Post colonial : An introduction paper no : 11 ( Post colonial literature)
Literature No
-
Upload
hazel-joyce-moleta -
Category
Documents
-
view
222 -
download
0
Transcript of Literature No
-
8/2/2019 Literature No
1/4
Hazel Joyce D. Moleta
LITERATURE NO. FINDINGS CLAIMS EVIDENCE
1) The Frequency andClinical Significance ofThrombocytopenia
Complicating Critical Illness
-Thrombocytopenia appearsto increase the risk of death-The main concern for the
critically illthrombocytopenic patient isbleeding-Thrombocytopenia was anindependent predictor ofdeath among critically illpatients in most studies
-Literature nos. 2 & 4presents similarity that ITPare most common in
children.
- Literature nos.2 & 7presented that VWFsfunction affect in Plateletand hemostasis
- Literature nos. 2 & 3proved that Autoimmunediseases and bleedingdisorders have genetic
linkage
- drug of choice common inITP is steroids based onliterature nos. 6, & 4however it was contrast inliterature no.9 because thestudy shown that there is aremission in takingprednisone
-ITP is common in SouthAfrica based on literaturenos.10 & 4
- Weakness, bruising andbleeding is commonsymptoms of ITP that wascited on literature nos. 4 &8
-6 out of 8 studies usingmultivariate analysis foundthat thrombocytopenia
increased the risk of death-5 studies ofthrombocytopenia in theICU reported bleedingoutcomes-5 out of 8 studies weremore likely to receive RBCtransfusions-6 out of 8 studies foundthat thrombocytopenia wasan independent predictor of
death2) Evaluating the child withpurpura
-both genders are equallyaffected-anemia withthrombocytopenia indicatesleukemia-platelet disorder presentvasculitic disorder includingVWF-chronic idiopathicthrombocytopenic purpura
is more likely in teenagegirls and children-genetic counseling is usefulin families with inheritedbleeding disorder
-Idiopathicthrombocytopenic purpurais usually a temporarydisorder, with 80 to 90percent of childrenrecovering within 6-12months, usually within afew weeks
3) Autoimmune diseases ina Nigerian woman-A casereport
-genetic influence via thehistocompatibility leukocyteantigen is prominent amongthe autoimmune disease
-presence of combinationsof autoimmune diseasespectrum in this case aswell as the presence ofvitiligo in her daughter may
-
8/2/2019 Literature No
2/4
Hazel Joyce D. Moleta
-Thrombocytopenia/ ITP isa rare condition and itsserious if not treatedcorrectly
well suggest a genetic link-the roles of genetic,environmental andimmunoregulatory factorswere outlined by Van Noort
et al, when they reinforcedthe multifactorial origin ofautoimmunity
4) A survey of themanagement of idiopathicthrombocytopenic purpurain South Africa: Do we needguidelines for developingcountries
-steroids were the first lineof choice in treating ITP-ITP is the most commonbleeding disorder ofchildhood-ITP is the most commonbleeding disorder inchildren in south africa
-vast majority of doctorswould prescribe steroids orimmunoglobulins-most cases are treated inacademic centers indicatinga high rate referrals
5) The Diagnostic dilemmaof thromboticthrombocytopenicpurpura/hemolytic uremicsyndrome in the obstetrictriage and emergencydepartment: lessons from 4tertiary hospitals
-TTP /HUS are both rare-the most common reportedsymptoms includeweakness, bleeding, andeasily bruisabilty
-they afflict 1 in 100,000pregnancies to 1:1,000,000people in generalpopulation
6) International consensusreport on the investigation
and management ofprimary immunethrombocytopenia
-ITP is an acquired immunemediated disorder
characterized by isolatedthrombocytopenia, definedas a peripheral bloodplatelet, count less than100X10g/L-incidence in adults isapproximately equal for thesexes-Corticosteroids are thestandard initial treatment
-a positive directantiglobulin test (DAT) was
found in 22% of 205patients with ITP
-
8/2/2019 Literature No
3/4
Hazel Joyce D. Moleta
-Prednisone is the standardinitial first line therapy forITP patients
7) The Laboratory diagnosisof Platelet disorder
- an abnormality of VWF hasbleeding symptoms verysimilar to plateletdysfunction, and evaluationfor von Willebrand diseaseshould be included in theinitial evaluation of apossible platelet disorder
-platelets adhere to VWFand to fibrinogen throughglycoprotein receptoraccording to Arch PatholLab Med-Vol 126, February2002 Laboratory Diagnosisof Platelet Disorders-Kottke-Marchant et al
8) Current Concepts inThromboticThrombocytopenic Purpura
-Patients typically presentwith weakness,pallor,petechiae, headacheor subtle mental changes.Ifnot treated, the diseasemay rapidly deteriorate tostupor, coma or cardiacarrest
-TTP ha reduced its casefatality from 90% to 10%-20% by the use of plasmainfusion and plasmaexchange
9)Autoimmunethrombocytopenic Purpuraand Common VariableImmuodeficiency: Analysisof 21 Cases and review ofthe literature
-steroids seem to have thesame efficacy as inidiopathic AITP, but theincreased risk of severeinfections must be takeninto considerations-AITP I not prevented by
IVIG substitutive therapy
-62% were in treatment freeremission and 23% where inremission while onprednisone
10) Platelet Counts andmean Platelet VolumeAmongst elderly Nigerians
-healthy elderly and youngadult control femaleshaving higher plateletcounts than the elderly andyoung adult control males-there is need for separatevalues for platelet countand mean platelet volumefor the elderly
-Lazomo et al(1998)reported sex difference inplatelet count with highervalues in females than inmales-study suggests that thereis significant difference inplatelet count between thehealthy elderly subjects and
-
8/2/2019 Literature No
4/4
Hazel Joyce D. Moleta
young adult control