Maria Leggio Curriculum Vitae

Part I – Education Type Year Institution Notes PhD Degree 1997 Sapienza University of

Rome PhD Degree in “Neuropsychology”, score Excellent

Specialization 1992 “Sacro Cuore” Catholic University, Rome

Specialization in Neurology, score 50/50 cum laude

Licensure: Qualification for medical doctor

1988 “Sacro Cuore” Catholic University, Rome

Qualification for medical doctor (abilitazione all’esercizio della professione medica)

MD degree 1988 “Sacro Cuore” Catholic University, Rome

MD degree, score 110/110 cum laude

High School diploma 1982 High School (Liceo Classico) “Umberto I”, Ragusa

High school focusing on humanities (Liceo Classico), score 60/60

Part II – Appointments IIa – Academic Appointments Start End Institution Position 2017 At present Department of Psychology, Faculty of

medicine and Psychology, Sapienza University of Rome

Full Professor (Professore Ordinario)

2001 2017 Department of Psychology, Faculty of medicine and Psychology, Sapienza University of Rome

Associate Professor (Professore Associato)

1996 2001 Department of Psychology, Sapienza University of Rome

Permanent Research Position (Ricercatore a tempo pieno)

IIb – Academic Responsabilities Start End Institution Position 1998 at present Sapienza University of Rome Member of the board of the PhD Course

in “Psychobiology and Psychopharmacology”, at present “Behavioral Neuroscience”

2011 2014 Sapienza University of Rome Member of the Executive Board (Giunta di Facoltà) of the Faculty of Medicine and Psychology

2011 2012 Sapienza University of Rome Member of the Scientific Research Board (Commissione di Ricerca Scientifica) of the Sapienza University of Rome

2004 2009 Sapienza University of Rome Member of the Evaluation Board (Nucleo di valutazione) of the Faculty of Psychology 1, Sapienza University of Rome

2004 2004 Sapienza University of Rome President of the I State Board (Esami di Stato) for Psychologists

1998 2004 Sapienza University of Rome Member of the Executive Board (Giunta di Dipartimento) of the Department of Psychology, Faculty of Psychology 1, Sapienza University of Rome

Part III – Teaching experience IIIa – Teaching: Degree Courses Year Institution Lecture/Course 2012 – at present

Sapienza University of Rome “Cognitive Neuroscience” at the Degree Course (three years) "Psychology and Health", Department of Psychology, Faculty of Medicine and Psychology. Appointed GOMP 9 CFU

2014 – at present

Sapienza University of Rome Laboratory of “Neuropsychological evaluation and Rehabilitation” at the Specialized Degree Course (two years) "Cognitive Neuroscience Evaluation and Neuropsychological Rehabilitation ", Department of Psychology, Faculty of Medicine and Psychology. Appointed GOMP 2 CFU

2009 - 2012

Sapienza University of Rome “Cognitive Neuroscience” at the Degree Courses (three years) "Psychological Sciences and Techniques of analysis and evaluation of the cognitive processes", Department of Psychology, Faculty of Medicine and Psychology. Appointed GOMP 8 CFU (6 + 2 CFU of Laboratory)

2008 - 2009

Sapienza University of Rome “Basis of Psychobiology and Psychophysiology” at the Degree Courses (three years) "Psychological Sciences and Techniques of analysis and evaluation of the cognitive processes ", Faculty of Psychology 1. Appointed GOMP 8 CFU

2003 - 2009

Sapienza University of Rome “Neuroscience laboratory: preclinic models of cognitive dysfunctions” at the Specialized Degree Course (two years) "Evaluation and Treatment of cognitive dysfunctions", Faculty of Psychology 1. Appointed GOMP 2 CFU

2002 - 2008

Sapienza University of Rome “Basis of Psychophysiology” at the Degree Courses (three years) "Normal and pathological cognitive processes", Faculty of Psychology 1. Appointed GOMP 4 CFU

2002 -2008

Sapienza University of Rome “Behavioral physiological basis” at the Degree Courses (three years) "Psychological Sciences and Techniques of the Clinical Intervention for the Individual, the Group and the Institutions", Faculty of Psychology 1. Appointed

GOMP 4 CFU

2003 - 2005

Sapienza University of Rome “Basic Neuroanatomy and Neurophysiology” at the Specialized Degree Course (two years) "Dynamic and Clinical Psychology of Individual, Organizations and Community", Faculty of Psychology 1. Appointed GOMP 4 CFU

2000 - 2002

Sapienza University of Rome “Psychophysiology”, at the Degree Courses “Psychology”, Faculty of Psychology 1. Academic year duration (annualità)

1999 - 2000

Sapienza University of Rome “Basic Neuroanatomy and Neurophysiology”, at the Degree Courses “Psychology”, Faculty of Psychology 1. Academic year duration (annualità)

IIIb – Teaching: PhD Courses Year Institution Lecture/Course 1998 – at present

Sapienza University of Rome Member of the teaching staff of the PhD Course in “Psychobiology and Psychopharmacology”, at present “Behavioral Neuroscience”

IIIc – Teaching: Master and Specialization Courses Year Institution Lecture/Course 2013 – at present

Sapienza University of Rome “Neuropsychology of the Neurodegenerative diseases” at the Specialization Course in "Neuropsychology ", Department of Psychology, Faculty of Medicine and Psychology Appointed GOMP 2 CFU

2013 – at present

Sapienza University of Rome “Neurobiological basis in Autism Spectrum Disorders:

role of the Cerebellum” at the 2nd level University

Master degree"Autism Spectrum Disordersin the Adolescence", Faculty of Medicine and Psychology Appointed GOMP 2 CFU

2009 – 2013 Sapienza University of Rome “Clinical framework of the main neurodegenerative diseases” at the Specialization Course in "Neuropsychology ", Department of Psychology, Faculty of Medicine and Psychology Appointed GOMP 4 CFU

IIId – Tutoring and Supervisor activity Year Institution Lecture/Course 1996 – at present

Sapienza University of Rome Tutoring and supervisory activity of degree students, PhD students, Postdoctoral researchers (Assegnisti di Ricerca)

Part IV - Society memberships, Awards and Honors

IVa – Society Memberships

Year Title 1994 – at present Society for Neuroscience (SfN)

1995 – at present European Brain and Behaviour Society (EBBS)

1997 – at present Società Italiana di Neurologia (SIN)

2007 – at present Società Italiana di Neuropsicologia (SINP)

2007 – at present Società Italiana di Riabilitazione Neurologica (SIRN)

2008 – at present Society for Research on the Cerebellum (SRC)

2008 – at present Federation of the European Societies of Neuropsychology (ESN)

2008 – at present Federation of European Neuroscience Societies (FENS)

2016 – at present Society for Research on the Cerebellum and Ataxias (SRCA)

IVb – Reviewing Activity Journal Brain, Journal of Neuroscience, Cortex, NeuroImage, Journal of Neurology Neurosurgery and Psychiatry, Neurobiology of Learning and Memory, Plos One, Experimental Brain Research, Behavioural Brain Research, Brain and Language, The Cerebellum, Cerebellum & Ataxias, Neuropsychologia, Neuropsychology, Progress in Neuro-Psychopharmacology & Biological Psychiatry, European Journal of Neurology, Behavioural Neurology, Behavioural Processes, Cognition and Emotion, Neurological Sciences, Physiotherapy Theory and Practice, Scientific Reports.

Scientific Projects

- Blue-Sky Programme, Agence Nationale de la Recherche - ANR

- FIRB, Ministero dell'Istruzione, dell'Università e della Ricerca - MIUR IVc – Congress Organization Year Title 2014 Member of the Scientific Committee of the “Sixth International SRC Congress”

2012 Member of the Scientific Committee of the symposium on “The Cerebellum in the cognitive functions: actor or walk-on?” at the Annual meeting of the Italian Society of Neuropsychology.

2008 Member of the Scientific Committee of the symposium on “Cerebellum and Language” at the

1st Meeting of the Federation of the European Societies of Neuropsychology.

1992 Member of the Scientific Secretary of Satellite Symposium of the 15th Annual Meeting of the European Neuroscience Association on “Thalamic networks for relay and modulation"

Part V - Funding Information [grants as PI-principal investigator or I-investigator]

Year Title Program Grant value

2016 Study on the cerebellar role in Pathological Gambling: an insight into the neurobiological basis of Impulse Control Disorders.

Ricerca Universitaria, Sapienza University of Rome

4000,00 euros Principal Investigator

2015 "Combined behavioral, neuroimaging and noninvasive brain stimulation studies of

Ricerca Universitaria, Sapienza University of

30.000,00 euros Investigator

the ability to understand another person's mental states in participants with Autism Spectrum Disorders and patients with Cerebellar Diseases." – Prot. C26H15MSBK

Rome

2014 "The cerebellar role in the emotional processing." – Prot. C26A14R2FP

Ricerca Universitaria, Sapienza University of Rome

10.000,00 euros Investigator

2013 "An integrate neuropsychological, morphofunctional and connectivity study of the cerebellar functionality" – Prot. C26A1329AR

Ricerca Universitaria, Sapienza University of Rome

11.000,00 euros Principal Investigator

2011-2012

Not-permitted to submit university grant applications as member of the Scientific Research Board (Commissione di Ricerca Scientifica) of the Sapienza University of Rome

2010 "Relazioni anatomo-funzionali tra circuitazioni sotto- e neo-corticali" – Prot. C26A10SY7C

Ricerca Universitaria, Sapienza University of Rome

9.000,00 euros Principal Investigator

2009 "Ruolo del cervelletto nella regolazione delle componenti cognitivo-emozionali sottese ai processi di scelta." – Prot. C26F09EYKZ

Ricerca di ateneo Federato di scienza e della Tecnologia AST, Sapienza University of Rome

3.600,00 euros Principal Investigator

2009 "Uno studio nell'uomo e nell'animale della funzionalità cognitiva cerebellare" – Prot. C26A09RR3J

Ricerca Universitaria, Sapienza University of Rome

24.050,00 euros Investigator

2008 "Interazione cerebello-frontale nel controllo delle funzioni esecutive. Studio clinico e sperimentale." – Prot. C26A08KFWE

Ricerca Universitaria, Sapienza University of Rome

10.000,00 euros Principal Investigator

2007 "Stimolazione ambientale e modificazioni neuronali. Studio morfologico nel ratto in un paradigma di "ambiente arricchito" – Prot. C26F07BB5L

Ricerca di ateneo Federato di scienza e della Tecnologia AST, Sapienza University of Rome

1.200,00 euros Principal Investigator

2007 "Ipotesi colinergica della malattia di Alzheimer: modificazioni comportamentali, strutturali e biochimiche in modelli sperimentali e clinici." – Prot. C26A07Z3FK

Ricerca Universitaria, Sapienza University of Rome

26.600,00 euros Investigator

2006 “Il ruolo del cervelletto nelle funzioni esecutive: studio clinico e sperimentale.” – Prot. C26A06XEEE

Ricerca di Ateneo, Sapienza University of Rome

7.000,00 euros Principal Investigator

2006 "Interazione cerebello-corticale nell'elaborazione di informazioni sensoriali. Studio neuropsicologico e neurofisiologico." – Prot. C26F06B7PL

Ricerca di Facoltà, Sapienza University of Rome

7.000,00 euros Principal Investigator

2005 “Contributo del Cervelletto all’elaborazione corticale dell’informazione sensoriale. Studio Neuropsicologico e neurofisiologico” – Prot. C26H15MSBK

PRIN, Ministero, dell’Istruzione, dell’Università e della Ricerca

Total 154.000,00 euros (Unit 27.900 euros) (Operative Unit)

2005 "Stop and Go! Ruolo del cervelletto nei Ricerca di Facoltà, 1.078,00 euros

processi di inibizione." – Prot. C26F052933

Sapienza University of Rome

Principal Investigator

2005 "Il ruolo del cervelletto nella funzione spaziale: uno studio sperimentale e clinico" – Prot C26A050120

Ricerca di Ateneo, Sapienza University of Rome

9.500,00 euros Investigator

2004 "Effetti dell'arricchimento ambientale sulle abilità spaziali. Studio morfologico e comportamentale in ratti." – Prot. C26F042114

Ricerca di Facoltà, Sapienza University of Rome

1.092,00 euros Principal Investigator

2004 “Ruolo dei circuiti cerebellari in compiti discriminativi" – Prot. C26A041020

Ricerca di Ateneo, Sapienza University of Rome

27.600,00 euros Investigator

2003 “Ruolo delle circuitazioni cerebellari nei processi di memoria spaziale “ – Prot. C26F038537

Ricerca di Facoltà, Sapienza University of Rome

1.279,00 euros Principal Investigator

2003 “Le funzioni cognitive nelle lesioni cerebellari:correlazioni fra modelli animali e dati clinici" – Prot. C26A039974

Ricerca di Ateneo, Sapienza University of Rome

10.000,00 euros Investigator

2002 "Valutazione del ruolo cerebellare nell'elaborazione di informazioni sensoriali ritmiche e sequenziali" – Prot. C26F023114

Ricerca di Facoltà, Sapienza University of Rome

1.226,00 euros Principal Investigator

2001 "Studio neuropsicologico delle abilità discriminative sensoriali in soggetti con danno cerebellare" – Prot. C26F011797

Ricerca di Facoltà, Sapienza University of Rome

1.441,00 euros Principal Investigator

Part VI – Research Activities VIa-Research Topics

Current research topics

Keywords Brief Description Cerebellum, cognition, Behaviour

Study of the cerebellar role on different cognitive and behavioral domains by means of integrated neuropsychological, neurophysiological and neuroimaging approach. Characterization of specific cognitive profiles according to etiology and localization of the cerebellar damage

Sequence theory Development of a “sequence hypothesis” that allows to explain the specificity of the cerebellar involvement in the multifarious motor and non-motor domains

Visuospatial functions, Sensorized platform

Study of the visuospatial abilities in cerebellar disorders. Study of the cerebellar role in spatial procedural learning. Setting up a sensor-equipped platform, named “SmarTile”, an innovative tool managed by a software developed ad hoc to study the sequential learning abilities within the spatial.

Mood, Emotion, Study of mood alterations and emotional functions in patients affected by

Decision-making, Cerebellum

cerebellar pathologies by means of MoMo, a mood monitoring device that has been developed at the Ataxia Lab to characterize mood alteration in patients. Study of a possible cerebellar role in the feelings subtending decision-making processes.

Social cognition, Cerebello-Cortical circuits

Study of the involvement of the cerebello-cortical circuits in the social cognition domain by using an integrated behavioral, neuroimaging and neurophysiological approach in patients affected by cerebellar pathology. Study of the effects of the cerebellar excitability modulation by means of transcranial direct current stimulation (tDCS) on specific social cognition aspects in healthy subjects.

Voxel-based morphometry, Diffusion-based tractography, Resting state functional MRI

Investigation of the structural and functional patterns of cerebello-cortical circuits in cerebellar patients and healthy subjects to explore the impact of cerebellar damage on cognitive and emotional functions. Investigation of the structural and functional patterns of cerebello-cortical circuits in subjects affected by autistic spectrum disorders, in order to explore whether specific features of these networks may account for specific aspects of the autistic disorders

Research topics – in progress

Keywords Brief Description Cerebellar tDCS, neurorehabilitation

Study of the behavioral effects of tDCS over the cerebellum, in order to clarify the specific role of cerebello-cortical networks in cognitive and emotional functions. Study of cerebellar tDCS effects in order to explore new rehabilitation approaches

Virtual reality, Cerebellar functions

Use of virtual reality to investigate the interaction between motor, cognitive, and behavioral functions of the cortico-cerebellar circuits within the framework of the “sequence detection theory”. Use of virtual reality techniques to implement new neuro-rehabilitation protocols, specifically aimed at the recovery of the cerebellar disabilities

Autism, Neuro-biological basis

Study of the Theory of Mind (ToM) performances and of the neuro-anatomical alterations in patients affected by cerebellar disease and in subjects with Autism Spectrum Disorders (ASDs). Characterization of the role of the cerebello-cortical circuits in specific ToM aspects by means of an ad-hoc ToM battery and advanced MRI methods to evaluate the structural and functional alterations in cerebellar-cortical circuits of cerebellar patients and ASDs subjects

Previous research topics

Keywords Brief Description Enviromental enrichment, Animal

Characterization of the effects of environmental enrichment on the cortical neuronal morphology in the rat.

model Study of the behavioral effects of environmental enrichment in a rat model of Alzheimer’s disease. Study of the relationship between environmental enrichment and cognitive reserve in rats with or without basal forebrain cholinergic lesions

Hemycerebellectomy, Rat

Characterization of the non-motor cerebellar role in a rat model of surgical hemicerebellectomy:

- acquisition of the procedural components of spatial exploration; - disentanglement of the cerebellar role in spatial procedural learning

and in spatial working memory; - study of the cerebellar role in observational learning.

Spatial procedural learning, NMDA receptor, Cerebellum, Hippocampus

Characterization of the hippocampal and cerebellar role in spatial procedural learning by using an NMDA receptor antagonist (CGS 19755) in the rat.

Thalamocortical networks, Animal model

Characterization of different aspects of the Thalamocortical networks: - hymmunoistochemical characterization of the Thalamic Intralaminar

Nuclei in the cat; - study of the nucleus-specific expression of GABAA receptor subunit in

monkey Thalamus; - hymmunoistochemical characterization of the Auditory

Thalamocortical pathways in the monkey.

VIb- Research Experience and Responsibility Years Institution Position 2003 – at present

Department of Psychology, University of Rome "La Sapienza"

Chief of the laboratory “Cognitive Neuroscience and Cerebellum”

2006 – at present

IRCCS Santa Lucia Foundation, Rome Chief of Ataxia Lab

1999 – at present

IRCCS Santa Lucia Foundation, Rome Scientific advice at the Research Institute

VIc- Research Experience in qualified International Institutions Years Institution Position 1993, 1994, 1995

Frontier Research Program (chief of the lab. Prof. E.G. Jones), RIKEN Institute, Wako, Saitama, Japan

Visiting Researcher

1993,1994 Institute of Anatomy and Neurobiology (chief of the lab. Prof. E.G. Jones), University of California Irvine, Irvine, CA, USA

Visiting Researcher

VId- Scientific Collaborations

- Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy - Psychology Department, Catholic University, Milan, Italy - Neuroscience Department, Catholic University, Rome, Italy - Center for Mind/Brain Sciences, University of Trento,Italy - Neurological and Spinal Cord Injury Rehabilitation Department A, IRCCS Santa Lucia Foundation,

Rome, Italy - Physiology and Pharmacology Department, Sapienza University of Rome, Italy - Clinical Imaging Science Center , Brighton and Sussex Medical School, Brighton , UK. - Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique (CNRS), Lyon

France - Sobell Department of Motor Neuroscience and Movement Disorders- UCL Institute of Neurology –

London - Department of Anatomy and Neurobiology, University of California, Irvine

- Laboratory for Neural Systems, Frontier Research Program

Part VII – Summary of Scientific Achievements

Total Impact factor 240,896

Total Citations Scopus: 2.874; ISI: 2.538; Google Scholar: 3.898.

Average Citations per Product Scopus: 41,65; ISI: 40,28; Google Scholar: 44,79.

Hirsch (H) index Scopus: 31; ISI: 30; Google Scholar: 34.

Part VIII – Publications

International indexed peer-reviewed publications

1. Clausi S., Iacobacci C., Lupo M, Olivito G., Molinari M., Leggio M.. The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review. Applied Sciences 7(5), 521, 2017 doi:10.3390/app7050521 In Press

2. Olivito G., Brunamonti E., Clausi S., Pani P., Chiricozzi F.R., Giamundo M., Molinari M., Leggio M., Ferraina S.. Atrophic degeneration of cerebellum impairs both the reactive and the proactive control of movement in the stop signal paradigm. Exp Brain Res 235(10), 2971-2981, 2017. doi: 10.1007/s00221-017-5027-z.

3. Olivito G., Dayan M., Battistoni V., Clausi S., Cercignani M., Molinari M., Leggio M., Bozzali M..

Bilateral effects of unilateral cerebellar lesions as detected by voxel based morphometry and diffusion imaging. PLoS ONE Jul 10;12(7):e0180439. doi:10.1371/journal.pone.0180439, 2017

4. Tedesco A.M., Bianchini F., Piccardi L., Clausi S., Berthoz A., Molinari M., Guariglia C., Leggio M.. Does the cerebellum contribute to human navigation by processing sequential information? Neuropsychology Online First Publication, February 23, 2017. http://dx.doi.org/10.1037/neu0000354 [Epub ahead of print]

5. Olivito G., Cercignani M., Lupo M., Iacobacci C., Clausi S., Romano S., Masciullo M., Molinari M., Bozzali M., Leggio M.. Neural substrates of motor and cognitive dysfunctions in SCA2 patients: a

network based statistics analysis. NeuroImage: Clinical 14, 719-725, 2017

6. Adamaszek M., D’Agata F., Ferrucci R., Habas C., Keulen S., Kirkby K.C., Leggio M., Marien P., Molinari M., Moulton E., Orsi L., Van Overwalle F., Papadelis C., Priori A., Sacchetti B., Schutter D.J., Styliadis C., Verhoeven J.. Consensus Paper: Cerebellum and Emotion. Cerebellum, [Epub ahead of print: 2016 Aug 2] 16(2), 552-576, 2017.

7. De Vico Fallani F., Clausi S., Leggio M., Chavez M., Valencia M., Maglione AG., Babiloni F., Cincotti F., Mattia D., Molinari M. Interhemispheric Connectivity.Characterizes Cortical Reorganization in Motor-Related Networks After Cerebellar Lesions. Cerebellum [Epub ahead of print: 2016 Jul 2.]16(2), 358-375, 2017.

8. Olivito G., Clausi S. , Laghi F., Tedesco A.M. , Baiocco R, Mastropasqua C., Molinari M.,

Cercignani M., Bozzali M., Leggio M.. Resting State functional connectivity changes between Dentate Nucleus and cortical social brain regions in Autism Spectrum Disorders. Cerebellum [Epub ahead of print: 2016 Jun 1] (2), 283-292, 2017.

9. Dayan M., Olivito G., Molinari M., Cercignani M., Bozzali M., Leggio M.. Impact of cerebellar

atrophy on cortical grey matter and cerebellar peduncles as assessed by voxel based morphometry and high angular resolution diffusion imaging. Functional Neurology, 31(3): 1-10, 2016

10. Clausi S., Coricelli G., Pisotta I., Pavone E.P., Lauriola M., Molinari M., Leggio M.. Cerebellar damage impairs the self-rating of regret feeling in a gambling task. Frontiers in Behavioral Neuroscience, 9:113, 2015.

11. Lupo M., Troisi E., Chiricozzi F.R., Clausi S., Molinari M., Leggio M. Inability to Process

Negative Emotions in Cerebellar Damage: a Functional Transcranial Doppler Sonographic Study. Cerebellum, 14(6), 663-669, 2015.

12. Baumann O., Borra R.J., Bower J.M., Cullen K.E., Habas C., Ivry R.B., Leggio M., Mattingley J.B.,

Molinari M., Moulton E.A., Paulin M.G., Pavlova M.A., Schmahmann J.D., Sokolov A.A. Consensus Paper: The Role of the Cerebellum in Perceptual Processes. Cerebellum, 14(2), 197-220, 2015.

13. Leggio M. and Molinari M. Cerebellar Sequencing: a Trick for Predicting the Future.

Cerebellum., 14(1), 35-38, 2015. 14. Brunamonti E., Chiricozzi F.R., Clausi S., Olivito G., Giusti M.A., Molinari M., Ferraina S., Leggio

M.G.. Cerebellar damage impairs executive control and monitoring of movement generation.. PLoS One, Jan 17;9(1):e85997, 2014.

15. Mariën P., Ackermann H., Adamaszek M., Barwood C.H.S., Beaton A., Desmond J., De Witte E.,

Fawcett A.J., Hertrich I., Küper M., Leggio M., Marvel C., Molinari M., Murdoch B.E., Nicolson R.I., Schmahmann J.D., Stoodley C.J., Thürling M., Timmann D., Wouters E., Ziegler W. Consensus Paper: Language and the cerebellum: an ongoing enigma. Cerebellum, 13(3), 386-410, 2014.

16. Clausi S., Aloise F., Contento M.P., Pizzamiglio L., Molinari M., Leggio M. Monitoring mood

states in everyday life: A new device for patients with cerebellar ataxia. Psychiatry Research, 220(1-2), 719-721, 2014.

17. Clausi S., De Luca M., Chiricozzi F.R., Tedesco A.M., Casali C., Molinari M., Leggio MG.. Oculomotor deficits affect neuropsychological performance in oculomotor apraxia type 2. Cortex, 49(3), 691-701, 2013.

18. Perciavalle V., Apps R., Bracha V., Delgado-García J.M., Gibson A.R., Leggio M., Carrel A.J.,

Cerminara N., Coco M., Gruart A., Sánchez-Campusano R.. Consensus Paper: Current Views on the Role of Cerebellar Interpositus Nucleus in Movement Control and Emotion. Cerebellum, 12(5), 738-757, 2013.

19. Tedesco A.M., Chiricozzi F.R., Clausi S., Lupo M., Molinari M., Leggio M.G.. The cerebellar

cognitive profile. Brain, 134(pt 12), 3672-3686, 2011. 20. Leggio M.G., Chiricozzi F.R., Clausi S. Tedesco A.M., Molinari M.. The neuropsychological

profile of cerebellar damage: the sequencing hypothesis. Cortex,47, 137-144, 2011.

21. Petrosini L., De Bartolo P., Foti F., Gelfo F., Cutuli D., Leggio M.G., Mandolesi L.. On whether the environmental enrichment may provide cognitive and brain reserve. Brain Research Rev, 61(2), 221-239, 2009.

22. Gelfo F., De Bartolo P., Giovine A., Petrosini L., Leggio M.G.. Layer and regional effects of enviromental enrichment on the pyramidal neuron morphology of the rat. Neurobiology of Learning and Memory, 91, 353-365, 2009.

23. Molinari M., Restuccia D., Leggio M.G.. State Estimation, Response Prediction, and Cerebellar

Sensory Processing for Behavioral Control.Cerebellum, 8(3), 399-402, 2009. 24. Clausi S., Bozzali M., Leggio M.G., Di Paola M., Hagberg G., Caltagirone C., Molinari M..

Quantification of grey matter changes in the cerebral cortex after isolated cerebellar damage: a voxel-based morphometry study. Neuroscience, 162(3), 827- 835, 2009.

25. Mandolesi L., De Bartolo P., Foti F., Gelfo F., Federico F., Leggio M.G., Petrosini L. Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion.Journal of Alzheimer’s Disease, 15, 11-28, 2008.

26. De Bartolo P., Leggio M.G., Mandolesi L., Foti F., Gelfo F., Ferlazzo F., Petrosini L.

Environmental enrichment mitigates the effects of basal forebrain lesions on cognitive flexibility behaviors. Neuroscience, 154, 444 - 453, 2008.

27. Leggio M.G., Tedesco A.M., Chiricozzi F.R., Clausi S., Orsini A.and Molinari M.. Cognitive sequencing impairment in patients with focal or atrophic cerebellar damage. Brain 131 (Pt 5), 1332-1343, 2008.

28. Chiricozzi F.R., Clausi S., Molinari M. and Leggio M.G.. Phonological short-term store impairment after cerebellar lesion: a single case study. Neuropsychologia, 46/7, 1940-1953,2008.

29. Molinari M., Chiricozzi F.R., Clausi S. Tedesco A.M., De Lisa G.M., Leggio M.G. Cerebellum and detection of sequences, from perception to cognition. Cerebellum, 7(4), 611-615, 2008.

30. Restuccia D., Della Marca G., Valeriani M., Leggio M.G., Molinari M.Cerebellar damage impairs detection of somatosensory input changes. A somatosensory mismatch-negativity study. Brain 130 (Pt 1), 276-287, 2007.

31. Mandolesi L., Leggio M.G., Spirito F., Federico F., Petrosini L. Is the cerebellum involved in the

visuo-locomotor associative learning? Behav Brain Res, 184: 47-56, 2007. 32. Molinari M. and Leggio M.G. Cerebellar information processing and visuospatial functions.

Cerebellum, 6: 214-220, 2007. 33. Molinari M., Leggio M.G. and Thaut M.H. The cerebellum and neural networks for rhythmic

sensorimotor synchronization in the human brain. Cerebellum 6(1): 18-23, 2007.

34. Leggio M. G., Federico F., Neri P., Graziano A., Mandolesi L. and Petrosini L. NMDA receptor activity in learning spatial procedural strategies: I. The influence of hippocampal lesions. Brain Research Bulletin 70, 347-355, 2006.

35. Federico F., Leggio M. G., Neri P., Mandolesi L. and Petrosini L. NMDA receptor activity in

learning spatial procedural strategies. II. The influence of cerebellar lesions Brain Research Bulletin 70, 356-367, 2006.

36. Federico F., Leggio M. G., Mandolesi L. and Petrosini L. The NMDA receptor antagonist CGS

19755 disrupts recovery following cerebellar lesions. Restorative Neurology and Neuroscience, 24, 1-7, 2006.

37. Molinari M., Leggio M.G., Filippini V., Gioia M.C., Cerasa A. and Thaut M. Sensorimotor

transduction of time information is preserved in subjects with cerebellar damage. Brain Res Bull, 67, 448-458, 2005.

38. Leggio M.G., Mandolesi L., Federico F., Spirito F., Gelfo F., Ricci B. and Petrosini L..

Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat. Behav Brain Res, 163, 78-90, 2005.

39. Mantuano E., Veneziano L., Spadaro M., Giunti P., Guida S., Leggio M.G., Verricello L., Wood

N., Jodice C. and Frontali M. Clusters of non-truncating mutation of P/Q type Ca2+ channel subunit Cav2.1 causing episodic ataxia 2. J Med Genet, 41, 2004.

40. Molinari M., Petrosini L., Misciagna S. and Leggio M.G.. Visuospatial abilities in cerebellar

disorders. J Neurol Neurosur Psychiat, 75, 235-240, 2004.

41. Petrosini L., Graziano A., Mandolesi L., Neri P., Molinari M. and Leggio M.G.. Watch how to do it! New advances in learning by observation. Brain Research Reviews, 42(3), 252-264, 2003.

42. Mandolesi L, Leggio M.G., Spirito F. and Petrosini L. Cerebellar contribution to spatial event processing: do spatial procedures contribute to formation of spatial declarative knowledge?European Journal of Neuroscience, 18(9), 2618-2626, 2003.

43. Leggio M.G., Graziano A ., Mandolesi L., Molinari M., Neri P. and Petrosini L. A new paradigm

to analyze observational learning in rats.Brain Research Protocols, 12(2), 83-90, 2003. 44. M. Molinari, Leggio M. G., De Martin M., Cerasa A., and Thaut M.. Neurobiology of rhythmic

motor entrainment.Annals of the New York Academy of Sciences. Vol 999, 313-321, 2003. 45. Molinari M., Filippini V. and Leggio M.G.. Neuronal plasticity of interrelated cerebellar and

cortical networks. Neuroscience, 111 (4), 863-870, 2002.

46. Graziano A., Leggio M.G., Mandolesi L., Neri P., Molinari M. and Petrosini L.. Learning power of single behavioral units in acquisition of a complex spatial behavior: an observational learning study in cerebellar-lesioned rats.Behavioral Neuroscience, 116, 116-125, 2002.

47. Mandolesi L., Leggio M.G., Graziano A., Neri P. and Petrosini L.. Cerebellar contribution to

spatial event processing: involvement in procedural and working memory components. European Journal of Neuroscience, 14(12), 2011-2022, 2001.

48. Leggio M.G., Molinari M., Neri P., Graziano A., Mandolesi L. and Petrosini L. . Representation of actions in rats: The role of cerebellum in learning spatial performances by observation. P Natl Acad Sci USA, 97, 2320-2325, 2000.

49. Leggio M.G., Silveri M.C., Petrosini L. and Molinari M. Phonological grouping is specifically

affected in cerebellar patients: a verbal fluency study. J Neurol Neurosur Psychiat, 69, 102-106, 2000.

50. Leggio M.G., Neri P., Graziano A., Mandolesi L., Molinari M. and Petrosini L. Cerebellar

contribution to spatial event processing: characterization of procedural learning. Exp Brain Res, 127, 1-11, 1999.

51. Silveri M.C., Misciagna S., Leggio M.G. and Molinari M.. Cerebellar spatial dysgraphia: further

evidence. J Neurol, 246, 312-313, 1999. 52. Silveri M.C., Di Betta A.M., Filippini V., Leggio M.G. and Molinari M.. Verbal short-term store-

rehearsal system and the cerebellum. Evidence from a patient with a right cerebellar lesion. Brain, 121, 2175-2187, 1998.

53. Petrosini L., Leggio M.G. and Molinari M.. The cerebellum in the spatial problem solving: a co-

star or a guest star? Prog Neurobiol, 56, 191-210, 1998.

54. Molinari M., Leggio M.G., Solida A., Ciorra R., Misciagna S., Silveri M.C. and Petrosini L.. Cerebellum and procedural learning: evidence from focal cerebellar lesions. Brain, 120, 1753-1762, 1997.

55. Silveri M.C., Misciagna S, Leggio M.G., Molinari M.. Spatial dysgraphia and cerebellar lesion: a case report. Neurology, 48, 1529-1532, 1997.

56. Molinari M., Leggio M.G., Silveri M.C.. Verbal fluency and agrammatism. Int Rev Neurobiol,

41, 325-339, 1997. 57. Huntsman M.M., Leggio M.G. and Jones E.G., Nucleus-specific expression of GABAA receptor

subunit mRNAs in monkey thalamus. J Neurosci, 16, 3571-3589, 1996. 58. Silveri M.C. and Leggio M.G.. Influence of disorders of visual perception in Word-to-Picture

Matching Tasks in patients with Alzheimer's disease. Brain and Language, 54, 326-334, 1996. 59. Leggio M.G., Cappa A., Molinari M., Corsello S.M. and Gainotti G.. Pseudotumor Cerebri as

presenting syndrome of Addisonian crisis. Ital J Neurol Sci, 16, 387-389, 1995.

60. Molinari M., Dell'Anna M.E., Rausell E., Leggio M.G., Hashikawa T. and Jones E.G.. Auditory Thalamocortical pathways defined in Monkeys by Calcium-Binding Protein Immunoreactivity. J Comp Neurol, 362, 171-194, 1995.

61. Huntsman M.M., Leggio M.G. and Jones E.G., Expression patterns and deprivation effects on

GABAA receptor subunit and GAD mRNAs in monkey lateral geniculate nucleus. J Comp Neurol,

352, 235-247, 1995.

62. Di Lazzaro V., Restuccia D., Nardone R., Leggio M.G., Oliviero A., Profice P., Tonali P., Molinari M.. Motor cortex changes in a patient with hemicerebellectomy. Electroencephalograpfy and Clinical Neurophysiology, 97, 259-263, 1995.

63. Silveri M.C., Leggio M.G., Molinari M.. The Cerebellum contributes to linguistic production: a

case of agrammatic speech following a right cerebellar lesion. Neurology, 44, 2047-2050, 1994. 64. Di Lazzaro V., Molinari M., Restuccia D., Leggio M.G., Nardone R., Fogli D., Tonali P.A..

Cerebro-Cerebellar interactions in man: neurophysiological studies in patients with focal cerebellar lesions. Electroenceph Clin Neurophysiol, 93, 27-34, 1994.

65. Di Lazzaro V., Restuccia D., Molinari M., Leggio M.G., Nardone R., Fogli D., Tonali P.A.. Excitability of the Motor Cortex to Magnetic Stimulation in patients with cerebellar lesions. J Neurol Neurosur Psychiat, 57, 108-110, 1994.

66. Hashikawa T., Leggio M.G., Hattori R. and Yui Y.. Nitric Oxide synthase immunoreactivity

colocalized with NADPH-diaphorase histochemistry in monkey Cerebral Cortex. Brain Res, 641, 341-349, 1994.

67. Molinari M., Leggio M.G., Dell' Anna M.E., Giannetti S., Macchi G.. Chemical

compartmentation and relationships between Calcium-binding protein immunoreactivity and layer-specific cortical and caudate-projecting cells in the anterior intralaminar nuclei of the cat. Eur J Neurosci, 6(3), 299-312, 1994.

International non indexed peer-reviewed publications

68. Molinari M., Restuccia D. and Leggio M.G.. Cerebellar information flow in the thalamus. Implications for cortical functions. Thalamus and Related Systems, 3 (2),141-146, 2005.

69. Popken G.J., Leggio M.G., Bunney Jr W.E. and Jones E.G.. Expression of mRNAs related to the GABAergic and glutamatergic neurotransmitter systems in the human thalamus: normal and schizophrenic. Thalamus and Related Systems, 1, 349-369, 2002.

70. Hashikawa T., Molinari M., Rausell E., Dell'Anna M.E., Leggio M.G. and Jones E.G.. Auditory Cortex: Chemoarchitecture and connectional organization. RIKEN Review, 9, 9-10, 1995.

National non indexed publications

71. Molinari M., Leggio M.G., Di Lazzaro V.. Experimental correlations between cerebral blood flow and cortical functions after cerebellar lesions. Acta Medica Romana 34 (3), 320-327, 1996.

Book Chapters

72. Leggio, M.. Clinical Functional Topography in Cognition. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (Eds.), Essentials of Cerebellum and Cerebellar Disorders, Springer. Chapter 53, pp. 391–396, 2016

73. Molinari, M., Leggio, M.. Cerebellum: Cognitive Functions. In: James D. Wright (editor-in-chief), International Encyclopedia of the Social & Behavioral Sciences, 2nd edition, Vol 3. Oxford: Elsevier. pp. 327–331, 2015

74. Molinari M. and Leggio M..Cerebellum and Verbal Fluency (Phonological and Semantic). In: “The Linguistic Cerebellum” P. Mariën and M. Manto (eds.), Academic Press, Chapter 4, pp. 63-80, 2015

75. Molinari M., Viscomi M.T. and Leggio M.G.. Hemicerebellectomy. In: “Handbook of the

Cerebellum and Cerebellar Disorders” M. Manto, D. Gruol, J. Schmahmann, N. Koibuchi and F. Rossi (eds.), Springer New York Heidelberg Dordrecht London. Part 5, pp. 1579-1594, 2013

76. Molinari M. and Leggio M.G..Cerebellar sequencing for cognitive processing. In: “Handbook

of the Cerebellum and Cerebellar Disorders” M. Manto, D. Gruol, J. Schmahmann, N. Koibuchi and F. Rossi (eds.), Springer New York Heidelberg Dordrecht London, Part 6, pp. 1701-1715, 2013

77. Molinari M. and Leggio M.G. Cerebellum: clinical pathology. In “ Encyclopedia of

Neuroscience” L.R. Squire (ed.), Oxford: Academic Press, vol. 2, pp. 737-742, 2009 78. Molinari M., Filippini V., Leggio M.G.. Cervelletto e comportamento. Deficit procedurale e

controllo affettivo. In:”Il Cervelletto. Dalle funzioni cognitive alla psicopatologia” P. Castrogiovanni and L. Luccarelli (eds.), SEE – Firenze, pp.69-80, 2000.