor
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Date of next meeting
Signed by candidate
Signed by Supervisor
Date
86
87
VIII – Evaluation Forms
To be completed at -------------------------------------
Candidate
Supervisor
Location
Aim of training
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Agreed educational objectives and timescale in which objectives should be
achieved.
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Candidate
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Supervisor
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Date of next meeting
Signed by candidate
Signed by Supervisor
Date
88
89
VIII – Evaluation Forms
To be completed at -------------------------------------
Candidate
Supervisor
Location
Aim of training
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Agreed educational objectives and timescale in which objectives should be
achieved.
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Candidate
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Supervisor
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Date of next meeting
Signed by candidate
Signed by Supervisor
Date
90
91
VIII – Evaluation Forms
To be completed at -------------------------------------
Candidate
Supervisor
Location
Aim of training
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Agreed educational objectives and timescale in which objectives should be
achieved.
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Candidate
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Supervisor
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Date of next meeting
Signed by candidate
Signed by Supervisor
Date
92
93
VIII – Evaluation Forms
To be completed at -------------------------------------
Candidate
Supervisor
Location
Aim of training
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Agreed educational objectives and timescale in which objectives should be
achieved.
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Candidate
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Comments by Supervisor
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
__________________________________________________________________
Date of next meeting
Signed by candidate
Signed by Supervisor
Date
94
95
Degree Program Evaluation Form by The Candidate
To be completed at the end of your degree.
Please consider each pair of statements and decide which most clearly reflects your
view and tick one box or answer the question.
I. Individual Information
1. Are you a graduate of ASU?
yes no to some degree
2. Year and semester when studies began:
II. General Questions
1. What are the advantages/disadvantages of the general study environment at the
University ASU?
2. What were your expectations when you applied to the degree?
3. Do you feel that the degree program prepares you well for your future studies or
employment according to the demands and expectations of those institutions?
yes no to some degree
4. Has the time limit of the program (two or three academic years) caused you any
difficulties or inconveniences?
yes no to some degree
III. Structure of Degree Program
1. Did you receive enough guidance in planning your study schedule in the
beginning of the program?
yes no to some degree
2. What were the main difficulties in the planning of your study schedule?
3. What is your general opinion on the structure of the degree program?
96
4. In your opinion, does the degree program offer a good balance of lectures,
seminars, conferences, and book exams?
yes no to some degree
a) General Studies
i) Do you feel that you have received enough guidance on academic writing?
yes no to some degree
ii) Do you feel that you have acquired sufficient knowledge on research skills (eg.
quantitative and qualitative research methods)?
yes no to some degree
b) Courses
i) Have you had some special difficulties in completing some of the courses?
Please specify.
ii) Has there been a sufficient variety of courses offered for your optional studies?
yes no to some degree
iii) Have you received enough guidance for the preparation of your thesis?
yes no to some degree
IV. Concluding Points
1. Did the degree program meet your expectations?
yes no to some degree
2. What aspects of the degree program do you particularly like?
3. What aspects of the degree program do you particularly dislike?
4. What are your suggestions on how to improve the program?
Thank you!