Making Standard Terminology Work In Clinical...
Transcript of Making Standard Terminology Work In Clinical...
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Making Standard Terminology Work InClinical Guidelines
Robert McClure1, James Campbell2,Julie Glasgow3, Mark Nyman4
1Apelon, Inc., Ridgefield, CT ; 2University of Nebraska Medical Center, Omaha, NE; 3GE Healthcare Integrated IT Solutions, Seattle, WA; 4Mayo Clinic, Rochester, MN
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Introductions
• Who are we?• Who we think you are…
– Training and experience: • Clinical understanding• Management of electronic information
– Interest• Prepare to implement clinical guidelines• Understand how terminology standards are
used in guidelines
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Objectives
• Gain general understanding of CDSS and standard terminologies
• Understand use of standard terminologies in CDSS
• Learn to manage challenges that arise in mapping local concepts to a CDSS
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Agenda
• Session Overview (McClure) – Intro – Guidelines overview – SAGE overview – Standard Terminologies
• What and why important• Guideline Abstraction (Glasgow)
– SAGE process– Identifying concepts in the guideline
• Making terminology work locally (Nyman) – Mapping – Issues to grapple with
• Wrap-up – Questions (McClure)
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What are Guidelines?• Guideline(n): a cord or rope to aid passage over a
difficult point (Merriam-Webster)• Systematic statements of evidence-based policy
rules or principles to assist clinicians and patients make decisions on healthcare alternatives
• Characteristics– May be developed by government agencies at any level,
institutions, professional societies, governing boards, or by convening expert panels.
– May be in narrative, outline, flowchart or tabular forms– Need to be formalized to provide computerized clinical
decision support at point of care
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Why Study Guidelines?President’s Information Technology Advisory Committee (2001)“Transforming Health Care through Information Technology”Findings…:• The U.S. lacks a broadly disseminated and accepted national
vision for information technology in health care• The introduction of integrated decision-support systems that can
proactively foster best practices and reduce errors requires enhanced information-technology methods and tools
Recommendations…: • Expand the range and granularity of routinely captured data• Standardize terminology • Develop guidelines based on evidences and best practices• Implement guidelines so that they are usable effectively at the
point of care, including embedded decision support that is continually updated as new evidence accumulates
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• Collaborative research and development project to develop a standards-based technology to enable encoding and dissemination of guidelines in executable format.
• Infrastructure will employ informatics standards including Protégé open source workbench, HL7 RIM, SNOMED CT and LOINC, and deployment technology to support encoding and dissemination of guidelines across vendor platforms and throughout the spectrum of care
• Guideline deployment technology will present guideline content to clinicians through active, patient-specific recommendationssurfaced through functions of the local clinical information system, and integrated into the care workflow
SAGE is partially supported under a grant from the U.S. Department of Commerce, National Institute of Standards and Technology, Advanced Technology Program, Cooperative Agreement Number 70NANB1H3049.
SAGE Project Overview
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Why Terminology Standards
• Interoperability– Common representation of meaning
• Robust terminology model
– Common coding– Interlingua
• Translate once
– Shared framework for collaborative improvement of the terminology
• Decision support needs all of this
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Selected NCVHS Terminology Standards
• SNOMED CT– CAP, soon International SDO
• LOINC– Regenstrief Institute
• ICD-9-CM– WHO/NCHS
• CPT– AMA
• NDC, RxNorm, NDF-RT, …
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SNOMED CT ®
• Under development by the College of American Pathologists since the 1960’s
• Provides a disambiguated, polyhierarchical representation of over 450,000 medical concepts, with approximately 1 million descriptions
• Under licensing agreement with the NLM• Crossmaps to other commonly-used
terminologies are built in• Presently the most complete formal medical
ontology in existence
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• Synonyms & homonyms– By assigning a unique numeric code to each
medical concept, SNOMED CT formalizes clinical terminology.
• Subsumption– By representing the complete set of relationships
among medical concepts, SNOMED CT automates classification logic.
• Expressiveness– By defining rules for combining concepts into
“expressions”, many clinical ideas can be encoded
Why do we need SNOMED CT?
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SNOMED CT StructureTermsConcepts
Relationships
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SNOMED CT StructureTermsConcepts
Relationships
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SNOMED CT StructureTermsConcepts
Relationships
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SNOMED CT StructureTermsConcepts
Relationships
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SNOMED CT StructureTermsConcepts
Relationships 4855003
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SNOMED CT StructureTermsConcepts
Relationships 4855003
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
Is-A
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
Is-A
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
Is-A
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
Is-A
Due-to
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
Is-A
Due-to
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
73211009
Is-A
Due-to
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
73211009
Is-A
Due-to
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
73211009 Diabetes mellitus
Is-A
Due-to
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SNOMED CT StructureTermsConcepts
Relationships 4855003 Diabetic retinopathy
29555009 Retinal disorder
73211009 Diabetes mellitus
Is-A
Due-to
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The Inheritance HierarchyConcepts are arranged in a tree hierarchy
Medication
Antibiotic Anti-HTN
Penicillin Quinolone
Ampicillin Methicillin
Beta-blocker Diuretic
Atenolol Betaxolol Metoprolol
. . .
is ais a
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The Inheritance HierarchyConcepts are arranged in a tree hierarchy
Medication
Antibiotic Anti-HTN
Penicillin Quinolone
Ampicillin Methicillin
Beta-blocker Diuretic
Atenolol Betaxolol Metoprolol
. . .
is ais a
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The Inheritance HierarchyConcepts are arranged in a tree hierarchy
Medication
Antibiotic Anti-HTN
Penicillin Quinolone
Ampicillin Methicillin
Beta-blocker Diuretic
Atenolol Betaxolol Metoprolol
. . .
is ais a
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The Inheritance HierarchyConcepts are arranged in a tree hierarchy
Medication
Antibiotic Anti-HTN
Penicillin Quinolone
Ampicillin Methicillin
Beta-blocker Diuretic
Atenolol Betaxolol Metoprolol
. . .
is ais a
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The Inheritance HierarchyConcepts are arranged in a tree hierarchy
Medication
Antibiotic Anti-HTN
Penicillin Quinolone
Ampicillin Methicillin
Beta-blocker Diuretic
Atenolol Betaxolol Metoprolol
. . .
is ais a
Antibiotic subsumes Penicillin and Methicillin
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Polyhierarchical structureA concept may have more than one parent in the
hierarchy
operation on gall bladder
laparoscopic cholecystectomy
laparoscopic procedure
procedure on abdomen
cholecystectomy
procedure
procedure by device
procedure by site
is a
is a
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Polyhierarchical structureA concept may have more than one parent in the
hierarchy
operation on gall bladder
laparoscopic cholecystectomy
laparoscopic procedure
procedure on abdomen
cholecystectomy
procedure
procedure by device
procedure by site
is a
is a
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Polyhierarchical structureA concept may have more than one parent in the
hierarchy
operation on gall bladder
laparoscopic cholecystectomy
laparoscopic procedure
procedure on abdomen
cholecystectomy
procedure
procedure by device
procedure by site
is a
is a
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Suprarenal Artery Embolus297143008
orOcclusion of Artery 2929001
Associated Morphology 116676008Embolus 55584005
Finding Site 363698007
Suprarenal Artery 89500000
Pre- and Post-Coordination
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Suprarenal Artery Embolus297143008
orOcclusion of Artery 2929001
Associated Morphology 116676008Embolus 55584005
Finding Site 363698007
Suprarenal Artery 89500000
Pre-Coordinated
Pre- and Post-Coordination
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Suprarenal Artery Embolus297143008
orOcclusion of Artery 2929001
Associated Morphology 116676008Embolus 55584005
Finding Site 363698007
Suprarenal Artery 89500000
Pre-Coordinated
Pre- and Post-Coordination
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Suprarenal Artery Embolus297143008
orOcclusion of Artery 2929001
Associated Morphology 116676008Embolus 55584005
Finding Site 363698007
Suprarenal Artery 89500000
Pre-Coordinated
Post-Coordinated
Pre- and Post-Coordination
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CDSS Vocabulary Services
Effective use of SNOMED vocabulary by the CDSS requires that these functions (at a minimum) be supported by the query/vocabulary management software:
1) Retrieve information about a single concept2) Determine if concept A is a “child” of concept B3) Query for a set of concepts, such as those defined
for use in clinical systemsa) “All the concepts that represent an immunocompromised
host””
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Guideline Abstraction
Julie Glasgow, MD
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Encoding Process
1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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CDC Adult Immunization Sub-guideline Schedule
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CDC Adult Immunization Sub-guideline Schedule
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Detail: US Adult Pneumococcal Guideline
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Detail: US Adult Pneumococcal Guideline
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Concepts in the Source Guideline• What is a chronic cardiovascular disease?• What defines diabetes mellitus?• What is functional or anatomic asplenia?• Who is an immunocompromised person?
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Concepts in the Source Guideline• What is a chronic cardiovascular disease?• What defines diabetes mellitus?• What is functional or anatomic asplenia?• Who is an immunocompromised person?
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Concepts in the Source Guideline• What is a chronic cardiovascular disease?• What defines diabetes mellitus?• What is functional or anatomic asplenia?• Who is an immunocompromised person?
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Concepts in the Source Guideline• What is a chronic cardiovascular disease?• What defines diabetes mellitus?• What is functional or anatomic asplenia?• Who is an immunocompromised person?
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Concepts in the Source Guideline• What is a chronic cardiovascular disease?• What defines diabetes mellitus?• What is functional or anatomic asplenia?• Who is an immunocompromised person?
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“Functional or anatomic asplenia”
• Clinical Definition– Congenital
asplenia– Functional asplenia– Splenectomy– Asplenia syndrome– Hyposplenism– Sickle cell disease
• SNOMED CT Concept– 93030006– 38096003– 234319005 (Procedure)– 17604001– 23761004– 127040003 (Hemoglobin
S disease)
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“Functional or anatomic asplenia”
• Clinical Definition– Congenital
asplenia– Functional asplenia– Splenectomy– Asplenia syndrome– Hyposplenism– Sickle cell disease
• SNOMED CT Concept– 93030006– 38096003– 234319005 (Procedure)– 17604001– 23761004– 127040003 (Hemoglobin
S disease)
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Concepts in the Encoded Guideline:Protégé
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Concepts in the Encoded Guideline:Protégé
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Concepts in the Encoded Guideline:ProtégéContext Nodes organize and specifythe relationship to workflow. • What triggers the session• Who is involved• Where the session occurs
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Concepts in the Encoded Guideline:ProtégéContext Nodes organize and specifythe relationship to workflow. • What triggers the session• Who is involved• Where the session occurs
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Concepts in the Encoded Guideline:ProtégéContext Nodes organize and specifythe relationship to workflow. • What triggers the session• Who is involved• Where the session occurs
Decision Nodes provide support for making choices:•Specification of alternatives•Logic used to evaluate choices
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Concepts in the Encoded Guideline:ProtégéContext Nodes organize and specifythe relationship to workflow. • What triggers the session• Who is involved• Where the session occurs
Decision Nodes provide support for making choices:•Specification of alternatives•Logic used to evaluate choices
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Concepts in the Encoded Guideline:ProtégéContext Nodes organize and specifythe relationship to workflow. • What triggers the session• Who is involved• Where the session occurs
Decision Nodes provide support for making choices:•Specification of alternatives•Logic used to evaluate choices
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Concepts in the Encoded Guideline:ProtégéContext Nodes organize and specifythe relationship to workflow. • What triggers the session• Who is involved• Where the session occurs
Decision Nodes provide support for making choices:•Specification of alternatives•Logic used to evaluate choices
Action Nodes define activity to be accomplished by the CIS:•User interaction, query, messaging•Order sets•Appointments and referrals•Goal setting•Documentation and recording
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Concepts in the Encoded Guideline:ProtégéContext Nodes organize and specifythe relationship to workflow. • What triggers the session• Who is involved• Where the session occurs
Decision Nodes provide support for making choices:•Specification of alternatives•Logic used to evaluate choices
Action Nodes define activity to be accomplished by the CIS:•User interaction, query, messaging•Order sets•Appointments and referrals•Goal setting•Documentation and recording
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Adult Pneumococcal Vaccine Logic
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Adult Pneumococcal Vaccine Logic
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Functional or Anatomic Asplenia
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Functional or Anatomic Asplenia
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Functional Asplenia
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Functional Asplenia
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SAGE Protégé Tool for Vocab. Inventory
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SAGE Protégé Tool for Vocab. Inventory
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Guideline Concepts ↔ Patient Record• Concepts must be defined in order to find them in
the electronic patient record• There is variation in data representation across
EMRs– Concepts used– Structures to hold concepts– Usage customs
• A standard representation allows translation of concepts for inclusion in database queries
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Example: Possible Representations of a Patient’s Diabetes Mellitus• Entry on Problem List
– Diabetes Mellitus type II• Observation
– Lab Value of Fasting Glucose > 125 mg/dL or– Lab value for two-hour 75-g oral glucose
tolerance test > 200 mg/dL• Entry in Diagnoses & Procedures list
– Diabetes Mellitus type II
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Example: Possible Representations of a Patient’s Diabetes Mellitus• Entry on Problem List
– Diabetes Mellitus type II• Observation
– Lab Value of Fasting Glucose > 125 mg/dL or– Lab value for two-hour 75-g oral glucose
tolerance test > 200 mg/dL• Entry in Diagnoses & Procedures list
– Diabetes Mellitus type IIData engineers must map standard guideline concept
representations to local concepts and structures
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Making terminology work locally
Mark Nyman, MD
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1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information
Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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1. AssembleSource
Guidelines
2. EnvisionClinical
Scenarios
3. FormalizeGuideline
Logic
4. DefineGuidelineConcepts
5. FormalizeVocabularyInventory
6. Specify Information
Queries
7. EncodeGuideline
Knowledgebase
GuidelineInstallation
and Execution
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SAGE Guideline Deployment System Execution Architecture
Encoded
Guideline
SAGE Execution
EngineClinical
Information System
VMR
Inter-face
Binding
Local Modifications
data
Event Listener
Event Notifications
Terminology Server
TerminologyFunctions
Data Query Service Calls
Action Service Calls
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Mapping
Decision Support System
Problems
Lab
Orders
Local Computer Information System
Problems
Lab
Orders
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Example:Mapping of Problems
Diabetes
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SNOMED: diabetes
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Local CIS
DM Coma2202581DM Type1 Hyperosmolarity2202578DM Type2 Hyperosmolarity2202577DM Type1 Ketoacidosis2202574DM Type2 Ketoacidosis2202573DM Ketoacidosis2202572DM Type1 Uncontrolled2202571DM Type2 Uncontrolled2202570DM Type12202569DM w/o Complications2202568DM Type22202567DM2202566
DM Type2 Retinopathy Prolif2202601DM Type2 Retinopathy Background2202600DM Type2 Retinopathy2202599DM Retinopathy Macular Edema2202598DM Retinopathy Background2202596DM Type2 Cataract2202594DM Retinopathy Proliferative2202593DM Retinopathy2202592DM Type1 Nephropathy Uncontrolled2202591DM Type2 Nephropathy Uncontrolled2202590DM Type1 Nephropathy2202589DM Type1 Nephrotic Syndrome2202588
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MAP
DM type 22202567Diabetes mellitus type 2
44054006
DM type 12202569Diabetes mellitus type 1
46635009DescriptionCIS #TermSNOMED #
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Example:Mapping of Lab Observations
Hgb A1c
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Retrieve Sub-guideline
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Retrieve Sub-guideline
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Retrieve Sub-guideline
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Mayo Lab Code for Hgb A1c
Kasson/in MICS82990Hemoglobin A1C, B 4548-4
New England/not in MICS124055Hemoglobin A1C, B 4548-4
Clinical Trials/not in MICS80947Hemoglobin A1C, B 4548-4
Central Clinical Lab/in MICS82080Hemoglobin A1C, B 4548-4
Performed/reportedUnit codeUnit code nameLOINC
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Mayo Lab Code for Hgb A1c
Kasson/in MICS82990Hemoglobin A1C, B 4548-4
New England/not in MICS124055Hemoglobin A1C, B 4548-4
Clinical Trials/not in MICS80947Hemoglobin A1C, B 4548-4
Central Clinical Lab/in MICS82080Hemoglobin A1C, B 4548-4
Performed/reportedUnit codeUnit code nameLOINC
100
Mayo Lab Code for Hgb A1c
Kasson/in MICS82990Hemoglobin A1C, B 4548-4
New England/not in MICS124055Hemoglobin A1C, B 4548-4
Clinical Trials/not in MICS80947Hemoglobin A1C, B 4548-4
Central Clinical Lab/in MICS82080Hemoglobin A1C, B 4548-4
Performed/reportedUnit codeUnit code nameLOINC
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Mayo Lab Code for Hgb A1c
Kasson/in MICS82990Hemoglobin A1C, B 4548-4
New England/not in MICS124055Hemoglobin A1C, B 4548-4
Clinical Trials/not in MICS80947Hemoglobin A1C, B 4548-4
Central Clinical Lab/in MICS82080Hemoglobin A1C, B 4548-4
Performed/reportedUnit codeUnit code nameLOINC
102
Mayo Lab Code for Hgb A1c
Kasson/in MICS82990Hemoglobin A1C, B 4548-4
New England/not in MICS124055Hemoglobin A1C, B 4548-4
Clinical Trials/not in MICS80947Hemoglobin A1C, B 4548-4
Central Clinical Lab/in MICS82080Hemoglobin A1C, B 4548-4
Performed/reportedUnit codeUnit code nameLOINC
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Mayo Lab Code for Hgb A1c
Kasson/in MICS82990Hemoglobin A1C, B 4548-4
New England/not in MICS124055Hemoglobin A1C, B 4548-4
Clinical Trials/not in MICS80947Hemoglobin A1C, B 4548-4
Central Clinical Lab/in MICS82080Hemoglobin A1C, B 4548-4
Performed/reportedUnit codeUnit code nameLOINC
104
Mayo Lab Code for Hgb A1c
Kasson/in MICS82990Hemoglobin A1C, B 4548-4
New England/not in MICS124055Hemoglobin A1C, B 4548-4
Clinical Trials/not in MICS80947Hemoglobin A1C, B 4548-4
Central Clinical Lab/in MICS82080Hemoglobin A1C, B 4548-4
Performed/reportedUnit codeUnit code nameLOINC
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Translation Table
610567382990-ROCLIS
Hemoglobin A1C, B (Kasson)
610526782080-ROCLIS
Hemoglobin A1C, B (Rochester)
Hemoglobin A1C
LOINC:4548-4
observation
/mapping/toMayo Lab Code
/mapping/to/@label
/mapping/from/concept/@label
/mapping/from/concept
/mapping/@context
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Translation Table
611289915958-ROCLIS
Hemoglobin A1C, B
Hemoglobin A1C, calculated
LOINC:17855-8
observation
610567382990-ROCLIS
Hemoglobin A1C, B (Kasson)
610526782080-ROCLIS
Hemoglobin A1C, B (Rochester)
Hemoglobin A1C
LOINC:4548-4
observation
/mapping/toMayo Lab Code
/mapping/to/@label
/mapping/from/concept/@label
/mapping/from/concept
/mapping/@context
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Translation Table
611289915958-ROCLIS
Hemoglobin A1C, B
610567382990-ROCLIS
Hemoglobin A1C, B (Kasson)
610526782080-ROCLIS
Hemoglobin A1C, B (Rochester)
Hemoglobin A1C
LOINC:4548-4
observation
/mapping/toMayo Lab Code
/mapping/to/@label
/mapping/from/concept/@label
/mapping/from/concept
/mapping/@context
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Example:Mapping of Lab Orders
Hgb A1c
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Instance of Order
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Translation Table
XSERVI #82080-ROCLISO
Hemoglobin A1C,B
Hemoglobin A1C
LOINC:4548-4
order
/mapping/toMayo Lab Code
/mapping/to/@label
/mapping/from/concept/@label
/mapping/from/concept
/mapping/@context
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Mapping Challenges
• Mismatch in vocabularies• Mismatch of data representation• Absence of data elements in the CIS
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Potential Solutions• Mismatch in vocabularies
– Petition change in standard– Change local vocabulary
• Mismatch of data representation – Search the problem list
• Absence of data elements in the CIS– Query the user– Accept absence
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Thanks for your attention..Questions?