Maria Kallergi, 1 John J. Heine, 2 and Ernest Wollin 3 1 TEI of Athens, Athens, Greece
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Transcript of Maria Kallergi, 1 John J. Heine, 2 and Ernest Wollin 3 1 TEI of Athens, Athens, Greece
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Magnetic Resonance Electrical Impedance Mammography (MREIM)
A new approach to breast cancer imaging
Maria Kallergi,1 John J. Heine,2 and Ernest Wollin3
1 TEI of Athens, Athens, Greece2 Moffitt Cancer Center & Research Institute, Tampa, FL3 Wollin Ventures, Inc, Sarasota, FL
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What do we propose? Combination of magnetic resonance and
electrical impedance for breast imaging Combination of magnetic differences with
electrical conductivity differences between normal and malignant breast tissue
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Why this combination? All in the effort to increase specificity which is
low to moderate in standard breast MRI and thus avoid false positive detections and negative biopsies
All in the effort of developing a more sensitive and specific tool than mammography for breast cancer screening and diagnosis without any unwanted effects
All in the effort of a highly sensitive and specific technique without the challenges of image reconstruction and patient risk (MREIT or Tomosynthesis)
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MREIM in a nutshell Current is supplied to electrodes embedded
within breast coil stabilization paddles during MR image acquisition
Current creates magnetic field that interferes with the normal MR image acquisition mainly in areas of higher conductivity (malignant tissue)
Subtraction of images obtained with current on and off will produce a signature of malignancy
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Can it deliver?
Theory Experiment Simulation
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Theory Malignant breast tissue has higher electrical
conductivity (3-40 times) than normal and benign breast tissue
Current creates magnetic field that interferes with the normal MR field Interference effect is particularly enhanced in
areas of higher conductivity such as breast malignant tissues
The subtraction of the images obtained with current on and off is likely to have a specific “signature” related to malignancy
Mathematically … it works out!
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THEORY: MREIM Effects
FE PE
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Experiment Breast Phantom Faraday Shields Phantom-Faraday Shields Coupling Circuitry Sequence for Phantom Imaging
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MREIM Apparatus & Circuitry
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Experimental Result
Images (sagittal view) of phantom with tumor surrogate acquired with a spin density spin echo sequence with TE=50 ms, TR=2 s, NEX=1, slice thickness=4mm, FOV=128 mm, dx=1 mm and df =60 Hz/pix
(a) Current off, (b) Current on (i = 10 A/m2 at f = 300 Hz), (c) Current off.
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Simulation Replicate and explain experimental results Determine MREIM effect for various tumor
models Optimize MREIM sequence for well-defined
differential signal at low applied currents Used MR spin-echo sequence
Frequency encode effect Detects the tumor bed
Phase encode effect Detects boundaries where conductivity changes
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Simulation Result
(a) Current off
(b) Current on (i = 10 A/m2 at f = 300.008 Hz, df = 60 Hz/pix and , STDnoise= 2)
(b)-(a) Subtraction image of current on and current off
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Where we are Theory and simulation agree Theory, simulation, and experiment agree Proof of concept demonstrated
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Next Step Develop modality specific phantom with
stable electrical and physical properties Optimize MREIM sequence through phantom
experiments Construct MR compatible, comfortable, and
patient safe clinical system Clinical trial
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Breaking News AB Miller, C Wall, CJ Baines, P Sun, T To, and
SA Narod (BMJ 2014;348-g366) 25-year follow up of mammography-based
screening “… education, early diagnosis, and excellent clinical
care should continue to be provided to women to ensure that as many breast tumours as possible are diagnosed at or less than 2 cm.”
“ … the value of mammography screening should be reassessed.”
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Thank you And … special thanks to Nataliya Kovalchuk,
who did most of the pilot experiments during her PhD work at University of South Florida and Moffitt Cancer Center & Research Institute