Liver

Tutorial 2

Normal Liver

Liver: response to injury

Liver: response to injury

Systemic responses to liver injury

Liver function tests

Signs and complications of liver disease

Bilirubin metabolism and

elimination

Normal production

Binding to albumin

Liver uptake

Conjugation

De-conjugation and excretion

Causes of Jaundice

Classification of hepatitis

Hepatitis A: serology response

Hepatitis B: serology response

Liver: Hep B

Hepatitis B: outcomes

Hep B: outcomes

Hepatitis C: outcomes

Hep C

Hep D and B co-infection

The hepatocyte in acute and chronic hepatitis

Morphological features of viral hepatitis

Other causes of hepatitis:

AlcoholDiabetes mellitusChronic active hepatitis (auto-immune)Neonatal hepatitisOther viral disorders

-EBV-CMV-Yellow fever-Rubella-Adenovirus-Enterovirus

Acute Pancreatitis

Metabolic:AlcoholHyperlipoproteinaemiaHypercalcaemiaDrugs (thiazides)Genetic

Mechanical:GallstonesTraumatic injuryPeri-operative injury

Vascular:ShockAtheroembolismPAN

Infections:MumpsCoxsackieMycoplasma

Mechanism of acute pancreatitis

Causes of Diabetes Mellitus

The adipocyte in Diabetes Mellitus

*Peroxisome proliferatoractivated receptor

*

Complications of Diabetes Mellitus

Metabolic derangementsIn Type I diabetes mellitus