Malignant Catarrhal Fever Symptoms
Transcript of Malignant Catarrhal Fever Symptoms
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Malignant Catarrhal FeverMalignant Catarrhal FeverSymptoms Symptoms
Jeffrey Musser, DVM, PhD Professor Moritz van VuurenJeffrey Musser, DVM, PhD Professor Moritz van VuurenSuzanne Burnham, DVMSuzanne Burnham, DVM
Texas A&M University Texas A&M University UniversityUniversity of Pretoriaof PretoriaCollege of Veterinary Medicine College of Veterinary Medicine Department of Department of
Veterinary Tropical DiseasesVeterinary Tropical Diseases
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Host RangeHost Range
The disease can The disease can occur in cattle, occur in cattle, domesticated domesticated buffaloes, a wide buffaloes, a wide range of captive range of captive antelopes and deer, antelopes and deer, and freeand free--living deer. living deer.
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Under natural conditions only Under natural conditions only domestic cattle and deer develop domestic cattle and deer develop clinical signs clinical signs
MCF has never been reported in freeMCF has never been reported in free--living wild animals in Africaliving wild animals in Africa
Host RangeHost Range
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Host RangeHost Range
In zoological collections a wide variety of In zoological collections a wide variety of ruminant species have been reported to ruminant species have been reported to develop clinical signsdevelop clinical signs
Rabbits can be infected experimentallyRabbits can be infected experimentally
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Host RangeHost Range
It was recently confirmed in pigs in It was recently confirmed in pigs in ScandinaviaScandinavia
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Reservoir ruminant speciesReservoir ruminant speciesReservoir ruminant species
Blue wildebeestBlue wildebeest
Black wildebeestBlack wildebeest
Domestic sheepDomestic sheep
GoatsGoats
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Blue WildebeestBlue Wildebeest
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Black WildebeestBlack Wildebeest
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Malignant Catarrhal FeverMalignant Catarrhal Fever
TransmissionTransmission
Neonatal and adolescent wildebeest shed virus Neonatal and adolescent wildebeest shed virus
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Transmission from reservoir Transmission from reservoir animals to domestic cattle, deeranimals to domestic cattle, deer
contact with calving wildebeest
contact with lambing sheep
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Cattle are more susceptible to Wildebeest derived MCF than to the sheep or goat MCF
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Congenital TransmissionCongenital Transmission
Cow will die then later calf will dieCow will die then later calf will die
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Malignant Catarrhal Fever: Malignant Catarrhal Fever: Clinical SignsClinical Signs
In some cases MCF presents as chronic In some cases MCF presents as chronic alopecia and weight loss as with deer alopecia and weight loss as with deer infected with the Caprine herpesvirus.infected with the Caprine herpesvirus.
However, MCF is typically fatal.However, MCF is typically fatal.
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical SignsThere are many factors that affect the There are many factors that affect the duration of the disease in different speciesduration of the disease in different speciesThe severity of the clinical symptoms will The severity of the clinical symptoms will depend on those factors. Mortality is depend on those factors. Mortality is usually 100% but some animals face usually 100% but some animals face weeks of progressive diseaseweeks of progressive diseaseFor this reasons, once the disease is For this reasons, once the disease is identified, most elect to euthanized the identified, most elect to euthanized the affected animal.affected animal.
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
High fever 106High fever 106--107107°°F (41F (41--41.541.5°°C)C)DepressionDepressionIn deer In deer -- sudden deathsudden deathDeer and bison that survive 2Deer and bison that survive 2--3 days:3 days:–– Hemorrhagic diarrheaHemorrhagic diarrhea–– Bloody urineBloody urine–– Corneal opacityCorneal opacity–– Then deathThen death
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
The longer the animal survives the course The longer the animal survives the course of the disease the more severe the signs of the disease the more severe the signs become.become.
For example, animals that die acutely may For example, animals that die acutely may not develop lymphadenopathy or corneal not develop lymphadenopathy or corneal opacityopacity
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Malignant Catarrhal FeverMalignant Catarrhal Fever
As the disease progresses:As the disease progresses:
Catarrhal inflammationCatarrhal inflammationErosions and exudates in upper Erosions and exudates in upper respiratory tract, ocular and oral mucosarespiratory tract, ocular and oral mucosaSwollen lymph nodesSwollen lymph nodesLamenessLamenessCNS signs (depression, tremors, stupor, CNS signs (depression, tremors, stupor, hypohypo--responsive, aggression, convulsionsresponsive, aggression, convulsions
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
On average the time to death for On average the time to death for European cattle is longer than for deer, European cattle is longer than for deer, bison and water buffalo; usually 7bison and water buffalo; usually 7--17 days 17 days after the appearance of clinical signsafter the appearance of clinical signs
In cattle the swollen lymph nodes and In cattle the swollen lymph nodes and severe eye lesions are more frequentsevere eye lesions are more frequent
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
Hemorrhagic enteritis and cystitis are Hemorrhagic enteritis and cystitis are more frequently seen in bison and deer more frequently seen in bison and deer than in cattlethan in cattleSkin lesions are common in animals that Skin lesions are common in animals that do not succumb quicklydo not succumb quicklyMost eventually die, about 5% recover Most eventually die, about 5% recover clinicallyclinically
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical signsClinical signs
Depressed and VERY SICKDepressed and VERY SICKStertorousStertorous respirationrespirationEnlarged lymph nodesEnlarged lymph nodes
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
Animals suffer, are painful and cannot breathe well
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
Secondary bacterial bronchopneumonia may be eventual cause of death if not euthanized first
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
Painful swollen eyes
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
Ocular and Ocular and nasal dischargenasal discharge
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Malignant Catarrhal FeverMalignant Catarrhal Fever
“snotsiekte”
Clinical SignsClinical Signs
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Mucopurulent discharge, crusting occludes the nostril; animal begins open mouth breathing.
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Malignant Catarrhal FeverMalignant Catarrhal Fever
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Malignant Catarrhal FeverMalignant Catarrhal Fever
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Progresses to total opacity
Early corneal opacity beginsat the limbus
Characteristic of MCF
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical SignsClinical Signs
Severe panophthalmitis, hypopion, corneal Severe panophthalmitis, hypopion, corneal erosions are more frequent in cattleerosions are more frequent in cattle
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Severe Ocular lesionsSevere Ocular lesions
Painful Conjunctivitis
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Severe Ocular lesionsSevere Ocular lesions
Progresses to corneal opacity beginning at Limbus
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Severe Ocular lesionsSevere Ocular lesions
Characteristic eye lesions
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Severe Ocular lesionsSevere Ocular lesions
Characteristic eye lesions
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Severe Ocular lesionsSevere Ocular lesions
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Oral LesionsOral Lesions
Erosions on gums, dental pad and near Erosions on gums, dental pad and near teethteeth
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Oral LesionsOral Lesions
Erosions near the teethErosions near the teeth
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Oral LesionsOral Lesions
Necrosis of papillae similar to rinderpestNecrosis of papillae similar to rinderpest
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Oral LesionsOral Lesions
Erosions here are similar to bluetongue in Erosions here are similar to bluetongue in AfricaAfrica
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Erosions of papillae
Oral LesionsOral Lesions
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Oral LesionsOral Lesions
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Erosions in squamous (anterior) portion of nasal cavity
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Enlarged and edematouslymph nodes
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Moist necroticdermatitis withexudation and encrustations
Skin lesions associated with both sheep form and wildebeest derived.Resembles foot-and-mouthdisease
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Mild diarrhea sometimes seen
which is black andtarry, but not
effusive
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Malignant Catarrhal FeverMalignant Catarrhal Fever
In terminal stages CNSsymptoms: falling, circling,head pressing, high steppingconvulsions, then death
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical Signs in SwineClinical Signs in SwineFrom a case in Norway:Symptoms reported as: hyperemic conjunctiva,
vomiting, restlessness and anorexia. The rectal temperature was 41° C, the respiratory rate was 33 per minute, and the heart rate was 110 per minute. Despite parenteral antibiotic treatment, the symptoms worsened and the pig died 5 days after onset of disease. Over a short period, three other adult swine in the same herd died after showing similar clinical signs.
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Clinical Features SummaryClinical Features SummaryIncubation period is LONG Incubation period is LONG –– weeks to monthsweeks to monthsMorbidity LOW Morbidity LOW Clinical illness Clinical illness –– weight loss, enlarged lymph weight loss, enlarged lymph nodes, corneal opacity, rhinitisnodes, corneal opacity, rhinitisMortality Mortality –– 100%100%
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Diagnosis at NecropsyDiagnosis at Necropsy
The disease is systemic and lesions can The disease is systemic and lesions can be found in any organbe found in any organInflammation and necrosis of the Inflammation and necrosis of the respiratory, alimentary and urinary mucosarespiratory, alimentary and urinary mucosaGeneralized lymphoid proliferation and Generalized lymphoid proliferation and necrosisnecrosisWidespread vasculitisWidespread vasculitis
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Focally disseminated erosions and Focally disseminated erosions and ulcerations in the GITulcerations in the GIT
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Focally disseminated erosions and Focally disseminated erosions and ulcerations in the GITulcerations in the GIT
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Malignant Catarrhal FeverMalignant Catarrhal Fever
““button ulcersbutton ulcers”” 55--10 cm erosions10 cm erosions
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Frequently see erosions in the bladder mucosa
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Lymphoid infiltration
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Multifocal lymphoid infiltrationMultifocal lymphoid infiltration
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Multifocal lymphoid infiltrationMultifocal lymphoid infiltration
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Malignant Catarrhal FeverMalignant Catarrhal Fever
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Enlarged lymphoid tissue – everywhere
– looks like lymphoma
Tonsils bulge
Lymph nodes –TOO BIG
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Spleen infiltrated
Hemal nodes are prominent
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Malignant Catarrhal FeverMalignant Catarrhal Fever
Peyer’s patches stand out
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Malignant Catarrhal FeverMalignant Catarrhal Fever
DiagnosisDiagnosis
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Malignant Catarrhal FeverMalignant Catarrhal Fever
DiagnosisDiagnosis
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Malignant Catarrhal FeverMalignant Catarrhal Fever
HistopathologyHistopathology
T lymphocytehyperplasia,cell necrosis
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Malignant Catarrhal FeverMalignant Catarrhal Fever
HistopathologyHistopathology
Severe necrotizingSevere necrotizingvasculitisvasculitis
Perivascular Perivascular lymphoid infiltrationlymphoid infiltration
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Malignant Catarrhal FeverMalignant Catarrhal Fever
HistopathologyHistopathology
Perivascular lymphoid Perivascular lymphoid infiltration of arteriolesinfiltration of arterioles
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Malignant Catarrhal FeverMalignant Catarrhal Fever
SummarySummaryThink Malignant Catarrhal fever when: Think Malignant Catarrhal fever when:
Only a few cattle are affected and they dieOnly a few cattle are affected and they dieCattle have been exposed to sheep during Cattle have been exposed to sheep during lambing seasonlambing seasonCattle have severe respiratory symptoms Cattle have severe respiratory symptoms and conjunctivitis with cornel opacityand conjunctivitis with cornel opacityLesions are on the ventral side of the Lesions are on the ventral side of the tonguetongue
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Malignant Catarrhal FeverMalignant Catarrhal Fever
This presentation is a collaborative effort