Management of Obstetrical Hemorrhage Jeffrey Stern, M.D.
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Transcript of Management of Obstetrical Hemorrhage Jeffrey Stern, M.D.
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Management of Obstetrical Hemorrhage
Jeffrey Stern, M.D.
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Incidence of Obstetrical Hemorrhage
• 4% of SVD• 6.4 % of C-sections• 13% of maternal deaths (1:10,000 to 1:1,000)• 10% risk of recurrence
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Etiology of Obstetrical Hemorrhage: Antepartum
• Placenta previa• Abruption• Coagulopathy: ITP/pre-eclampsia, FDIU
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Etiology of Obstetrical Hemorrhage: Intrapartum
• Placenta previa• Abruption• Abnormal placentation• Genital tract lacerations: (2.4 odds ratio)• Uterine rupture• Coagulopathy: infection, abruption, amniotic fluid
embolism
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Etiology of Postpartum Hemorrhage (Primary)(Within 24 hours of delivery)
• Uterine atony (3.3 odds ratio) • Induction or Augmentation of labor (1.4 odds
ratio)• Retained products of conception (3.5 odds ratio)• Placenta accreta, increta, percreta (3.3 odds
ratio)• Coagulopathy • Fetal death in utero• Uterine inversion – may need MgSO4,
Halothane, Terbutaline, NTG• Amniotic fluid embolism
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Etiology of Postpartum Hemorrhage (Secondary)(After 24 hours of delivery to 6 weeks postpartum)
• 0.5-2% of patients• Infection• Retained products of conception with atony• Placental site involution• Rx: D+C, ABX, uterotonic medications
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Uterine Atony: 1 in 20 to 1 in 100 deliveries (80% of PPH)
• Uterine over distension (Polyhydramnios, Multiple gestations, Macrosomia)
• Prolonged labor: “uterine fatigue” (3.4 odd ratio)• Precipitory labor• High parity• Chorioamnionitis• Halogenated anesthetic• Uterine inversion
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Treatment of Uterine Atony
• Message fundus continuously• Uterotonic agents• Foley catheter/Bakri balloon (500cc)• Uterine packing usually ineffective but can
temporize• Modified B-Lynch stitch (#2chromic)
– Uterine, utero-ovarian, hypogastric artery ligation– Subtotal/Total abdominal hyst.
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Treatment of Uterine Atony
• Oxytocin – 90% success– 10-40 units in 1 liter NS or LR rapid infusion
• Methylergonovine (Methergine) 90% success– 0.2 mg IM q 2-4 hours max. 5 doses; avoid with hypertension
• Prostaglandin F2 Alpha (Hemabate) 75% success– 250 micrograms IM, intramyometrial, repeat q 20-90 min. max. 8
doses; Avoid if asthma/Hi BP
• Prostaglandin E2 suppositories (Dinoprostone, Prostin E2) 75% success– 20 mg per rectum q 2 hours; avoid with hypotension
• Prostaglandin PGE 1 Misoprostol (Cytotec) 75% - 100% success– 1000 microgram per rectum or sublingual (ten 100 micrograms
tabs/five 200 micrograms tabs)
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Retained Products of Conception: Etiology
• Succentiurate lobe• Placenta accreta, increta, percreta• Previous C-section; hysterotomy• Previous puerperal curettage• Previous placenta previa• High parity
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Management of Retained Products of Conception
• Examine placenta carefully• Manual exploration of uterus• Careful curettage-Banjo curret
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Placenta Accreta, Increta, Percreta: Risk Factors
• High Parity• Previous placenta previa• Previous C-section• GTN• Advanced maternal age• Previous uterine abnormal placentation
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Management of Abnormal Placentation
• Placenta will not separate with usual maneuvers• Curettage of uterine cavity• Localized resection and uterine repair: (Vasopressin
1cc/10cc N.S-sub endometrial)• Leave placenta in situ
– If not bleeding: Methotrexate– Uterus will not be normal size by 8 weeks
• Uterine, utero-ovarian, hypogastric artery ligation• Subtotal/total abdominal hysterectomy
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Uterine Inversion: 1 in 2500 Deliveries
• Risk factors: Abnormal placentation, excessive cord traction
• Treatment– Manual replacement– May require halothane/general anesthesia– Remove placenta after re-inversion– Uterine tonics and massage after placenta is removed– May require laparotomy
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Coagulopathy
• Hereditary• Acquired
– Preganancy induced hypertension– Abruption– Sepsis– Fetal death in utero– Amniotic fluid embolism– Massive blood loss
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Genital Tract Laceration and Hematomas: Etiology
• Macrosomia• Forceps• Episiotomy• Precipitous delivery• C-section incision extension• Uterine rupture
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Therapy of Genital Tract Lacerations
• Superficial lacerations and small hematomas: expectant
• Large laceration– Repair in layers– Consider a drain
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Hematomas
• Below pelvic diaphragm: (vulva, paracolpos, ischiorectal fossa)– Leave alone if possible– Legate bleeder - often difficult to find– Pack open– Drain– May need combined abdominal/perineal approach
• Above the pelvic diaphragm– Laparotomy- especially if expanding– Combined abdominal/perineal approach
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Selective Artertial Embolization by Angiography
• Clinically stable patient – Try to correct coagulopathy
• Takes approximately 1-6 hours to work• Often close to shock, unstable, require close
attention• Can be used for expanding hematomas• Can be used preoperatively, prophylactically for
patients with accreta• Analgesics, anti-nausea medications, antibiotics
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Selective Artertial Embolization by Angiography
• Real time X-Ray (Fluoroscopy)• Access right common iliac artery• Single blood vessel best• Embolize both uterine or hypogastric arteries• Sometimes need a small catheter distally to prevent reflux into non-
target vessels• May need to treat entire anteriordivision or even all of the internal
iliac artery.• Risks: Can embolize nearby organs and presacral tissue, resulting
in necrosis• Technique
– Gelfoam pads – Temporary, allows recanalization– Autologous blood clot or tissue– Vasopressin, dopamine, Norepinephrine– Balloons, steel coils
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Evaluate for Ovarian Collaterals
May need to embolize
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Mid-Embolization “Pruned Tree Vessels”
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Post Embolization
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Post Embolization
Pre Embo Post Embo
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Uterine Rupture
• Scarred versus scarless uterus• Uterine scar dehiscence: separation of scar without
rupture of membranes– 2-4% of deliveries after previous transverse uterine incision– Morbidity is usually minimal unless placenta is underneath or it
tears into the uterine vessels– Diagnosis after vaginal delivery
• Often asymptomatic, incidental finding
• Difficult to diagnose because lower uterine segment is very thin
• Therapy is expectant if small and asymptomatic
– Diagnosed at C-section: Simple debridement and layered closure
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Uterine Rupture Etiology
• Previous uterine surgery - 50% of cases– C-section, Hysterotomy, Myomectomy
• Spontaneous (1/1900 deliveries)• Version-external and internal• Fundal pressure• Blunt trauma• Operative vaginal delivery• Penetrating wounds
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Uterine Rupture Etiology
• Oxytocics• Grand multiparity• Obstructed labor• Fetal abnormalities-macrosomia, malposition,
anomalies• Placenta percreta• Tumors: GTN, cervical cancer• Extra-tubal ectopics
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Classic Symptoms of Uterine Rupture
• Fetal distress• Vaginal bleeding• Cessation of labor• Shock• Easily palpable fetal parts• Loss of uterine catheter pressure
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Uterine Rupture
• Myth: Uterine incisions which do not enter the endometrial cavity will not
• subsequently rupture• Type of closure: no relation to tensile strength
– Continuous or interrupted sutures: chromic, vicryl, Maxon– Inverted or everted endometrial closure
• Degree of complications– Inciting event- spontaneous, traumatic– Gestational age– Placental site in relation to rupture site– Presence or absence of uterine scar
• Scar: 0.8 mortality rate• No scar: 13% mortality rate
– Location of scar• Classical scar- majority of catastrophic ruptures• Transverse scar- less vascular; less likely to involve placenta
– Extent of rupture
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Management of Uterine Rupture
• Laparotomy– Debride and repair in 2-3 layers of Maxon/PDS– Subtotal Hysterectomy– Total Hysterectomy
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Pregnancy After Repair of Uterine Rupture
• Not possible to predict rupture by HSG/Sono/MRI
• Repair location– Classical -------------------------48%– Low transverse------------------16%– Not recorded---------------------36%
• Re-rupture-------------------12%• Maternal death--------------1%• Perinatal death--------------6%• (Plauche, W.C 1993)
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Modified Smead-Jones Closure
• Running looped #1 PDS/Maxon– Contaminated wounds/under tension
• Additional Interruptured sutures - 2 cm apart
– Fascial edges should be approximated– No tension