Making Sense of Longitudinal Data Changes in ventricular function in babies with a functional single...
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![Page 1: Making Sense of Longitudinal Data Changes in ventricular function in babies with a functional single ventricle Travis Wilder, M.D. CHSS Data Center Kirklin-Ashburn.](https://reader034.fdocuments.in/reader034/viewer/2022050714/56649cae5503460f94971c0e/html5/thumbnails/1.jpg)
Making Sense of Longitudinal Making Sense of Longitudinal Data Data
Changes in ventricular function in babies with a functional single
ventricle
Travis Wilder, M.D. CHSS Data Center Kirklin-Ashburn Fellow
WSPCHS 2014 – Brazil
![Page 2: Making Sense of Longitudinal Data Changes in ventricular function in babies with a functional single ventricle Travis Wilder, M.D. CHSS Data Center Kirklin-Ashburn.](https://reader034.fdocuments.in/reader034/viewer/2022050714/56649cae5503460f94971c0e/html5/thumbnails/2.jpg)
No Disclosures No Disclosures
Wilder TJ, McCrindle BW, Hickey EJ, DeCampli WM, Williams WG, Caldarone CA, Blackstone EH
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Rajeswaran and Blackstone
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4
8
12
16
20
0 2 4 6 8 10 12
AF
Pre
vale
nce
(%
)
Months
CABG
No
Yes
Atrial FibrillationAtrial Fibrillation
Rajeswaran and Blackstone
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ObjectivesObjectives
Describe longitudinal data and a new method for analysis
Illustrate how a new method maximizes the information we can generate from longitudinal data– Clinical example of critical LVOTO
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Joint work of the Cleveland Clinic Clinical Investigations team under the direction of Drs. Eugene Blackstone, Rajeswaran Jeevanantham (HVI/QHS: biostatistics)
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Longitudinal DataLongitudinal Data
Rajeswaran and Blackstone Years after birth
Ventricular dysfunction
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Transfusion after SurgeryTransfusion after Surgery
Rajeswaran and Blackstone
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Pain ScorePain Score
Rajeswaran and Blackstone
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RV Function: 3882 echoes from 427 children with single RV
% O
f ec
ho
es in
eac
h s
tate
RV Dysfunction None Mild Moderate Severe
Years after birth
Mean age of SCPC = 7 mo.
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Analytic StrategyAnalytic Strategy
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% R
V D
ysfu
nct
ion
Years after birth
Data Exploration:Patten-Specific Profile
RV Dysfunction None/Mild Moderate/ Severe
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Data Analysis: Temporal Trends
Early Phase
Years after birth
% P
rob
abili
ty
Late Phase Raw Data
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Data Analysis: Temporal Trends
Years after birth
Late Phase
Early Phase
% P
rob
abili
ty
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Data Analysis:Risk Stratification
Probability of RV dysfunction: Norwood
Probability of RV dysfunction: Hybrid
Years after birth
% P
rob
abili
ty
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Areas of InterestAreas of Interest
What is the rate of ventricular failure, and what factors influence that rate at various phases?
Comparing children with Right vs. Left single ventricle physiology: LVOTO vs. TA–What are the differences in VF?–What are the differences AVVR?
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Thank YouThank You