Albemarle Low Temperature Chemistry

Albemarle Fine Chemistry Services has helped customers complete many successful projects

through a powerful combination of proven chemistry expertise, game-changing process

development and scale-up, high-quality custom manufacturing and exceptional service. From

innovative R&D, process development to convert a batch process into a continuous process or to

commercial-scale production, we deliver the knowledge, experience, resources, creativity and service

you need to move products to market faster and accelerate your business.

Albemarle has a history in low temperature chemistry with success at four of our manufacturing

facilities. Our facilities are well-equipped to provide contract R&D, custom synthesis and cGMP or

non-cGMP custom manufacturing, including cGMP polymers. Our lean and flexible organization can

provide a swift response for all of your fine chemicals needs. We have the appropriate reactors to

function within a low temperature environment, with some reactors operating as low as -100C.

CRYOGENIC ARYL LITHIUM ADDITION TO AN ALDEHYDE

An intermediate for a drug candidate produced at the 1000 gallon scale.

1) THF, -60C

2)nBuLi

CRYOGENIC ARYL LITHIUM ADDITION TO A CHLOROPHOSPHITE

An intermediate for a drug candidate produced at the 2700 gallon scale.

1) THF, -90C

2) nBuLi

Targeted investments in these cryogenic reaction systems position us well to develop and scale-up reactions to make APIs and late-stage pharmaceutical intermediates, allowing us to better serve our customers needs and ensure the success of all their projects.

ArBr ArLi

ArIIBr ArIILi

Find out how we say yes to hundreds of fine chemistry projects annually.

FCS-0016 (03/13)

The information presented herein is believed to be accurate and reliable, but is presented without guarantee or responsibility on the part of Albemarle Corporation. It is the responsibility of the user to comply with all applicable laws and regulations and to provide for a safe workplace. The user should consider any information contained herein, including information about any health or safety hazards, only as a guide, and should take those precautions that are necessary or prudent to instruct employees and to develop work practice procedures in order to promote a safe work environment. Further, nothing contained herein shall be taken as an inducement or recommendation to manufacture or use any of the herein described materials or processes in violation of existing or future patents.

www.albemarle.com/fcs

A M E R I C A S

Fine Chemistry Services

Tel: +1 225 388 7402

FCS@albemarle.com

E U RO PE , M I D D L E E A ST, A F R I C A

EMA Fine Chemistry Services

Tel: +32 10 48 1711

FCS@albemarle.com

CRYOGENIC ARYL LITHIUM ADDITION TO A KETONE

An intermediate for a catalyst ligand.

1) n-Butyllithium

Et2O, -65C2) E-Cl

INDUSTRIAL CHEMICAL

n-Butyllithium, THF/Toluene

-80C

WORLD-CLASS FACILITIES & EQUIPMENT

Tyrone, PA: 1000 gallon non-cGMP Hastelloy reactor operating at -80C and as low as -100 Orangeburg, SC: 3500 gallon cGMP stainless steel reactor qualified at -95C Baton Rouge, LA: 200 gallon non-cGMP reactor operating as low as -60C South Haven, MI: Commercial scale reactors (1000-2000 gallon) that are cryogenic compatible

THE ALBEMARLE LOW TEMPERATURE CHEMISTRY ADVANTAGE

Controls reactivity to maximize selectivity Use of thermally unstable reactive intermediates Higher yields with combination of low temperature chemistry and high reactivity reagents than compared to more mainstream approaches High reactivity agents can result in shorter processing times

Albemarle is experienced and equipped to provide high-quality products and services to customers worldwide.

To move your high-pressure project into production, contact your Albemarle representative today.

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