Marini 2004 This vaccine webinar series is provided as a community service by Homefirst Natural...

Marini 2004Marini 2004

www.vaccinationcouncil.org

This vaccine webinar series is provided as a community service by Homefirst Natural Pharm

Source www.homefirst.com


A Medical School Professor A Medical School Professor of Immunology’s Lesson for of Immunology’s Lesson for

All PhysiciansAll PhysiciansNEUROIMMUNOLOGY PATTERNS OF INTERFERENCENEUROIMMUNOLOGY PATTERNS OF INTERFERENCE

Stephen C. Marini, M.S., D.C., Stephen C. Marini, M.S., D.C., Ph.DPh.D

Stephen C. Marini, M.S., D.C., Ph.DStephen C. Marini, M.S., D.C., Ph.DFamilyFamily

Chiropractic CenterChiropractic Center3301 Ryan Avenue3301 Ryan Avenue

Philadelphia, PA 19136Philadelphia, PA 19136Tel: (215) 332-8686Tel: (215) 332-8686Fax: (215) 332-8691Fax: (215) 332-8691

Ciccarone Chiropractic & Rehab Centers144 East DeKalb Pike, Suite 202King of Prussia, PA 19406Tel: (610) 337-3555Fax: (610) 337-8235E-Mail: [email protected]


CHANGING PARADIGMS

Mechanistic:

CHEMISTRY STRUCTURE FUNCTION

Vitalistic:

ENERGY FIELD CHEMISTRY STRUCTURE UNIFIED FIELDS FUNCTION


Immune System

HumoralImmunityAntibodies

Cell-Mediated ImmunityCellular CytotoxicityDTH

T HelpersCytokines

Antigen-presentingCells

ReticuloendothelialSystem

Stem cells,Cytokines

HaemopoieticSystem

Neuro-endocrineSystem

The Current Consensus Model of the Immune System and Its Relationship to the Neuroendocrine System


Regulation of Immune Responses and the Involvement of Other Systems

Immune System

PositiveRegulatorsT Helpers

Cell-MediatedImmunityCellular CytotoxicityDTH

HumoralImmunityAntibodies

NegativeRegulatorsT Suppressors

Reticulo-endothelial

System

HaemopoieticSystem


OPTIMUM IMMUNITY

THE HUMAN IMMUNE SYSTEM: YOUR MOST RESPONSIVE ALLY

PNI (Psychoneuroimmunology)

PSYCHO – Experience, Interpretation, Translation, Transformation, Mind, Thoughts, Feelings, Notions, Memory, Opinions, Spirit, Soul, Energy-information, Unified Fields

NEURO – Brain (right and left), Spinal cord, Cranial nerves, Spinal nerves, Autonomic nervous system, Memory, Neurotransmitters, Neuropeptides, Neurohormones, Interference by the VSC (Vertebral Subluxation Complex)

IMMUNO – Central and peripheral lymphoid organs, T cells, B cells, Antigen processors, Lymphokines, Cytokines, Neurochemicals, Memory

GASTROENTERO – Gut associated lymphoid tissues, Lymphokines, Neurotransmitters, Breast feeding, Oral tolerance, Memory, Gut reactions

MUSCULOSKELETAL – Receptors, Biomechanics, Posture, Memory, Spinal Learning, Interference from VSC, Exercise Neurochemistry


Rationale For ImmunizationRationale For Immunization

Immunoprophylaxis/Primary Prevention

Herd Immunity

Pre & Post Exposure Immunization


TYPES OF IMMUNITY & TYPES OF IMMUNITY & IMMUNIZATIONIMMUNIZATION

Active

Passive

Natural

Artificial


T HELPER CELL SUBSETS Th 1 Cells (CD4+)

These cells mediate functions connected with cytotoxicity and local inflammatory reactions. Th 1 cells promote development of Tc Cells, the expression of the delayed hypersensitivity, and the production of 1gG2a.

This subset secretes gamma interferon, interleukin 2,3 tumor necrosis factor, lympotoxin, and antibody mediated cell cytotoxicity. Regulation of the Th 2 reactions.

Th 2 Cells (CD4+)

This subset directs immune responses toward production of IgE (atopic diseases), IgA, IgG1.

Eosinophil proliferation via interleukin 5, and mast cells via Il-3 and 4. Th 2 cells secrete Interleukin 3,4,5,6,10. Interleukin 4,5,6 stimulate antibody production.

The Th subsets down-regulate one another1. Gamma interferon secreted from Th 1 cells suppresses the maturation of Th 2 cells

and suppresses the enhancing effect of IL-4 produced by the Th 2 cells on IgE and IgG1 – synthesis

2. IL-10 secreted the Th 2 cells suppresses production of Th 1 cells3. Il-10 possesses cross-regulatory role of inhibiting cytokine synthesis by Th 1 cells

IMMUNOGENS ELICITING A STRONG CELL MEDIATED RESPONSE WILL INHIBIT HUMORAL ACTIVITYSTRONG HUMORAL RESPONSES INHIBIT CELL MEDIATED RESPONSES TO THE SAME ANTIGEN


Ab Titer vs. Time

Time

Ab

Tit

er

Ab Titer Values

Th2 Humoral Immune Response

Ab Titer Values

Time

Ab

Tit

er

Ab Titer Values

Th1 Cell-Mediated Response


Prenatal Skewing toward Th2• Natural

• Artificial/Environmental

Neonatal/Infantile Th1 Stimuli•Birth Canal Flora

•Colostrum

•Breast Milk

•Prebiotics

•Probiotics

•Environmental exposure

•Viruses

•Gram negative bacteria

•Fungi

Neonatal/Infantile Inhibitors to the Th1/Th2 Balance

•C Sections

•Vaccinations

•Antibiotics

•Formula Feeding

•Dysbiosis


JOURNAL ARTICLEISSN

0367-6102Country of Publication

JAPANDatabase: med93-95 – Record 2 of 4 selected.Title

Vaccine strategies: targeting helper T cell responses.Author

Golding B; Scott DEAddressLaboratory of Plasma Derivatives, United States Food and Drug Administration, Bethesda, Maryland 20892, USASource

Ann N Y Acad Sci, 754(-VI-):126-37 1995 May 31AbstractVaccine strategies need to take into account the balance of T helper subsets they induce. TH1 cells, which secrete IFN gamma and IL-2, are associated with CMI, rather than humoral responses, and afford protection against intracellular infections including parasites. In contrast, TH2 cells secrete IL-4, IL-5, and IL-10; elicit high-titer antibody responses and poor CMI; and are associated with susceptibility to infection with intracellular pathogens. Depending on the type of TH cell bias required, it is possible to manipulate the immune response to a protein or peptide by employing (1) different adjuvants, (2) conjugating the protein to various carriers, (3) immunizing in the presence of cytokines, (4) using alternative routes of administration, or (5) using different forms or doses of antigen. To apply these approaches to a particular vaccine, it is necessary to identify which component of the infection agent (e.g., envelope protein or peptide) or allergen to target. Once the type of TH cell response that is protective is identified, it may be possible to combine a protein with an adjuvant or link it to a carrier that will promote responses towards the most advantageous TH subset.


A. Antibody Response following Immunization

PRIMARY & SECONDARYIMMUNE RESPONSES

ANTIBODY FORMATION

Ab Concentration

1* Response 2* Response

195

75

IgM

IgG

5 10 15 20 25 30 35 40 45

DAYS

Characteristic Primary Response vs. Secondary ResponseDose of Immunogen Required >Induction Period <Total Antibody Produced <Duration of Response <IgM antibody produced =IgG antibody produced <

1. A summary of the solvent features of the primary & secondary immune responses


VACCINE TYPES

Whole Organisms (Bacterial)Live Attenuated Inactivated

Tuberculosis (BCG) AnthraxTyphoid Cholera

PertussisPlagueViral Particles

Live Attenuated InactivatedMeasles Hepatitis AMumps InfluenzaRubella Polio (IPV) SalkPolio (OPV) Sabin RabiesVaricellaYellow FeverRotavirus

Purified Macromolecules

Toxoids (Inactivated Exotoxin)

DiphtheriaTetanus

Capsular PolysaccharidesHaemophilus influenza, Type B

(HIB)Neisseria MeningitidesStreptococcus Pneumoniae

Surface AntigensHepatitis B (Recombinant

surface antigen)HbsAg

DNA Vaccines/Genetically Engineered Satellite DNA


TYPICAL COURSE OF AN AUTISTIC PATIENT1. Hepatitis B immunization at 12 hours after birth. DPT immunization at 4 and 8 weeks*,

oral polio immunization also at 4 and 8 weeks, again at 3 months. Schedule now being changed; children will receive 2 doses of live attenuated oral polio and 2 doses killed polio; oral polio can cause disease; only killed polio is used in Europe.

2. Because of great decrease in cell-mediated immunity (CMI) in infants, the vaccines lower CMI further; one decreases CMI by 50%; two together by 70%. Longest safety trail of the triple vaccine (MMR, all live attenuated viruses) was three weeks.

3. Repeated immunizations with 3 vaccines simultaneously, e.g., Pneumococcus, Haemophilus, etc. from 4 weeks to 12 to 18 months. Repeat DPT is given at 12 months. *All these triple vaccines markedly impair CMI.

4. Resultant decrease in CMI predisposes to recurrent viral infections, especially otitis media, since CMI controls response to viruses (also fungi [e.g., Candida], parasites [e.g., leishmaniasis], mycobacterium [e.g., tuberculosis, even if drug resistant] and leprosy).

5. When infections occur, bacterial cultures rarely performed, yet infants repeatedly given antibiotics. Antibiotics are of absolutely no help in viral infections; in some countries, antibiotic administration without a prior culture is considered malpractice.

6. Antibiotics wipe out helpful bacteria in the gut (e.g., lactobacilli, bifidobacteria), which have important protective functions, including prevention of infection by yeast, pathogenic bacteria, and/or parasites. The protection is provided in part by the helpful bacteria clinging to the intestinal cell wall, thus preventing pathogenic microorganisms from getting to it. The pathogenic bacteria compete with the body for vitamin B-12 and perhaps other vitamins and minerals.


Breast FeedingBreast Feeding (PNIEG) -(PNIEG) - PSYCHO-PSYCHO- NEURO-NEURO- ENDOCRINO-ENDOCRINO- IMMUNO-IMMUNO- GASTROINTESTINO-GASTROINTESTINO- NUTRITIONNUTRITION

• BREAST MILK vs. FORMULABREAST MILK vs. FORMULA TOXICITYTOXICITY

• MOTHER – FETUSMOTHER – FETUS• MOTHER - BABYMOTHER - BABY


IMMUNIZATION QUESTIONSAND ISSUES

1. Are vaccines effective? Temporary immunity/deferred susceptibility.

2. Are vaccines safe?Doctors, legislators, parents not informed.

3. Informed consent or conscription?

4. Avoid vaccine reactions by asking:• Is my child sick right now?• Do I know if my child is at risk?• History in family of vaccine reactions or health problems?• Do I know the adverse reactions to the vaccines given to my child?• Do I know the manufacturer and lot number of the vaccine?• Do I know how to report an adverse reaction?

5. Do I know my rights under the state law to exempt my child from vaccines?

6. If I choose not to vaccinate my child, do I know how to recognize and appropriately manage illnesses that vaccines protect against?


CURRENT VACCINATION CONCERNS

1. Emergency State Powers Act

2. State Registry

3. Exemptions Under the Law

4. Thimerosal and Vaccines

5. Autism and Vaccines• Mercury Induced• Autistic

Enterocolitis• Immune Complex Disorder


ImmunostasisTh1/Th2 Balance

High Ratio FXNCMI (Cell Mediated Immunity)

Surveillance

Tolerance

Cytotoxicity

Infection Externalization

Intracellular Infection

Th1 Up Regulators

Welfare Consciousness Patterns

Antioxidants

Glucans & Mushroom Extracts

Melatonin

DHEA (Dehydroepinandrosterone)

Selenium, Zinc

Probiotics

Breast Feeding

Fish Oils

Beta Sterols (Beta-sitosterol & sterolin)

Viral and Bacterial Inf.

Dirt, Dust, Dander

Th2 Up Regulators

Vaccinations

Antibiotics

Emergency Consciousness

Sympathetic Activity+HPAC

Purulent & Parasitic Infection

Trans & Saturated Fats, 6EFA

Oxidation Damage

Mercury Toxicity

Nicotine and Caffeine

Progesterone

Sugar

Environmental Toxins, Hormones, Pesticides, Diesel Fumes

Food Deprivation

Low Ratio FXN

Humoral Immune

Atopic Dermatitis

Allergies & Asthma

Eczema/Psoraisis

Infection Internalization

Toxin Neutralization

Extracellular Infection

System Autoimmunity (Lupus, Graves, Type II Diabetes, RA)

Cancer

AIDS


MAP OF CONSCIOUSNESS God-view Life-View Level Log Emotion Process

Self Is Enlight- 700- Ineffable Pure Con- Enment 1000 sciousness All-Being Perfect Peace 600 Bliss Illumination

One Complete Joy 540 Serenity Transfiguration Loving Benign Love 500 Reference RevelationWise Meaningful Reason 400 Understanding Abstraction

Merciful Harmonious Acceptance 350 Forgiveness Trans- cendence

Inspiring Hopeful Willingness 310 Optimism IntentionEnabling Satisfactory Neutrality 250 Trust Release

Permitting Feasible Courage 200 Affirmation Empowerment Indifferent Demanding Pride 175 Scorn Inflation

Vengeful Antagonistic Anger 150 Hate Aggression Denying Disappointing Desire 125 Craving Enslavement

Punitive Frightening Fear 100 Anxiety WithdrawalDisdainful Tragic Grief 75 Regret Despondency

Condemning Hopeless Apathy 50 Despair AbdicationVindictive Evil Guilt 30 Blame DestructionDespising Miserable Shame 20 Humiliation Elimination

POWER VS. FORCE David R. Hawkins, M.D.,Ph.D.


Health

Interference

Patterns of Interference

Symptoms

Symptom Constellations

Disease

Dis-ease


HEALTH CARE ERAS

Era IChemical, Mechanical, material or physical medicine

Described by being causal, deterministic, hierarchical, bound to classical concepts of space-time. Mind is not a factor; mind is purely the result of brain mechanisms.

Examples are any form of therapy focusing solely on the effects of things (chemical or physical) on the body. Almost all forms of modern allopathic-drugs, surgery, irradiation, etc.


Era IIMind-Body medicine. The role of energy/information on the physical-chemical body is embraced.

Described by the mind being a major factor in healing WITHIN the single person; mind has causal powers. Healing not fully explainable by classical concepts of science. Era 2 includes but goes beyond Era 1.

Examples are any therapy, which has the patient as the focus, complementary approaches are incorporated. Therapies emphasizing the effect of consciousness solely within the individual body: psychoneuroimmunology, chiropractic, hypnosis, homeopathy, acupuncture, biofeedback, relaxation therapies, therapeutic touch, and imagery based therapies.


Era IIINon-local therapy or Eternity Medicine

Described by the mind factoring into healing both WITHIN and BETWEEN persons. Mind not completely localized to points in space (brains or bodies) or time (present moment or single lifetimes). Mind is unbounded in space and time and is ultimately unitary or one. Distance healing possible. Not explainable by classical concepts of space-time or matter-energy.

Examples are any therapy in which effects of consciousness bridge between different persons: all forms of distant healing, intercessory prayer, and transpersonal imagery.

DISEASES ARE SEEN AS IMBALANCES TO BE CORRECTED. IMBALANCES AFFECT THE ENTIRE PERSON (BOTH THE PHYSICAL BODY AND THE ENERGY BODY). IMBALANCES HAVE THE CAPACITY OF AFFECTING THE INDIVIDUAL AS WELL AS THOSE LINKED BY ENERGY. PROPER HEALING NECESSITATES BALANCING ENERGY AS WELL AS CHEMISTRY AND STRUCTURE OF THE BODY. HEALTH AND HEALING CAN BE AFFECTED BY ENERGY/INFORMATION FROM A DISTANCE. PRAYER HAS BOTH A LOCAL AND NON-LOCAL EFFECT ON THE MIND-BODY.


HEALTH CARE ERAS

ERA I MEDICINE: Allopathic Therapies

Paradigm: CHEMISTRY ↔ STRUCTURE ↔ FUNCTION

ERA II MEDICINE: Holistic/Holoenergetic Therapies

Paradigm: ENERGY ↔ CHEMISTRY ↔ STRUCTURE ↔ FUNCTION


ERA III MEDICINE: Intercessory Therapies

Paradigm:UNIFIED ↔ ENERGY ↔ CHEMISTRY ↔ STRUCTURE ↔ FUNCTION FIELDS

Marini 2004 This vaccine webinar series is provided as a community service by Homefirst Natural...

Documents

Transcript of Marini 2004 This vaccine webinar series is provided as a community service by Homefirst Natural...