Mark L. Trudell, Ph - SACSCOC Accreditation | University of...

Mark L. Trudell, Ph.D. Department of Chemistry telephone: (504)-280-7337 University of New Orleans FAX: (504)-280-6860 Lakefront Campus E-mail: [email protected] New Orleans, Louisiana, 70148 Present Title: Distinguished Professor

BACKGROUND

1. EDUCATION

Ph.D., University of Wisconsin-Milwaukee, May 1989 (Organic/Medicinal Chemistry)

BS, Hope College, August 1983, (Chemistry, A.C.S.)

2. EXPERIENCE

ACADEMIC

Distinguished Professor, Department of Chemistry, University of New Orleans New Orleans, Louisiana (May 2011 to present). Chancellor’s Research Professor, Department of Chemistry, University of New Orleans New Orleans, Louisiana (May 2010 to May 2011). University Research Professor of Chemistry, Department of Chemistry, University of New Orleans New Orleans, Louisiana (August 2000 April 2010). Professor of Chemistry, Department of Chemistry, University of New Orleans New Orleans, Louisiana (August 1998 to December 1999). Associate Professor of Chemistry, Department of Chemistry, University of New Orleans New Orleans, Louisiana (August 1996 to July 1998). Assistant Professor of Chemistry, Department of Chemistry, University of New Orleans New Orleans, Louisiana (August 1991 to July 1996). Postdoctoral Research Associate with Professor Steven V. Ley, FRS. Imperial College of Science, Technology and Medicine, London, United Kingdom (March 1989 - June 1991). Ph.D. Thesis work supervised by Professor James M. Cook III. University of Wisconsin-Milwaukee, Milwaukee, Wisconsin. (September 1983 - March 1989). Undergraduate Research Associate with Professor Micheal P. Doyle. Hope College, Holland, Michigan (January 1980 - August 1983).

Mark L. Trudell University of New Orleans

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SCHOLARLY AND CREATIVE PRODUCTIVITY 1. PUBLICATIONS A. Books

a. Scholarlybooks

i. Refereed Dopamine Transporter; Chemistry, Biology and Pharmacology, Trudell, M. L.; Izenwasser, S. (Eds.), Wiley & Sons, Inc: New York 2008

ii. Nonrefereed(None)

b. Textbooks

i. Refereed(None)ii. Nonrefereed(None)

B. Refereed/Invited Publications

a. Book Chapters CrO3-Second Update. Shu, H.; Trudell, M. L. (2007), Encyclopedia of Reagents for

Organic Synthesis John Wiley & Sons Ltd: New York. www.mrw.interscience.wiley.com/eros/. DOI: 10.1002/047084289X.rc169.pub2

b. Journal Articles (109 articles in print and in press)

110) Solvent-free, base-free, microwave-mediated iridum catalyzed N-alkylation of amides with alcohols. Apsunde, T.; Trudell, M. L. Synthesis, 2014, 46, 230-234.

109) Synthesis of Glycerol Homologues. Thota, K.; Trudell, M.L. Synthesis 2013, 45,

2280-2286. 108) Microwave-assisted iridum catalyzed syntheis of nicotine and anabasine

derivatives. Apsunde, T.; Trudell, M. L. Synthesis, 2013 45, 2120-2124. 107) 3-Aryl-3-arylmethoxyazetidines. A new class of high affinity ligands for

monoamine transporters. Thaxton, A.; Izenwassee, S.; Wade, D.; Stevens, E.D.; Mobley, D. L.; Jaber, V.; Lomenzo, S.; Trudell, M. L.; Bioorg Med Chem Lett. 2013, 23, 4404-4407

106) Regioselective synthesis and cannabinoid receptor binding affinity of N-alkylated

4,5-diaryl-1,2,3-triazoles. Papadipu, M. R.; Shu. H.; Izenwasser, S. Wade, D. Gulasey, G.; Fournet, S.; Stevens, E. D. Lomenzo, S.; Trudell, M. L. Med. Chem. Res. 2012, 21, 4473-4484. DOI: 10.1007/s00044-012-9991-3.


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105) Synthesis of Phloroglucinol Monoaryl Ethers Sherwood, A. M; Pond, D.; Trudell, M. L. Synthesis. 2012, 44, 1208-1212.

104) 8-Substituted-3-[2-diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane

Derivatives with High Affinity and High Selectivity for Dopamine Transporters. Cararas, S. A.; Izenwasser, S.; Wade, D.; Housman, A.; Verma, A.; Lomenzo, S. A.; Trudell, M. L. Bioorg. Med. Chem. 2011, 19, 7551-7558.

103) Synthesis and Structrue-Activity Studies of Benzyl Ester Meperidine and

Normeperidine Derivatives as Selective Serotonin Transporter Ligands. Gu, X.; Izenwasser, S.; Wade, D.; Housman, A.; Gulasey, G.; Savoie, C. D.; Mobley, D. L.; Lomenzo, S. A.; Trudell, M. L. Bioorg. Med. Chem. 2010, 18, 8356-8365.

102) An Enantioslective Formal Synthesis of (+)-Gephyrotoxin 287C. Miao, L.; Shu,

H.; Noble, A. R.; Fornet, S. P.; Stevens, E. D.; Trudell, M. L. ARKIVOC. 2010, (iv), 6-14.

101) A Tribute to James M. Cook on the Occasion of His 65th Birthday. Trudell, M. L.

Arkivoc 2010, 1-5. 100) Enantioselective Syntheses of Both Enantiomers of cis-Pyrrolidine 225H. Shu, H.;

Noble, A. R.; Zhang, S.; Miao, L.; Trudell, M. L. Tetrahedron 2010, 66, 4428-4433.

99) Hydroxyketones via Ring-Opening of Lactones with Aryllithium Reagents. An

Expedient Synthesis of (±)-Anabasamine. Miao, L.; DiMaggio, S.; Trudell, M. L Synthesis 2010, (10) 91-97.

98) Synthesis and Monoamine Transporter Affinity of 3α-Arylmethoxy-3β-

arylnortropanes. Kaur , H.; Izenwasser, S.; Verma, A.; Wade, D.; Housman, A.; Stevens, E. D.; Mobley, D.; Trudell, M. L. . Bioorg. Med. Chem. Lett. 2009, 19, 6865-6868.

97) Ir-Catalyzed N-Heterocyclization for Enantioselective Synthesis of Noranabasamine. Miao, L.; DiMaggio, S.; Shu, H.; Trudell, M. L. Synfacts 2009, 7, 773.

96) First Multigram Synthesis of SCP-123, A Novel Water-Soluble Analgesic. Miao, L.; Xu, L.; Narducy, K. W.; Trudell, M. L. Org. Proc. Res. Dev. 2009, 13, 820-822.

95) Enantioselective Synthesis of Both Enantiomers of Noranabasamine. Miao, L.; DiMaggio, S.; Shu, H.; Trudell, M. L. Org. Lett. 2009, 11, 1579-1582.

94) Synthesis and CB1 Cannabinoid Receptor Affinity of 4-Alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles Shu, H.; Izenwasser, S.; Wade, D.; Stevens, E.D.; Trudell, M. L. Bioorg. Med. Chem. Lett. 2009, 19, 891-893.


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93) Synthesis and Neuronal Nicotinic Receptor Affinity of Divalent Tropane-3-carboxlates. Zhang, S.; Izenwasser, S. Wade, D.; Liu, Y.; Cheng, J.; Xu, L. Trudell, M. L. J. Heterocyclic Chem. 2007,44,1425-1430.

92) General Strategy for the Construction of Enantiopure Pyrrolidine Alkaloids. Total

Synthesis of (-)-Monomorine. Zhang, S.; Xu, L. Miao, L.; Shu, H.; Trudell, M. L. J. Org. Chem. 2007, 72, 3133-3136.

91) Synthesis and In Vivo Evaluation of Non-hepatoxic Actominophen Analogs.

Vaccarino, A. L.; Paul, D.; Mukherjee, P. K.; Rodriguez de Turco, E. B.; Marcheselli, V. L.; Xu, L.; Trudell, M. L.; Matia, M. P.; Sunkel, C.; Alverez-Bullia, J.; Bazan, N. G. Bioorg. Med. Chem. 2007, 15, 2206-2215.

90) Synthesis of Dopamine Transporter Selective 3-(Diarylmethoxymethyl)-8-

alkylaryl-8-azabicyclo[3.2.1]octane Derivatives. Zhang, S.; Izenwasser, S.; Wade, D.; Trudell, M. L. Bioorg. Med. Chem. 2006, 14,7943-7952.

89) Oxidative Cyclization of N-Alkyl-o-methyl-arenesulfonamides to Biologically

Important Saccharin Derivatives. Xu, L.; Shu, H.; Liu, Y.; Zhang, S.; Trudell, M. L. Tetrahedron 2006, 62, 7902-7910

88) Structure-Activity Studies of 3’,4’-Dichloromeperidine Analogues at Dopamine

and Serotonin Transporters. Rhoden, J.; Bouvet, M.; Izenwasser, S.; Wade, D.; Lomenzo, S. A.; Trudell, M. L. Bioorg. Med. Chem. 2005, 13, 5623-5634.

87) Selective Oxidation of Benzylic Alcohols and TBDMS Ethers to Carbonyl

Compounds with CrO3-H5IO6 Zhang, S.; Xu, L.; Trudell, M. L. Synthesis 2005, (10), 1757-1760.

86) Synthesis of Labeled N-(4-hydroxy-[14C(U)]phenyl)-2-[2,3-dihydro-3-oxo-1,2-

benisothiazol-2-yl-1,1-dioxide]acetamide Xu, L.; Trudell, M. L. J. Label Compd and Radiopharm 2005, 48, 219-222

85) Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine

Transporters, Lomenzo, S. A.; Rhoden, J.; Izenwasser, S.; Wade, D.; Kopajtic, T.; Katz, J. L.; Trudell, M. L. J. Med. Chem 2005, 48, 1336-143.

84) Stereoselective Synthesis of Conformationally Constrained Tropane Analogues:

6-Chloro-2,5-diazatetracyclo[8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one and 6-Chloro-2,7-diazatetracyclo-[8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one. Cheng, J.; Xu, L.;. Stevens, E. D.; Izenwasser, S.; Wade, D.; Trudell, M. L. J. Heterocyclic Chem. 2004 46, 569-574.

83) Facile Synthesis of 1, 2-Benzisothiazole-3-one-1, 1-dioxide Methylsulfonyl

Derivatives. Xu, L.; Trudell, M. L. J. Heterocyclic Chem. 2004, 46, 235-238


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82) Novel N-Dealkylation of N-Alkyl Sulfonamides and N,N-Dialkyl Sulfonamides with Perodic Acid catalyzed by Chromium (III) Acetate Hydroxide. Xu, L.; Zhang, S.; Trudell, M. L. Synlett. 2004, 1901-1904.

81) Novel Chromium(VI) Catalyzed Oxidation of N-Alkylamides to Imides with

Periodic Acid. Xu, L.; Zhang, S.; Trudell, M. L. Chem Commun. 2004, 1668-1669.

80) Stereoselective Synthesis of the cis 275B Decahydroquinoline ring System.

Banner, E. J.; Stevens, E. D.; Trudell. M. L. Tetrahedron Lett 2004, 45, 4411-4414.

79) Synthesis and Monoamine Transporter Binding of 2-(Diarylmethoxy-methyl)-3β-

aryltropane Derivatives. Xu, L; Kulkarni, S. K.; Izenwasser, S.; Katz, J. L.; Kopajtic, T.;, Lomenzo, S. A.; Newman, A.; Trudell, M. L. J. Med. Chem. 2004, 47, 1676-1682.

78) Synthesis and Nicotinic Acetylcholine Receptor Binding Affinities of 2- and 3-

Isoxazolyl-8-azabicyclo[3.2.1]octanes. Cheng, J.; Izenwasser, S.; Zhang, C.; Zhang, S.; Wade, D.; Trudell, M. L. Bioorg. Med. Chem. Lett. 2004, 14, 1775-1778.

77) Synthesis, Lipophilicity and Structure of 2,5-Disubstituted 1, 3, 5-Dithiazine

Derivatives. Winfield, L.; Zhang, C.; Reid, C. A.; Stevens, E. D.; Izenwasser, S.; Wade, D.; Trudell, M. L. J. Het. Chem. 2003, 40, 827-832.

76) Chromium (VI) Oxide Catalyzed Oxidations of Sulfides to Sulfones with Periodic

Acid. Xu, L.; Cheng, J.; Trudell, M. L. J. Org. Chem. 2003, 68, 5388-5391. 75) Spinally Mediated Analgesia and receptor Binding Affinity of Epibatidine

Analogs. Nishiyama, T.; Gyermek, L.; Trudell, M. L.; Hanaoka, K. Eur. J. Pharm. 2003, 470, 27-31.

74) A Mild and Efficient Oxidation of Alcohols to Aldehydes and Ketones with

Periodic Acid Catalyzed by Chromium (III) Acetylacetonate. Xu, L.; Trudell. M. L. Tetrahedron Lett. 2003, 44, 2553-2555.

73) Synthesis of Dopamine Transporter Selective 3-{2-(Diarylmethoxyethylidene)}-

8-alkylaryl-8-azabicyclo[3.2.1]octanes. Bradley, A. L.; Izenwasser, S.; Wade, D.; Cararas, S. A.; Trudell, M. L. Bioorg. Med. Chem. Lett. 2003, 13, 629-632.


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72) Structural Study of Cocaine Analogs: X-Ray Crystal Structure of N-Methyl-2β-

hydroxymethyl-3β-p-toyltropane Hydrochloride, N-Methyl-2β-Bis(p-flourophenyl)methoxymethyl-3β-tolyltropane Tetrahydrate and N-Methyl-2β-Bis(p-flourophenyl)methoxymethyl-3β-p-chlorophenyltropane Tetrahydrate. Zhu, N.; Manning, K.; Xu, L.; Trudell, M. L.; Klein-Stevens, C. L. J. Undergrad. Chem. Res. 2002, 3, 101-106

71) Synthesis and Dopamine Transporter Binding Affinities of 3α-Benzyl-8-

(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes. Bradley, A. L.; Izenwasser, S.; Wade, D.; Klein-Stevens, C.; Zhu, N.; Trudell, M. L. Bioorg. Med. Chem. Lett. 2002, 12, 2387-2390.

70) Stereoselective Syntheses of the Three Isomers of Ethylene Glycol Di-(tropane-3-

carboxylate). Cheng, J.; Moore, Z.; Stevens, E. D.; Trudell, M. L. J. Org. Chem. 2002, 67, 5433-5436.

69) Synthesis and Biological Evaluation at Nicotinic Acetylcholine Receptors of N-

Arylalkyl- and N-Aryl- 7-Azabicyclo[2.2.1]heptanes. Cheng, J.; Zhang, C.; Stevens, E. D.; Izenwasser, S.; Wade, D.; Chen, S.; Paul, D.; Trudell, M. L. J. Med. Chem. 2002, 45, 3041-3047.

68) Suzuki-Miyaura Cross-Coupling Reactions Mediated By Palladium /Imidazolium Salt Systems. Grasa, G. A.; Viciu, M. S.; Huang, J.; Zhang, C.; Trudell, M. L.; Nolan, S. P. Organometallics, 2002, 21, 2866-2873.

67) Synthesis and Dopamine Transporter Binding Affinity of 2,6-Dioxopiperazine

Analogues of GBR 12909. Winfield, L.; Izenwasser, S.; Wade, D.; Trudell, M. L. Med. Chem. Res. 2002, 11, 102-105.

66) Synthesis and Biological Evaluation of 2-Substituted 3β-Tolyltropane Derivatives at

Dopamine, Serotonin and Norepinephrine Transporters. Xu, L.; Izenwasser, S.; Katz, J.; Kopajtic , T.; Klein-Stevens, C.; Zhu, N.; Lomenzo, S. A.; Winfield, L.; Trudell, M. L. J. Med. Chem. 2002, 45, 1203-1210.

65) Synthesis and Nicotinic Acetylcholine Receptor Binding Affinity of Exo- and Endo-

2-(Pyridinylmethoxy)-7-azabicyclo[2.2.1]heptanes. Cheng, J.; Izenwasser, S.; Wade, D.; Trudell, M. L. Med. Chem. Res. 2001, 10, 356-365.

64) Synthesis of N-Heteroaryl-7-Azabicyclo[2.2.1]-heptane Derivatives Via

Palladium-bisimidazol-2-ylidene Complex Catalyzed Amination Reactions. Cheng, J.; Trudell, M. L. Org. Lett. 2001, 3, 1371-1374.


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63) Synthesis of 1-Substituted 1,2,3-Triazolopyridazines. Ramanaiah, K. C. V.; Stevens, E. D.; Pagoria, P.; Trudell, M. L. J. Heterocyclic Chem., 2000, 37, 1597-1602.

62) Synthesis, Thermal Stability, and Impact Sensitivity of Novel Tetranitro-Dipyrido-

tetraazapentalene Derivatives. Balachari, D.; Stevens, E. D.; Beardall, D.; Wight, C. A.; Trudell, M. L. Propellants Explosives Pyrotechnics 2000, 25, 75-80.

61) A Study of Molecular Structure and Spectroscopic Properties of Benzo- and Pyrido-

Tetraazapentalenes. Galasso, V.; Jones, D.; Modelli, A.; Trudell, M. L. Chemical Physics, 2000, 254, 375-384.

60) Palladium-Bisimidazolylidene Complexes as Catalysts for Efficient Suzuki

Cross-Coupling Reactions of Aryl Chlorides with Arylboronic Acids. Zhang, C.; Trudell, M. L. Tetrahedron Lett. 2000, 41, 595-598.

59) Synthesis, Dopamine and Serotonin Binding Affinities of Novel Analogues of

Meperidine. Lomenzo, S. A.; Izenwasser, S.; Gerdes, R. M.; Katz, J. L.; Kopajtic, T.; Trudell, M. L. Bioorg. Med. Chem. Lett. 1999, 9, 3273-3276.

58) Synthesis and Stereochemical Assignment of Exo and Endo-7-Methyl-7-

azabicyclo[2.2.1]heptan-2-ol. Ramanaiah, K. V. C.; Zhu, N.; Klein-Stevens, C. Trudell, M. L. Organic Lett. 1999, 1, 1439-1441

57) Palladium-Imidazol-2-ylidene Complexes as Catalysts for Facile and Efficient Suzuki

Cross-Coupling Reactions of Aryl Chlorides with Arylboronic Acids. Zhang, C.; Huang, J.; Nolan, S. P.; Trudell, M. L., J. Org. Chem. 1999, 64, 3804-3805.

56) QSAR and CoMFA study of Cocaine Analogs. Crystal and Molecular Structure of (-)-

Cocaine Hydrochloride and N-methyl-3β-(p-fluorophenyl)tropane-2β-carboxylic Acid Methyl Ester. Zhu, N.; Harrison, A.; Trudell, M. L.; Klein-Stevens, C. L. Structural Chem. 1999, 10, 91-103.

55) 2-Bromoethynyl Aryl Sulfones as Versatile Dienophiles: A Formal Synthesis of

Epibatidine. Zhang, C.; Ballay, C. J.; Trudell, M. L. J. Chem. Soc. Perkin Trans. I 1999, 675-676.

54) Synthesis and Dopamine Transporter Affinity of the Four Stereoisomers of (±)-2-

(Methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane. Zhang, C.; Izenwasser, S.; Katz, J. L.; Terry, P. D.; Trudell, M. L. J. Med. Chem. 1998, 41, 2430- 2435.

53) A Convenient Route to Alkyl, Alkynyl and Aryl Substituted 7-

Azabicyclo[2.2.1]heptadienes. Zhang, C.; Trudell, M. L. Tetrahedron, 1998, 8349-8354.


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52) The Effects of Alkyl Substituents at the 6-Position of Cocaine Analogues on Dopamine Transporter Binding Affinity and Dopamine Uptake Inhibition. Lomenzo, S. A.; Izenwasser, S.; Katz, J. L.; Trudell, M. L. Med. Chem. Res. 1998, 8, 35-42.

51) Synthesis and Structure of Dinitroazofurazan. Zelenin, A. K.; Gilardi, R. D.;

Trudell, M. L.J. Heterocyclic Chem. 1998, 35, 151-155. 50) Synthesis and Cocaine Binding Site Affinity at the Dopamine Transporter of Novel 6-

Alkyl-3-benzyl-2-(methoxycarbonylmethyl)tropane Derivatives. Lomenzo, S. A.; Izenwasser, S.; Terry, P. D.; Katz, J. L.; Trudell, M. L. J. Med. Chem. 1997, 40, 4406-4414.

49) Synthesis of New Dipyridotetraazapentalenes. Balachari, D.; Trudell, M. L. Tetrahedron

Lett. 1997, 38, 8607-8610 48) A New [4+2] Cycloaddition Strategy for the Synthesis of N-Acyl 7-

azabicyclo[2.2.1]heptan-2-ones: A Formal Synthesis of (±)-Epibatidine. Pavri, N. P.; Trudell, M. L. Tetrahedron Lett. 1997, 38, 7993-7996.

47) Improved Synthesis of (+)-2-Tropinone. Zhang, C.; Lomenzo, S. A. ; Ballay, C. F.;

Trudell, M. L. J. Org. Chem. 1997, 62, 7888-7889. 46) Regiospecific Synthesis of 6-Alkyl Tropan-2-ones. Lomenzo, S. A.; Bradley, A. L.; Zhu,

N.; Klein, C. L.; Trudell, M. L. J. Heterocyclic Chem. 1997, 34, 1139-1146. 45) Synthesis and Structure of 4-[(4-Nitro-1,2,5-oxadiazol-3-yl)-NNO-azoxyl]-1,2,5-

oxadiazol-3-amine. Zelenin, A. K.; Stevens, E. D.; Trudell, M. L. Structural Chemistry, 1997, 8, 373-377.

44) Synthesis of Optically Pure Epibatidine Analogs: (1R, 2R, 5S)-2β-(2-Chloro-5-

pyridinyl)-8-azabicyclo[3.2.1]octane and (1R, 2S, 5S)-2α-(2-Chloro-5-pyridinyl)-8-azabicyclo[3.2.1]-octane From (-)-Cocaine. Zhang, C.; Gyermek, L.; Trudell, M. L. Tetrahedron Lett. 1997, 38, 5619-5622.

43) Regioselective Synthesis of η3-(N-Methoxycarbonyl)azabicyclo[2.2.1]heptadienyl)-η5-

(C5Me5)RuCl Complexes. Chen, Z.; Luo, L.; Nolan, S. P.; Petersen, J. L.; Trudell, M. L. J. Organomet. Chem. 1997, 533, 25-30.

42) A Two-Step Synthesis of Diaminofurazan and Synthesis of N-Monoarylmethyl and

N,N’-Diarylmethyl Derivatives. Zelenin, A. K.; Trudell, M. L. J. Heterocyclic Chem. 1997, 34, 1057-1060

41) An Efficient Method for the Synthesis of 3-Aryl Pyrroles. Pavri, N. P.; Trudell, M. L. J.

Org. Chem. 1997, 62, 2649-2651.


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40) Synthesis of 2,6-Diethyl-3-methacroyloxymethyl-1,5,7,8-tetramethylpyrromethene-BF2 for the Preparation of New Solid-State Laser Dyes. Chen, T.; Boyer, J. H.; Trudell, M. L. Heteroatom Chem. 1997, 8, 51-54.

39) Synthesis, Dopamine Transporter Affinity, Dopamine Uptake Inhibition and Locomotor

Stimulant Activity of 2-Substituted-3β-phenyltropane Derivatives. Xu, L.; Kelkar, S. V.; Lomenzo, S. A.; Izenwasser, S.; Katz, J. L.; Kline, R. L.; Trudell, M. L. J. Med. Chem. 1997, 40, 858-863.

38) Stereoselective Synthesis of 2β-Carbomethoxy-3β-phenyltropane Derivatives. Enhanced

Stereoselectivity Observed for the Conjugate Addition Reaction of Phenylmagnesium Bromide Derivatives with Anhydroecgonine Methyl Ester in Dichloromethane. Xu, L.; Trudell, M. L. J. Heterocyclic Chem. 1996, 33, 2037-2039.

37) (-)-Thebaine. Mahler, C. H.; Stevens, E. D.; Trudell, M. L.; Nolan, S. P. Acta Cryst.

1996, C52, 3193-3195. 36) Synthesis and Dopamine Transporter Affinity of 2-(Methoxycarbonyl)-9-methyl-3-

phenyl-9-azabicyclo[3.3.1]nonane Derivatives. Chen, Z.; Izenwasser, S.; Katz, J. L.; Zhu, N.; Klein, C. L.; Trudell, M. L. J. Med. Chem. 1996, 39, 4744-4749.

35) A Short and Efficient Synthesis of (±)-Epibatidine. Zhang, C.; Trudell, M. L. J. Org

Chem. 1996, 61, 7189-7191. 34) Synthesis of Benzotriazolo[1,2-a]benzotriazole Derivatives as New High

DensityInsensitive Energetic Compounds. Subramanian, G.; Eck, G.; Boyer, J. H.; Trudell, M. L. J. Org Chem. 1996, 61, 5801-5803.

33) `Chemistry of 7-Azabicyclo[2.2.1]hepta-2,5-diene, 7-Azabicyclo[2.2.1]hept-2-ene and

7-Azabicyclo[2.2.1]heptane Derivatives. Chen, Z.; Trudell, M. L. Chem. Rev. 1996, 96, 1179-1193.

32) Synthesis and Ligand Binding at Cocaine Receptors of η6-(2β-Carbomethoxy-3β-

phenyltropane) Transition Metal Complexes. Aronson, B.; Enmon, J. L.; Izenwasser, S.; Katz, J. L.; Kelkar, S. V.; Luo, L.; Nolan, S. P.; Trudell, M. L. J. Med. Chem. 1996, 39, 1560-1563.

31) Reactions of Benzotriazolo[2,1-a]benzotriazole Derivatives. 2. A Novel

Hydrolysis/Oxidation Reaction. Subramanian, G.; Boyer, J. H.; Koppes, W.; Trudell, M. L. J. Org Chem. 1996, 61, 1898-1900.

30) Reactions of Benzotriazolo[2,1-a]benzotriazole Derivatives.1. Synthesis of New High

Density Insensitive Energetic Compounds. Subramanian, G.; Boyer, J. H.; Trudell, M. L. J. Org Chem. 1995, 60, 6110-6113.


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29) Facile and Efficient Synthesis of (±)-Tropan-2-one. Lomenzo, S. A.; Enmon, J.; Troyer, M. C. Trudell, M. L. Syn. Commun. 1995, 25, 3681-3690.

28) A Convenient Synthesis of Diaminoglyoxime and Diaminofurazan: Useful Precursors

for the Synthesis of High Density Energetic Materials. Gunasekaren, A.; Jayachandran, T.; Boyer, J. H.; Trudell, M. L. J. Heterocyclic Chem. 1995, 32, 1405-1407.

27) Dense Energetic Compounds of C,H,N and O Atoms. IV. Nitro and Azidofurazan

Derivatives. Gunasekaran, A.; Trudell, M. L.; Boyer, J. H. Heteroatom Chem. 1994, 5/6, 441-444

26) Synthesis of Highly Functionalized 7-Azabicyclo[2.2.1]heptadienes, Chen, Z.;

Trudell, M. L. Tetrahedron Lett. 1994, 35, 9649-9652. 25) Synthesis, Cocaine Receptor Affinity and Dopamine Uptake Inhibition of Several New

2β-Substituted 3β-Phenyltropanes. Kelkar, S. V.; Izenwasser, S.; Katz, J. L.; Klein, C. L.; Zhu, N.; Trudell, M. L. J. Med. Chem. 1994, 24, 3875-3877.

24) Crystal and Molecular Structure of (-)-Norcocaine. Zhu, N.; Reynolds, M.; Klein, C.

L.; Trudell, M. L. Acta. Cryst. 1994, C50, 2067-2069. 23) A Simplified Method for the Preparation of Ethynyl p-Tolyl Sulfone and Ethynyl Phenyl

Sulfone. Chen, Z.; Trudell, M. L. Syn. Comm. 1994, 24, 3149-3155. 22) Synthesis of (η5-C5Me5)Ru(η6-Tryptamine)(CF3SO3) Complexes. Chemospecific η6-

Coordination of the η5-C5Me5Ru+ Moiety. Lomenzo, S. A.; Nolan, S. P.; Trudell, M. L. Organometallics 1994, 13, 676-681.

21) Synthesis, Thermochemistry and Structural Characterization of Organoruthenium Arene

and Triene Complexes. Nolan, S. P.; Martin, K. L.; Buzatu, D.; Trudell, M. L.; Stevens, E. D.; Fagan, P. J. J. Struct. Chem. 1993, 4, 373-381.

20) Molecular Yardsticks. Rigid Probes To Define the Spatial Dimensions of the

Benzodiazepine Receptor Binding Site. Martin, M. J.; Trudell, M. L.; Diaz-Arauzo, H.; Allen, M. S.; LaLoggia, A. J.; Dorn, L. J.; Koehler, K. F.; Skolnick, P.; Cook, J. M. J. Med. Chem. 1992, 35, 4105-4117.

19) Pictet-Spengler Reactions in Aprotic Media: Total Synthesis of (±)-Suaveoline.

Trudell, M. L.; Soerens, D.; Weber, R. W.; Cook, J. M. Tetrahedron 1992, 48, 1805-1822.

18) Structure of 2-Chloro-7,12-dihydropyrido[3,2-b:5,4-b']diindole. Szkaradzinska, M. B.;

Roszak, A. W.; Trudell, M. L.; Cook, J. M.; Codding, P. W. Acta. Cryst. 1992, C48, 382-384.


11

17) The Total Synthesis of Agglomerin A and (±)-Carolinic Acid. A General Method for the Preparation of 3-Acyl Tetronic Acids Via Direct Acylation of O-Methyl 3-Stannyl Tetronates. Ley, S. V.; Trudell, M. L.; Wadsworth, D. J. Tetrahedron 1991, 47, 8285-8296.

16) Enantioselective Synthesis of the C3-C11 Hydrocarbon Fragment of the Ionophore

Antibiotic Tetronasin (ICI 139603). Ley, S. V.; Maw, G. N.; Trudell, M. L. Tetrahedron Lett. 1990, 31, 5521-5524.

15) Synthesis of Substituted 7,12-Dihydropyrido[3,2-b:5,4-b']diindoles. Rigid, Planar

Templates of the Benzodiazepine Receptor with Inverse Agonist/Antagonist Properties. Trudell, M. L.; Lifer, S.; Tan, Y. C.; Martin, M. J.; Skolnick, P.; Cook, J. M. J. Med. Chem. 1990, 33, 2412-2420.

14) Synthetic and Computer Assisted Analysis of the Pharmacophore for the

Benzodiazepine Receptor Inverse Agonist Site. Allen, M.; Tan, Y. C.; Trudell, M. L.; Narayanan, K.; Schindler, L.; Martin, M.; Hagen, T. J.; Koehler, K.; Codding, P.; Skolnick, P.; Cook, J. M. J. Med. Chem. 1990, 33, 2343-2357.

13) Structural Requirements for Agonist Actions at Benzodiazepine Receptors. Studies

with Analogs of ZK-93423. Hollinshead, S. P.; Trudell, M. L.; Skolnick, P.; Cook, J. M. J. Med. Chem. 1990, 33, 1062-1068.

12) [3,3]-Sigmatropic Rearrangements in Indoloazabicyclo[3.3.1]nonene Systems.

Reversal of Stereofacial Selectivity in the Claisen vs. the Orthoester Claisen Rearrangement. Zhang, L. H.; Trudell, M. L.; Hollinshead, S. P.; Cook, J. M. J. Am. Chem. Soc. 1989, 111, 8263-8265.

11) The Total Synthesis of (±)-Suaveoline. Trudell, M. L.; Cook, J. M. J. Am. Chem.

Soc. 1989, 111, 7504-7507. 10) Synthesis of 7,12-Dihydropyridopyrroloindoles (Azapyridodiindoles) via the Fischer

Indole Cyclization. A Search for Water Soluble Benzodiazepine Receptor Ligands. Tan, Y. C.; Trudell, M. L.; Cook J. M. Heterocycles 1988, 27, 1607-1614.

9) Regioselective Methylation of 7,12-Dihydropyrido[3,2-b:5,4-b']diindoles:

Experimental and Computational Results. Trudell, M. L.; Tan, Y. C.; Cook, J. M. J. Org. Chem. 1988, 53, 4873-4875.

8) Reactivity of 7,12-Dihydropyrido[3,2-b:5,4-b']diindole with Electrophilic Reagents.

Experimental and Computational Results. Trudell, M. L.; Lifer, S. L.; Tan, Y. C.; England, W.; Cook, J. M. J. Org. Chem. 1988, 53, 4185-4190.


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7) Synthesis of Novel 3-Substituted β-Carbolines as Benzodiazepine Receptor Ligands:

Probing the Benzodiazepine Receptor Pharmacophore. Allen, M. S. ; Hagen, T. J.; Trudell, M. L.; Codding, P. W.; Skolnick, P.; Cook, J. M. J. Med. Chem. 1988, 31, 1854-1861.

6) Hydrazine-Mediated One-Pot Amination-Oxidation Reaction. Facile Synthesis of

4-Amino-β-Carbolines and 4-Aminoisoquinolines. Trudell, M. L.; Fukada, N.; Cook, J. M. J. Org. Chem. 1987, 54, 4293-4296.

5) Synthesis of 7,12-Dihydropyrido[3,2-b:5,4-b']diindoles. A Novel Class of Rigid,

Planar Benzodiazepine Receptor Ligands. Trudell, M. L.; Basile, A. S.;Shannon, H. E.; Skolnick, P.; Cook, J. M. J. Med. Chem. 1987, 30, 456-458.

4) Synthetic Studies in the β-Carboline Area. New Entry Into 4-Substituted and 3,4-

Disubstituted β-Carbolines. Fukada, N.; Trudell, M. L.; Johnson, B.; Cook, J. M. Tetrahedron Lett. 1984, 26, 2139-2142.

3) Stereoselectivity of Catalytic Cyclopropanation Reactions. Catalyst Dependence in

Reactions of Ethyl Diazoacetate with Alkenes.Doyle, M. P.; Dorrow, R. L.; Buhro, W. E.; Griffin, J. H.; Tamblyn, W. H.; Trudell, M. L. Organometallics 1984, 3, 44-52.

2) Catalytic Role of Copper(II) Triflate in Lewis Acid Promoted Reactions of Diazo

Compounds. Doyle, M. P.; Trudell, M. L. J. Org. Chem. 1984, 49, 1196-1199. 1) Homologations of Acetals of α,β-Unsaturated Carbonyl Compounds with Diazo

Esters. Synthesis of Acetals of β,γ-Unsaturated Carbonyl Compounds. Doyle, M. P.; Trudell, M. L.; Terpstra, J. W. J. Org. Chem. 1983, 48, 5146-5148.

c. Refereed Monographs (None)

d. Refereed Proceedings

2) Synthesis of High Density Insensitive Energetic Tetraazapentalene

Derivatives. Subramanian, G.; Boyer, J. H.; Eck, G.; Trudell, M. L. In Proceedings of the Materials Research Society: Decomposition, Combustion and Detonation Chemistry of Energetic Materials. Brill, T. B.; Russell, T. P.; Tao, W. C; Wardle, R. B. (eds.) Materials Research Society: Pittsburgh, PA 1995, Vol 418, pp. 37-42.


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1) Fluorescence Properties of Laser Dyes in Polymeric Media. Jones, G.; Morias, J.; Trudell, M. L.; Chen, T. H.; Boyer, J. H. Proceedings of the International Conference on Lasers '95, Corcoran, V. J.; Goldman, T. A. (eds.) STS Press: McClean, VA, 1996, pp. 375-382.

C. Other Publications a. Non-refereed academic journal articles (None) b. Other (Non-refereed conference proceedings) Electrospray Ionization Mass Spectrometry of Metallocenes and Organometallic Salts. X. Xu, S. P. Nolan, M. L. Trudell, R. B. Cole Proceedings of the 41st Annual Conference on Mass Spectrometry and Allied Topics, San Francisco, CA June 3, 1993, pp. 1072a- 1072b.

2. ITEMS ACCEPTED FOR PUBLICATION BUT NOT YET PUBLISHED


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3. ARTISTIC OR OTHER CREATIVE ACTIVITIES

PATENTS 4. Synthesis of Glycerol Tripyruvate. M. L. Trudell and S. A. Cararas. Application No.

60/893,176 (March 6, 2007) 3. Reaction system comprising transition metal and Imidizoline-2ylidene or Imidazolidine-2-

ylidine and its use in coupling reactions. Steven P. Nolan, Jinkun Huang, Mark L. Trudell, Chunming Zhang WO 20010666248 A2 20010913 CAN 135:228509 AN 20001:676668

2. Solid State Laser Dyes, their copolymerization and methathesis catalysts therefor. Mark L.

Trudell and Steven P. Nolan. WO2001016141 A1 20010308 CAN 134:224017 AN 168000 1. Preparation and binding affinity of cocaine analogs. Mark L. Trudell and Stacey A.

Lomenzo US 5,834,484 A 19981110 CAN 129:343619 AN 1998:735052

4. PARTICIPATION AT PROFESSIONAL MEETINGS/INVITED LECTURES (* Denotes invited lecture)

80) Palladium catalyzed synthesis of benzofuran from diarly ether. Akram, S.; Sherwood,

A.; Trudell, M. L.; ACS 245th National Meeting, New Orleans, LA, April 7-11, 2011; ORGN. Abstr. 875.

79) Iridium catalyzed amination of alcohols with alpha-amino esters. Lindsay, M.

McGinn, M.; Trudell, M. L.; ACS 245th National Meeting, New Orleans, LA, April 7-11, 2011; ORGN. Abstr. 811.

78) Synthesis of amphibian alkaloids via iridium catalyzed N-heterocyclization reactions.

Thota, K. ; Trudell, M. L. ACS 245th National Meeting, New Orleans, LA, April 7-11, 2011; ORGN. Abstr. 570.

77) Synthesis and biological evaluation of diaryl ether cannabinoids. Sherwood, A.;

Noble, A.; Pond, D.; Schroeder, R.; Izenwasser, S.; Wade, D.; Trudell, M. L. ACS 245th National Meeting, New Orleans, LA, April 7-11, 2011; MEDI. Abstr. 178.

76) Design, synthesis, and biological evaluation of 3-aryl-3-arylmethoxyazetdine

derivatves as monoamine transporter ligands. Thaxton, A.; Izenwasser, S.; Wade, D.; Trudell, M. L. ACS 245th National Meeting, New Orleans, LA, April 7-11, 2011; MEDI. Abstr. 144.


15

75) Design, synthesis, and biological evaluation of a novel cannainoid antagonist. Verma,

A.; Izenwasser, S.; Trudell, M. L. ACS 245th National Meeting, New Orleans, LA, April 7-11, 2011; MEDI. Abstr. 143.

74) Synthesis and biological evaluation of 3-aryl-3-arylmethoxy pyrrolidines on

monoamine transporters. Apsunde, T,; Izenwasser, S.; Wade, D.; Trudell, M. L. ACS 245th National Meeting, New Orleans, LA, April 7-11, 2011; MEDI. Abstr. 138.

73) *Synthetic Cannabinoids, Oklahoma Bureau on Narcotics, Oklahoma State

University, Edmund OK April 1-2, 2013. 72) Synthesis and biological evaluation of novel cannabinoid antagonists. Verma, A.;

Izenwasser, S.; Wade, D.; Booth, C.; Trudell, M. L. 73rd Annual Scientific Meeting of the College on Problems of Drug Dependence, June 18-23, 2011. Abstr. 65.

71) Synthesis and Monoamine Transporter Affinity of 3-Aryl-3-arylmethoxtropane

derivatives. Kaur, H.; Izenwasser, S.; Verma, A.; Wade, D.; Housman, A.; Gulasey, G.; Trudell, M. L. 73rd Annual Scientific Meeting of the College on Problems of Drug Dependence, June 18-23, 2011. Abstr. 64

70) *Research Opportunities within the UNO Chemistry Department. Department of

Pharmacology and experimental therapeutics. LSU Health Science Center, May 3, 2011.

69) Synthesis and biological evaluation of novel cannabinoid receptor ligands.

Sherwood, A. S.; Noble, A.R.; Trudell M. L. 66th Southwest and 62nd Southeastern Regional ACS Meeting, New Orleans, LA, Dec 1-4, 2010; Abstr. 108.

68) Experimental electron density determinations of CB1 receptor agonists. Fournet,

S.; Stevens, E. D.; Trudell, M. L. 66th Southwest and 62nd Southeastern Regional ACS Meeting, New Orleans, LA, Dec 1-4, 2010; Abstr. 113.

67) Synthesis and biological evaluation of novel cannabinoid antagonists. Verma, A.;

Izenwasser, S.; M. L. Trudell. 66th Southwest and 62nd Southeastern Regional ACS Meeting, New Orleans, LA, Dec 1-4, 2010; Abstr. 794.

66) Synthesis and biological evaluation of novel azetidine derivatives as cannabinoid

receptor ligands. Forsyth, A. N.; Izenwasser, S.; Trudell, M. L.. 66th Southwest and 62nd Southeastern Regional ACS Meeting, New Orleans, LA, Dec 1-4, 2010; Abstr. 122.

65) Synthesis and Biological Evaluation of Novel [1,2,3]Triazoles at Cannabinoid

Receptors. A. Verma, S. Izenwasser, and M. L. Trudell, ACS 239th National Meeting, San Francisco ,CA, March 21-25, 2010; Medi. Abstr. 211.


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64) *New Directions in Pharmacotherapies for Drugs of Abuse. M. L. Trudell, Xavier University, New Orleans LA, Nov. 5, 2008.

63) General Strategies for the Enantioselective Construction of Pyrrolidine-based

Alkaloids. Total synthesis of (+)-cis-Pyrrolidine 225H. A. R. Noble, M. L. Trudell, ACS 235th National Meeting, New Orleans, LA, April 6-10, 2008; Orgn. Abstr. 123.

62) Total synthesis of (S)-anabasine and (S)-Noranabasamine. L. Miao, M. L. Trudell,

ACS 235th National Meeting, New Orleans, LA, April 6-10, 2008; Orgn. Abstr. 124. 61) Synthesis and Biological Evaluation of Novel Cannabinoid Receptor Ligands. H Shu,

S. Izenwasser, and M. L. Trudell, ACS 235th National Meeting, New Orleans, LA, April 6-10, 2008; Medi. Abstr. 335.

60) Synthesis and Biological Evaluation of 3-Aryl-3β-Arylmethoxytropane Derivatives at

Monoamine Transporters. H Kaur, S. Izenwasser, and M. L. Trudell, ACS 235th National Meeting, New Orleans, LA, April 6-10, 2008; Medi. Abstr. 249.

59) Synthesis and Biological Activity of Meperidine Analogues as Selective

Serotonin Reuptake Inhibitors. X. Gu , S. Izenwasser, and M. L. Trudell, ACS 235th National Meeting, New Orleans, LA, April 6-10, 2008; Medi. Abstr. 281

58) Synthesis and Biological Activity of Meperidine Analogues as Selective

Serotonin Reuptake Inhibitors. X. Gu , S. Izenwasser, and M. L. Trudell, ACS 233th National Meeting, Chicago, IL, March, 25-29, 2007; Medi. Abstr. 270

57) Synthesis and Biological Evaluation of 3-Aryl-3β-Arylmethoxytropane Derivatives at

Monoamine Transporters. H Kaur, S. Izenwasser, and M. L. Trudell, ACS 233th National Meeting, Chicago, IL, March, 25-29, 2007; Medi. Abstr. 271

56) Synthesis and Biological Activity at Monoamine Transporters of 3-[2-

(diarylmethoxy-ethylidenyl)]-N-Substituted Tropane and Azetidine Analogues S. Cararas, S. Izenwasser, and M. L. Trudell, ACS 233th National Meeting, Chicago, IL, March, 25-29, 2007; Medi. Abstr. 272

55) Synthesis and Biological Activity at Monoamine Transporters Affinity of 3-{2-

(Diarylmethoxy-Ethylidene)}-8-Substituted 8-Azabicyclo[3.2.1]octane Analogues. S. A Cararas, S. Izenwasser, and M. L. Trudell, ACS 229th National Meeting, San Diego, CA, March, 13, 2005; Medi. Abstr. 57

54) Synthesis and Monoamine Transporter Affinity of GBR12909-Benztropane Hybrid

Analogues. Z. Zhang S. Izenwasser, and M. L. Trudell, ACS 229th National Meeting, San Diego, CA, March, 13, 2005; Medi. Abstr. 59.


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53) *New Directions in Pharmacotherapies for Drugs of Abuse. Amphibian Alkaloids and the Nicotinic Acetylcholine Receptor. M. L. Trudell, Spelman College, Atlanta GA, April 22, 2004.

52) Studies Directed Toward the Synthesis of the Decahydroquinoline 275B Series. E. J.

Banner, M. L. Trudell, ACS 225th National Meeting, New Orleans, LA, March 23, 2003; Orgn. Abstr. 427.

51) *Synthesis and Structure-Activity Relationship Studies of Novel Dopamine Uptake

Inhibitors Trudell, M. L.; Izenwasser, S.; Katz, J. L 28th National Medicinal Chemistry Symposium, San Diego, CA, June10, 2002.

50) Synthesis and Biological Evalucation of Novel Epibatidine Analogues. J. Cheng, C.

Zhang, E. Stevens, S. Izenwasser, D. Wade, S. Chen, D. Paul and M. L. Trudell, ACS 223rd National Meeting, Orlando, FL, April 7, 2002; Medi. Abstr. 15.

49) Structure-Activity Studies of Meperidine as a Dopamine Inhibitor. J. B. Rhoden, D.

Wade, S. Izenwasser and M. L. Trudell, ACS 223rd National Meeting, Orlando, FL, April 7, 2002; Medi. Abstr. 52.

48) Synthesis of novel GBR 12909-Tropane hybrid analogues as potent dopamine transporter

ligands. A. L Bradley, S. Izenwasser, D. Wade, and M. L. Trudell, ACS 223rd National Meeting, Orlando, FL, April 7, 2002; Medi. Abstr. 53.

47) *Analogues of Meperidine as Ligands for the Dopamine Transporter. M. L.

Trudell, Wayne State University, Department of Medicinal Chemistry, March 20, 2002.

46) *Analogues of Meperidine as Ligands for the Dopamine Transporter. M. L.

Trudell, S. A. Lomenzo, J. B. Rhoden, J. L. Katz, T. Kopajtic, D. Wade and S. Izenwasser, College on Problems of Drug Dependence, 63rd Annual Scientific Meeting, Scottsdale AZ, June 19, 2001. Abstr. 649.

45) Synthesis and Pharmacological Activity of GBR12909-Tropame Hybrid Analogs. A. L.

Bradley, S. Izenwasser, D. Wade and M. L. Trudell. ACS 221st National Meeting, San Diego, CA, April 1, 2000; Medi. Abstr. 86.

44) Synthesis and Structure-Activity Relationship Studies of Meperidine Analogues at the

Dopamine Transporter. J. B. Rhoden, S. A. Lomenzo, S. Izenwasser, D. Wade, J. L. Katz, T. Kopajtic and M. L. Trudell. ACS 221st National Meeting, San Diego, CA, April 1, 2000; Medi. Abstr. 93.

43) Synthesis of 7-Heteroaryl-7-azabicyclo[2.2.1]heptane Derivatives as Potential Nicotinic

Receptor Ligands. J. Cheng,, M. L. Trudell, , D. Wade and S. Izenwasser. ACS 221st National Meeting, San Diego, CA, April 1, 2000; Medi. Abstr. 102.


18

42) Synthesis and Evaluation of Meperidine Analogues as Dopamine Uptake Inhibitors. M. L. Trudell, S. A. Lomenzo, J. B. Rhoden, S. Izenwasser, R. M. Gerdes, D. Wade, J. L. Katz, and T. Kopajtic. ACS 219th National Meeting, San Francisco, CA. March 29, 2000; Medi. Abstr. 266.

41) *Synthesis of 7-Azabicyclo[2.2.1]heptane Derivatives as Potential Nicotinic Receptor

Ligands. J. Cheng, S. Izenwasser, D. Wade and M. L. Trudell. ACS 52nd Southeast/56th SouthwestCombined Regional Meeting, New Orleans, LA. December 6, 2000; Medi. Abstr. 434.

40) *Synthesis and Nicotinic Receptor Binding Affinity of 7-Azabicyclo[2.2.1]heptane

Derivatives. M. L. Trudell, S. Izenwasser, J. Cheng, S. DiMaggio, D. Wade, C. Zhang, Society for Neuroscience 30th Annual Meeting, November 5, 2000. Abstr. 139.9

39) *From Freud to Crack: Search for Cocaine Addiction Therapuetics. Mark L. Trudell,

ACS Southeastern Louisiana Section Meeting, November 16, 2000. 38) High Affinity 2-Substituted Phenyltropanes Lacking Cocaine-Like Behavioral Effects, T.

Kopajtic, J. L. Katz, S. Izenwasser, L. Xu, S. A. Lomenzo, M. L. Trudell. Society for Neuroscience 30th Annual Meeting, November 8, 2000. Abstr. 675.11

37) Synthesis, Dopamine Transporter Affinity and Dopamine Uptake Inhibition of

Meperidine Analogues. M. L. Trudell, S. A. Lomenzo, S. Izenwasser, R. M. Gerdes, J. L. Katz, and T. Kopajtic. ACS 219th National Meeting, San Francisco, CA. March 29, 2000; Medi. Abstr. 324.

36) Synthesis of 7-Azabicyclo[2.2.1]heptane Derivatives as Potential Nicotinic Receptor

Ligands. J. Cheng, C. Zhang and M. L. Trudell. ACS 219th National Meeting, San Francisco, CA. March 28, 2000; Medi. Abstr. 274

35) Synthesis and Nicotinic Receptor Affinity of 2-Acetoxytropane Derivatives. S.

DiMaggio, S. A. Lomenzo, L. Gyermek and M. L. Trudell. ACS 219th National Meeting, San Francisco, CA. March 28, 2000; Medi. Abstr. 274

34) Synthesis, Dopamine Transporter Affinity and Dopamine Uptake Inhibition of Meperidine

Analogues/ Synthesis of Epibatidine and Related Analogues. M. L. Trudell. National Institute on Drug Abuse IRP Seminar Program, Baltimore, MD. Sept. 29, 1999.

33) Synthesis, Dopamine Transporter Affinity and Dopamine Uptake Inhibition of Meperidine

Analogues. S. A. Lomenzo, S. Izenwasser, R. M. Gerdes and M. L. Trudell. ACS 217th National Meeting, Anaheim, CA. March 21, 1999; Medi. Abstr. 105.

32) Studies Directed Toward the Synthesis of New Solid State Pyrromethene•BF2 Laser

Dyes. D.E. Boler, S. P. Nolan and M. L. Trudell. ACS 217th National Meeting, Anaheim, CA. March 24, 1999; Orgn. Abstr. 421.


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31) 2-Bromoethynyl Aryl Sulfones as Versatile Dienophiles: A Formal Synthesis of Epibatidine. C. Zhang, C. J. Ballay and M. L Trudell. ACS 217th National Meeting, Anaheim, CA. March 24, 1999; Orgn. Abstr. 477.

30) Preparation of 1-Substituted 1,2,3-Triazolo[4,5-d]pyridazines and Pyridazino-Benzotetra-

azapentalene Derivatives. K. C. V. Ramanaiah and M. L. Trudell. ACS 217th National Meeting, Anaheim, CA. March 24, 1999; Orgn. Abstr. 478.

29) Synthesis and Biological Activity of Novel 6-Alkyl-3-benzyl-2-

(methoxycarbonylmethyl)tropane Derivatives. S. A. Lomenzo, S. Izenwasser, J. L. Katz, and M. L. Trudell. ACS 213th National Meeting, San Francisco, CA. April 16, 1997; Medi. Abstr. 192.

28) Regiospecific Synthesis of 6-Alkyl Tropan-2-ones. S. A. Lomenzo, A. L. Bradley, M. L.

Trudell. ACS 213th National Meeting, San Francisco, CA. April 16, 1997; Orgn. Abstr. 550.

27) Studeis Directed Toward the Synthesis of Epibatidine and Related Analogs. N. P. Pavri,

M. L. Trudell. ACS 213th National Meeting, San Francisco, CA. April 16, 1997; Orgn. Abstr. 549.

26) Synthesis of Triazolopyridazines as Precursors for Novel High Density Insensitive

Energetic Materials. K. C. V. Ramanaiah, M. L. Trudell. ACS 213th National Meeting, San Francisco, CA. April 14, 1997; Orgn. Abstr. 165.

25) Synthesis of Dipyridotetraazapentalene Derivatives as Potential High Density Insensitive

Energetic Materials. D. Balachari, M. L. Trudell. ACS 213th National Meeting, San Francisco, CA. April 14, 1997; Orgn. Abstr. 166.

24) Synthesis and Structure of New Furazan Derivatives. A. Zelenin, M. L. Trudell. ACS

213th National Meeting, San Francisco, CA. April 14, 1997; Orgn. Abstr. 167. 23) [4+2]Cycloaddition Reaction of Pyrroles with 3-Bromopropiolates. C. Zhang, M. L.

Trudell. ACS 213th National Meeting, San Francisco, CA. April 14, 1997; Orgn. Abstr. 168.

22) *Synthesis of New Azadibenzotetraazapentalene Derivatives as Potential High Density

Insensitive Energetic Materials. M. L. Trudell. 1996 Energetic Materials Workshop, Annapolis, MD. December 4, 1996.

21) *Synthesis, Structure and Biological Activity of 2-Substituted-3-Phenyltropanes. Mark L. Trudell, NIDA Technical Meeting, "Cocaine Medications - Better Treatment

Through Chemistry" NIH Rockville, MD. April 29 - 30, 1996.


20

20) Stereoselective Synthesis of 6-Alkyl Tropane Derivatives. S. A. Lomenzo, C. L. Klein, N. Zhu, M. L. Trudell. ACS 211th National Meeting, New Orleans, LA. March 27, 1996; Orgn. Abstr. 289.

19) Synthesis of Highly Functionalized 7-Azabicylco[2.2.1]heptadienes. N. Pavri, Z. Chen,

M. L. Trudell. ACS 211th National Meeting, New Orleans, LA. March 27, 1996; Orgn. Abstr. 290.

18) Synthesis of High Density Insensitive Energetic Tetraazapentalene Derivatives.G.

Subramanian, J. H. Boyer, G. Eck, M. L. Trudell, ACS 211th National Meeting, New Orleans, LA. March 27, 1996; Orgn. Abstr. 291.

17) (1997) Synthesis and Structure-Activity Studies of 9-Azabicyclo[3.3.1]nonane Cocaine

Analogs. Z. Chen, S. Izenwasser, J. L. Katz, and M. L. Trudell. ACS 211th National Meeting, New Orleans, LA. March 24, 1996; Medi. Abstr. 63.

16) Synthesis and Biological Evaluation of 2β-Carbomethoxy-3β-aryltropane Derivatives. L.

Xu, S. V. Kelkar, S. A. Lomenzo, S. Izenwasser, J. L. Katz, C. L. Klein, N. Zhu and M. L. Trudell. ACS 211th National Meeting, New Orleans, LA. March 24, 1996; Medi. Abstr. 65.

15) *Synthesis of High Density Insensitive Energetic Tetraazapentalene Derivatives. J. H.

Boyer, G. Eck, G. Subramanian, and M. L. Trudell Materials Research Society Fall 1995 Meeting, Boston, MA. November 27, 1995; Abstr. GG1.6

14) *Studies Directed Toward the Synthesis of New Energetic Materials. J. H. Boyer, P. A.

Politzer, A. Gunasekaran, G. Subramanian, and M. L. Trudell. DEA 5660 Group 4 Data Exchange Meeting, Vert le Petit, France. June 19 - 21, 1995.

13) Synthesis and Ligand Binding of 2β-Substituted WIN 35,065-2 Analogs. Shreekrishna V.

Kelkar, Sari Izenwasser, Jonathan L. Katz, Cheryl L. Klein, Naijue Zhu and Mark L. Trudell. ACS 208th National Meeting,Washington D.C. August 24, 1994; Medi. Abstr. 184.

12) *Studies Directed Toward the Synthesis of Insensitive Energetic Materials. J. H. Boyer,

A. Gunasekaran, G. Subramanian, and M. L. Trudell. Energetic Materials, Gordon Research Conference, New Hampton, NH.June 28 - July 2, 1994.

11) Selective Formation of (η5-C5Me5)Ru(η6-Arene)OSO2CF3 Complexes 35. Stacey A.

Lomenzo, Steven P. Nolan and Mark L. Trudell. NSF Organometallic Workshop New Orleans, LA. May 13-15, 1993.

10) Selective Formation of (η5-C5Me5)Ru(η6-Arene)OSO2CF3 Complexes. Stacey A.

Lomenzo, Steven P. Nolan and Mark L. Trudell. ACS 205th National MeetingDenver, Colorado. March 29, 1993.


21

9) *Synthetic Studies Directed Toward the Total Synthesis of Tetronasin. Mark L. Trudell. Symposium on Recent Developments in the Area of Ionophore Antibiotics. Cambridge University, Cambridge, U.K. May 3, 1990.

8) *The Total Synthesis of the Indole Alkaloid Suaveoline. Mark L. Trudell.

Organic Chemistry Colloquium, Imperial College of Science, Technology and Medicine, London, U.K. December 5, 1989.

7) Studies Directed Toward the Total Synthesis of the Indole Alkaloid

Suaveoline.Mark L. Trudell and James M. Cook ACS 20th Central Regional Meeting, West Virginia University, Morgantown, West Virginia. June 2, 1988; Abstr. 139.

6) Pyridodiindoles. Synthesis of Rigid, Planar Ligands of the Benzodiazepine

Receptor. Mark L. Trudell and James M. Cook ACS 193rd National Meeting, Denver, Colorado. April 5, 1987; Medi. Abstr. 36.

5) *Hydrazine Mediated One-Pot Amination-Oxidation Reaction: Facile Synthesis

of 4-Amino-β-carbolines and 4-Aminoisoquinolines. Mark L. Trudell, N. Fukada, Barry M. Johnson and James M. Cook Olin Hydrazine Symposium, ACS 193rd National Meeting, Denver, Colorado. April 5, 1987; Org. Abstr. 253.

4) Synthetic Studies in the β-Carboline Area. A Simple One-Pot Amination-

Oxidation Reaction. Mark L. Trudell, N. Fukada, B. Johnson and James M. Cook ACS 20th Great Lakes Regional Meeting, Marquette University, Milwaukee, Wisconsin. June 2, 1986; Abstr. 303.

3) Synthesis of the Anticonvulsant 2-Chloro-7,12-dihydropyrido[3,2-b:5,4-

b']diindole. A Selective Benzodiazepine Agonist with No Sedative Activity. Mark L. Trudell, Phil Skolnick, Harlan Shannon and James M. Cook ACS 191st National Meeting, New York, New York. April 13, 1986; Medi. Abstr. 47.

2) Synthesis of the Anticonvulsant 2-Chloro-7,12-dihydropyrido[3,2-b:5,4-

b']diindole. A Selective Benzodiazepine Agonist with No Sedative Activity. Mark L. Trudell, Phil Skolnick, Harlan Shannon and James M. Cook ACS 20th Great Lakes Regional Meeting, Marquette University, Milwaukee, Wisconsin. June 2, 1986; Abstr. 261.

1) Simple Synthesis of 3,4-Indolosubstituted β-Carbolines. A New Class of Benzodiazepine

Antagonists. Mark L. Trudell, Phil Skolnick, Harlan Shannon and James M. Cook ACS 190th National Meeting, Chicago, Illinois . September 8, 1985; Medi. Abstr. 87.


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5. OTHER SCHOLARLY OR CREATIVE ACTIVITIES A. Service in role of discussant, critic, reviewer for professional meeting or publications NIDA-L Review Committee, Permanent Member 09/2003 – 08/2008 NIDA Ad-Hoc Review Committee 2001 -2012

Session Chairman, ACS 211th National Meeting, New Orleans, LA. March 27, 1996. Referee, Materials Research Society Fall 1995 Meeting, Boston, MA. November 27, 1995. Session Chairman, NSF Organometallic Workshop, New Orleans, LA. May 13-15, 1993.

Manuscript Reviewer for: Journal of the American Chemical Society, Journal of Medicinal Chemistry, Journal of Organic Chemistry, Journal of Chemical Reviews, Tetrahedron Letters, Heterocyclic Chemistry, Heteroatom Chemistry, Medicinal Chemistry Research, Structural Chemistry, Accounts of Chemical Research.

Grant Proposal Reviewer for: National Institute on Drug Abuse (NIH Medication Development Study Section), National Science Foundation, Petroleum Research Fund, Research Corporation

B. Serviceinroleofofficerofprofessionalorganization,programcommitteemember,

sessionorganizerforprofessionalmeeting Chairman, Technical Program ACS Southeastern/ Southwestern Regional Meeting, New Orleans, LA. Dec. 1-4, 2010 Chairman, Medicinal Chemistry Symposium,.

ACS 52nd Southeastern/56th Southwestern Combined Regional Meeting, New Orleans, LA. Dec. 6-8, 2000.

Chairman, Public Relations Committee, Louisiana Section, American Chemical Society 1994 -1995. Chairman, Mardi Gras Symposium in Chemistry, University of New Orleans, New Orleans, LA 1995. Co-Chairman, Mardi Gras Symposium in Chemistry, University of New Orleans, New Orleans, LA 1994.


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C. Editorship of journal, monograph series, book series Drug Design, Development and Therapy- Honorary Editorial Board-2007-2010

Commemorative Issue in Honor of Prof. James Cook on the occasion of his 65th anniversary. ARKIVOC 2010. Facilitator: Mark L. Trudell

Dopamine Transporter; Chemistry, Biology and Pharmacology, Trudell, M. L.;

Izenwasser, S. (Eds.), Wiley & Sons, Inc: New York 2008.

D. PROFESSIONAL SOCIETY MEMBERSHIP

American Chemical Society (member since 1980). Divisions: Medicinal Chemistry and Organic Chemistry

6. AWARDS, HONORS, LECTURESHIP OR PRIZES

• Research Highlighted in C&E News: “Safer, more versatile acetominophen.”. C&EN, August 3, 2009, p. 28.

• Book Highlighted in Clinical Pharmacology and Therapeutics 2009, 85(1), 16-17. • 2000 UNO Research Professor • Research Highlighted in Chemistry in Britain: “Amphibious Medicine Chest”.

Chemistry in Britain, February, 1997, p. 19 • Research Highlighted in C&E News: “Practical syntheses for two potent natural

products”. C&EN, October 21, 1996, p. 32 • 1994 UNO Alumni Association Early Career Achievement Award for Excellence in

Research. • National Institute on Drug Abuse, Young Investigator Award 1992-1997. • UNO Research Council/Summer Scholar Award 1992.


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7. GRANTS AND CONTRACTS (Total funding as of October 31, 2010: $9,087,485) A. SINGLE PRINCIPAL INVESTIGATOR AWARDS

Development of Cannabinoid Receptor-Based Medications for Drug Addiction National Institute on Drug Abuse

9/15/07 - 08/31/12. $1,750,124 Synthesis of [13C]SCP-123 St. Charles Pharmaceuticals-Contract 1/1/2009-2/1/2009, $30,000 Synthesis of SCP-Analogues St. Charles Pharmaceuticals-Contract 5/1/2008-6/1/2008, $30,000 Development of Peptide Based Strategies to Enhance the Therapeutic Efficacy of Anti-HIV Agents. BOR-RC/EEP Contract 9/07-8/10 $287,000 Large Scale Synthesis of SCP-Analogues St. Charles Pharmaceuticals-Contract 9/1/2007-11/1/2007, $30,000 Synthesis of Potential Cocaine Abuse Therapeutics.

National Institute on Drug Abuse 9/30/03 - 10/1/08. $1,543,532

Synthesis of Purine Anitviral Agents LSUEye Center Subcontract –NIH (H. Kaufman-PI) 1/1/01-12/31/02 $100,000. Development of Novel Nicotine Receptor Mediated Therapeutic Agents.


Synthesis of Potential Cocaine Abuse Therapeutics.


Synthesis of Novel High Density Insensitive Energetic Materials. Lawrence Livermore National Laboratory (DOE) 05/01/98 - 09/30/99. $81,000


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SINGLE PRINCIPAL INVESTIGATOR AWARDS (continued) Synthesis of Novel Fluorescent Molecules for the Development of Optical Glucose Sensors. Lawrence Livermore National Laboratory (DOE) 05/06/98 - 09/30/98. $32,000

Synthesis of Novel High Density Energetic Materials. Office of Naval Research-Materials Division

3/1/97 - 2/28/98. $175,000 Investigations on the Chemistry of Organic Derivatives of Nitroso and Nitro Groups.

Low (zero) Hydrogen Content and/or Enhanced Insensitivity. Office of Naval Research-Materials Division

3/1/96 - 2/28/97. $200,000 Investigations on the Chemistry of Organic Derivatives of Nitroso and Nitro Groups.

Low (zero) Hydrogen Content and/or Enhanced Insensitivity. Office of Naval Research-Materials Division

3/1/95 - 2/28/96. $200,000 Heterocyclic-BF2 Complexes and Related Structures as Laser Dyes.

Army Office of Research, Chemical and Biological Division 1/1/95 - 12/31/98. $127,000

Search for Cocaine Agonists and Antagonists.

National Institute on Drug Abuse 10/1/92 - 9/31/97. $496,080

Synthesis of Teleocidin Alkaloids.

Cancer Association of Greater New Orleans 6/93 - 8/93. $1,500 UNO Research Council/Summer Scholar Award

6/1/92 - 7/1/92. $5,000

Synthesis of Cocaine Analogs. UNO NIH-BRSG Award

2/1/92 - 3/31/92. $2,000

Total funding as a Single P.I.: $7,521,655


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B. CO-PRINCIPAL INVESTIGATOR OR EQUIVALENT AWARDS

Systemic and State-Wide Initiatives to Support the Louisiana DEPSCoR Proposal Louisiana Education Quality Support Fund (LEQSF) Louisiana Board of Regents 4/1/96 - 3/31/99. $800,000 Co-Project Directors: V. Raghavan (USL), M. L. Trudell (UNO).

Computational and Synthetic Approaches to Developing Novel Energetic Materials to Stabilize Rocket Motors.

Ballistic Missile Defense Organization, 1/11/95 - 7/31/98. $450,000 Co-P.I.s: M. L. Trudell, P. A. Politzer. Studies Directed Toward the Synthesis of Insensitive Energetic Materials. Office of Naval Research-Materials Division, 3/1/94 - 2/28/95. $200,000 Co-P.I.s: J. H. Boyer, M. L. Trudell.

Acquisition of a FT-IR/Raman Spectrophotometer. Louisiana Educational Quality Support Fund-Enhancement Program, 1992. $114,830 Co-P.I.s: B. Jursic, S. P. Nolan, R. Sweany, M. L. Trudell.

Chemistry of Cp*Ru(arene)Complexes. Thermochemistry and Application to Organic Chemistry. Johnson-Matthey Metal Loan Program, 1992. $1,000 Co-P.I.s: S. P. Nolan, M. L. Trudell. Total funding as a Co-P.I.: $1,565,830.

C. PENDING AWARDS (1) Single Principal Investigator

Cannabinoid Based Medications for Drug Abuse. M. L. Trudell-PI National Institute on Drug Abuse Multi-Targeted Regulation of Mephadrone. M. L. Trudell-PI National Institute on Drug Abuse

(2) Co-principal Investigator or Equivalent Awards None D. NOT PRINCIPAL INVESTIGATOR None


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8. TEACHING ACTIVITIES A. COURSES TAUGHT (1991-2012) Student Evaluations: GPA range: 3.6 to 4.0 (scale of 4.0) (1) Undergraduate Courses: CHEM 2217 Organic Chemistry I CHEM 2218 Organic Chemistry II CHEM 2026 Organic Chemistry Laboratory CHEM 3027 Advanced Synthesis Laboratory CHEM 4210 Intermediate Organic Chemistry (2) Graduate Courses: CHEM 4210G Intermediate Organic Chemistry CHEM 6210 Advanced Organic Chemistry CHEM 6211 Synthetic Organic Chemistry CHEM 6213 Physical Organic Chemistry CHEM 7000 Thesis Research CHEM 7025 Graduate Research CHEM 7050 Dissertation Research B. THESIS/DISSERTATION COMMITTEE SERVICE

1) Committee Chairman (21 PhD students)

34) Alexander M. Sherwood, Ph.D. Design, Synthesis and Biological Evaluation of Novel Compounds with CNS-Activity Targeting Cannabinoid and Biogenic Amine Receptors. May 2014

33) Amber N. Thaxton, PhD. Synthesis of Novel Azetidines. Dec. 2013 32) Tushar Apsunde, MS. (Non-Thesis) “Microwave Assisted Iridium Catalysis”. May

2013 31) Kiran Thota, MS. (Non-Thesis) “Synthesis of Glycerol Homologues ”. May 2013 30) Amber Thaxton, MS. (Non-Thesis) “Synthesis of Azetidines ”. May 2013. 29) Abha Verma, PhD. Synthesis and Biological Evaluation Cannabinoid Anagonists.

August 2012. 28) Alexander M. Sherwood, MS. (Non-Thesis) “Synthesis of Phloroglucinol Monoaryl Ethers ”. May 2012 27) Kimari Slaughter MS (Thesis) “Synthesis and Development of Potential CB1

Receptor Neutral Antagonists”. May 2012


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26) Andrea Natassia Forsyth, PhD. “Synthesis and Biological Evaluation Rigid

Analoguesof Methamphetamine”. May 2012. 25) Xiaobo Gu, PhD. “Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs).” May 2010. 24) Abha Verma, MS. (Non-Thesis) “Synthesis of [1,2,3]Triazoles”. May 2010 23) April Noble, PhD. “Synthesis of Amphibian Alkaloids and Synthesis and Affinity of

Novel Cannabinoid Receptor Ligands”. December 2009. 22) Hong Shu, PhD. “Design and Synthesis of CB1 Receptor Ligands and Synthesis of

Pyrrolidine 225H and A Formal Synthesis of (+)-Gephyrotoxin”. December 2009. 21) Lei Miao, PhD. “Synthesis of Amphibian Alkaloids and Development of Acetaminophen

Derivatives”. August 2009. 20) Shaine A. Cararas, Ph.D. “Synthesis and Biological Evaluation of Novel GBR 12909

Tropane and Azetidine Hybrid Analogues”. December 2007. 19) Harneet Kaur, Ph.D. “Synthesis And Evaluation Of Novel Tropane Compounds As Potential

Therapeutics For Drug Abuse”. August 2007. 18) Hong Shu, MS. “Epibatidine Bivalent Ligands”. August 2006. 17) Suhong Zhang, Ph.D. “Synthesis of Novel Compounds as Potential Therapeutics for Drug

Abuse. May 2006. 16) Stanhope Turnbull, Ph.D. “Study of Bis-Imidazol-2-ylidens as Ligands for Transition Metal

Catalyzed Coupling Reactions.” December 2004. 15) Edith J. Banner, Ph.D. “Stereoselective Synthesis of the cis-275B Decahydroquinoline Ring

System.” May 2004. 14) Ying Liu, MS. “Synthesis and Biological Evaluation of Novel Epibatidine Analogs.”

December 2003. 13) Jill B. Rhoden, Ph.D., “Synthesis of Meperidine Analogues as Ligand for the Dopamine

Transporter”. August 2003. 12) Stassi DiMaggio, Ph.D. “Development of Novel Nicotinic Receptor Mediated Therapeutic

Agents. Synthesis and Biological Evaluation of Novel Epibatidine Analogues and the First Total Synthesis of (±)-Anabasamine and Related Analogues.” August 2003.


29

11) Jie Cheng, PhD. “Development of Novel Nicotinic Receptor Mediated Therapeutic Agents. Synthesis of Novel Analogues of Epibatidine.” May 2003.

10) Amy L. Bradley, Ph.D. “Synthesis of Novel Tropane Hybrid Analogues of GBR 12909 as

Potent Dopamine Transporter Ligands. December 2002. 9) Leyte L. Winfield, Ph.D. “: Synthesis, Structure, Octanol/Water Partition Coefficients and

Dopamine Transporter Affinity of Novel Less Lipophilic GBR 12909 Analogs. August 2002. 8) Jie Cheng, M.S. “Synthesis and Biological Evaluation at Nicotinic Acetylcholine Receptors

of N-Arylalkyl- and N-Aryl- 7-Azabicyclo[2.2.1]heptanes.” May 2002. 7) Neville P. Pavri, Ph.D. "Studies Directed Toward the Synthesis of Epibatidine" December

1997. 6) Stacey A. Lomenzo, Ph.D. "Synthesis, Structure, Binding Affinity at the Dopamine

Transporter and Dopamine Uptake Inhibition of Novel Cocaine Analogues"December 1997. 5) Lifen Xu, Ph.D. "Synthesis and Biological Evaluation of New Cocaine Analogs." December

1996. 4) Lifen Xu, M.S.(Non-Thesis) "Stereoselective Synthesis of 2β-Carbomethoxy-3β-

phenyltropane Derivatives. Enhanced Stereoselectivity Observed for the Conjugate Addition Reaction of Phenylmagnesium Bromide Derivatives with Anhydroecgonine Methyl Ester in Dichloromethane. May 1996.

3) Stacey A. Lomenzo, M.S.(Non-Thesis) "Facile and Efficient Synthesis of (±)-Tropan-2-one"

May 1996. 2) Hong Huang, M.S. "Studies Directed Toward the Synthesis of Indolactam V: A Convergent

Synthetic Approach." December 1995. 1) Zhengming Chen, Ph.D. "Part I. The Synthesis and Study of Functionalized 7-Aza-

bicyclo[2.2.1]hepta-2,5-dienes. Part II. Studies Directed Towards the Synthesis of Novel Cocaine Analogs for the Elucidation of the Role of the 8-Azabicyclo[3.2.1]octane Ring System for High Affinity Binding at Cocaine Receptors." May 1995.

(2) Committee Member

41) Roy Kelly, PhD. “New Metal-NHC Complexes”. May 2014 40) Rajesh Komati, PhD. “Cu(II) Catalyzed Gateways in the Synthesis of Acridine

Derivatives”. May 2014 39) Tammy Prachiel, PhD. “Regulation of the Target of Rapamycin Signaling Pathway in

Saccharomyces cerevisiae.” May 2013.


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38) Monika Madav, “Synthesis and Antifungal Evaluation of Barbiturate Saponins”.

May 2013. 37) Sarah Ioup, Ph.D. “ Water-Soluble Deep-Cavity Cavitands: Synthesis, Molecular

Recognition, and Interactions with Phospholipid Membranes”. December 2012. 36) Hao Yang, Ph.D. “Synthesis and Characterization of Low Molecular Weight

Gelators” May 2012. 35) Jianxia Zhang, Ph.D. “Active Response of Polymer Materials” May 2012. 34) Naveet Goyal, Ph.D. “Synthesis and Biolgical Evaluation of Aerginosin based

compounds” December 2011. 33) Sunil Kumar Upadhyay, Ph.D. “Towards the Synthesis of Antifungal Compounds” December 2011. 32) Subramanya Ravi Kiran Pingali, Ph.D. “Towards the Synthesis of Magnesidin” May 2011. 31) Suorav Chakraborty PhD. “Molecular Probes for Biologically Important Molecules:

A Study of Thiourea, Hydroxyl Radical, Peroxynitrite and Hypochlorous Acid.” May 2010.

30) Sherwin Cheuk, Ph.D. “Glucose and Glucosamine Derivatives as Low Molecular

Weight Gelators.” December 2008. 29) Sarada Sagirahu, Ph.D. “Cyclodextrins and Enantioselection”. May 2008. 28) Pierre de Fremont, Ph.D. “Syntheis of Well-Defined N-Heterocyclic Carbene

Complexes of Late Transition Metals”. May 2008. 27) Jean-Rene Ella-Menye, Ph.D. “Synthesis of Novel Heterocyclic Compounds for

Antibacterial Agents and Peptidomimetics”. December 2007. 26) Rohit Singh, PhD. “Development of N-Heterocyclic Carbenes as Organic Catalysts

and Efficient Ligands for Palladium Mediated Transformations”. August 2007. 25) Katherine Bowdy, Ph.D. “Toward the Synthesis of CAY-1, an Antifungal Steriodal

Saponin.” May 2007. 24) Paresh Patel, Ph.D. “Cyclodextrin Assisted Enantiomeric Recognition of Amino

Acids Imides and Toward the Synthesis of Dolabellane Diterpeniod B” May 2006.


31

23) Oscar Navarro, Ph.D. “Transition Metal Catalyzed Coupling Reactions.” December 2005.

22) Zachary Laughrey, Ph.D. “Synthesis of Molecular Baskets and Inward Facing

Functionality”. December 2005. 21) Jiachang Gong, Ph.D. “Biomimetics and Host-Guest Chemistry”. December 2004. 20) Donna Neumann, Ph.D. “Design and Synthesis of Novel Barbiturates of Pharmaceutical

Interest.” May 2004. 19) Xuehe Li, Ph.D. “Self-Assembly, Templation and Biomimetics”. December 2002. 18) Thuvan Nguyen, Ph.D . “Optochemical sensing by immobilizing fluorophore-

encapsulating liposomes in sol-gel thin films.” May 2002 17) Thuvan Nguyen, M.S. “Optochemical sensing by immobilizing fluorophore-

encapsulating liposomes in sol-gel thin films.” December 2001. 16) Jin Ji, Ph.D. Chemical Sensors of Single Cell Analysis, August 2001. 15) Weiwei Wang, Ph.D. “Nitrogeneous Photodegradation from Dissolved Organic Matter in

Natural Water Systems.” August 2000 14) Anthony Haag, Ph.D. “Mass Spectometric Analysis of Bacteria for the Development of

Immunologically Based Detection Methods.” May 2000 13) Md. Tafazzal Hossain, Ph.D. “I. Synthesis of Bis-bicyclo[1.1.1]pentyldiazene. II.

Attempted Synthesis of Metal Cyclic Azodioxide Complex. III. Attempted Synthesis of Chiral Amines.” May 2000.

12) Jinkun Huang, Ph.D. “Nucleophilic Carbenes: Application isn Homogeneous Catalysis”

December 1999 11) Bin Tao, Ph.D. "Studies on Anticonvulsant Drugs.” December 1997. 10) Scafford Serron, Ph.D. "Thermalchemistry of Organoruthenium and Organoiron

Complexes." December 1996. 9) Chunbang Li, Ph.D. "Thermalchemistry of Organoruthenium and Organoiron

Complexes." December 1996. 8) Scafford Serron, M.S. (Non-Thesis) "Thermalchemistry of Ruthenium Complexes."

May 1996.


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7) Chunbang Li, M.S. (Non-Thesis) "Thermalchemistry of Ruthenium Complexes." May 1996.

6) Lubin Luo, Ph.D. "Thermalchemistry of Ruthenium Complexes." May 1995. 5) Tanghua Chen, Ph.D. "Single Electron Transfer Probe. The Studies of 2,2-Dimethyl-

cyclopropyl Phenyl Ketone and 2,2-Dimethylcyclopropyl-4-methylphenyl Ketone by Reductive Cleavage of SmI2 with DMPU." May 1994.

4) Dawei Pan, Ph.D. "Part I: 2,2'-Dimesityl-2,2'-Azopropane. Part II: Stereochemistry of

2-Mesitylpropene and Its Derivatives. Part III: Organocerium Reagents in Organic Synthesis."December 1992.

3) Noemi DelaCruz Jesalva, Ph.D. " Synthetic Approaches to Selected Hydantoins." May

1993. 2) Nayanie Champika Bandra, Ph.D. "Synthetic Studies of Some Unsymmetrically

Substituted Sulfamides and 5,5-Diphenylhydantoin. Photoinduced Generation of Glycosyl Cations from Thioglycosides for Possible Application in Oligosaccaride Synthesis." May 1992.

1) Michael A. Polito, Ph.D. "An Investigation into the Efficiency of Ultrasound as Applied

to Organic Synthesis. A Simple Aqueous Method for the Synthesis of γ-Hydroxy ButyraldehydeAcetals and Their Application to a New Synthesis of (Z)-6-Heneicosen-11-one: The Phermone of the Douglas-Fir Tussock Moth." December 1991.

9. MAJOR AREAS OF CREATIVE OR RESEARCH INTEREST

Synthesis and Structure-Activity Relationships of Cocaine Agonists, Antagonists and Potential Abuse Therapeutic Agents. Synthesis and Structure-Activity Relationships of Nicotine Agonists, Antagonists and Potential Abuse Therapeutic Agents. Total Synthesis of Natural Products (Epibatidine, amphibian alkaloids). Synthesis of Energetic Materials. Development of New Synthetic Methods


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10. OTHER PROFESSIONAL ACCOMPLISHMENTS

A. Manuscriptsundersubmission DiscoveryofNovel1,2,3‐TriazoleDerivativesasNeutralCannabinoid Antagonists.Verma,A.;Shu,H.;Izenwasser,S.;Wade,D.;Savoie,C.D.; Mobley,D.L.;Trudell,M.L.J.Med.Chem.2013

Solvent-Free, Base-Free Microwave Mediated Iridium Catalyzed N-Alkylation of Amides with Alcohols. Apsunde, T.; Trudell, M. L. Adv Cat and Synth. 2013

B. Course/Programdesignanddevelopment a.Courses CHEM3027‐AdvancedSynthesisLaboratory CHEM3710MedicinalChemistry b.Programs

Development of Medicinal Chemistry Graduate Curriculum in the Department of Chemistry

C. Specialrecognitionforteaching(None)D. Academicservice a.Oncampus(asadministrator,committeemember,etc.)

Assistant Chair, Department of Chemistry, 2012-2013 Head, Organic/Medicinal Chemistry Division (1999- to date) Chair, Graduate Affairs Committee (2004-2013) University Senator 2006-2009, 2009-2012 Chair, MedChem Search Committee (2007-2008) Chair, Organic Search Committee (2000-2002) Chemistry Graduate Coordinator (1994 -2002, 2007-2010, 2012) Chemistry Graduate Selections Committee (1993-2002, 2012) Chemistry Club Advisor (1991-1995) Chemistry Graduate Affairs Committee (1992-1993) Chemistry Recording Secretary (1992-1993) Chemistry Undergraduate Affairs Committee (1991-1993, 2003-2006) Chemistry Chair, CSB Reclamation Committee (2005-2006) Chemistry Representative on the UNO Pre-Med Advising Committee (1991-1994) Festival UNO, Chemistry Academic Booth (1993 - 1994) UNO Family Day, Chemistry Department Representative (1993)


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b.Offcampus(includespeakingengagements)Executive Committee, Southeastern Section, ACS (1994-1995) Co-Project Director Louisiana DEPSCoR Proposal (1995-1998) Louisiana Stimulus for Excellence in Research (LaSER) Steering Committee(1995-1998)

E. Otherservice Chemistry Coordinator Greater New Orleans Science Olympiad (1992-1997) Event Coordinator Louisiana State Science Olympiad (1993-1997) Guest Lecturer, Ben Franklin High School Honors Science Club (April 24, 1994) Student Advisor, Louisiana State Science Fair Project (Bonnebel High School, 1995-1996) Student Advisor, Louisiana State Science Fair Project (St. Martin’s HS1998-1999)

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