2006

AlcoholsQ 0230 Long Chain Phenols. Part 41a. The Synthesis of 2-Hydroxymethyl Derivatives of

Phenols. — Key step of the new approach to title compounds (IV) is the regiospecific reaction of phenols (I) with paraformaldehyde (II) in the presence of SnCl4 and NBu4. Cyclic acetals [cf. (VI)] of the intermediate aldehydes are readily accessible. — (PAYNE, P.; TYMAN*, J. H. P.; MEHET, S. K.; NINAGAWA, A.; J. Chem. Res. 2006, 6, 402-405; Dep. Chem., Brunel Univ., Uxbridge, Middlesex UB8 3PH, UK; Eng.) — H. Haber

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