Longer Life, Better Life

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Company LOGO Longer Life, Better Life Presenter: 陈陈 Representing The third group ——Current research progress on Alzheimer Disease

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Longer Life, Better Life. ——Current research progress on Alzheimer Disease. Presenter: 陈昊 Representing The third group. 21 st century--time for the aged. Number of the aged is so huge!. 0.7 billion is the old! Almost 1 in 10 on the world is over 60!. VS. October 31st, 2011 - PowerPoint PPT Presentation

Transcript of Longer Life, Better Life

Page 1: Longer Life, Better Life

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LOGO Longer Life, Better Life

Presenter:陈昊Representing The third group

——Current research progress on Alzheimer Disease

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21st century--time for the aged

Number of the aged is so huge!

October 31st, 2011

7 billion people on the world?

0.7 billion is the old!Almost 1 in 10 on the world

is over 60!

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Aging is everywhere!

Number of the aged (current and predicted) of some continents

4-5 times increasing in 50 years, just like a

rocket!

What about China?

The pace is faster.

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The Result of aging: Enjoy a longer life

Life expectancy worldwide on 2007

From Wikipedia

CIA World Fact book 2007 :Over 100 nations or regions enjoy the life expectancy over 70!

Quality

of life?

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Living quality---A better life as well?

Economic influence

Social problems

Health and diseases

Aging is good Aging is good or not? This is or not? This is

a question.a question.

The tragedy of aging:

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The position of Alzheimer

diabetes

CHF Stroke

Neurodegenerativedisease hypertension

Aged diseases

When we become old……

Cancer

Alzheimer

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Contents

1 The characters of Alzheimer

2 Alzheimer----the killer of life quality

3 Research on Mechanism of Alzheimer

4 Current drug and therapy

5 Can Alzheimer be prevented?

Fight against

Alzheimer!

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1 Alzheimer--- four stages characters

Early Middle Severe Final

1. slow, progressive loss of intellectual ability

2. difficulty learning

3. mild depression

1. an increase in memory loss

2. Decrease losing of daily living ability

1. unable to recognize objects and family members

1. cannot speak or walk, even breathe

2. has profound memory loss

Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30

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Epidemiology: the high rate of AD in the aged

60-6565-70

70-75over 80

over 90

2 4

8

20

40

0

5

10

15

20

25

30

35

40

Age

The percentage of AD (%)

The older one is, the more risky on getting AD!

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2. Alzheimer destroys the quality of life

Danger of the patients

Remember lossRemember loss

Ability lossAbility loss

cognition losscognition loss

15-20 years!

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Alzheimer destroys the quality of life

Social problems

TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661

Have you remembered or not? !

Mercy killing!

Living without quality or die at once, this is a question!

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3.The mechanism of Alzheimer—so many hypothesis

Cholinergic hypothesis

The mechanismOf Alzheimer

Amyloid hypothesis

Acetylcholine (ACh)

production elimination

imbalance

11C-PIB PET images characteristic

Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011)

Rubbish in brain!

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New research: The interaction between these hypothesis

MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111

Amyloid hypothesis to Cholinergic one:The more rubbish, the less Ach is!

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New research: The interaction between these hypothesis

MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111

Cholinergic hypothesis to Amyloid one:Ach inhibits the rubbish’s producing!

amyloid

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4.Current Drug and therapy

CurrentDrug for AD H3

antagonist

5-HTreceptor

ACEIs

NewACEIs

Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210

Donepezil

Rivastigmine

Galantamine

……

Huperzine AMianserin 5-HT2A antagonist

Effect in cognition loss 2004

Ciproxifan 2009

Thioperamide 2006

Anti-depre

ssant o

nly?

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A large market in AD drug and therapy

•Drugs for AD have a large

market.

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The mechanism of ACEIs

The Cholinergic pass way

decompose Ach

Re-uptake

X

AChE: Acetylcholinesterase

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5. Can Alzheimer be prevented?

EmotionalTherapy?

anti-amyloidTherapy?

DietTherapy?

ChineseTraditionalmedicine?

Virus-likeVaccine?

PreventionOf AD

Biotech therapy

Self

therapy

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Current research: Biotech vaccine

Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease.

Human Vaccines.2010 Volume 6, Issue 11

Virus-like particle based vaccines for AD

2010

Virus-like particle based antigen

High-affinity antibody anti- amyloid!

currently in human clinical trials

virus

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---Live longer, live better!Conclusion

Our loveTo the old?

Better prevention

More drugs

Mechanismclearer

live longer, live better.

It’s not only for the old, but also for our

future!

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Reference and acknowledgements

1 Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30

2 TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661

3 Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011)

4 MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111

5 Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210

6 Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease. Human Vaccines.2010 Volume 6, Issue 11

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We not only focus on study progress, but also the research areas around the world!

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