M ultiscale modelling to predict the risk of osteoporotic bone fractures
description
Transcript of M ultiscale modelling to predict the risk of osteoporotic bone fractures
Multiscale modelling to predict the risk of osteoporotic bone
fracturesVPHOP Integrated project
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Osteoporosis is a killer• OP fractures kill as many women as breast
cancer • 30 to 50% of all women and 15 to 30% of all
men will face an osteoporotic fracture in their lifetime
• 4,000,000 fractures every year cost Europe €30,000,000,000
• Forecast to double by 2050• 250,000 elders will die of related
complications within 12 months, all others will remain impaired
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The VPHOP Consortium
• 21 partners• 7 industrial partners• 5 clinical centres• Research leaders in:
Biomechanics, biomaterials, computer sciences, biomedical informatics, mechanobiology, CAS, technology assessment, medical imaging & instrument.
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EOSTM Dual Energy system
• Scanning area: 5-175 cm (sitting - upright)
• Sim. bi-planar acquisition, 20 s, head-to-toe
• Low dose (÷ 10 vs. film/screen)• 3D reconstruction of ext. geometry• Bi-planar DXA
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Actibelt®
• 3D accelerometer integrated in belt buckle
• Objective measurement of neuromuscular condition during ambulatory visit
• Monitoring long term activity (5 days)
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Organ-level Model
Bone RemodellingModel
AugmentationModel
Tissue-levelModel
Clinical workflow
Body-level Model
Loading spectru
m
Constitutive
Equation
Personalised riskof fracture
Dise
ase
& ph
arm
a(p
re-
com
pute
d) Effect of augmentation
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VPHOP PR(t) curve [predicted]
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Disclaimer• VPHOP is a project co-funded by the European
Commission Seventh FRAMEWORK PROGRAMME• The research reported upon in this presentation has
either directly or indirectly been supported by the European Commission, Directorate General Information Society and Media, Brussels.
• The results, analyses and conclusions derived there from reflect solely the views of its authors and of the presenter.
• The European Community is not liable for any use that may be made of the information contained therein.