Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the...
Transcript of Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the...
![Page 1: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/1.jpg)
Making Lasting Memories
James L. McGaugh
Center for the Neurobiology of
Learning and Memory
And
Department of Neurobiology and Behavior
![Page 2: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/2.jpg)
“Memory is assisted by anything that makes an impression on a powerful passion, inspiring fear, for example, or wonder, shame or joy.” Francis Bacon, 1620
![Page 3: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/3.jpg)
“The usefulness of all of the passions consists in their strengthening and prolonging in the soul thoughts which are good for it to conserve…
Descartes, The Passions of the Soul, 1650
![Page 4: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/4.jpg)
![Page 5: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/5.jpg)
Stress-Released Hormones
Arousal/Stress
Brain Activation
Anterior Pituitary Autonomic Nervous System
Adrenal Cortex Adrenal Medulla
Cortisol (corticosterone) Epinephrine (Adrenaline)
![Page 6: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/6.jpg)
Inhibitory
Avoidance
![Page 7: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/7.jpg)
Saline
Controls
Epinephrine
100
50
200
0
250
150 Retention Latencies
0 10 30 120
Epinephrine Administered
After Training Enhances Memory of
Inhibitory Avoidance Training
Time of Posttraining Injection (min)
Gold and van Buskirk, 1975
![Page 8: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/8.jpg)
Amygdala
![Page 9: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/9.jpg)
![Page 10: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/10.jpg)
Object recognition test in rats
Interval
A3
?
B
Training trial
A1
Retention trial
A2
![Page 11: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/11.jpg)
Roozendaal et al., 2008
Object Recognition Memory
![Page 12: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/12.jpg)
Adrenal Corticosterone
Modulates Consolidation
Mediation via Basolateral Amygdala
Basolateral Amygdala NE Activation Required
![Page 13: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/13.jpg)
-20
-10
0
10
20
30
40
50
Dis
cri
min
ati
on
in
de
x (
%)
Saline Propranolol (0.5 µg)
Intra-BLA infusion
Vehicle
Cort 0.3 mg/kg
Cort 1 mg/kg
Cort 3 mg/kg
BLA β-Adrenoceptors mediate corticosterone
effects on
object recognition memory
**
**
Okuda , Roozendaal and McGaugh PNAS 2006
No prior habituation
![Page 14: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/14.jpg)
Norepinephrine Activation in the Amygdala
Influences Memory Consolidation
in vivo microdialysis
HPLC
![Page 15: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/15.jpg)
![Page 16: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/16.jpg)
Norepinephrine Release in the Amygdala After
Inhibitory Avoidance Training
0
100
200
300
400
500
600
700
800
1 2 3 4 5 IA 7 8 9 10 11 12 13 14
15 min sample
% o
f B
aselin
e N
E
600 SEC
600 SEC
600 SEC
600 SEC
342 SEC
227 SEC
10 SEC
McIntyre, Hatfield and McGaugh, 2000
Retention Latencies
![Page 17: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/17.jpg)
Neuromodulatory and Amygdala Regulation of Memory in Human
Subjects
![Page 18: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/18.jpg)
4
2
8
12
10
6
0.03 0.04 0.05 0.06 0.07 0.08
r = + 0.93
Number of Films Recalled
Amygdala Activity (PET)
During Encoding and Long-
Term Explicit Memory
Cahill, et al
1996
Right Amygdala Glucose
![Page 19: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/19.jpg)
Learning
Experience Cortex
Hippocampus
Caudate Nucleus
Other Brain Regions
Basolateral
Amygdala
Adrenal Gland
Initiation of Memory Consolidation
Glucocorticoid Epinephrine
Modulating Influences
![Page 20: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/20.jpg)
“The usefulness of all of the passions consists in their strengthening and prolonging in the soul thoughts which are good for it to conserve… And all the harm they can do consists in their strengthening and conserving these thoughts more than is necessary.”
Descartes, The Passions of the Soul, 1650
![Page 21: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/21.jpg)
Preventing PTSD with drugs affecting norepinephrine?
![Page 22: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/22.jpg)
Highly Superior Autobiographical Memory
![Page 23: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/23.jpg)
![Page 24: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/24.jpg)
Five new subjects
![Page 25: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/25.jpg)
![Page 26: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/26.jpg)
Testing for memory of events
Professional violinist
![Page 27: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/27.jpg)
![Page 28: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/28.jpg)
Subject’s discussion of the remembering process
![Page 29: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/29.jpg)
![Page 30: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/30.jpg)
Testing for dates
![Page 31: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/31.jpg)
![Page 32: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/32.jpg)
Testing for memory of sporting events
TV producer
![Page 33: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/33.jpg)
![Page 34: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/34.jpg)
Memory of an Italian event:
Hollywood actress Marilu Henner
![Page 35: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/35.jpg)
![Page 36: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/36.jpg)
![Page 37: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/37.jpg)
Temporoparietal Junction
HSAM region > Control
region TBM
![Page 38: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/38.jpg)
Some questions: Neurobiological bases –fMRI, genetics Importance of selectivity in memory? What possible insights concerning memory – a novel capacity? or, for most of us, a lost capacity? What “price” is paid for this ability?
![Page 39: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/39.jpg)
With thanks to --
Benno Roozendaal
Larry Cahill
Christa McIntyre
Shoki Okuda
Emily Malin
Areg Barsegyan
Daniel Berlau
Ryan LaLumiere
John Guzowski
Craig Stark
Aaron Mattfeld
Frithjof Kruggel
Aurora LePort … and many others
![Page 40: Making Lasting Memories - WordPress.comMaking Lasting Memories James L. McGaugh Center for the Neurobiology of Learning and Memory And Department of Neurobiology and Behavior](https://reader036.fdocuments.in/reader036/viewer/2022070805/5f0384597e708231d40972d3/html5/thumbnails/40.jpg)
The end