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Making the Most of Your Cell Press Journal Access onEgyptian Knowledge Bank

Sponsored by Egyptian Knowledge Bank and Cell Press

Dr / Ahmed MokhtarResearcher activity Coordinator

Accessing journals on EKB

Finding Cell Press journals on EKB

Finding journals on EKB

Introduction to Cell Press

• History

• Content

• Areas of Coverage

– Life Sciences

– Expansion into Physical Sciences

• Role in Innovation

– Article of the Future, Article 360

– Sneak Peek

– Cross Talk Blog

Cell was launched in 1974

"a journal of exciting biology“Founder Benjamin Lewin

Solicit and manage

submissions

Manage peer review

Production

Publish and disseminate

Edit and prepare

Archive and promote

use

• 30 Million Researchers• 180+ countries• 480 million+ downloads per year

• 7,000 editors•70,000 editorial board members• 7 million author/publisher communications / year

• 500,000 reviewers• 600,000 authors publishing

• 2,500 journals• 19,000 books• 2,000 new books per year

• 40 – 90% of articles rejected

• 10.4 million articles now available

• 450,000 new articles produced each year• 185 years of back issues scanned, processed and data-tagged

Cell Press familyis part of Elsevier publishing

Family of Journals• 19 Primary Research Journals

– Chem and Joule are the newest launched in physical sciences

• 7 partner journals (including E BioMedicine)

• 15 Trends Review journals

• 6 Open Access journals, now including iScience

• Cell Press is part of Elsevier (over 2500 journals)

Primary research journals

Life and Physical Sciences

Publisher of record 2017

NEWEST

NEWEST

Reviews Journals

NEWEST

Trends in ChemistryLaunching April 2019

Open Access Journals

NEW

Cell is the most downloaded ScienceDirect journal

• Cell is the most downloaded journal on SD with 11M in 2017

• Cell Press has more than 65 million downloads on ScienceDirect in

2017

• Cell Press journals deliver 1 out of every 25 article downloaded on SD

• Cell Press represents 1% of all content but accounts for 6% of SD usage

• Avg. usage per title is 14 times higher than all other titles on SD

is highly read and cited content on ScienceDirect

Most read content on ScienceDirect

With 65 million downloads in 2017,Cell

Press Journals is the most widely downloaded

journals group on ScienceDirect .

Most Cited content on ScienceDirect

Cell Press has 160,000 articles available

online; these articles received 5.5 million

citations between 1996 and 2014.

in the global news network

Chinese Monkeys

https://www.youtube.com/watch?v=N-4Y6ZCIRig

https://www.youtube.com/watch?v=lVRYA8MD0S8

https://www.youtube.com/watch?v=N-4Y6ZCIRig

https://www.youtube.com/watch?v=lVRYA8MD0S8

Publishes Seminal Research, and the World Takes Notice

Timely

innovates in delivering content

Activity

STAR Methods found within Cell Press

Innovates in delivering content

innovates in delivering content

encourages dialog & connections

Journals

Cell Press Content on EKB

CellCell Aims and Scope

Cell publishes findings of unusual significance in any area of experimental biology, including but not limited to cell biology,

Impact and Utility▪ Content: >19,800 articles online▪ Usage: >13 million global downloads in 2017▪ Impact Factor: 30.41▪ Cite Score: 22.79▪ Issues Per Year: 26 issues per year

Journal Profile Cell

CellJournal Profile Cell

• Molecular biology (transcription, RNAi splicing,• RNA editing, DNA replication and repair, protein

synthesis and editing, protein modification and degradation, and chromatin)

• Cell biology (cell cycle, subcellular organization, protein and membrane transport, protein folding and stability, and signal transduction)

• Immunology (T Systems biology• cell selection, lymphocytes and immunoglobulins, and

somatic hypermutation)• Neuroscience (learning and memory, neuronal

guidance and connections, and synaptic transmission)• Biophysics

Topics

Molecular Cell Aims and Scope

Molecular Cell aims to publish the best research in molecular biology and welcomes submissions which:

– Provide interesting mechanistic insights into the pathways covered by the journal, and that connect these pathways to important biological and disease contexts.

– Use large-scale, systems-level, and high-throughput datasets to derive new biological insights not easily obtained by other approaches

Impact and Utility▪ Content: >7,000 articles online▪ Usage: >3.7 million global downloads in 2017▪ Impact Factor: 14.71▪ Cite Score: 12.18▪ Issues Per Year: 24 issues per year

Journal Profile Molecular Cell

Journal Profile Molecular Cell

• DNA replication, recombination, and repair• Chromatin biology and genome organization• Transcription• RNA processing and decay• Non-coding RNA function• Translation• Protein folding, modification, and quality control• Signal transduction pathways• Cell cycle and checkpoints• Cell death• Metabolism

Topics

Cancer Cell Aims and ScopeCancer Cell provides a high-profile forum to promote major advances in cancer research and oncology.


Journal Profile Cancer Cell


•Genetics, epigenetics, and genomic instability

•Cell signaling and communication•Cell cycle and DNA repair•Diagnostics (molecular profiling and pharmacogenomics)

•Angiogenesis and metastasis•Cancer therapy (rational drug design and small-molecule and biological molecule therapeutics)

Topics

Cell Stem Cell Aims and Scope

Cell Stem Cell is a broad-spectrum journal that covers the entire spectrum of stem cell biology.

Cell Stem Cell publishes research reports describing novel results of unusual significance in all areas of stem cell research.

Cell Stem Cell is edited by an expert team of in-house editors and is

affiliated with the International Society for Stem Cell Research (ISSCR). For more information about the ISSCR, see http://www.isscr.org.

Impact and Utility▪ Content: >2,100 articles online▪ Usage: >1.7 million global downloads in 2017

▪ Impact Factor: 23.39▪ Cite Score: 14.04▪ Issues Per Year: 12 issues per year

Journal Profile Cell Stem Cell

http://www.isscr.org/


• Embryonic stem cells (Chinese monkeys)• Tissue-specific stem cells• Stem cell differentiation• Epigenetics• Stem cell genomics and systems biology• Genome reprogramming• Cancer stem cells• Stem cell-based disease models• Bioengineering• In vivo imaging of stem cells• Therapeutic applications• Regenerative medicine

Topics

Immunity Aims and ScopePublishes papers that report the most important advances in immunology research. The range of subjects includes, but is not limited to, immune cell development and senescence, signal transduction, gene regulation, innate and adaptive immunity, autoimmunity, infectious disease, allergy and asthma, transplantation, and tumor immunology.

Impact and Utility

▪ Content: >4,600 articles online▪ Usage: >2.7 million global downloads in 2017▪ Impact Factor: 22.85▪ Cite Score: 17.17▪ Issues Per Year: 12 issues per year

Journal Profile Immunity


• Immune cell development and senescence• Signal transduction• Gene regulation• Innate and adaptive immunity• Cytokines and inflammatory responses• Autoimmunity and tolerance• Infectious disease• Tumor immunology• Vaccine biology• Transplantation biology• Allergy and asthma

Topics

Cell Metabolism Aims and ScopeCell Metabolism's scope includes diabetes, obesity, pancreatic beta cell function, adipose tissue biology(white, brown, and beige), lipid metabolism, cardiovascular biology, immunometabolism, bone homeostasis, aging and stress responses, a, neuronal control of metabolism and metabolic derangements causing neurodegeneration, circadian biology,


Journal Profile Cell Metabolism


• Diabetes• Obesity• Energy balance• Cardiovascular disease• Adipocyte and lipid biology• Aging and stress response• Mitochondria• Hypertension• Bone homeostasis• Molecular endocrinology

Topics

Cell Host & Microbe Aims and Scopepublishes novel findings related to microbes (which includes

bacteria, fungi, parasites, and viruses) from molecular and cellular biology to translational studies with particular emphasis on the interface between the microbe and its host (vertebrate, invertebrate, or plant; unicellular or multicellular).

Cell Host & Microbe publishes expert analysis, commentary,and reviews on topics of current interest in the field


Journal Profile Cell Host & Microbe

Neuron Aims and Scope

Neuron has established itself as one of the most influential and relied upon journals in the field of neuroscience. The editors embrace interdisciplinary strategies that integrate biophysical, cellular, developmental, and molecular approaches with a systems approach to sensory, motor, and higher-order cognitive functions.

Neuron serves as one of the premier intellectual forums of the entire neuroscience community.


Journal Profile Neuron


•Developmental neurobiology•Cellular and molecular neuroscience•Synaptic transmission and plasticity•Ion channel structure and function•Behavioral and systems neuroscience•Cognitive neuroscience•Neurological and psychiatric disease•Computational neurobiology

Topics

Developmental Cell Aims and Scopea broad-spectrum journal that brings together the fields of cell biology and developmental biology. filled with exciting research describing results of unusual significance. In addition to work spanning all areas of cell biology and development

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.


Journal Profile Developmental Cell


• Cell migration

• Cell polarity

• Cell proliferation

• Developmental roles of genes or pathways

• Evolutionary relationships

• Intracellular targeting

• Membrane traffic

• Signaling pathways

Topics

The American Journal of Human Genetics (AJHG) Aims and Scope

AJHG provides a record of research and review relating to heredity/genetics in humans and to the application of genetic principles in medicine and public policy, as well as in related areas of molecular and cell biology. AJHG welcomes submissions of articles and reports on timely subjects concerning all aspects of human genetics, including studies of model organisms that are of direct relevance to human genetics.


Journal Profile AJHG

Current Biology Aims and Scope

Current Biology is a general journal that publishes original research across all areas of biology together with an extensive and varied set of editorial sections. A primary aim of the journal is to foster communication across fields of biology, both by publishing important findings of general interest from diverse fields and through highly accessible editorial articles that explicitly aim to inform non-specialists.


Journal Profile Current Biology


• Cell biology, including cell signaling, cell-cycle regulation,

• Cellular and systems neuroscience

• Neurobiology and behavior

• Gene expression, including genomics and proteomics

• DNA and RNA metabolism, including transcription and translation

• Ecology and evolution

Topics

Cell Systems Aims and Scope

The journal’s scope includes systems at all scales-from molecules, pathways, cells, and tissues to whole organisms, populations, and ecosystems-and a diversity of traditional disciplines,

In addition to peer-reviewed research, Cell Systems publishes Reviews, Previews, and Commentariescovering research topics and broader societal issues related to the scope of the journal.

Impact and Utility▪ Content: >430 articles online▪ Usage: >280,000 global downloads in 2017▪ Impact Factor: 8.41▪ Cite Score: 4.31▪ Issues Per Year: 12 issues per year

Journal Profile Cell Systems, newly launched 2015


•Systems at all scales•Plant biology•Computational biology•Proteomics•Translational medicine•Digital healthcare•Biological engineering•Systems and synthetic biology

Topics

Cell Chemical Biology Aims and Scope

publishing research and review content of exceptional

interest for the chemical biology community., the journal was the first to recognize the growing importance of investigations done at the interface of chemistry and biology, and its mission has always been to support and promote chemical biology and conversation and collaboration between chemical and life sciences.

Cell Chemical Biology strongly encourages submission of articles that provide significant conceptual advancement of broad general interest to both chemists and biologists. We also encourage submissions that are focused on method development for basic life sciences or that have practical impact of either clinical or biotechnological nature.

Journal Profile Cell Chemical Biology*


• Chemical insights into signaling, catalysis, and gene expression• Novel chemical and biological methods for molecular design,

synthesis, and analysis

• Chemical genetics

• Chemistry and biology of natural and unnatural biopolymers

• Drug design

• The nature of molecular recognition in biological systems

• Novel procedures for the large-scale analysis of genes and

proteins

Topics

.

Impact and Utility▪ Content: >3,400 articles online▪ Usage: >370,000 global downloads in 2017▪ Impact Factor: 8.85▪ Cite Score: 6.74▪ Issues Per Year: 12 issues per year▪ *Formerly Chemistry & Biology


Molecular Therapy Aims and Scope

Is the leading journal for research in the areas of gene transfer, vector development and design, stem cell manipulation, development of gene-, peptide-, protein-, oligonucleotide-, and cell-based therapeutics to correct genetic and acquired diseases, vaccine development, pre-clinical target validation, safety/efficacy studies, and clinical trials.

Molecular Therapy is dedicated to promoting the sciences in genetics, medicine, and biotechnology.


Journal Profile Molecular Therapy

Structure Aims and ScopeStructure aims to publish papers of exceptional interest in the field of structural biology., as well as biologists and biochemists that are interested in macromolecular structure and function.

We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Like wise,reportsdescribing single-molecule analysis of biological mechanisms are welcome.

In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships..

Journal Profile Structure

• Atomic resolution analysis

• X-ray crystallography

• Nuclear magnetic resonance spectroscopy

• Computational analyses, simulations, and predictions

• Electron microscopy

• Hydrodynamics

• X-ray absorption spectroscopy

• Biochemical studies

• Biophysical analyses

• Fluorescence energy transfer


Topics

Biophysical Journal Aims and ScopeIs to publish the highest quality work that elucidates important biological, chemical, or physical mechanisms and provides quantitative insight into fundamental problems at the molecular, cellular, and systems and whole-organism levels.

BJ publishes original articles, letters, and perspectives on important problems in modern biophysics.. Experimental studies of a purely

descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ.

Journal Profile Biophysical Journal

Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ.

Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.



• Proteins

• Biophysical theory and modeling

• Cell biophysics

• Photo biophysics

• Spectroscopy, imaging, and other techniques

• Muscle and contractility

• Supramolecular assemblies

• Bioenergetics

• Electrophysiology


Topics

Trends in Cancer Aims and Scope

Trends in Cancer is a new member of the Trends review journals, offering concise and engaging expert commentary articles that address key frontline research topics and cutting-edge advances in the rapidly changing field of cancer discovery and medicine. The journal provides a unique platform for multidisciplinary information, discussion and education that is valuable for scientists, clinicians, and policy makers, as well as patients & advocates.

The latest opportunities, challenges and potential impact of basic, translational and clinical findings, industry R&D, technology and innovation, ethics, or cancer policy and funding are equally presented and debated in an authoritative but reader-friendly format.

Journal Profile Trends in Cancer, newly launched 2015


Impact and Utility▪Newly Introduced Content, now indexed in PubMed: >250 articles online▪Usage: >75,000 global downloads in 2017▪Impact Factor: TBD, too new▪Cite Score: 3.77▪Issues Per Year: 12 issues per year

Journals

vs

Nature publishing Gp

Cell Press // Nature Publishing Group Content Comparison


Cell Press Titles indicated in red // All other from NPG


The Nature titles included are reviews titles, which have higher metrics.


Some Nature titles included are reviews titles, which have higher metrics.

Egypt Research in Cell Press

Egypt publishes in Cell PressTop Cited Articles with Egypt-based Collaboration Cell Press Journal

Mutations in WNT1 cause different forms of bone fragility American Journal of Human Genetics

WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta American Journal of Human Genetics

Guide RNA functional modules direct Cas9 activity and orthogonality Molecular Cell

Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout miceMolecular Therapy

Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome American Journal of Human Genetics

Loss-of-function mutations in TBC1d20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humansAmerican Journal of Human Genetics

Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems Molecular Cell

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis Cancer Cell

Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities American Journal of Human Genetics

Mutations in ANTXR1 cause GAPO syndrome American Journal of Human Genetics

Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8American Journal of Human Genetics

AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder Cell

Evolution and Spread of Ebola Virus in Liberia, 2014-2015 Cell Host and Microbe

Mutations in CSPP1 lead to classical joubert syndrome American Journal of Human Genetics

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation Cell

The classical lancefield antigen of group A Streptococcus is a virulence determinant with implications for vaccine design Cell Host and Microbe

Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors Neuron

A novel protein, ubiquitous in marine phytoplankton, concentrates iron at the cell surface and facilitates uptake Current Biology

The genome of the foraminiferan reticulomyxa filosa Current Biology

Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation Cell

Pathogenic Variants in PIGG Cause Intellectual Disability with Seizures and Hypotonia American Journal of Human Genetics

Biallelic truncating mutations in FMN2, encoding the actin-regulatory protein formin 2, cause nonsyndromic autosomal-recessive intellectual disabilityAmerican Journal of Human Genetics

Whole-exome sequencing identifies mutated C12orf57 in recessive corpus callosum hypoplasia American Journal of Human Genetics

Egypt publishes in Cell PressCell Press Journal Egypt Scholarly Output

American Journal of Human Genetics 65

Current Biology 48

Cell 24

Cell Host and Microbe 22

Molecular Therapy 17

Immunity 13

Biophysical Journal 11

Chemistry and Biology 6

Neuron 5

Cancer Cell 4

Cell Chemical Biology 4

Cell Metabolism 4

Molecular Cell 2

Structure 2

Chem 1

Egypt Reads Cell Press

Cell Press Journal Articles Downloaded

Biophysical Journal 1,861

Cancer Cell 3,488

Cell 5,247

Cell Chemical Biology 316

Cell Host & Microbe 505

Cell Metabolism 991

Cell Stem Cell 969

Cell Systems 189

Current Biology 1,912

Developmental Cell 466

Immunity 849

Molecular Cell 1,044

Molecular Therapy 403

Neuron 1,590

Structure 902

The American Journal of Human Genetics 606

Trends in Cancer 360

2017-Mar 2018 21,698

Accessing Cell Press Content on Egyptian Knowledge Bank


Demo

What’s New at ?

Now Available

Why is Chem different?

• Chem is the first title launched in the physical sciences.

• Chem, a sister journal to Cell, provides a home for seminal and insightful research and showcases how fundamental studies in chemistry and its sub-disciplines may help in finding potential solutions to the global challenges of tomorrow.

• Chem is the new home for high-impact chemistry from across all of the field's sub-disciplines.

Content is categorized following 10 Sustainable Development Goals identified by the United Nations:

▪ Good health and well-being▪ Affordable and clean energy▪ Clean water and sanitation▪ Climate action▪ Zero hunger

▪ Responsible consumption and production▪ Industry, Innovation, and Infrastructure ▪ Life on land▪ Sustainable cities and communities▪ Life below water

https://sustainabledevelopment.un.org/sdgs

Chem: Award Winning in Its First Year

Introducing Joule

Promotional launch Sept 2017: freely available through June

What is Joule?

▪ A home for outstanding and insightful research, analysis and ideas addressing a key global

challenge: the need for more sustainable energy.▪ A distinctive and forward-looking journal, bridging disciplines and scales of energy research. Joule

connects all who are researching and analyzing the challenges — scientific, technical, economic, policy and social — of providing sustainable energy solutions.

▪ Joule spans scales of energy research, from fundamental laboratory research into energy conversion and storage up to impactful analysis at the global level.

Joule in the Global Media

Joule: Science People Are Talking About

A study published in Joule and included on the cover

of Newsweek, and elsewhere, details how thousands of

bacteria feed on the leftovers from making Greek yogurt

and then turn it into caproic acid and caprylic acid—or bio-

oil. The research is another attempt toward revolutionizing

the food production system by creating a “circular

economy,” wherein all waste products are recovered for

something useful and profitable. Joule in Newsweek

Joule in NYT -- Joule earned its first story in the New York

Times, and elsewhere, last week, with a paper on how

staying home is saving energy. "A new study in the

journal Joule suggests that the spread of technologies

enabling Americans to spend more time working remotely,

shopping online — and, yes, watching Netflix and chilling —

has a side benefit of reducing energy use, and, by

extension, greenhouse gas emissions." - NYT

http://www.newsweek.com/2017/12/29/greek-yogurt-waste-could-be-used-jet-fuel-and-livestock-feed-746965.html?utm_campaign=Subscriptions Newsletter&utm_source=hs_email&utm_medium=email&_hsenc=p2ANqtz-_TmVNuAADmp2Y1o2UcFH2XtQg1rXQFsEdW00sPV4zEXpVDGpUg3c3VLyR3jtkf8UYzhEz8

https://www.nytimes.com/2018/01/29/climate/americans-staying-home-energy.html?utm_campaign=Subscriptions Newsletter&utm_source=hs_email&utm_medium=email&_hsenc=p2ANqtz-_TmVNuAADmp2Y1o2UcFH2XtQg1rXQFsEdW00sPV4zEXpVDGpUg3c3VLyR3jtkf8UYzhEz8

Announcing iScienceAn inter-disciplinary open access title

http://www.cell.com/iscience/

Elsevier Researcher Academy

Additional Resources for Authors at Cell Press, The Lancet, and Elsevier

Elsevier Researcher Academy

https://researcheracademy.elsevier.com

Additional Resources for Authors at Cell Press, The Lancet, and Elsevier

Elsevier Research Academy (Certificate)

https://researcheracademy.elsevier.com

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Appendix

Top 10 Highly-Cited Articles


1. Verhaak, R.G.W., Hoadley, K.A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M.D., Miller, C.R., Ding, L., Golub, T., Mesirov, J.P., Alexe, G., Lawrence, M., O'Kelly, M., Tamayo, P., Weir, B.A., Gabriel, S., Winckler, W., Gupta, S., Jakkula, L., Feiler, H.S., Hodgson, J.G., James, C.D., Sarkaria, J.N., Brennan, C., Kahn, A., Spellman, P.T., Wilson, R.K., Speed, T.P., Gray, J.W., Meyerson, M., Getz, G., Perou, C.M., Hayes, D.N. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 (2010) Cancer Cell, 17 (1), pp. 98-110. Cited 2739 times.

2. Yanaihara, N., Caplen, N., Bowman, E., Seike, M., Kumamoto, K., Yi, M., Stephens, R.M., Okamoto, A., Yokota, J., Tanaka, T., Calin, G.A., Liu, C.-G., Croce, C.M., Harris, C.C. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis (2006) Cancer Cell, 9 (3), pp. 189-198. Cited 2219 times.

3. Levine, R.L., Wadleigh, M., Cools, J., Ebert, B.L., Wernig, G., Huntly, B.J.P., Boggon, T.J., Wlodarska, I., Clark, J.J., Moore, S., Adelsperger, J., Koo, S., Lee, J.C., Gabriel, S., Mercher, T., D'Andrea, A., Fröhling, S., Döhner, K., Marynen, P., Vandenberghe, P., Mesa, R.A., Tefferi, A., Griffin, J.D., Eck, M.J., Sellers, W.R., Meyerson, M., Golub, T.R., Lee, S.J., Gilliland, D.G. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis (2005) Cancer Cell, 7 (4), pp. 387-397. Cited 1936 times.

4. Paszek, M.J., Zahir, N., Johnson, K.R., Lakins, J.N., Rozenberg, G.I., Gefen, A., Reinhart-King, C.A., Margulies, S.S., Dembo, M., Boettiger, D., Hammer, D.A., Weaver, V.M. Tensional homeostasis and the malignant phenotype (2005) Cancer Cell, 8 (3), pp. 241-254. Cited 1905 times.

5. Guertin, D.A., Sabatini, D.M. Defining the Role of mTOR in Cancer (2007) Cancer Cell, 12 (1), pp. 9-22. Cited 1859 times.

6. Neve, R.M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F.L., Fevr, T., Clark, L., Bayani, N., Coppe, J.-P., Tong, F., Speed, T., Spellman, P.T., DeVries, S., Lapuk, A., Wang, N.J., Kuo, W.-L., Stilwell, J.L., Pinkel, D., Albertson, D.G., Waldman, F.M., McCormick, F., Dickson, R.B., Johnson, M.D., Lippman, M., Ethier, S., Gazdar, A., Gray, J.W. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes (2006) Cancer Cell, 10 (6), pp. 515-527. Cited 1766 times.

7. Taylor, B.S., Schultz, N., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B.S., Arora, V.K., Kaushik, P., Cerami, E., Reva, B., Antipin, Y., Mitsiades, N., Landers, T., Dolgalev, I., Major, J.E., Wilson, M., Socci, N.D., Lash, A.E., Heguy, A., Eastham, J.A., Scher, H.I., Reuter, V.E., Scardino, P.T., Sander, C., Sawyers, C.L., Gerald, W.L. Integrative Genomic Profiling of Human Prostate Cancer (2010) Cancer Cell, 18 (1), pp. 11-22. Cited 1628 times

8. Pàez-Ribes, M., Allen, E., Hudock, J., Takeda, T., Okuyama, H., Viñals, F., Inoue, M., Bergers, G., Hanahan, D., Casanovas, O. Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis (2009) Cancer Cell, 15 (3), pp. 220-231. Cited 1626 times.

9. Phillips, H.S., Kharbanda, S., Chen, R., Forrest, W.F., Soriano, R.H., Wu, T.D., Misra, A., Nigro, J.M., Colman, H., Soroceanu, L., Williams, P.M., Modrusan, Z., Feuerstein, B.G., Aldape, K. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis (2006) Cancer Cell, 9 (3), pp. 157-173. Cited 1620 times.

10. Singh, D., Febbo, P.G., Ross, K., Jackson, D.G., Manola, J., Ladd, C., Tamayo, P., Renshaw, A.A., D'Amico, A.V., Richie, J.P., Lander, E.S., Loda, M., Kantoff, P.W., Golub, T.R., Sellers, W.R. Gene expression correlates of clinical prostate cancer behavior (2002) Cancer Cell, 1 (2), pp. 203-209. Cited 1611 times.

Cell Stem Cell Aims and Scope

Cell Stem Cell is a broad-spectrum journal that covers the entire spectrum of stem cell biology. We will consider studies from any model system that provides insights into stem cell biology, and we encourage submissions on human stem cells.

Cell Stem Cell publishes research reports describing novel results of unusual significance in all areas of stem cell research. Each issue also contains a wide variety of review and analysis articles covering topics relevant to stem cell research ranging from basic biological advances to ethical, policy, and funding issues.

Cell Stem Cell is edited by an expert team of in-house editors and is affiliated with the International Society for Stem Cell Research (ISSCR). For more information about the ISSCR, see http://www.isscr.org.



• Embryonic stem cells• Pluripotency• Germline stem cells• Tissue-specific stem cells• Stem cell differentiation• Epigenetics• Stem cell genomics and systems biology• Genome reprogramming• Cancer stem cells• Stem cell niches

• Stem cell-based disease models• Nuclear transfer technology• Bioengineering• Drug discovery• In vivo imaging of stem cells• Therapeutic applications• Regenerative medicine• Clinical and translational insights• Stem cell research policies, ethical issues, and

technical or resource-based innovations

http://www.isscr.org/



1. Ginestier, C., Hur, M.H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C.G., Liu, S., Schott, A., Hayes, D., Birnbaum, D., Wicha, M.S., Dontu, G. ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome (2007) Cell Stem Cell, 1 (5), pp. 555-567. Cited 2214 times.

2. Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T.S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., Norotte, C., Teng, P.-N., Traas, J., Schugar, R., Deasy, B.M., Badylak, S., Buhring, H.-J., Giacobino, J.-P., Lazzari, L., Huard, J., Péault, B. A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs (2008) Cell Stem Cell, 3 (3), pp. 301-313. Cited 2000 times.

3. Hermann, P.C., Huber, S.L., Herrler, T., Aicher, A., Ellwart, J.W., Guba, M., Bruns, C.J., Heeschen, C. Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer (2007) Cell Stem Cell, 1 (3), pp. 313-323. Cited 1690 times.

4. Warren, L., Manos, P.D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P.K., Smith, Z.D., Meissner, A., Daley, G.Q., Brack, A.S., Collins, J.J., Cowan, C., Schlaeger, T.M., Rossi, D.J. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA (2010) Cell Stem Cell, 7 (5), pp. 618-630. Cited 1389 times.

5. Zhou, H., Wu, S., Joo, J.Y., Zhu, S., Han, D.W., Lin, T., Trauger, S., Bien, G., Yao, S., Zhu, Y., Siuzdak, G., Schöler, H.R., Duan, L., Ding, S. Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins (2009) Cell Stem Cell, 4 (5), pp. 381-384. Cited 1284 times.

6. Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., Plath, K., Hochedlinger, K. Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution (2007) Cell Stem Cell, 1 (1), pp. 55-70. Cited 1184 times.

7. Kim, D., Kim, C.-H., Moon, J.-I., Chung, Y.-G., Chang, M.-Y., Han, B.-S., Ko, S., Yang, E., Cha, K.Y., Lanza, R., Kim, K.-S. Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins (2009) Cell Stem Cell, 4 (6), pp. 472-476. Cited 1157 times.

8. Ren, G., Zhang, L., Zhao, X., Xu, G., Zhang, Y., Roberts, A.I., Zhao, R.C., Shi, Y. Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide (2008) Cell Stem Cell, 2 (2), pp. 141-150. Cited 933 times.

9. Guilak, F., Cohen, D.M., Estes, B.T., Gimble, J.M., Liedtke, W., Chen, C.S. Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix (2009) Cell Stem Cell, 5 (1), pp. 17-26. Cited 922 times.

10. Lee, R.H., Pulin, A.A., Seo, M.J., Kota, D.J., Ylostalo, J., Larson, B.L., Semprun-Prieto, L., Delafontaine, P., Prockop, D.J. Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6 (2009) Cell Stem Cell, 5 (1), pp. 54-63. Cited 817 times.

Immunity Aims and Scope

Immunity publishes papers that report the most important advances in immunology research. The range of subjects includes, but is not limited to, immune cell development and senescence, signal transduction, gene regulation, innate and adaptive immunity, autoimmunity, infectious disease, allergy and asthma, transplantation, and tumor immunology. We also encourage the submission of manuscripts that pertain to related areas of research but have broad implications for immune responses in all aspects of human and experimental animal biology.



• Immune cell development and senescence• Signal transduction• Gene regulation• Innate and adaptive immunity• Cytokines and inflammatory responses• Autoimmunity and tolerance• Infectious disease• Tumor immunology• Vaccine biology• Transplantation biology• Allergy and asthma



1. Zlotnik, A., Yoshie, O. Chemokines: A new classification system and their role in immunity (2000) Immunity, 12 (2), pp. 121-127. Cited 2791 times.

2. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., Akira, S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components (1999) Immunity, 11 (4), pp. 443-451. Cited 2456 times.

3. Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells (2006) Immunity, 24 (2), pp. 179-189. Cited 2442 times.

4. Wiley, S.R., Schooley, K., Smolak, P.J., Din, W.S., Huang, C.-P., Nicholl, J.K., Sutherland, G.R., Smith, T.D., Rauch, C., Smith, C.A., Goodwin, R.G. Identification and characterization of a new member of the TNF family that induces apoptosis (1995) Immunity, 3 (6), pp. 673-682. Cited 2341 times.

5. Geissmann, F., Jung, S., Littman, D.R. Blood monocytes consist of two principal subsets with distinct migratory properties (2003) Immunity, 19 (1), pp. 71-82. Cited 1979 times.

6. Oppmann, B., Lesley, R., Blom, B., Timans, J.C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., Zonin, F., Vaisberg, E., Churakova, T., Liu, M.-R., Gorman, D., Wagner, J., Zurawski, S., Liu, Y.-J., Abrams, J.S., Moore, K.W., Rennick, D., De Waal-Malefyt, R., Hannum, C., Bazan, J.F., Kastelein, R.A. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 (2000) Immunity, 13 (5), pp. 715-725. Cited 1832 times.

7. Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T.K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., Gorman, D.M., Bazan, J.F., Kastelein, R.A. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines (2005) Immunity, 23 (5), pp. 479-490. Cited 1820 times.

8. Tivol, E.A., Borriello, F., Schweitzer, A.N., Lynch, W.P., Bluestone, J.A., Sharpe, A.H. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 (1995) Immunity, 3 (5), pp. 541-547. Cited 1802 times.

9. Fontenot, J.D., Rasmussen, J.P., Williams, L.M., Dooley, J.L., Farr, A.G., Rudensky, A.Y. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3 (2005) Immunity, 22 (3), pp. 329-341. Cited 1637 times

10. Murali-Krishna, K., Altman, J.D., Suresh, M., Sourdive, D.J.D., Zajac, A.J., Miller, J.D., Slansky, J., Ahmed, R. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection (1998) Immunity, 8 (2), pp. 177-187. Cited 1596 times.

Cell Metabolism Aims and Scope

Established in 2005, Cell Metabolism is the top research journal dedicated to publishing novel, impactful papers spanning basic to clinical metabolic research. We are interested in original research addressing the molecular mechanisms underlying physiological homeostasis and what goes awry in disease.

The journal's mission is to provide the metabolic community a forum for the exchange of ideas and concepts and to promote cross-disciplinary research and collaboration. In line with this, we aim to publish work that is not only of exceptional significance within its field, but also of interest to researchers outside the immediate area, promoting idea cross-pollination.

Cell Metabolism's scope includes diabetes, obesity, pancreatic beta cell function, adipose tissue biology (white, brown, and beige), lipid metabolism, cardiovascular biology, immunometabolism, bone homeostasis, aging and stress responses, sarcopenia, intermediary metabolism and cancer, cachexia, neuronal control of metabolism and metabolic derangements causing neurodegeneration, circadian biology, stem cell energetics, exercise metabolism, the biology of mitochondria and other metabolic organelles such as peroxisomes and the ER, etc.



• Diabetes• Obesity• Energy balance• Cardiovascular disease• Adipocyte and lipid biology• Aging and stress response• Mitochondria• Hypertension• Bone homeostasis• Molecular endocrinology



1. Kahn, B.B., Alquier, T., Carling, D., Hardie, D.G. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism (2005) Cell Metabolism, 1 (1), pp. 15-25. Cited 1790 times.

2. DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G., Thompson, C.B. The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation (2008) Cell Metabolism, 7 (1), pp. 11-20. Cited 1693 times.

3. Kim, J.-W., Tchernyshyov, I., Semenza, G.L., Dang, C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia (2006) Cell Metabolism, 3 (3), pp. 177-185. Cited 1496 times

4. Drucker, D.J. The biology of incretin hormones (2006) Cell Metabolism, 3 (3), pp. 153-165. Cited 1300 times.

5. Esau, C., Davis, S., Murray, S.F., Yu, X.X., Pandey, S.K., Pear, M., Watts, L., Booten, S.L., Graham, M., McKay, R., Subramaniam, A., Propp, S., Lollo, B.A., Freier, S., Bennett, C.F., Bhanot, S., Monia, B.P. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting (2006) Cell Metabolism, 3 (2), pp. 87-98. Cited 1295 times.

6. Lin, J., Handschin, C., Spiegelman, B.M. Metabolic control through the PGC-1 family of transcription coactivators(2005) Cell Metabolism, 1 (6), pp. 361-370. Cited 1141 times.

7. Papandreou, I., Cairns, R.A., Fontana, L., Lim, A.L., Denko, N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption (2006) Cell Metabolism, 3 (3), pp. 187-197. Cited 1039 times.

8. Newgard, C.B., An, J., Bain, J.R., Muehlbauer, M.J., Stevens, R.D., Lien, L.F., Haqq, A.M., Shah, S.H., Arlotto, M., Slentz, C.A., Rochon, J., Gallup, D., Ilkayeva, O., Wenner, B.R., Yancy Jr., W.S., Eisenson, H., Musante, G., Surwit, R.S., Millington, D.S., Butler, M.D., Svetkey, L.P. A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance (2009) Cell Metabolism, 9 (4), pp. 311-326. Cited 1026 times

9. Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S.J., Di Lisi, R., Sandri, C., Zhao, J., Goldberg, A.L., Schiaffino, S., Sandri, M. FoxO3 Controls Autophagy in Skeletal Muscle In Vivo (2007) Cell Metabolism, 6 (6), pp. 458-471. Cited 944 times.

10. Hawley, S.A., Pan, D.A., Mustard, K.J., Ross, L., Bain, J., Edelman, A.M., Frenguelli, B.G., Hardie, D.G. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase (2005) Cell Metabolism, 2 (1), pp. 9-19. Cited 926 times.

Cell Host & Microbe Aims and Scope

Cell Host & Microbe was launched in March 2007. The journal's mission is to provide a forum for the exchange of ideas and concepts between scientists studying the microbe with those studying the host immune, cell biological, and molecular response upon colonization or infection by a microbe.

Cell Host & Microbe publishes novel findings related to microbes (which includes bacteria, fungi, parasites, and viruses) from molecular and cellular biology to translational studies with particular emphasis on the interface between the microbe and its host (vertebrate, invertebrate, or plant; unicellular or multicellular). The unifying theme is the integrated study of microbes (pathogenic, non-pathogenic, and commensal) in conjunction and communication with each other, their host, and the cellular environment they inhabit. Work published in Cell Host & Microbe is expected not only to be of exceptional significance within its field, but also of interest to researchers outside the immediate area. In addition to primary research manuscripts, Cell Host & Microbe publishes expert analysis, commentary, and reviews on topics of current interest in the field.


Journal Profile Cell Host & Microbe

• Molecular and cell biology of microbes• Microbial pathogenesis• Host cellular and immune response to microbes• Immune evasion• Therapeutics• Evolution, epidemiology, and natura history of

microbes• Vaccine design, development, and trials• Emerging pathogens

Neuron Aims and Scope

Neuron has established itself as one of the most influential and relied upon journals in the field of neuroscience. The editors embrace interdisciplinary strategies that integrate biophysical, cellular, developmental, and molecular approaches with a systems approach to sensory, motor, and higher-order cognitive functions. Neuron serves as one of the premier intellectual forums of the entire neuroscience community.



• Developmental neurobiology• Cellular and molecular neuroscience• Synaptic transmission and plasticity• Ion channel structure and function• Behavioral and systems neuroscience• Cognitive neuroscience• Neurological and psychiatric disease• Computational neurobiology



1. Choi, D.W. Glutamate neurotoxicity and diseases of the nervous system (1988) Neuron, 1 (8), pp. 623-634. Cited 3845 times.

2. Fischl, B., Salat, D.H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., Van Der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., Montillo, A., Makris, N., Rosen, B., Dale, A.M. Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain (2002) Neuron, 33 (3), pp. 341-355. Cited 3247 times.

3. Dauer, W., Przedborski, S. Parkinson's disease: Mechanisms and models (2003) Neuron, 39 (6), pp. 889-909. Cited 2657 times.

4. Monyer, H., Burnashev, N., Laurie, D.J., Sakmann, B., Seeburg, P.H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors (1994) Neuron, 12 (3), pp. 529-540. Cited 2439 times.

5. Malenka, R.C., Bear, M.F. LTP and LTD: An embarrassment of riches (2004) Neuron, 44 (1), pp. 5-21. Cited 2210 times

6. Oddo, S., Caccamo, A., Shepherd, J.D., Murphy, M.P., Golde, T.E., Kayed, R., Metherate, R., Mattson, M.P., Akbari, Y., LaFerla, F.M. Triple-transgenic model of Alzheimer's Disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction (2003) Neuron, 39 (3), pp. 409-421. Cited 2206 times.

7. Tominaga, M., Caterina, M.J., Malmberg, A.B., Rosen, T.A., Gilbert, H., Skinner, K., Raumann, B.E., Basbaum, A.I., Julius, D. The cloned capsaicin receptor integrates multiple pain-producing stimuli (1998) Neuron, 21 (3), pp. 531-543. Cited 2133 times.

8. Mayberg, H.S., Lozano, A.M., Voon, V., McNeely, H.E., Seminowicz, D., Hamani, C., Schwalb, J.M., Kennedy, S.H. Deep brain stimulation for treatment-resistant depression (2005) Neuron, 45 (5), pp. 651-660. Cited 2048 times.

9. Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J., Monteggia, L.M. Neurobiology of depression (2002) Neuron, 34 (1), pp. 13-25. Cited 1954 times.

10. DeJesus-Hernandez, M., Mackenzie, I., Boeve, B., Boxer, A., Baker, M., Rutherford, N., Nicholson, A., Finch, N., Flynn, H., Adamson, J., Kouri, N., Wojtas, A., Sengdy, P., Hsiung, G.-Y., Karydas, A., Seeley, W., Josephs, K., Coppola, G., Geschwind, D., Wszolek, Z., Feldman, H., Knopman, D., Petersen, R., Miller, B., Dickson, D., Boylan, K., Graff-Radford, N., Rademakers, R. Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS (2011) Neuron, 72 (2), pp. 245-256. Cited 1852 times.

Developmental Cell Aims and Scope

Developmental Cell was launched in 2001 as a broad-spectrum journal that brings together the fields of cell biology and developmental biology. Our PhD-trained scientific editors work with authors, reviewers, and editorial board members with the goal of publishing 24 issues each year, filled with exciting research describing results of unusual significance. In addition to work spanning all areas of cell biology and development, we emphasize the interfaces and relationships between these two disciplines. Each issue also contains review articles tailored to the journal's broad readership. With this wide coverage, Developmental Cell is a unique cross-disciplinary resource for researchers in both these fields and for the general scientific community.Developmental Cell will consider papers in any area of cell biology and developmental biology. Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways. The primary criterion for publication in Developmental Cell, as for all Cell Press journals, is new biological insight. We are happy to consider any study that leads to important new conclusions about biological function.



• Cell migration• Cell polarity• Cell proliferation• Developmental roles of genes or pathways• Differentiation• Evolutionary relationships• Genome-wide analysis• Intracellular targeting• Membrane traffic• Morphogenesis• Signaling pathways



1. McBeath, R., Pirone, D.M., Nelson, C.M., Bhadriraju, K., Chen, C.S. Cell shape, cytoskeletal tension, and RhoAregulate stem cell lineage commitment (2004) Developmental Cell, 6 (4), pp. 483-495. Cited 2432 times

2. Levine, B., Klionsky, D.J. Development by self-digestion: Molecular mechanisms and biological functions of autophagy (2004) Developmental Cell, 6 (4), pp. 463-477. Cited 2343 times.

3. MacDonald, B.T., Tamai, K., He, X. Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases (2009) Developmental Cell, 17 (1), pp. 9-26. Cited 2306 times.

4. Yang, J., Weinberg, R.A. Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis (2008) Developmental Cell, 14 (6), pp. 818-829. Cited 1692 times.

5. Kloosterman, W.P., Plasterk, R.H.A. The Diverse Functions of MicroRNAs in Animal Development and Disease (2006) Developmental Cell, 11 (4), pp. 441-450. Cited 1345 times.

6. Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., Wagner, E.F., Mak, T.W., Kodama, T., Taniguchi, T. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts (2002) Developmental Cell, 3 (6), pp. 889-901. Cited 1301 times.

7. Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., Kirchhausen, T. Dynasore, a Cell-Permeable Inhibitor of Dynamin (2006) Developmental Cell, 10 (6), pp. 839-850. Cited 1089 times.

8. Frank, S., Gaume, B., Bergmann-Leitner, E.S., Leitner, W.W., Robert, E.G., Catez, F., Smith, C.L., Youle, R.J. The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis (2001) Developmental Cell, 1 (4), pp. 515-525. Cited 1056 times

9. Karsenty, G., Wagner, E.F. Reaching a genetic and molecular understanding of skeletal development (2002) Developmental Cell, 2 (4), pp. 389-406. Cited 994 times.

10. Cai, C.-L., Liang, X., Shi, Y., Chu, P.-H., Pfaff, S.L., Chen, J., Evans, S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart (2003) Developmental Cell, 5 (6), pp. 877-889. Cited 986 times

The American Journal of Human Genetics (AJHG) Aims and Scope

AJHG provides a record of research and review relating to heredity in humans and to the application of genetic principles in medicine and public policy, as well as in related areas of molecular and cell biology. Topics explored by AJHG include behavioral genetics, biochemical genetics, clinical genetics, cytogenetics, dysmorphology, gene therapy, genetic counseling, genetic epidemiology, genomics, immunogenetics, molecular genetics, neurogenetics, and population genetics.

AJHG welcomes submissions of articles and reports on timely subjects concerning all aspects of human genetics, including studies of model organisms that are of direct relevance to human genetics. Manuscripts should be written in a manner accessible to investigators representing diverse backgrounds in human genetics. Descriptions of new statistical methods of general interest to the genetics community are welcome. New methods should be compared to existing methods with the use of real data and/or simulations with parameters (e.g., haplotype frequencies, effect sizes) that are based on a real data example (e.g., marker or haplotype data from the HapMap project). All novel computer programs must be made publicly available by the time that the manuscript is published, and a URL for the website must be included in the Web Resources section of the manuscript. Letters commenting on material previously published in AJHG are also welcome.



• Behavioral genetics• Biochemical genetics• Clinical genetics• Cytogenetics• Dysmorphology• Gene therapy• Genetic counseling• Genetic epidemiology• Genomics• Immunogenetics• Molecular genetics• Neurogenetics• Population genetics



1. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A.R., Bender, D., Maller, J., Sklar, P., De Bakker, P.I.W., Daly, M.J., Sham, P.C. PLINK: A tool set for whole-genome association and population-based linkage analyses (2007) American Journal of Human Genetics, 81 (3), pp. 559-575. Cited 11017 times.

2. Stephens, M., Smith, N.J., Donnelly, P. A new statistical method for haplotype reconstruction from population data (2001) American Journal of Human Genetics, 68 (4), pp. 978-989. Cited 5506 times

3. Botstein, D., White, R.L., Skolnick, M., Davis, R.W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms (1980) American Journal of Human Genetics, 32 (3), pp. 314-331. Cited 4767 times.

4. Spielman, R.S., McGinnis, R.E., Ewens, W.J. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM) (1993) American Journal of Human Genetics, 52 (3), pp. 506-516. Cited 3098 times.

5. Weber, J.L., May, P.E. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction (1989) American Journal of Human Genetics, 44 (3), pp. 388-396. Cited 2731 times.

6. Stephens, M., Donnelly, P. A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data (2003) American Journal of Human Genetics, 73 (5), pp. 1162-1169. Cited 2595 times.

7. Kruglyak, L., Daly, M.J., Reeve-Daly, M.P., Lander, E.S. Parametric and nonparametric linkage analysis: A unified multipoint approach (1996) American Journal of Human Genetics, 58 (6), pp. 1347-1363. Cited 2488 times.

8. Almasy, L., Blangero, J. Multipoint quantitative-trait linkage analysis in general pedigrees (1998) American Journal of Human Genetics, 62 (5), pp. 1198-1211. Cited 2317 times.

9. Ford, D., Easton, D.F., Stratton, M., Narod, S., Goldgar, D., Devilee, P., Bishop, D.T., Weber, B., Lenoir, G., Chang-Claude, J., Sobol, H., Teare, M.D., Struewing, J., Arason, A., Scherneck, S., Peto, J., Rebbeck, T.R., Tonin, P., Neuhausen, S., Barkardottir, R., Eyfjord, J., Lynch, H., Ponder, B.A.J., Gayther, S.A., Birch, J.M., Lindblom, A., Stoppa-Lyonnet, D., Bignon, Y., Borg, A., Hamann, U., Haites, N., Scott, R.J., Maugard, C.M., Vasen, H., Seitz, S., Cannon-Albright, L.A., Schofield, A., Zelada-Hedman, M. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families (1998) American Journal of Human Genetics, 62 (3), pp. 676-689. Cited 2164 times.

10. Antoniou, A., Pharoah, P.D.P., Narod, S., Risch, H.A., Eyfjord, J.E., Hopper, J.L., Loman, N., Olsson, H., Johannsson, O., Borg, Å., Pasini, B., Radice, P., Manoukian, S., Eccles, D.M., Tang, N., Olah, E., Anton-Culver, H., Warner, E., Lubinski, J., Gronwald, J., Gorski, B., Tulinius, H., Thorlacius, S., Eerola, H., Nevanlinna, H., Syrjäkoski, K., Kallioniemi, O.-P., Thompson, D., Evans, C., Peto, J., Lalloo, F., Evans, D.G., Easton, D.F. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies (2003) American Journal of Human Genetics, 72 (5), pp. 1117-1130. Cited 2014 times.

Current Biology Aims and Scope

Current Biology is a general journal that publishes original research across all areas of biology together with an extensive and varied set of editorial sections. A primary aim of the journal is to foster communication across fields of biology, both by publishing important findings of general interest from diverse fields and through highly accessible editorial articles that explicitly aim to inform non-specialists.

Current Biology publishes papers reporting findings in any area of biology that have sufficient claim to be of general interest—this could be, for example, because the advance is important for a specific field, or because it is intrinsically of wide interest to biologists generally. We have several formats for publishing original research (Articles, Reports, and Correspondences.)

.



• Cell biology, including cell signaling, cell-cycle regulation, and apoptosis

• Developmental biology• Cellular and systems neuroscience• Neurobiology and behavior• Cancer biology• Gene expression, including genomics and

proteomics• DNA and RNA metabolism, including transcription

and translation• Immunology• Ecology and evolution



1. Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., Tuschl, T. Identification of tissue-specific MicroRNAs from mouse (2002) Current Biology, 12 (9), pp. 735-739. Cited 2163 times.

2. Alessi, D.R., James, S.R., Downes, C.P., Holmes, A.B., Gaffney, P.R.J., Reese, C.B., Cohen, P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα (1997) Current Biology, 7 (4), pp. 261-269. Cited 1963 times.

3. Dos D. Sarbassov, Ali, S.M., Kim, D.-H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., Tempst, P., Sabatini, D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton (2004) Current Biology, 14 (14), pp. 1296-1302. Cited 1590 times.

4. Jacks, T., Remington, L., Williams, B.O., Schmitt, E.M., Halachmi, S., Bronson, R.T., Weinberg, R.A. Tumor spectrum analysis in p53-mutant mice (1994) Current Biology, 4 (1), pp. 1-7. Cited 1512 times

5. Paull, T.T., Rogakou, E.P., Yamazaki, V., Kirchgessner, C.U., Gellert, M., Bonner, W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage (2000) Current Biology, 10 (15), pp. 886-895. Cited 1396 times.

6. Pappin, D.J.C., Hojrup, P., Bleasby, A.J. Rapid identification of proteins by peptide-mass fingerprinting (1993) Current Biology, 3 (6), pp. 327-332. Cited 1316 times.

7. Liou, J., Kim, M.L., Won, D.H., Jones, J.T., Myers, J.W., Ferrell Jr., J.E., Meyer, T. STIM is a Ca2+sensor essential for Ca2+-store- depletion-triggered Ca2+influx (2005) Current Biology, 15 (13), pp. 1235-1241. Cited 1299 times.

8. Chiu, W.-L., Niwa, Y., Zeng, W., Hirano, T., Kobayashi, H., Sheen, J. Engineered GFP as a vital reporter in plants (1996) Current Biology, 6 (3), pp. 325-330. Cited 1098 times.

9. Stambolic, V., Ruel, L., Woodgett, J.R. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells (1996) Current Biology, 6 (12), pp. 1664-1668. Cited 1049 times.

10. Heim, R., Tsien, R.Y. Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer (1996) Current Biology, 6 (2), pp. 178-182. Cited 1034 times

Cell Systems Aims and Scope

Cell Systems is a broad, multidisciplinary monthly journal for outstanding research that provides, supports, or applies systems-level understanding in the life sciences and related disciplines. Manuscripts describing novel discoveries, milestone achievements, broadly useful tools or resources, or insights into the use of technology may all be appropriate. Quantitative integrative studies that reveal general principles of systems are particularly welcome.

The journal’s scope includes systems at all scales-from molecules, pathways, cells, and tissues to whole organisms, populations, and ecosystems-and a diversity of traditional disciplines, including but not limited to microbiology, cancer, immunology, plant biology, computational biology, genomics, proteomics, translational medicine, digital healthcare, biological engineering, and systems and synthetic biology.

In addition to peer-reviewed research, Cell Systems publishes Reviews, Previews, and Commentaries covering research topics and broader societal issues related to the scope of the journal. Through services that rise to the challenges inherent in quantitative system-scale studies, the journal aims to publish and facilitate research for our communities of readers and authors.

.

Impact and Utility▪ Content: >430 articles online▪ Usage: >280,000 global downloads in 2017▪ Impact Factor: 8.41▪ Cite Score: 4.31▪ Issues Per Year: 12 issues per year


• Systems at all scales• Microbiology• Cancer• Immunology• Plant biology• Computational biology• Genomics• Proteomics• Translational medicine• Digital healthcare• Biological engineering• Systems and synthetic biology

Top 10 Emerging Articles by Citations


1. Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J., Tamayo, P. The Molecular Signatures Database Hallmark Gene Set Collection (2015) Cell Systems, 1 (6), pp. 417-425. Cited 194 times.

2. Horwitz, A.A., Walter, J.M., Schubert, M.G., Kung, S.H., Hawkins, K., Platt, D.M., Hernday, A.D., Mahatdejkul-Meadows, T., Szeto, W., Chandran, S.S., Newman, J.D. Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas (2015) Cell Systems, 1 (1), art. no. 2, pp. 88-96. Cited 73 times.

3. Afshinnekoo, E., Meydan, C., Chowdhury, S., Jaroudi, D., Boyer, C., Bernstein, N., Maritz, J.M., Reeves, D., Gandara, J., Chhangawala, S., Ahsanuddin, S., Simmons, A., Nessel, T., Sundaresh, B., Pereira, E., Jorgensen, E., Kolokotronis, S.-O., Kirchberger, N., Garcia, I., Gandara, D., Dhanraj, S., Nawrin, T., Saletore, Y., Alexander, N., Vijay, P., Hénaff, E.M., Zumbo, P., Walsh, M., O'Mullan, G.D., Tighe, S., Dudley, J.T., Dunaif, A., Ennis, S., O'Halloran, E., Magalhaes, T.R., Boone, B., Jones, A.L., Muth, T.R., Paolantonio, K.S., Alter, E., Schadt, E.E., Garbarino, J., Prill, R.J., Carlton, J.M., Levy, S., Mason, C.E. Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics (2015) Cell Systems, 1 (1), art. no. 1, pp. 72-87. Cited 70 times.

4. Mimee, M., Tucker, A.C., Voigt, C.A., Lu, T.K. Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota (2015) Cell Systems, 1 (1), art. no. 5, pp. 62-71. Cited 56 times.

5. Geyer, P.E., Kulak, N.A., Pichler, G., Holdt, L.M., Teupser, D., Mann, M. Plasma Proteome Profiling to Assess Human Health and Disease (2016) Cell Systems, 2 (3), pp. 185-195. Cited 54 times

6. Muraro, M.J., Dharmadhikari, G., Grün, D., Groen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M.A., Carlotti, F., de Koning, E.J.P., van Oudenaarden, A. A Single-Cell Transcriptome Atlas of the Human Pancreas (2016) Cell Systems, 3 (4), pp. 385-394. Cited 46 times.

7. Griffith, M., Miller, C.A., Griffith, O.L., Krysiak, K., Skidmore, Z.L., Ramu, A., Walker, J.R., Dang, H.X., Trani, L., Larson, D.E., Demeter, R.T., Wendl, M.C., McMichael, J.F., Austin, R.E., Magrini, V., McGrath, S.D., Ly, A., Kulkarni, S., Cordes, M.G., Fronick, C.C., Fulton, R.S., Maher, C.A., Ding, L., Klco, J.M., Mardis, E.R., Ley, T.J., Wilson, R.K. Optimizing Cancer Genome Sequencing and Analysis (2015) Cell Systems, 1 (3), art. no. 35, pp. 210-223. Cited 41 times.

8. Baron, M., Veres, A., Wolock, S.L., Faust, A.L., Gaujoux, R., Vetere, A., Ryu, J.H., Wagner, B.K., Shen-Orr, S.S., Klein, A.M., Melton, D.A., Yanai, I. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure (2016) Cell Systems, 3 (4), pp. 346-360. Cited 40 times.

9. Durand, N.C., Robinson, J.T., Shamim, M.S., Machol, I., Mesirov, J.P., Lander, E.S., Aiden, E.L. Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom (2016) Cell Systems, 3 (1), pp. 99-101. Cited 40 times

10. Bordbar, A., McCloskey, D., Zielinski, D.C., Sonnenschein, N., Jamshidi, N., Palsson, B.O. Personalized Whole-Cell Kinetic Models of Metabolism for Discovery in Genomics and Pharmacodynamics (2015) Cell Systems, 1 (4), pp. 283-292. Cited 35 times

Cell Chemical Biology Aims and ScopeCell Chemical Biology is a Cell Press journal publishing research and review content of exceptional interest for the chemical biology community. Launched in 1994 under the title Chemistry & Biology, the journal was the first to recognize the growing importance of investigations done at the interface of chemistry and biology, and its mission has always been to support and promote chemical biology and conversation and collaboration between chemical and life sciences.

Cell Chemical Biology strongly encourages submission of articles that provide significant conceptual advancement of broad general interest to both chemists and biologists. We are especially interested in papers that combine the use of chemical tools to perturb, visualize, and measure biological systems and properties and offer unique insights into molecular mechanism or physiology. We also encourage submissions that are focused on method development for basic life sciences or that have practical impact of either clinical or biotechnological nature.

Impact and Utility▪ Content: >3,400 articles online▪ Usage: >370,000 global downloads in 2017▪ Impact Factor: 8.85▪ Cite Score: 6.74▪ Issues Per Year: 12 issues per year▪ *Formerly Chemistry & Biology


• Chemical insights into signaling, catalysis, and gene expression

• Novel chemical and biological methods for molecular design, synthesis, and analysis

• Glycomics• Chemical genetics• Chemistry and biology of natural and unnatural

biopolymers• The use of natural and designed molecules as probes of

cellular pathways• Drug design• The nature of molecular recognition in biological

systems• Novel procedures for the large-scale analysis of genes

and proteins• Functional and structural genomics• Molecular basis of evolution



1. Handelsman, J., Rondon, M.R., Brady, S.F., Clardy, J., Goodman, R.M. Molecular biological access to the chemistry of unknown soil microbes: A new frontier for natural products (1998) Chemistry and Biology, 5 (10), pp. R245-R249. Cited 859 times.

2. Kisselev, A.F., Goldberg, A.L. Proteasome inhibitors: From research tools to drug candidates (2001) Chemistry and Biology, 8 (8), pp. 739-758. Cited 822 times.

3. Pommier, Y., Leo, E., Zhang, H., Marchand, C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs (2010) Chemistry and Biology, 17 (5), pp. 421-433. Cited 744 times.

4. Stachelhaus, T., Mootz, H.D., Marahiel, M.A. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases (1999) Chemistry and Biology, 6 (8), pp. 493-505. Cited 741 times.

5. Breaker, R.R., Joyce, G.F. A DNA enzyme that cleaves RNA (1994) Chemistry and Biology, 1 (4), pp. 223-229. Cited 733 times.

6. Coghlan, M.P., Culbert, A.A., Cross, D.A.E., Corcoran, S.L., Yates, J.W., Pearce, N.J., Rausch, O.L., Murphy, G.J., Carter, P.S., Roxbee Cox, L., Mills, D., Brown, M.J., Haigh, D., Ward, R.W., Smith, D.G., Murray, K.J., Reith, A.D., Holder, J.C. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription (2000) Chemistry and Biology, 7 (10), pp. 793-803. Cited 664 times.

7. Lambalot, R.H., Gehring, A.M., Flugel, R.S., Zuber, P., LaCelle, M., Marahiel, M.A., Reid, R., Khosla, C., Walsh, C.T. A new enzyme superfamily - The phosphopantetheinyl transferases (1996) Chemistry and Biology, 3 (11), pp. 923-936. Cited 616 times.

8. Blankman, J.L., Simon, G.M., Cravatt, B.F. A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol (2007) Chemistry and Biology, 14 (12), pp. 1347-1356. Cited 571 times.

9. Harper, J.D., Wong, S.S., Lieber, C.M., Lansbury Jr., P.T. Observation of metastable Aβ amyloid protofibrils by atomic force microscopy (1997) Chemistry and Biology, 4 (2), pp. 119-125. Cited 556 times.

10. Speers, A.E., Cravatt, B.F. Profiling enzyme activities in vivo using click chemistry methods (2004) Chemistry and Biology, 11 (4), pp. 535-546. Cited 555 times.

▪*Formerly Chemistry & Biology

Molecular Therapy Aims and ScopeMolecular Therapy is the leading journal for research in the areas of gene transfer, vector development and design, stem cell manipulation, development of gene-, peptide-, protein-, oligonucleotide-, and cell-based therapeutics to correct genetic and acquired diseases, vaccine development, pre-clinical target validation, safety/efficacy studies, and clinical trials. Molecular Therapy is dedicated to promoting the sciences in genetics, medicine, and biotechnology. Publishing important peer-reviewed research and cutting-edge reviews and commentaries, the journal continues to attract the best material in the field.

Also in the Molecular Therapy Family of Journals Open Access:

Molecular Therapy — Methods & Clinical Developments

Molecular Therapy — Nucleic Acids

Molecular Therapy — Oncolytics





1. Morgan, R.A., Yang, J.C., Kitano, M., Dudley, M.E., Laurencot, C.M., Rosenberg, S.A. Case report of a serious adverse event following the administration of t cells transduced with a chimeric antigen receptor recognizing ERBB2 (2010) Molecular Therapy, 18 (4), pp. 843-851. Cited 816 times

2. Moghimi, S.M., Symonds, P., Murray, J.C., Hunter, A.C., Debska, G., Szewczyk, A. A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy (2005) Molecular Therapy, 11 (6), pp. 990-995. Cited 640 times.

3. Rejman, J., Bragonzi, A., Conese, M. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes (2005) Molecular Therapy, 12 (3), pp. 468-474. Cited 511 times.

4. Nakase, I., Niwa, M., Takeuchi, T., Sonomura, K., Kawabata, N., Koike, Y., Takehashi, M., Tanaka, S., Ueda, K., Simpson, J.C., Jones, A.T., Sugiura, Y., Futaki, S. Cellular uptake of arginine-rich peptides: Roles for macropinocytosis and actin rearrangement (2004) Molecular Therapy, 10 (6), pp. 1011-1022. Cited 498 times.

5. Burger, C., Gorbatyuk, O.S., Velardo, M.J., Peden, C.S., Williams, P., Zolotukhin, S., Reier, P.J., Mandel, R.J., Muzyczka, N. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system (2004) Molecular Therapy, 10 (2), pp. 302-317. Cited 458 times.

6. Zincarelli, C., Soltys, S., Rengo, G., Rabinowitz, J.E. Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection (2008) Molecular Therapy, 16 (6), pp. 1073-1080. Cited 457 times.

7. Wu, Z., Asokan, A., Samulski, R.J. Adeno-associated Virus Serotypes: Vector Toolkit for Human Gene Therapy (2006) Molecular Therapy, 14 (3), pp. 316-327. Cited 454 times.

8. Tannous, B.A., Kim, D.-E., Fernandez, J.L., Weissleder, R., Breakefield, X.O. Codon-optimized gaussia luciferase cDNA for mammalian gene expression in culture and in vivo (2005) Molecular Therapy, 11 (3), pp. 435-443. Cited 441 times.

9. Howard, K.A., Rahbek, U.L., Liu, X., Damgaard, C.K., Glud, S.Z., Andersen, M.Ø., Hovgaard, M.B., Schmitz, A., Nyengaard, J.R., Besenbacher, F., Kjems, J. RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System(2006) Molecular Therapy, 14 (4), pp. 476-484. Cited 412 times.

10. Milone, M.C., Fish, J.D., Carpenito, C., Carroll, R.G., Binder, G.K., Teachey, D., Samanta, M., Lakhal, M., Gloss, B., Danet-Desnoyers, G., Campana, D., Riley, J.L., Grupp, S.A., June, C.H. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo (2009) Molecular Therapy, 17 (8), pp. 1453-1464. Cited 408 times

Structure Aims and ScopeStructure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome.

In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.

• Atomic resolution analysis• X-ray crystallography• Nuclear magnetic resonance spectroscopy• Computational analyses, simulations, and predictions• Electron microscopy• Neutron scattering• Hydrodynamics• X-ray absorption spectroscopy• Biochemical studies• Biophysical analyses• Fluorescence energy transfer• Design, construction, and analysis of novel protein and RNA structures• Catalytic activities• Medium- to low-resolution structural analysis• Single-molecule analysis• Small-angle X-ray scattering• Emerging methods in structure determination





1. Orengo, C.A., Michie, A.D., Jones, S., Jones, D.T., Swindells, M.B., Thornton, J.M. CATH - A hierarchic classification of protein domain structures (1997) Structure, 5 (8), pp. 1093-1108. Cited 1862 times

2. Davies, G., Henrissat, B. Structures and mechanisms of glycosyl hydrolases (1995) Structure, 3 (9), pp. 853-859. Cited 1234 times.

3. Nicolet, Y., Piras, C., Legrand, P., Hatchikian, C.E., Fontecilla-Camps, J.C. Desulfovibriodesulfuricans iron hydrogenase: The structure shows unusual coordination to an active site Fe binuclear center (1999) Structure, 7 (1), pp. 13-23. Cited 1026 times.

4. Wang, Y., Patel, D.J. Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex (1993) Structure, 1 (4), pp. 263-282. Cited 930 times.

5. Koepke, J., Hu, X., Muenke, C., Schulten, K., Michel, H. The crystal structure of the light-harvesting complex II (B800-850) from Rhodospirillum molischianum (1996) Structure, 4 (5), pp. 581-597. Cited 871 times.

6. Ermler, U., Fritzsch, G., Buchanan, S.K., Michel, H. Structure of the photosynthetic reaction centre from Rhodobactersphaeroides at 2.65 å resolution: cofactors and protein-cofactor interactions (1994) Structure, 2 (10), pp. 925-936. Cited 761 times.

7. Linding, R., Jensen, L.J., Diella, F., Bork, P., Gibson, T.J., Russell, R.B. Protein disorder prediction: Implications for structural proteomics (2003) Structure, 11 (11), pp. 1453-1459. Cited 749 times.

8. Uppenberg, J., Hansen, M.T., Patkar, S., Jones, T.A. The sequence, crystal structure determination and refinement of two crystal forms of lipase B from Candida antarctica (1994) Structure, 2 (4), pp. 293-308. Cited 603 times.

9. Martin, J.L. Thioredoxin -a fold for all reasons (1995) Structure, 3 (3), pp. 245-250. Cited 588 times.

10. Hanson, M.A., Cherezov, V., Griffith, M.T., Roth, C.B., Jaakola, V.-P., Chien, E.Y.T., Velasquez, J., Kuhn, P., Stevens, R.C. A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor(2008) Structure, 16 (6), pp. 897-905. Cited 567 times.

Biophysical Journal Aims and ScopeThe mission of Biophysical Journal (BJ) is to publish the highest quality work that elucidates important biological, chemical, or physical mechanisms and provides quantitative insight into fundamental problems at the molecular, cellular, and systems and whole-organism levels. Articles published in the Journal should be of general interest to quantitative biologists, regardless of their research specialty

BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding of experimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.

• Channels, receptors, and electrical signaling• Proteins• Biophysical theory and modeling• Cell biophysics• Photobiophysics• Membranes• Spectroscopy, imaging,and other techniques• Muscle and contractility• Supramolecular assemblies• Bioenergetics• Nucleic acids• Electrophysiology





1. Basser, P.J., Mattiello, J., LeBihan, D. MR diffusion tensor spectroscopy and imaging (1994) Biophysical Journal, 66 (1), pp. 259-267. Cited 3211 times.

2. FitzHugh, R. Impulses and Physiological States in Theoretical Models of Nerve Membrane (1961) Biophysical Journal, 1 (6), pp. 445-466. Cited 2904 times.

3. Schuck, P. Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lammequation modeling (2000) Biophysical Journal, 78 (3), pp. 1606-1619. Cited 2236 times.

4. Lo, C.-M., Wang, H.-B., Dembo, M., Wang, Y.-L. Cell movement is guided by the rigidity of the substrate (2000) Biophysical Journal, 79 (1), pp. 144-152. Cited 1778 times.

5. Hess, S.T., Girirajan, T.P.K., Mason, M.D. Ultra-high resolution imaging by fluorescence photoactivation localization microscopy (2006) Biophysical Journal, 91 (11), pp. 4258-4272. Cited 1757 times.

6. Axelrod, D., Koppel, D.E., Schlessinger, J., Elson, E., Webb, W.W. Mobility measurement by analysis of fluorescence photobleaching recovery kinetics (1976) Biophysical Journal, 16 (9), pp. 1055-1069. Cited 1681 times

7. Evans, E., Ritchie, K. Dynamic strength of molecular adhesion bonds (1997) Biophysical Journal, 72 (4), pp. 1541-1555. Cited 1674 times.

8. Wilson, H.R., Cowan, J.D. Excitatory and Inhibitory Interactions in Localized Populations of Model Neurons (1972) Biophysical Journal, 12 (1), pp. 1-24. Cited 1593 times.

9. Thompson, R.E., Larson, D.R., Webb, W.W. Precise nanometer localization analysis for individual fluorescent probes (2002) Biophysical Journal, 82 (5), pp. 2775-2783. Cited 1373 times.

10. Svergun, D.I. Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing (1999) Biophysical Journal, 76 (6), pp. 2879-2886. Cited 1271 times.

Trends in Cancer Aims and ScopeTrends in Cancer is a new member of the Trends review journals, offering concise and engaging expert commentary articles that address key frontline research topics and cutting-edge advances in the rapidly changing field of cancer discovery and medicine. The journal provides a unique platform for multidisciplinary information, discussion and education that is valuable for scientists, clinicians, and policy makers, as well as patients & advocates. The latest opportunities, challenges and potential impact of basic, translational and clinical findings, industry R&D, technology and innovation, ethics, or cancer policy and funding are equally presented and debated in an authoritative but reader-friendly format.

Impact and Utility▪ Newly Introduced Content, now indexed in PubMed: >250 articles online▪ Usage: >75,000 global downloads in 2017▪ Impact Factor: TBD, too new▪ Cite Score: 3.77▪ Issues Per Year: 12 issues per year


Top 10 Emerging Articles by Citation


1. Sahu, A., Singhal, U., Chinnaiyan, A.M. Long Noncoding RNAs in Cancer: From Function to Translation (2015) Trends in Cancer, 1 (2), pp. 93-109. Cited 59 times.

2. Lipinski, K.A., Barber, L.J., Davies, M.N., Ashenden, M., Sottoriva, A., Gerlinger, M. Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine (2016) Trends in Cancer, 2 (1), pp. 49-63. Cited 48 times.

3. Aceto, N., Toner, M., Maheswaran, S., Haber, D.A. En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition (2015) Trends in Cancer, 1 (1), pp. 44-52. Cited 42 times.

4. Bhagwat, A.S., Vakoc, C.R. Targeting Transcription Factors in Cancer (2015) Trends in Cancer, 1 (1), pp. 53-65. Cited 40 times

5. Obenauf, A.C., Massagué, J. Surviving at a Distance: Organ-Specific Metastasis (2015) Trends in Cancer, 1 (1), pp. 76-91. Cited 39 times.

6. Antonioli, L., Yegutkin, G.G., Pacher, P., Blandizzi, C., Haskó, G. Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities (2016) Trends in Cancer, 2 (2), pp. 95-109. Cited 32 times

7. Demaria, S., Coleman, C.N., Formenti, S.C. Radiotherapy: Changing the Game in Immunotherapy (2016) Trends in Cancer, 2 (6), pp. 286-294. Cited 30 times.

8. Baker, L.A., Tiriac, H., Clevers, H., Tuveson, D.A. Modeling Pancreatic Cancer with Organoids (2016) Trends in Cancer, 2 (4), pp. 176-190. Cited 30 times.

9. Hambardzumyan, D., Bergers, G. Glioblastoma: Defining Tumor Niches (2015) Trends in Cancer, 1 (4), pp. 252-265. Cited 27 times.

10. Dilley, R.L., Greenberg, R.A. ALTernative Telomere Maintenance and Cancer (2015) Trends in Cancer, 1 (2), pp. 145-156. Cited 27 times.

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