M. Balali-Mood, Toxic Trauma Mechanisms of Gene A Basic...

Biomedicine springer.com/NEWSonline

12

D. J. Baker, SAMU de Paris, Paris, France

Toxic TraumaA Basic Clinical Guide

This book provides practical guidance to emergen-cy personnel and others in the event of having to manage individual or mass chemical casualties as part of their work in a civilian ambulance service or hospital. The text considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals and toxins (which although of biological origin behave as chemicals in terms of their effects and transmis-sion). Individual chapters cover the development and classification of chemical toxic agents, how exposure can occur and how medical personnel should be involved in its management .

Features 7 A practical reference guide for medical person-nel faced with the management of casualties fol-lowing exposure to toxic chemical agents 7 The approach to the effects of chemical agent exposure will be one that parallels conventional trauma management teaching systems (eg ATLS) 7 The text will go beyond existing literature on poison-ing and clinical toxicology to provide a holistic approach to the management of exposure to industrial and chemical warfare agents

Contents Introduction.- Toxic trauma: an historical per-spective.- The classification and properties of toxic hazards.- Properties of toxic chemical agents.- Ex-posure to toxic hazards.- Responding to chemical releases: essentials of organization and incident management.- The pathophysiology of toxic trauma.- The clinical presentation of toxic trauma: assessment and diagnosis.- The treatment of toxic trauma.- The longer term consequences of toxic trauma.- Preparing for toxic trauma.

Fields of interestPharmacology/Toxicology; Emergency Medicine

Target groupsProfessional/practitioner

Discount groupProfessional Non-Medical

Due January 2014

2014. Approx. 200 p. 40 illus., 20 in color. Hardcover7 approx. $209.00ISBN 978-1-4471-5597-3

9<HTMEPH=bffjhd>

M. Balali-Mood, Mashhad University of Medical Sciences, Mashhad, Iran; M. Abdollahi, Tehran University of Medical Science, Tehran, Iran (Eds)

Basic and Clinical Toxicology of Organophosphorus CompoundsThis book explains the chemistry of Organophos-phorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical manage-ment of affected patients to reduce their toxic side effects.

Features 7 A comprehensive reference for clinical toxicologists and emergency physicians involved in teaching and research on the health effects of organophosphorus compounds 7 Provides updated information on different aspects of or-ganophosphorus compounds including neurologi-cal complications of exposure 7 A basic guide to organophosphorus compounds for regulatory authorities in agriculture, works, environment, industries, military and health

Contents Chemistry and classification of OP com-pounds.- History of use and epidemiology of organophosphorus poisoning.- Acute toxicity of organophosphorus compounds.- Chronic toxicity of organophosphorus compounds.- Toxicity and novel biomarkers of OP exposure.- Clinical man-agement of acute OP pesticide poisoning.- Clinical management of organophosphorus nerve agents’ poisonings.- Occupational and environmental aspects of organophosphorus compounds.- Sum-mary, discussion and conclusions.

Fields of interestPharmacology/Toxicology; Emergency Medicine; Molecular Medicine



Due December 2013

2014. XX, 219 p. 26 illus., 5 in color. Hardcover7 approx. $189.00ISBN 978-1-4471-5624-6

9<HTMEPH=bfgceg>

C. Carlberg, F. Molnár, University of Eastern Finland, Kuopio, Finland

Mechanisms of Gene RegulationThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the vari-ous phenotypes of cells and tissues and as such, regulation of expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading from students of all the biomedi-cal sciences in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research.

Features 7 Figure-driven textbook, i.e. ratio of text to figures is low 7 Expertly written textbook on a modern field of general interest, based on 10 years experience of teaching the course for which the textbook is designed 7 Many figures are based on real protein structures, i.e. not only on schemes

Contents Overview: What is gene expression?.- The impact of chromatin.- The basal transcriptional machin-ery.- Transcription factors.- Linking signal trans-duction and gene regulation.- Switching genes on and off at the example of nuclear receptors.- Map-ping the genome.- Chromatin modifiers.- Ge-nomic imprinting.- The epigenome.- Chromatin remodeling.- Chromatin architecture.- Regulatory RNA.

Fields of interestGene Expression; Protein Structure

Target groupsGraduate


Due December 2013

2014. Approx. 200 p. 83 illus., 64 in color. Hardcover7 $89.99ISBN 978-94-007-7904-4

9<HTUELA=hhjaee>

www.springer.com/978-1-4471-5597-3



News 11/2013 Biomedicine

13

T. J. Cleophas, Albert Schweitzer Hospital, Sliedrecht, The Netherlands; A. H. Zwinderman, Academic Medical Center, Amsterdam, The Netherlands

Machine Learning in MedicinePart Three

Machine learning is concerned with the analysis of large data and multiple variables.

Features 7 Electronic health records of modern health facilities, are increasingly complex and systematic assessment of these records is virtually impos-sible without special computationally intensive methods 7 Clinicians and other health profes-sionals are not familiar with these methods, and this book is the first publication that systemati-cally reviews such methods, particularly, for this audience 7 The book is written as a hand-hold presentation also accessible to non-mathemati-cians, and as a must-read publication for those new to the methods 7 The book includes step by step data analyses in SPSS, and can, therefore, also be used as a cookbook-like guide for those starting with the novel methodologies machine learning

Contents Preface.- Introduction to Machine Learning Part Three.- Evolutionary Operations.- Multiple Treatments.- Multiple Endpoints.- Optimal Bin-ning.- Exact P-Values.- Probit Regression.- Over - dispersion.10 Random Effects.- Weighted Least Squares.- Multiple Response Sets.- Complex Samples.- Runs Tests.- Decision Trees.- Spectral Plots.- Newton’s Methods.- Stochastic Processes, Stationary Markov Chains.- Stochastic Processes, Absorbing Markov Chains.- Conjoint Models.- Machine Learning and Unsolved Questions.- In-dex.

Fields of interestBiomedicine general; Medicine/Public Health, general; Statistics, general

Target groupsUpper undergraduate


Due December 2013

2014. X, 226 p. 27 illus., 8 in color. Hardcover7 $89.99ISBN 978-94-007-7868-9

9<HTUELA=hhigij>

J. A. das Neves, University of Porto Faculty of Pharmacy, , Portugal; B. F. Sarmento, Instituto Superior de Ciências da Saúde Pharmaceutical Technology, Gandra, Portugal (Eds)

Mucosal Delivery of BiopharmaceuticalsBiology, Challenges and Strategies

Contents Concepts in Mucosal Immunity and Mucosal Vaccines.- Mucoadhesion and Characterization of Mucoadhesive Properties.- Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems.- Epithelial Permeation and Absorption Mecha-nisms of Biopharmaceuticals.- Oral Delivery of Biopharmaceuticals.- Buccal Delivery of Biophar-maceuticals: Vaccines and Allergens.- Pulmonary Delivery of Biopharmaceuticals.- Nasal Delivery of Biopharmaceuticals.- Ocular Delivery of Biophar-maceuticals.- Vaginal Delivery of Biopharmaceuti-cals.- Nanoparticles-in-Microsphere Oral Delivery Systems (NiMOS) for Nucleic Acid Therapy in the Gastrointestinal Tract.- Bacteria-Based Vectors for Oral Gene Therapy.- Self-Assembled Polysaccha-ride Nanogels for Nasal Delivery of Biopharma-ceuticals.- Pheroid™ Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals.- Delivery Strategies for Developing siRNA-Based Vaginal Microbicides.- Delivery Strategies for Developing Vaginal DNA Vaccine Combining Cell-Penetrat-ing Peptides and Jet Injection.- Vaccine Delivery Systems for Veterinary Immunization.- Eligen® Technology for Oral Delivery of Proteins and Pep-tides.- The RapidMist™ System for Buccal Delivery of Insulin.- The Pharmaceutical Development of rhDNase (Dornase Alpha) for the Treatment of Cystic Fibrosis.- Development of the Exubera® Insulin Pulmonary Delivery System. [...]

Fields of interestPharmaceutical Sciences/Technology; Pharmacol-ogy/Toxicology

Target groupsResearch


Due February 2014

2014. VIII, 492 p. 134 illus., 23 in color. Hardcover7 approx. $209.00ISBN 978-1-4614-9523-9

9<HTMERB=ejfcdj>

J. Decety, The University of Chicago, Chicago, IL, USA; Y. Christen, Fondation IPSEN pour la Recherche Therapeutique, Boulogne Billancourt Cedex, France (Eds)

New Frontiers in Social NeuroscienceContents Preface.- Robin Dunbar: What’s so social about the social brain?.- Steve Rogers: The neurobiology of a transformation from asocial to social life during swarm formation in desert locusts.- Jakob Bro-Jorgensen: Social neuroscience and the study of animal communication.- Jay J. van Bavel et al.: The group mind: the pervasive influence of social identity on cognition.- Sarah Blaffer Hrdy: Devel-opment and social selection in the emergence of “emotionally modern” humans.- Mark van Vugt: On faces, gazes, votes, and followers: evolutionary psychological and social neuroscience approaches to leadership.- Craig Ferris: Using awake animal imaging to understand neural circuits of emotion: studies ranging from maternal care to aggression.- Jean Decety: The neuro-evolution of empathy and caring for others: why it matters for moral-ity.- Beatrice de Gelder and Ruud Hortensius: The many faces of the emotional body.- Kiley J. Hamlin: The origins of human morality: complex socio-moral evaluations by preverbal infants.- Ila-nit Gordon: Can oxytocin improve core brain and behavioral features of Autism Spectrum Disorders in children?.- Jack van Honk et al.: Testosterone and dominance in humans: behavioral and brain mechanisms.- Subject index.

Fields of interestNeurosciences; Behavioral Therapy



Due December 2013

2014. X, 280 p. 36 illus., 22 in color. (Research and Perspectives in Neurosciences, Volume 21) Hardcover7 $189.00ISBN 978-3-319-02903-0

9<HTODMJ=acjada>





14

A. J. Domb, School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, , Israel; W. Khan, School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel (Eds)

Focal Controlled Drug DeliveryContents Biodegradable Polymers for Focal Delivery Systems.- Implantable Medical Devices.- Systemic Targeting Systems-EPR Effect, Ligand Targeting Systems.- Liposomal formulations for Focal and Targeted Drug Delivery in Cancer and Other Diseases.- Polymer Drug Conjugate in Focal Drug Delivery.- Pharmacokinetic and Pharmacody-namic Aspects of Focal and Targeted Delivery of Drugs.- Treatment of Brain Tumors.- Intranasal Delivery of Neuropeptide-Loaded Nanopar-ticles and Their Application to Nervous System Therapeutics.- Focal Drug Delivery in Inner Ear Therapy.- Nanotechnology Based Ophthalmic Drug Delivery System.- Site Specific Ocular Nucleic Acid Delivery.- Topical Iontophoresis for Targeted Local Drug Delivery to the Eye and Skin.- Local Drug Delivery to the Oral Cavity.- Focal Drug Delivery for Management of Oral Infections.- Segmental-Dependent Drug Absorp-tion and Delivery: The Stomach.- Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract.- Nanotechnology Applications in Local Arterial Drug Delivery.- Drug Eluting Stents.- Drug-Eluting Vascular Grafts.- Delivery Systems for Lymphatic Targeting.- Spatio-tempo-ral Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair.- Spatio-tempo-ral Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair.- Polymer Based Drug Delivery Systems for Solid Tumor Treat-ment.- Topical Nanointerventions for Therapeutic and Cosmeceutical Applications.- Focal Drug Delivery to the Nail. [...]

Field of interestPharmaceutical Sciences/Technology



Due December 2013

2014. XIV, 736 p. 99 illus., 75 in color. (Advances in Delivery Science and Technology) Hardcover7 $209.00ISBN 978-1-4614-9433-1

9<HTMERB=ejeddb>

New SeriesCurrent Topics in NeurotoxicityT. Archer, Series editor: R. M. Kostrzewa

Current Topics in Neurotoxicity consists of volumes that cover the latest developments in neurotoxicity studies including neurodegenera-tion, neuroprotection, and neuroregeneration. The series has a translational focus and addresses the causes of neurotoxicity associated with diseases such as Alzheimers, Parkinsons Disease, autism, HIV associated dementia etc.

K. Foster, Syntaxin Ltd., Abingdon, UK (Ed)

Molecular Aspects of Botulinum NeurotoxinCurrently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotox-ins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation.

Features 7 Featuring chapters from the leading authori-ties responsible for the most significant current scientific and clinical research on neurotox-ins 7 Valuable reference text providing up to date information 7 Contains information useful to researchers and clinicians in neuroscience and neurology, biochemistry, microbiology and cell biology

Contents Author List.- Overview and history of botulinum neurotoxin research and exploitation.- Pharma-cology of botulinum neurotoxins.- Absorption and transport of botulinum neurotoxins.- The botulinum neurotoxin complex and the role of ancillary proteins.- Neurotoxin structure.- The dual receptor recognition of botulinum neurotox-ins.- Translocation, entry into the cell.- Protease activity of the botulinum neurotoxins.- Molecular basis for persistence of botulinum neurotoxins.- Clostridium botulinum genomes and genetic diversity.- Botulinum neurotoxin risks and detec-tion in environment, agriculture and food chains.- Botulism as a disease of humans.- Prevention and treatment of botulism.

Fields of interestMolecular Medicine; Pharmacology/Toxicology; Biomedicine general



Due May 2014

2014. X, 600 p. 54 illus., 40 in color. (Current Topics in Neurotoxicity, Volume 2) Hardcover7 approx. $239.00ISBN 978-1-4614-9453-9

9<HTMERB=ejefdj>




15

J.-J. Feige, iRTSV/BCI, Grenoble cedex 9, France; G. Pagès, Centre Antoine Lacassagne, Nice, France; F. Soncin, Institut de Biologie de Lille, Lille, France (Eds)

Molecular Mechanisms of AngiogenesisFrom Ontogenesis to Oncogenesis

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological situations including can-cer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progeni-tor cells,…) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable bloodproof neovessels. This book reviews recent advances made in our understanding of the mo-lecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observa-tions into the context of developmental, post-natal and pathological neovascularization.

Features 7 Offers the latest information on the major signaling pathways that control angiogenesis, which is integrated into the description of the cellular events driving developmental, post-natal and pathological angiogenesis 7 Presents con-tributions by the leading international experts in the field 7 Published under the auspices of the French society of angiogenesis

Fields of interestMolecular Medicine; Oncology; Cancer Research



Due February 2014

2014. Approx. 500 p. 50 illus., 30 in color. Hardcover7 approx. $209.00ISBN 978-2-8178-0465-1

9<HTNIMH=iaegfb>

B. C. Gilger, North Carolina State University, Raleigh, NC, USA (Ed)

Ocular Pharmacology and ToxicologyFeatures 7 Serves as an ideal training manual for explor-ing design and conduct of ocular pharmacology and toxicology studies 7 Features practical methodologies that are tested and success-ful 7 Includes study design, analysis, and routes to regulatory approval for a variety of ophthalmic drugs

Contents Challenges in Ocular Pharmacokinetics, Phar-macodynamics, and Toxicology.- Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models.- Challenges and Strategies in Drug Residue Measurement (Bioanalysis) of Ocular Tissues.- Chemistry, Manufacturing, and Control of Ophthalmic Formulations.- ADME and Ocular Therapeutics: Retina.- Compositions, Formulation, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intra-vitreal Ophthalmic Drugs.- Sustained-Release Ocular Drug Delivery Systems: Bench to Bedside Development.- The Ophthalmic Examination as It Pertains to General Ocular Toxicology: Basic and Advanced Techniques and Species-Associated Findings.- Study Design and Methodologies for Evaluation of Anti-Glaucoma Drugs.- Study Design and Methodologies for Study of Ocular Medical Devices.- Methodologies for Microscopic Characterization of Ocular Toxicity.- Nanopar-ticles for Drug and Gene Delivery in Treating Diseases of the Eye.

Field of interestPharmacology/Toxicology



Due March 2014

2014. 320 p. 91 illus., 62 in color. (Methods in Pharmacology and Toxicology) Hardcover7 $139.00ISBN 978-1-62703-744-0

9<HTMGNH=adheea>

J. T. Halper, The University of Georgia, Athens, GA, USA (Ed)

Progress in Heritable Soft Connective Tissue DiseasesThis volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scien-tists and for clinicians seeing patients.

Features 7 Provides an update on the pathophysiology of heritable soft connective tissue diseases 7 Dis-cusses the role of individual components of the extracellular matrix in specific aspects of various soft tissue disorders 7 Can be used as a diag-nostic guide for clinicians with tables correlating syndromes with symptoms, clinical signs and laboratory findings 7 Offers new management options and therapeutic directions

Contents Structure, physiology and biochemistry of col-lagens.- Basic components of connective tissues and extracellular matrix.- Proteoglycans and diseases of soft tissues.- Advances in the use of growth factors for treatment of disorders of soft tissues.- Clinical, diagnostic, and therapeutic aspects of the Marfan syndrome.- Loeys-Dietz syndrome.- Connective Tissue Disorders and Cardiovascular Complications: The indomitable role of Transforming Growth Factor-beta signal-ing.- The Ehlers-Danlos Syndrome.- Ehlers–Dan-los syndrome associated with glycosaminoglycan abnormalities.- Cutis laxa.- Collagen type VI myopathies.- Mouse Models in Tendon and Liga-ment Research.- Connective tissue disorders in domestic animals.

Fields of interestHuman Genetics; Cell Physiology; Internal Medicine

Target groupsGraduate


Due December 2013

2014. Approx. 400 p. 35 illus., 29 in color. (Advances in Experimental Medicine and Biology, Volume 802) Hardcover7 $209.00ISBN 978-94-007-7892-4

9<HTUELA=hhijce>





16

K.-l. Han, Chinese Academy of Sciences, Dalian, People’s Republic of China; X. Zhang, The Scripps Research Institute, La Jolla, CA, USA; M.-j. Yang, Chinese Academy of Sciences, Dalian, People’s Republic of China (Eds)

Protein Conformational DynamicsContents Protein folding simulations by generalized-en-semble algorithms.- Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules.- Understanding protein dynamics using conformational en-sembles.- Generative Models of Conformational Dynamics.- Generalized spring tensor models for protein fluctuation dynamics and conformation changes.- The Joys and Perils of Flexible Fitting.- Coarse-Grained Models of the Proteins Backbone Conformational Dynamics.- Simulating protein folding in different environmental conditions.- Simulating the peptide folding kinetic related spectra based on the Markov State Model.- The Dilemma of Conformational Dynamics in Enzyme Catalysis: Perspectives from Theory and Experi-ment.- Exploiting protein intrinsic flexibility in drug design.- NMR and computational methods in the structural and dynamic characteriza-tion of ligand-receptor interactions.- Molecular Dynamics Simulation of Membrane Proteins.- Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics.- Coordination and control inside simple biomolecular machines.- Multi-state Targeting Machinery Govern the Fidelity and Efficiency of Protein Localization.- Molecular dynamics simulations of F1-ATPase.- Chemosen-sorial G-proteins-coupled receptors: a perspective from computational methods.

Fields of interestBiomedicine general; Protein Science; Computer Appl. in Life Sciences



Due December 2013

2014. Approx. 295 p. 126 illus., 105 in color. (Advances in Experimental Medicine and Biology, Volume 805) Hardcover7 $189.00ISBN 978-3-319-02969-6

9<HTODMJ=acjgjg>

S. Kanner, Astex Pharmaceuticals, Inc., Salt Lake City, UT, USA (Ed)

Tumor Metabolome Targeting and Drug DevelopmentIn this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells.

Features 7 Provides expert reviews of multiple meta-bolic targets covering the glycolytic pathway, Krebs cycle, tumor microenvironment, hy-poxia, and therapeutic strategies 7 Explores experimental models for evaluating the tumor metabolome to provide knowledge and access to the field 7 Bridges the fields of cancer cell metabolism, tumor/stroma microenvironments, autophagy, drug discovery and development, and translational application of novel cancer therapies

Contents Tumor cell metabolic reprogramming and drug targeting.- Cancer metabolism: a nexus of matter, energy and reactive oxygen species.- Regulating mitochondrial respiration in cancer.- Regulation of cancer cell metabolism by hypoxia.- Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs.- Modulating autophagy and the “reverse Warburg effect”.- Metabolic adap-tation in reprogrammed cancer cells.- Index.

Fields of interestCancer Research; Metabolomics; Molecular Medicine



Due December 2013

2014. I, 318 p. 22 illus., 12 in color. (Cancer Drug Discovery and Development) Hardcover7 $189.00ISBN 978-1-4614-9544-4

9<HTMERB=ejfeee>

Y. Kato, University of Hyogo, Himeji, Japan (Ed)

Lipid Hydroperoxide-Derived Modification of BiomoleculesContents Preface. I Lipid peroxidation and small molecule adducts.- Lipid hydroperoxides as a source of singlet molecular oxygen.- The formation of lipid hydroperoxide-derived amide-type lysine adducts on proteins: a review of current knowledge.- Lipid hydroperoxide-derived adduction to amino-phospholipid in biomembrane.- Amide-type adduct of dopamine - Plausible cause of Parkinson diseases.- Determination of HEL (hexanoyl-lysine adduct): a novel biomarker for omega-6 PUFA oxidation.- Hexanoyl-lysine as a deterioration marker for rice during storage.- Cholesterol hydroperoxides and their degradation mechanism. II Pathophysiological consequences.- Amide-adducts in atherosclerosis.- Oxidative Modifica-tion of Lipoproteins.- Immunochemical Detection of Lipid Hydroperoxide- and Aldehyde-Modified Proteins in Diseases.- Role of Lipid Peroxide in the Neurodegenerative Disorders.- Lipid Hydroperox-ide-Derived Modification of Proteins in Gastro-intestinal Tract. III Applications for diagnosis and development of functional food.- Low-cost and easy-to-use “on-chip ELISA” for developing health-promoting foods.- Hexanoyl-lysine as an oxidative-injured marker - application of develop-ment of functional food.- Potential role of oxida-tive protein modification in energy metabolism in exercise.- Suppressive effects of cacao polyphenols on the development of atherosclerosis in apolipo-protein E-deficient mice.- Index.

Fields of interestCancer Research; Posttranslational Modification; Food Science



Due December 2013

2014. XV, 230 p. 77 illus., 25 in color. (Subcellular Biochemistry, Volume 77) Hardcover7 $189.00ISBN 978-94-007-7919-8

9<HTUELA=hhjbji>





17

A. Malek, Petrov Institute of Oncology, St Petersburg, Russia (Ed)

Experimental Metastasis: Modeling and AnalysisMetastatic dissemination of cancer is a main cause of cancer related deaths, therefore biologi-cal mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases develop-ment. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as ana-tomical specificity of aria of dissemination.

Features 7 Structure of the book is based on anatomical areas of cancer dissemination that has clinical relevance 7 Any chapter is written/supervised by leading researcher in specific area of metastasis research 7 The book is focused on experimental approach of metastatic cancer research: any chap-ter contains supportive theoretical information and detailed description of relevant laboratory procedures 7 The book is supplemented by in-formative illustrations, schemes and tables 7 Ex-tensive lists of references for any chapter provides with possibility of effective deep study

Contents Preface.- Introduction.- Head and neck cancer.- Breast cancer invasion and metastasis.- Mouse models of pancreatic cancer.- Brain Metastasis.- Lung metastasis.- Liver Metastases.- Malignant pleural effusion.- Mathematic modeling of meta-static process. Index.

Fields of interestCancer Research; Laboratory Medicine; Animal Models



Due December 2013

2014. I, 230 p. 71 illus., 32 in color. Hardcover7 $189.00ISBN 978-94-007-7834-4

9<HTUELA=hhidee>

S. Nagar, Temple University School of Pharmacy, Philadelphia, PA, USA; U. A. Argikar, Novartis Inst. for BioMedical Research, Cambridge, MA, USA; D. J. Tweedie, Boehringer Ingelheim, Ridgefield, CT, USA (Eds)

Enzyme Kinetics in Drug MetabolismFundamentals and Applications

Contents Enzyme Kinetics in Drug Metabolism – Fun-damentals and Applications.- Fundaments of Enzyme Kinetics.- Different Enzyme Kinetic Mod-els.- Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance.- Irreversible Enzyme Inhibition Kinetics and Drug-Drug Inter-actions.- Multi-Enzyme Kinetics and Sequential Metabolism.- Consideration of the Unbound Drug Concentration in Enzyme Kinetics.- Enzyme Kinetics of Oxidative Metabolism – Cytochromes P450.- Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase.- Enzyme Kinetics of Conjugative Enzymes – PAPS.- Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs).- Principles and Experimental Considerations for in vitro Transporter Interaction Assays.- Rationalis-ing Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data – from in vitro Tools to Mechanistic Modeling.- The Struc-tural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers.- Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism.- Variability in Human in vitro Enzyme Kinetics.- Sources of Interindividual Vari-ability.- Case Study 1. Practical Considerations with Experimental Design and Interpretation. [...]

Fields of interestPharmacology/Toxicology; Enzymology



Due January 2014

2014. 520 p. 141 illus., 15 in color. (Methods in Molecular Biology, Volume 1113) Hardcover7 $159.00ISBN 978-1-62703-757-0

9<HTMGNH=adhfha>

S. Redline, Harvard Medical School Brigham and Women’s Hospital, Boston, MA, USA; N. A. Berger, Case Western Reserve University School of Medicine, Cleveland, OH, USA (Eds)

Impact of Sleep and Sleep Disturbances on Obesity and CancerSleep has recently been recognized as a criti-cal determinant of energy balance regulating, restoration and repair of many of the physiologic and psychologic processes involved in modulating energy intake and utilization.

Features 7 Focuses on the relation of sleep disorders, both qualitative and quantitative, to obesity and cancer across the lifespan 7 Discusses epidemiologic considerations, research on mechanisms of sleep and cancer, as well as potential approaches to interventions 7 Constitutes a valuable addition at the cutting edge of studies on Energy Balance and Cancer

Contents Preface.- Sleep Across the Lifespan.- Effects of Sleep Deficiency on Hormones, Cytokines, and Metabolism.- Sleep Disorders and Melato-nin.- Biomedical Effects of Circadian Rhythm Disturbances.- Intermittent Hypoxia: Mechanistic Pathways Influencing Cancer.- Association of Sleep Apnea and Cancer: From Animal Studies to Human Epidemiological Data.- Shift Work, Obesity, and Cancer.- Sleep Disorders and Cancer Risk.- Contribution of Sleep Disturbance to Cancer Fatigue.- Sleep Disturbances in Cancer Survivors.- Sleep-focused interventions: Inves-tigating the effects of sleep restriction on energy balance.- Index.

Fields of interestCancer Research; Human Physiology; Endocrinol-ogy



Due December 2013

2014. X, 254 p. 30 illus., 19 in color. (Energy Balance and Cancer, Volume 8) Hardcover7 $129.00ISBN 978-1-4614-9526-0

9<HTMERB=ejfcga>





18

P. Ruben, Simon Fraser University, Burnaby, BC, Canada (Ed)

Voltage Gated Sodium ChannelsA number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior.

Features 7 Gives unprecedented insight into the structural basis of sodium channel function 7 Explores so-dium channels from the perspectives of their bio-physical behavior 7 Written by leading experts in the field

Contents Overview:biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels.- Slow inactivation of Na+ chan-nels.- Regulation/modulation of sensory neuron sodium channels.- Ubiquitylation of voltage-gated sodium channels.- Probing gating mechanisms of sodium channel using pore blockers.- Animal toxins influence voltage-gated sodium chan-nel function.- Voltage-sensor trapping toxins: Isoform-specific ligands for sodium channels.- Pharmacological insights and quirks of bacterial sodium channels.- The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.- The role of late INa in development of cardiac arrhythmias.- Proton modulation of cardiac INa: A potential arrhythmogenic trigger.- Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents.

Fields of interestPharmacology/Toxicology; Neurosciences; Car-diology



Due April 2014

2014. Approx. 400 p. (Handbook of Experimental Pharmacology, Volume 221) Hardcover7 approx. $419.00ISBN 978-3-642-41587-6

9<HTOGPC=ebfihg>

A. Satoskar, The Ohio State University, Columbus, OH, USA; R. Durvasula, University of New Mexico, Albuquerque, NM, USA (Eds)

Pathogenesis of LeishmaniasisNew Developments in Research

This book will discuss recent developments in several laboratories studying leishmaniasis. Se-quencing of the human genome, as well as of the leishmania genome, has led to significant advances in our understanding of host-immune responses against leishmania, and mechanisms of infection-induced pathology, which is responsible for morbidity and mortality. The book will focus on the latest basic research into leishmaniasis, but will also address how advances in understanding can be applied to prevention, control and treatment of what the WHO has classified a neglected tropical disease.

Features 7 Will address the most recent developments in the understanding of leishmaniasis 7 Uses information gained from the sequencing of the leishmania genome to assess the host-immune response 7 Focus is primarily on the most recent basic research, but will also consider how to apply the knowledge gained to prevention, control and treatment of this neglected tropical disease

Contents Immunopathology of leishmaniasis.- Immune evasion in leishmaniasis.- Biomarkers in preven-tion and treatment of leishmaniasis.- Para-transgenesis and Leishmaniasis.- Vaccines for leishmaniasis.- Reservoir control strategies.- Vec-tor control strategies.- Global epidemiology (Dr. Caryn Bern).- Newer approaches to cutaneous and visceral leishmaniasis (Satoskar and Shyam Sundar).

Fields of interestParasitology; Immunology; Medical Microbiology



Due February 2014

Only available in print

2014. Approx. 275 p. Hardcover7 approx. $189.00ISBN 978-1-4614-9107-1

9<HTMERB=ejbahb>

J. R. Seckl, University of Edinburgh Queen’s Medical Research Inst, Edinburgh, UK; Y. Christen, Fondation IPSEN, Boulogne-Billancourt Cedex, France (Eds)

Hormones, Intrauterine Health and ProgrammingContents Foreword.- Early growth and later health: findings from the Helsinki Birth Cohort Study by Johan G. Eriksson.- Male and female placentas have di-vergent transcriptomic and epigenomic responses to maternal diets: not just hormones by Anne Gabory, Alexandre Vigé, Jean Lesage, Isabelle Fa-jardy, Laure Ferry, Linda Attig, Anne Vambergue, Didier Vieau, Jean-Philippe Jais, Luc Jouneau, and Claudine Junien.- Glucocorticoids and fetal programming; necessary and sufficient? By Jona-than R. Seckl.- Developmental programming and the placenta: focusing in on glucocorticoids by Caitlin S. Wyrwoll.- Maternal stress and in utero programming by Louise C. Kenny, Claire Everard and Ali S. Khashan.- Developmental epigenetics and risks of later non-communicable disease by M.A. Hanson, P.D. Gluckman and K.M. Godfrey.- Epigenetic effects of extreme intrauterine growth in humans by John M. Greally.- The Role of the Placenta in Fetal Programming by John Chal-lis, Debora Sloboda, Shaofu Li, Thorsten Braun, Frank Bloomfield, Ghazala Begum, Anne White, Felice Petraglia, John Newnham.- Developmental Origins of Diabetes: The Role of Epigenetics by Rebecca A. Simmons.- Glucocorticoids, pro-gramming and the transmission of effects across generations by Amanda J. Drake.- Subject index.

Fields of interestHuman Genetics; Endocrinology; Obstetrics/Perinatology



Due December 2013

2014. X, 150 p. 10 illus. in color. (Research and Perspectives in Endocrine Interactions, Volume 12) Hardcover7 approx. $139.00ISBN 978-3-319-02590-2

9<HTODMJ=acfjac>





19

C. W. Stevens, Oklahoma State University, Tulsa, OK, USA (Ed)

G Protein-Coupled Receptor GeneticsResearch and Methods in the Post-Genomic Era

Contents G Protein-Coupled Receptors: Research and Methods in the Post-Genomic Era.- Examining the Dynamic Evolution of G Protein-Coupled Receptors.- Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors.- Discovery and Function of the Very Large G Protein-Coupled Receptor.- Functional Evolution of Opioid Family G Protein-Coupled Receptors.- Investigation of G Protein-Coupled Receptor Function and Regulation Using Anti-sense.- Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Recep-tors.- Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors.- Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cells.- Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors.- The CRE Luc Mouse Model for Bio-imaging Ligand Activation of G Protein-Coupled Receptors.- Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Cou-pling.- Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Coopera-tion.- Design of Super-Arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Protein-Coupled Receptors.- Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine.- Pharmacogenomics of G Protein-Coupled Receptor Signaling and Other Pathways in Essential Hypertension. [...]

Fields of interestPharmacology/Toxicology; Proteomics



Due January 2014

2014. 460 p. 66 illus., 31 in color. (Methods in Pharmacology and Toxicology) Hardcover7 $139.00ISBN 978-1-62703-778-5

9<HTMGNH=adhhif>

F. Storici, Georgia Institute of Technology, Atlanta, GA, USA (Ed)

Gene CorrectionMethods and Protocols

Contents RecTEPsy Mediated Recombineering in Pseu-domonas syringae.- Genome Manipulations with Bacterial Recombineering and Site-Specific Integration in Drosophila.- Multiple Genetic Manipulations of DT40 Cell Line.- Gene Targeting of Human Pluripotent Stem Cells by Homologous Recombination.- Methods for the Assessment of ssODN-Mediated Gene Correction Frequencies in Muscle Cells.- Small Fragment Homologous Re-placement (SFHR): Sequence-Specific Modifica-tion of Fenomic DNA in Eukaryotic Cells by Small DNA Fragments.- Preparation and Application of Triple Helix Forming Oligonucleotides and Single Strand Oligonucleotide Donors for Gene Correction.- Triplex-Mediated Genome Targeting and Editing.- Targeting piggyBac Transposon Inte-grations in the Human Genome.- Gene Targeting in Human Induced Pluripotent Stem Cells with Adenoviral Vectors.- Enhanced Gene Targeting of Adult and Pluripotent Stem Cells Using Evolved Adeno-Associated Virus.- Lentiviral Vectors Encoding Zinc-Finger Nucleases Specific for the Model Target Locus HPRT1.- Designing and Test-ing the Activities of TAL Effector Nucleases.- A Bacterial One-Hybrid System to Isolate Homing Endonuclease Variants with Altered DNA Target Specificities.- Design and Analysis of Site-Specific Single-Strand Nicking Endonucleases for Gene Correction.- CRISPR-Cas Mediated Targeted Genome Editing in Human Cells.- RNA-Guided Genome Editing of Mammalian Cells.- Nuclease-Mediated Double Strand Break (DSB) Enhance-ment of Small Fragment Homologous Recom-bination (SFHR) Gene Modification in Human Induced Pluripotent Stem Cells (hiPSCs). [...]

Fields of interestHuman Genetics; Gene Function



Due January 2014


9<HTMGNH=adhgaa>

S. Valla, R. Lale, Norwegian University of Science and Technology, Trondheim, Norway (Eds)

DNA Cloning and Assembly MethodsFeatures 7 Includes methods based on mecha-nisms 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents BioBrick Assembly Standards and Techniques and Associated Software Tools.- Plasmid Construction by SLIC or Sequence and Ligation Independent Cloning.- Quick and Clean Cloning.- Hierar-chical Ligation-Independent Assembly of PCR Fragments.- USER-Derived Cloning Methods and Their Primer Design.- Application of the Restriction-Free (RF) Cloning for Multi-Compo-nents Assembly.- A Single-Tube Assembly of DNA Using the Transfer-PCR (TPCR) Platform.- Circu-lar Polymerase Extension Cloning.- Golden Gate Cloning.- Design and Construction of Multigenic Constructs for Plant Biotechnology Using the GoldenBraid Cloning Strategy.- FX cloning: A Simple and Robust High-Throughput Cloning Method for Protein Expression.- Minimum GC-rich Sequences for Overlap Extension PCR and Primer Annealing.- Simple Cloning and DNA Assembly in Escherichia coli by Prolonged Over-lap Extension PCR.- Combinatorial Assembly of Clone Libraries Using Site-Specific Recom-bination.- Application of In-Fusion™ Cloning for the Parallel Construction of Escherichia coli Expression Vectors.- SeamLess Ligation Cloning Extract（SLiCE）Cloning Method.- j5 DNA As-sembly Design Automation.- FASTPCR Software for PCR, in silico PCR, and Oligonucleotide As-sembly and Analysis.

Fields of interestHuman Genetics; Gene Function



Due January 2014


9<HTMGNH=adhgdb>




M. Balali-Mood, Toxic Trauma Mechanisms of Gene A Basic...

Documents

Transcript of M. Balali-Mood, Toxic Trauma Mechanisms of Gene A Basic...