Long-acting Reversible Contraception (LARC) David Hubacher, PhD Senior Epidemiologist FHI.
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Transcript of Long-acting Reversible Contraception (LARC) David Hubacher, PhD Senior Epidemiologist FHI.
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Long-acting Reversible Contraception (LARC)
David Hubacher, PhDSenior EpidemiologistFHI
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Outline of Talk
• Description of long-acting reversible contraception (LARC)
• Worldwide use of long-acting• Advantages and Disadvantages• Service delivery factors• Comparison to short-acting reversible
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Characteristics of Long-acting Reversible Contraception (LARC)
• Device is inserted• Products lasts from 3 to 10+ years• Removal is required at some point• Simple clinic environment for services• Nurse practitioners can insert/remove
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Two body locations, three products
• Intrauterine contraception1. Copper IUD: ParaGard® - 10+ years• T-shaped plastic frame with copper attached• Non-hormonal
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ParaGard – Copper intrauterine device (IUD)
How it works:1. Prevents fertilization by
creating intrauterine environment hostile to sperm
2. Copper ions enhance anti-sperm action
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Two body locations, three products
• Intrauterine contraception1. Copper IUD: ParaGard® - 10+ years• T-shaped plastic frame with copper attached• Non-hormonal
2. Intrauterine system (IUS): Mirena® - 5 years• T-shaped plastic frame with reservoir to
release progestin (levonorgestrel)• Levonorgestrel absorbed in genital tract
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Mirena
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Intrauterine Contraception
• Since 1930s• The first long-acting reversible• In US, nine major products used over 50 yrs• Wide variety of shapes/sizes in other
countries
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Two body locations, three products
• Intrauterine contraception1. Copper IUD: ParaGard® - 10+ years2. Intrauterine system (IUS): Mirena® - 5 years
• Subdermal implant – upper arm3. Implanon ® - 3 years• Match-stick sized rod that releases progestin
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Implanon
How it works:Mostly by preventing ovulation
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Implants
• Developed in 1960s• First came Norplant (6 rods), then Jadelle
(2), Implanon (1), Sino-implant (2)• Countries with highest use: Indonesia
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• Varies tremendously• Information from national surveys
• Limitation: most data sheets do not list implants separately because use is low
• IUD is only LARC method reported
Worldwide LARC Use
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Countries with High IUD Use20-29%Tunisia, Mongolia, Tajikistan, Israel, Jordan, Syria, Turkey, Belarus, Moldovia, Russia, Finland, Latvia, Norway, Slovenia, France
30-39% Egypt, Kyrgyzstan, Kazakhstan, Turkmenistan, Estonia, Cuba
40+ %China, Dem PR Korea, Uzbekistan, Vietnam
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IUD Use in Other Countries
Brazil 1%India 2%South Africa 1%Mexico 12%Nigeria 1%USA 5%
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IUD Use in the US: 45 Years of Change
1965 1970 1975 1980 1985 1990 1995 2000 2005 20100
2
4
6
8
10
12
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Disadvantages of LARC
• Invasive insertion procedure• Requires removal procedure– Thus more difficult to stop using it– Less control over fertility
• Side effects like all methods– but different
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Advantages of LARC
• One procedure/clinic visit• Easy to use• Nothing to remember• Discrete use• Return to fertility is very rapid• Most effective reversible strategy
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WHO Classification of Methods
More effective Less than 1 pregnancy per 100 women in one year
Less effective About 30 pregnancies per 100 women in one year
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• Fewer commodities needed• More cost effective• More effective at preventing unintended
pregnancy• One visit• One LARC insertion =
39 to 65 to 130 packs of pills…or 9 to 20 to 30 injections
• More LARC fewer stock-outs of methods
Program Advantages of LARC
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• Trained personnel• Equipment and supplies• Autoclave for sterilizing equipment• Clinic needs electricity supply• Contraceptive commodities
Service Provision Requirements
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• Cost varies tremendously• ParaGard copper IUD:– $1 for international donors but $800 in US
• Mirena:– $850 in US, $200 in Kenya, limited donations
• Jadelle and Implanon implants– $25 to international donors
• Sino-implant (II)– $8 to international donors
Cost of LARC
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• Injectables and Oral Contraceptives–Great methods if used consistently and
correctly–40-60% of users stop within 12 months– For variety of reasons, not always by choice– This can lead to unintended pregnancy
LARC vs. Short-acting Methods
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Cumulative Probability of Discontinuation
0 3 6 9 12 15 180
10
20
30
40
50
60
70
Short-actingImplantDMPA/OC
months
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Some obstacles to perfect use
• Commodity stock-outs at public sector clinics• Cost at pharmacies/private facilities• Ambivalence toward contraception/pregnancy• Motivation can wane over time• Great effort required• Abstinence episodes• Partner opposition• Side effects: who wants another dose?• The FP queue: who wants to be seen there?
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Risk of Unintended Pregnancy
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• 18M users of injectable/orals in sub-Saharan Africa
• If 20% switched to implant• If apply regular discontinuation patterns
• Prevent 1.8M unintended pregnancies in 5 yr
Estimating Impact *
* Hubacher D, Mavranezouli I, McGinn E. Unintended pregnancy in sub-Saharan Africa: magnitude of the problem and potential role of contraceptive implants to alleviate it. Contraception 2008;78(1):73-78.
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• Long-acting reversible contraception– Underused in many countries– Women need more choices– Expanded use could have tremendous benefit– Essential components: Voluntary uptake and removal
on demand
Conclusions