Manchester April 10th 2008 1 Hadrontherapy in France Proton Clinical centers; Centre de...
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Manchester April 10th 20081
Hadrontherapy in FranceProton
Clinical centers; Centre de Protonthérapie d’Orsay ~ 1000 pts/year(new cyclotron)- Restricted beam time for research (Institut Curie)-A room dedicated to reseach is planned in new installation
Centre Lacassagne à Nice 3185 pts since 92 up to 06 - practically no reseach activity
New Clinical and research proton center planned in Toulouse ???
Carbon Clinical center ETOILE in Lyon A room dedicated to reseach is planned but high clinical activity from Heath Minister planning (~1000pts/year)
R&D center ARCHADE in CaenInstallation dedicated to reseach in cooperation with IBA
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Manchester April 10th 20082
Proton beam lineProton beam line
Treatment roomTreatment room
NICE
MEDICYCMEDICYC65 MeV protons 65 MeV protons Isochronus cyclotronIsochronus cyclotron
3
CYBERKNIFE
18O (p,n) 18F18O (p,n) 18F
GDR MI2B , Paris CPO, 5 juin 2007
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Manchester April 10th 20083
Cyclotron et voie de faisceau
GDR MI2B , Paris CPO, 5 juin 2007GDR MI2B , Paris CPO, 5 juin 2007
Autorisation 01-1987
Bâtiment 07-1989
1er traitement proton 06-1991
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Manchester April 10th 20084
Voie de faiceau protonthérapie oculaire
5 10 -3 cm
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Manchester April 10th 20085
Protonthérapie oculaire
Activité du Cyclotron Biomédical (06/91-12/06)
Mélanomes Choroïdiens
Mélanomes iriens
Conjonctives
Angiomes
Autres
DMLA
2474
78
123
65
16
429
Total 3185
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Manchester April 10th 20086
J. Remillieux ETOILE
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Manchester April 10th 20087
Building implantation (one gantry, two tratment’ rooms with horizontal beam and one reseach
dedicated room)
Synchrotron
Gantry
Salles d'irradiation avec faisceau
horizontal
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Manchester April 10th 20088
J. Remillieux
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Manchester April 10th 20089
J. Remillieux
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Manchester April 10th 200810
J. Remillieux
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Manchester April 10th 200811
UN CENTRE DE RESSOURCES EUROPEEN
EN HADRONTHERAPIE A CAEN
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Manchester April 10th 200812
Building’s project
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Manchester April 10th 200813
Implantation of the Archade center at GANIL in Caen
GANIL (Grand Accélérateur d’ions lourds
CIRIL : centre de recherches interdisciplinaires
LARIA: centre de recherches en radiobiologie
CYCERON : centre d’imagerie médicale
LPC/ENSI Caen: laboratoire avec spécialité dosimétrie
CHU : centre hospitalier universitaire
Baclesse : centre anticancéreux
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Manchester April 10th 200814
Faire si nécessaire des expériences sur animaux pour vérifier le plan de traitement
La société IBA propose de construire le cyclotron à Louvain-la-Neuve, de le tester, puis de le démonter et l’installer à Caen sur le campus du GANILARCHADE aurait la charge de construire le bâtiment pour abriter cette machine, puis de mener, avec une équipe de 12 à 15 chercheurs, les études nécessaires définissant les conditions requises pour traiter un premier patient en mode recherche vers à fin 2011.
contribuer à améliorer un modèle radio biologique applicable à la planification de traitements par faisceau de carbone
Contribuer au développement, à l’adaptation et à la validation d’un système de plan de traitement incluant le calcul des EBR pour aller de la dose physique à la dose biologique équivalente
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Manchester April 10th 200815
Dans le cadre du Programme National de Recherches en Hadronthérapie (PNRH), émanation de l’INCa : Archade vient en complément des activités de l’Institut Curie, d’ETOILE, du Centre A. Lacassagne (Nice). Ouverture aux laboratoires du CEA, de l’INSERM et de l’IN2P3/CNRS
Outil de développement mis à disposition de recherches pour des laboratoires et centres cliniques européens.
Partenariat avec des industriels
Le financement du bâtiment et des fluides est assuré par le Conseil Régional de Basse-Normandie (CRBN) Un pré-accord a été signé le 7 février entre le CRBN et IBA d’une part, et entre ARCHADE et IBA d’autre part
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Manchester April 10th 200816
Review of the main actors involved in hadrontherapy in
France
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Manchester April 10th 200817
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Manchester April 10th 200818
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Manchester April 10th 200819
Activities at the interface between physics, biology and medicine need a
frame to allow involved patners to cooperate
Creation of a specific entity like a virtual laboratory
« Groupement de Recherche MI2B» for instrumentation and simulation in medical
and molecular imaging
R&D for new mehods and instruments for health and life science based on R&D for high energy
physics
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Manchester April 10th 200820
Imaging for therapy and diagnostic in oncology and neurology
Multimodal imaging
per-operatoir probes
in vivo imaging for small animals
in vivo imaging for hadrontherapy
and also:-Radiobiology (EBR)-in situ 3D Dosimetry-Microdosimetry -Measurement of physical data for TPS (cross section)-Simulation for TPS
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Manchester April 10th 200821
8 of the IN2P3 Laboratories are involved in GDR MI2B:CENBG Bordeaux, CPP Marseille, IMNC Orsay, IPN Lyon, LPC Caen, LPC Clermont, LPSC Grenoble, Subatech Nantes
~45 physicists~30 Eng.&Tech.
~15 PhD
~1/3 are specifically involved in R&D for hadrontherapy
IN2P3 urge communauty to federate into one main and visible project (at European level)