MASTER 2 Research MASTER 2 Research Fragrances & Fine ChemistryFragrances & Fine Chemistry

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Co diploma Co diploma MASTER 2 Chemistry MASTER 2 Chemistry

Nice

Nice

Grasse

Grasse

11stst SemesterSemesterOctoberOctober--DecemberDecember

MASTER 2 Research MASTER 2 Research Fragrances & Fine ChemistryFragrances & Fine Chemistry

Organic synthesisOrganic synthesis

Fragrance Fragrance ChemistryChemistry

Analytical Analytical chemistrychemistry

Bibliography Bibliography & Project & Project

managementmanagement

English coursesEnglish courses

11stst SemesterSemesterOctoberOctober--DecemberDecember

MASTER 2 Research MASTER 2 Research Fragrances & Fine ChemistryFragrances & Fine Chemistry

Organic synthesisOrganic synthesis

Fragrance Fragrance ChemistryChemistry

Analytical Analytical chemistrychemistry

Bibliography Bibliography & Project & Project

managementmanagement

English coursesEnglish courses

22ndnd SemesterSemesterJanuaryJanuary--JuneJune Practical activity

http://www.unice.fr/ecomers/http://www.unice.fr/ecomers/

Host laboratories Host laboratories

http://www.unice.fr/icn/http://www.unice.fr/icn/ http://lpmc.unice.fr/http://lpmc.unice.fr/

LaboratoirePhysique de la Matière Condensée

http://www.cepam.cnrs.fr/http://www.cepam.cnrs.fr/

http://www.unice.fr/icn/http://www.unice.fr/icn/

Bioactive molecules

Marine Natural ProductsFluorescent Probes

Decorporation

Eco-Friendly Materials and Polymers

Bioinspiration

Catalysis & Fine Chemistry

Fragrance chemistry Origin of Life

Bioactive molecules

Natural

Synthetic

RNA

Proteins

Induce stress in cancer cells

Selective targeting of cancer stem cells

Marine Natural Products

Applications: • Pharmaceutical • Environmental (antifoulings)• Cosmetics

Marine Natural Products

Applications: • Pharmaceutical • Environmental (antifoulings)• Cosmetics

IsolationIsolation

MetabolomeMetabolome

Structural determinationStructural 

determination

SynthesisSynthesis

ValorizationValorization

ExtractionExtraction

Fluorescent Probes

ObjectiveTo understand nucleic acid / protein and nucleic acid / nucleic acid assemblies.

How ?Synthesis of dedicated fluorescent tools for in vitro studies and cell imaging

InternalLabeling

ε ≈ 18,000 M-1.cm-1

Ф ≈ up to 38 %

O

O

O

PO O

O

OHO

S

370 nm 440 nm

540 nm

Br Br N BrR2

R1

Pd-catalyzed monoamination

[12 examples][air-stable cat. syst.]

[practical & gram-scale] [varied-amine tolerance]

NR2

R1 O

AcceptorFunctionalization

R1,R2 = H, aryl & aliphatic

ClickableBioconjugation

Applications

Decorporation

Eco-Friendly Materials and Polymers

*Biobased and/or eco-friendly polymers and (nano)composites

*Valorization of : - second generation biomass - co-products from industry and bioraffineries

*Recycling and circular economy

Eco-Friendly Materials and Polymers

Bioinspiration

Inspiration from natural surfaces (Animal and vegetal)

Applications for Surface Elaboration :

Chemistry

Electropolymerization

Surface characterizations

Bioinspiration

Catalysis & Fine Chemistry

MA + B A B

Sustainable developmentDevelopment of selective methods: C-C, C-O, C-N, C-F…High production, optimization of process

Recyclable catalyst Water-soluble catalystChiral catalyst

Catalysis & Fine Chemistry

Fragrance chemistry

O

Mimosa Violet Atlas Cedarwood

Vetiver Frankincense

Characterisation of the odorants of natural raw materials :Chemical and Sensorial Analysis of Volatiles

Fragrance chemistry

Characterisation of pheromones :Chemical Analysis & Behavioral studies

Murine model : Human model :

Origin of Life

Myrgorodska, Meinert, Meierhenrich et al.: Angew. Chem. Int. Ed. 54 (2015), 1402

MASTER 2 Research MASTER 2 Research Fragrances & Fine ChemistryFragrances & Fine Chemistry

CONTACT : CONTACT : baldovin@unice.frbaldovin@unice.fr