Liver, Gall Bladder, and Pancreatic Disease. Manifestations of Liver Disease Inflammation -...
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![Page 1: Liver, Gall Bladder, and Pancreatic Disease. Manifestations of Liver Disease Inflammation - Hepatitis –Elevated AST, ALT –Steatosis –Enlarged Liver Portal.](https://reader036.fdocuments.in/reader036/viewer/2022081506/56649dca5503460f94ac0e9f/html5/thumbnails/1.jpg)
Liver, Gall Bladder,and Pancreatic Disease
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Manifestations of Liver Disease
• Inflammation - Hepatitis– Elevated AST, ALT– Steatosis– Enlarged Liver
• Portal Hypertension• Functional
– Jaundice– Lowered albumin (and other proteins)
• Cirrhosis– Scarring– Small liver
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Hepatitis
• Alcohol
• Hepatitis – A,B,C,D,E,G– 44% Hep B (present in all secretions, STD)– 37% Hep A (oral-fecal route)– 19% Hep C (percutaneous)– Liver damage – Immune mediated necrosis– Systemic effects – Type III reaction
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Hepatitis
• Symptoms– Latent: 30% HBV, 80% HCV– Acute Phase: 1 – 4 months
• Malaise, anorexia, fatigue, NV, abd pain• Fever, H/A, Icterus (optional)
– Convalescence: 2 – 4 months– Chronic
• Uncommon for HAV• Most common HCV
– Fulminant Hepatitis
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Hepatitis Tests
• LFTs– AST, ALT (SGOT, SGPT)– Albumin– Globulins
• Specific– Antibodies: surface and core, IgM, IgG
• e.g., HBcIgM, HBcIgG
– Antigens: surface and core• e.g., HBsAg, HBcAg
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Portal Vein System
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Portal Hypertension
• Etiology– Intrahepatic
• Thrombosis• Inflammation• Fibrosis (cirrhosis)
– Posthepatic• Cardiac insufficiency
– Prehepatic• Narrowing of portal vein• Increased splanchnic artery vasodilation
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Pathophysiology
• Blood backs up– Mesenteric veins– Spleen (splenomegaly)– Collateral circulation
• Esophagus (varices)• Abdominal wall (caput medusa)• Rectum (hemorrhoids)
• Splanchnic artery dilation– Drop in blood pressure– RAAS activation, epinephrine
• Ascites• Hepatic Encephalopathy
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Splenomegaly
• Premature erythrocyte removal
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Esophageal Varices
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Splanchnic Artery Dilation
• Inappropriate dilation of gut arteries– Lowers systemic BP
• Increased Epi and Norepi• Increased RAAS• Even though fluid overloaded, at risk for
hypotension
– Increased Portal Pressure• Worsens portal hypertension• Increases ascites
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Ascites
• Transudate• Accumulation of • Increased portal hydrostatic pressure• Decreased oncotic pressure• Manifestations
– Distended abdomen– Fluid wave– Respiratory distress– Electrolyte imbalance
• Treatment– Underlying cause– Paracentesis
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Paracentesis
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Other Hepatic Manifestations
• Jaundice– Excess bilirubin– Liver cannot conjugate bilirubin– Liver cannot excrete conjugated bilirubin– Icterus include yellowing of sclera
• Decreased liver function– Decreased plasma enzymes
• Edema, increased bleeding, increased infection– Decreased removal of waste
• Drug levels become toxic• Increased ammonia levels
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Hepatic Encephalopathy
• Ammonia buildup from protein digestion• Manifestations
– Changes in personality – Memory, confusion– Asterixis (Hand flapping)– Stupor, Coma
• Treatment– Low protein diet– Lactulose
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Gall Bladder Diseases
• Cholecyst – fills from biliary tract– Stores and secretes bile into the common bile
duct
• Cholelithiasis/Cholecystitis– Genetic component– High fat diets– Cholecystectomy
• Requires diet modification
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Acute Pancreatitis
• Ranges from mild edema to necrosis– May resolve completely or– Become chronic/episodic
• Etiology– Biliary tract disease (most common in women)– Alcoholism (most common in men)– Trauma, surgery, drugs, vascular disease
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Acute Pancreatitis
• Pathophysiology– Autodigestion: lipase, amylase, trypsin
• Clinical Manifestations– Pain…unbelievable pain
• Worse with eating• Patient often writhes
– Other• Fever, leukocytosis• Hypotension, tachycardia, jaundice
– Complications• Pseudocyst, pancreatic abcess
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Acute Pancreatitis
• Eval– Amylase and lipase levels– Various radiographic tests
• Treatment– PAIN management– Antispasmodics– NPO– Support blood pressure– Surgery
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Chronic Pancreatitis
• Progressive inflammatory replacement of parenchyma with fibrous tissue– Chronic obstructive pancreatitis
• Gall bladder disease– Chronic calcifying pancreatitis
• Alcholic
• Eval: Same• Tx:
– Dietary/alcohol modification– Cholecystecomy– Pancreatic Enzymes– Treat flares like acute pancreatitis