Madrid, November 8th 2006

Spanish National Cancer CenterOverview

History and Research Model

Páge 2 Strictly Confidential CNIO, 2006

Previous Hospital Victoria Eugenia:-Basic research laboratories-General offices

Extension Building-Applied research-Animal Facility Unit

CNIO Overview

CNIO Building

Páge 3 Strictly Confidential CNIO, 2006

CNIO Research Model

Basic ResearchApplied Research

-Structural Biologyand Biocomputation-Molecular Oncology-Cancer Genetics

-Molecular Pathology

-Experimental therapeutics (Medicinal Chemistry)

-Biotechnology

Páge 4 Strictly Confidential CNIO, 2006

CNIO Goal Roadmap

CNIO Goal: From Bench ToCNIO Goal: From Bench Top to Bed Sidep to Bed Side

4 – 8 YEARS4 – 8 YEARS

+ 4 YEARS+ 4 YEARS

Proof of Principle – Pre Phase I Proof of Principle – Pre Phase I

New Therapy New Therapy RegisterRegister

Center SetupCenter Setup+ 4 YEARS+ 4 YEARS

From zero to excellent scienceFrom zero to excellent science

+ 4 YEARS+ 4 YEARS

Páge 5 Strictly Confidential CNIO, 2006

Building Trust

The key success factors for knowledge based industries are an excellence science that allows the CNIO to generate the enough trust in the players needed to generate business opportunities.

TRUSTTRUST

SCIENCESCIENCE

EXCELENCEXCELENCEE

Critical Mass (Scientific Production – Sci. Staff)

Impact Factor

Grants/Projects

Mentions/Awards

IP (Patents/Royalties)

Social Community

Investors

Industry

Páge 6 Strictly Confidential CNIO, 2006

Success key factors

Converting such opportunities into feasible business models require the conjunction of some success factors

Private-Public Ethic

considerations

Excellent Scientific Resources

11

Professional Management

2244

Funding and Credits

55

IP Management33