Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015II

List of Abstracts

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Analysis of insulin mimetic phytochemicals with a complementary chick embryo model

HTS for screening of selective muscarinic cholinergic receptors antagonists

Update on 3Rs activities at the EU institutional level and beyond the borders.

Systematic Assessment of Different Computational Approaches for Prediction of Toxic Effects of New Chemical Structures

A 3D in vitro iPSC derived mini-brain model to study Parkinson’s disease

Human intervertebral disc as an efficient source for annulus fibrosus and nucleus pulpous cell isolation

Isolated human intervertebral disc cells as a useful platform for in vitro toxicology tests

Modular human biochip-based organoid models in sepsis research

Development of Micro-Engineered 3-Dimensional Biomimetic Hydrogel Culture System by using Gelatin Methacrylate

Systems Toxicology-based assessment of Aerosols using Human Organotypic Tissue Cultures of Nasal and Bronchial Epithelium

28-day microphysiological monitoring of human hepatocellular cells

BoNT Activity Determination by Stimulus-dependent Release of Neuro-secretory Vesicle-targeted Luciferase from Neuronal Cell lines

In vitro assays for the potency determination of botulinum neurotoxin serotypes A and B

A novel human organotypic tumor invasion model of cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS) to reduce animal experiments in preclinical oncology

Legal issues in the work of the German National Committee: an overview

Working together to develop and implement a 'culture of care'

Renate Haselgrübler, Verena Stadlbauer, Otmar Höglinger, Klaus R. Schröder, Peter Lanzerstorfer, Julian Weghuber

Valerii Tonkopii

Francois Busquet

Priyanka Banerjee, Vishal B Siramshetty, Malgorzata Drwal, Mathias Dunkel, Robert Preissner

David Pamies

Tomaz Velnar, Lidija Gradisnik

Lidija Gradisnik, Tomaz Velnar

Alexander Mosig, Marko Gröger, Knut Rennert, Benjamin Giszas, Ralf Claus, Otmar Huber

Su Su Htwe, Alan Knox, Amir Ghaemmaghami

Julia Hoeng

Joachim Wiest

Andrea Pathe-Neuschäfer-Rube, Frank Neuschäfer-Rube, Lara Genz, Gerhard Püschel

Emina Wild, Heike Behrensdorf-Nicol, Ursula Bonifas, Jolanta Klimek, Beate Krämer, Birgit Kegel

Sebastian Konzok, Susann Schindler, Danny Jonigk, Peter Braubach, Armin Braun, Katherina Sewald

Justyna Chmielewska, Barbara Grune, Bettina Bert, Nora Leich, Gilbert Schönfelder

Kirsty Reid

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 III

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Application of in silico methods for predictions of different toxicological endpoints

Preliminary validation studies of a 3D in vitro inhalation model, using cytokine and gene expression responses to metal-oxide particles

Do scientists have an adequate overview of global 3R resources?

Ending severe suffering: the scientific animal welfare organisation as a catalyst for change

Animal Research: Critical, Challenging & Creative Thinking about the 3Rs

The Role of the National Committee in Germany - Severity Assessment of Genetically Altered Animals

Towards the prediction of nanoparticle-induced inhalation toxicity: Evaluation of an in vitro mac-rophage assay

Reboot3R - Design Thinking Workshops for scientists to constructively find ways to apply 3Rs within their own career

AniMatch – An innovative approach to reduce lab animal usage addressing article 18 of the EU directive 2010/63/EU

Molecular modelling of Osteoarthritis – Evaluat-ing pathways in vitro

Understanding Chemical Allergen Potency: Role of NLRP-12 and BLIMP-1 in the Induction of IL-18 in Keratinocytes

Examination of human bone tissue regeneration using the chorioallantoic membrane (CAM): an ex vivo replacement model for animal research.

Predicting Protein Targets for Chemical Toxins us-ing Molecular Similarity Search, in Silico Docking and in Vitro Validation

Conversion of the draft OECD guideline for the Testing of Chemicals: The Cytosensor Microphysiometer Test Method

Effects of Glycine and Taurine on Cell Viability and Function of Cryopreserved Primary Rat Hepatocytes

Quantitative analysis of cell migration in the wound healing scratched assay by Using Active Contour Model and Speeded Up Robust Features

Malgorzata Drwal, Janette Nickel, Priyanka Banerjee, Vishal Babu Siramshetty, Mathias Dunkel, Robert Preissner

Ingeborg Kooter, Mariska Gröllers, Evert Duister-maat, Yvonne Staal, Frederique van Acker, Eric Schoen, Eugene van Someren, Frieke Kuper

Adrian Smith, Tim Allen, Karina Smith, Øyvind Wærenskjold, Bente Bergersen, Siri Knudsen, Anton Krag, Anne Ramstad

Elliot Lilley, Penny Hawkins

Juliet Dukes, Nikki Osborne, Elliot Lilley, Penny Hawkins

Bettina Bert, Barbara Grune, Justyna Chmielewska, Nora Leich, Gilbert Schönfelder

Martin Wiemann, Antje Vennemann, Lan Ma-Hock, Karin Wiench, Robert Landsiedel

Cecilia Hilmer, Laura Behm, Annemarie Lang

Annemarie Lang, Benjamin Zimmer, Resa Ebadi, Jan Saam

Annemarie Lang, Johannes Neuhaus, Igor Ponomarev, Timo Gaber

Angela Papale, Elena Kummer, Valentina Galbiati, Emanuela Corsini

Ines Moreno

Yaroslav Chushak, Jeanette Frey, Camilla Mauzy, Jeffery Gearhart

Sebastian Eggert, Frank Alexander, Joachim Wiest

Omid Farshad, Akram Jamshidzadeh, Reza Heidari, Aminreza Akbarizadeh

Melika Farshad, Sara Mardani Samani, Akram Jamshidzadeh

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015IV

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B-13 Progenitor-Derived Hepatocytes (B-13/H cells) as a Model for Lipid Storage Disorders.

Virtual Physiology: Computer Laboratories as Alternatives in Life-Science Education

An advanced 3D human epithelial airway model to study the biokinetics of aerosolized biomedical nanoparticles after repeated exposures

A Mismatch between Micro-Motives and Macro-Behaviour: The Inefficiency of Efforts toward Replacement at the Individual Level

Follow-up on 2013 EUSAAT’s Congress and its impact for Sri Lankan scientific community in 3Rs

Standardization of the experimental conditions leads to reliable and relevant predictions of the photo-toxic effects in vitro

Establishment of in-vitro models for the study of repeated exposure to toxicants by the respiratory route

Micellar liquid chromatography as an alternative for in vivo and expensive in vitro tests commonly used in prediction of human intestinal absorption.

In vitro investigation on uptake, cytotoxicity and genotoxicity of two similar sized titanium oxide nanoparticles on the human hepatic cells HepaRG

Optimization of a new in vitro method for inhalation toxicology and its application for the study of zinc oxide nanoparticle toxicity.

Characterization of Stably Transfected HEK-293 Cells Expressing Uptake Transporters Using Fluorescent Substances

Characterization of Transporter Activities in Fresh Isolated Primary Hepatocytes of Different Species by Using Fluorescent Substrates

Evaluation of the scientific validity of animal experiments in Switzerland

The Lush Prize – Rewarding innovative animal-free science around the world

40 years of Animalfree Research. Results and lessons learned from a quality assessment

Evaluation of developmental neurotoxic-ity triggered by N-methyl-D-aspartate receptor (NMDAR) antagonists based on the Adverse Outcome Pathway (AOP) concept

Adverse Outcome Pathway Knowledge Base: A crowdsourcing tool to add value to existing information on Alternative Methods results

Alistair Leitch, Philip Probert, Matthew Wright

Aubin Tchaptchet, Hans Albert Braun

Savvina Chortarea, Kleanthis Fytianos, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Barbara Rothen-Rutishauser

Jan Lauwereyns

Mangala Gunatilake, Francois Busquet, Helena Kandarova, Mohammad Akbarsha

Alzbeta Líšková, Soňa Jantová, Tatiana Milasová, József Bakos, Milan Mikula, Helena Kandarova

Kristin Öhlinger, Claudia Meindl, Eleonore Fröhlich

Dina Shokry, Laura Waters, Gareth Parkes

Pegah Jalili

Emilie Da Silva, Søren Thor Larsen, Jorid Birkelund Sørli

Jia Jia, Claudia Garve, Markus Keiser, Dieter Runge, Anett Ullrich

Anett Ullrich, Jia Jia, Dieter Runge

Lucile Vogt, Thomas Reichlin, Hanno Würbel

Rebecca Ram

Stefanie Schindler, Monica Gaiffi

Anna Price, Sharon Munn, Magdalini Sachana

Clemens Wittwehr, Stephen Edwards, Hristo Aladjov

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 V

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Evaluating non-animal methods for identifying skin sensitisation hazards: A Bayesian value of information analysis

Geometrically confined cell differentiation and migration model for human teratogen detection

Chip-based co-culture of neurospheres and liver spheroids for long-term substance testing

In vitro model of hair follicle for high-through-put in vitro screening

Integration of the epidemiological data with the experimental toxicity studies on pesticides use of the AOP framework for the definition of biological plausibility

Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events.

The Interspecies Database and the Humane End-points website: essential tools to implement the 3Rs

Generation of the molecular basis for studying thyroid hormone disruption in neural progenitor cells of humans and rats.

Building a Framework of Communication between Industry and Regulators to Identify In Vitro Meth-ods Suitable for Tobacco Regulatory Science

The Asian Congress on Alternatives and Animal Use in the Life Sciences 2016

Human in vitro Blood-Brain Barrier model gener-ated from stem cells: reducing attrition in the Central Nervous System area.

Assessment of the Wound Healing Effect of Selected Flavonoids on In Vitro Irritation Model

Versatile, polymer-based devices for multi-param-eter in vitro toxicology

Strategies of refinement concerning the keeping and the breeding of C57BL/6

Advances in in vitro testing: the route to replace animal testing

MIEs – The Gateways to Pathway Prediction

Training as a Means to Hasten the Implementation of 3Rs Methods for Cosmetics: A Case Study of China

From Pathways to People: Applying the Skin Sensitisation AOP to Risk Assessment

Maria Leontaridou, Silke Gabbert, Ekko van Ierland, Robert Landsiedel, Andrew Worth

Jiangwa Xing, Yi-Chin Toh, Shuoyu Xu, Hanry Yu

Anja Ramme, Eva-Maria Materne, Ana Paula Terrasso, Margarida Serra, Paula Marques Alves, Catarina Brito, Roland Lauster, Uwe Marx

Beren Atac, Tobias Grix, Isabel Ruetschle, Gerd Lindner, Reyk Horland, Roland Lauster, Uwe Marx

Andrea Terron, Arianna Chiusolo

Jenny Baumann, Kathrin Gassmann, Stefan Masjosthusmann, Denise DeBoer, Farina Bendt, Susanne Giersiefer, Ellen Fritsche

Maite van Gerwen, Coenraad Hendriksen, Ilse Naus, Jan van der Valk, Esther Brandon

Susanne Giersiefer, Katharina Dach, Farina Bendt, Ulrike Huebenthal, Heike Heuer, Ellen Fritsche

Erin Hill

Hajime Kojima

Aurore Drolez, Elodie Vandenhaute, Fabien Gosselet, Lino Ferreira, Roméo Cecchelli, Marie-Pierre Dehouck, Caroline Mysiorek

Jana Juráňová, Jana Franková, Bohumil Zálešák, Jitka Ulrichová

Roisin Owens

Charlotte Sophie Leidinger

Kelly Davidge, Stella Homer, Malcolm Wilkinson, Matthew Walters

Paul Russell

Erin Hill, Quanshun Zhang, Rodger Curren

Gavin Maxwell, Richard Cubberley, Seraya Dhadra, Nichola Gellatly, Ruth Pendlington, Juliette Pickles, Joe Reynolds, Ouarda Saib, Richard Stark, Dawei Tang, Cameron MacKay

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015VI

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CERST-NRW – a platform for developing human in vitro methods for (neuro)developmental toxicitiy testing

Transatlantic collaboration of Cosmetics Europe with NICEATM/ILS to assess and develop strategy for skin sensitisation safety assessment without animal testing

Reconstituted Human Epidermis Models and IL-18 Levels for Identification and Potency Rank-ing of Skin Sensitizers: Identification of Critical Steps and Harmonization of Existing Protocols for the Purpose of Validation.

Strategies for combining skin and vasculature in a Multi-Organ-Chip Platform

Health safety of food contact paper evaluated by in vitro toxicological methods

Safety evaluation of nanosilver using reconstructed human GIT tissues

Modeling of early intestinal infection events of enterotoxigenic Escherichia coli using an in vitro system with porcine jejunal tissue

Emulating the Human Vasculature in a Multi-Organ-Chip Platform

Numbers do not lie? Why the lives of ”surplus animals” need to count, too.

Brain melanoma metastasis cell line and clones - A model system for in vitro research

Romanian Center for Alternative Test Methods (ROCAM) – a newly established 3Rs Center to promote and support the alternative methods field in Romania

Generation of three-dimensional cortical tissues – an innovative cell culture model for toxicity testing, drug development and basic research

Quantitative data on toxicant classification derived from transcriptomics studies of stem cell development

LLNA variability: an essential ingredient for a comprehensive assessment of non-animal skin sensitisation test methods and strategies

Janette Goniwiecha, Laura Nimtz *equal contribu-tion, Maxi Hofrichter, Ellen Fritsche

Sebastian Hoffmann, Nathalie Alepee, Dave Allen, Takao Ashikaga, Magalie Cluzel, Nichola Gellatly, Jalila Hibatallah, Petra Kern, Martina Klaric, Nicole Kleinstreuer, Jochen Kühnl, Karsten Mewes, Marion Millet, Masaaki Miyazawa, Eileen Phillips, Silvia TEISSIER, Erwin van Vliet, Dirk Petersohn

Erwin L Roggen, Els Adriaens, Eric Andres, Fanny Boisleve, Sun-A Cho, Emanuela Corsini, George DeGeorge, Horst Fuchs, Pierre-Jacques Ferret, Sue Gibbs, Patrick Hayden, Dagmar Lehmeier, Silvia Letasiova, Jean-Philippe Therrien

Katharina Schimek, Leo Krohne, Ulrike Will, Alexandra K. Lorenz, Ilka Maschmeyer, Roland Lauster, Uwe Marx, Gerd Lindner

Kristina Kejlova, Adam Vavrous, Marketa Dvorakova, Jitka Sosnovcova, Dagmar Jirova

Marketa Dvorakova, Kristina Kejlova, Lucie Kasparova, Daniel Krsek, Dagmar Jirova

Ulrike Dr. Lodemann, Salah Amasheh, Judith Radloff, Martina Kern, Astrid Bethe, Lothar Wieler, Robert Pieper, Jürgen Zentek, Joerg R. Aschenbach

Tobias Hasenberg, Katharina Schimek, Severin Mühleder, Andrea Dotzler, Sophie Bauer, Alexandra K. Lorenz, Wolfgang Holnthoner, Heinz Redl, Roland Lauster, Uwe Marx

Kristina Wagner

Beate Rinner, Katharina Meditz, Marie-Therese Frisch, Dagmar Kolb-Lenz, Ellen Heitzer, Birgit Reininger-Gutmann, Helmut Schaider, Bernadette Liegl-Atzwanger, Sabrina Riedl, Dagmar Zweytick

Lucian Farcal, Adela Pintea, Zorita Diaconeasa, Adrian Oros, Carmen Socaciu

Christopher Weidner, Konrad Gulich, Birgitta Slawik, Elisa Opitz, Gilbert Schönfelder, Andrea Seiler

Marcel Leist

Sebastian Hoffmann

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 VII

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Omnisphero: A novel computational approach for high content image analyses (HCA) of organoid neurosphere cultures in vitro.

Analysis of effects of the adoption of alternative methods on the number of animals used for eye irritation in the European Union

Characterization of molecular and cellular effects of thyroid hormone within an AOP frame for thyroid hormone disruption using human and murine neural progenitor cells

The official German “AnimalTestInfo” – A role model for more transparency on animal experiments through NTPs?

Reconstructed Human Epidermis (RhE) Monitor-ing via the IMOLA-IVD

Functional neurons from cancer cells: a novel in vitro model exhibits appropriate functional parameters

Microheated thermoresponsive cell culture sub-strate for spatiotemporal control of cell growth

A Relevant In Vitro Model for Safety Testing of Chemicals and Efficacy Testeing of Pharmaceuti-cals

Generation of 3D neurospheres from human induced pluripotent stem cells as an alternative in vitro method to study neurodevelopmental defects of Cockayne Syndrome patients

Automation of production and quality control of a reconstructed human epidermis

Vascular-like Network Enhances Structural and Functional Maturation of Human Pluripotent Stem Cell derived Cardiomyocytes in Cardiovascular Construct

In House Validation of the Bovine Corneal Opac-ity and Permeability Assay and EpiOcular™ Eye Irritation Test

Biophysical and metabolic properties of striae dis-tensae evaluated ex vivo compared to normal skin.

Development of a shipping protocol for human hemicornea constructs to facilitate their widespread use in in vitro drug absorption studies

Pro- and pre- hapten mechanisms in skin sensitization

Martin Roland Schmuck, Thomas Temme, Marta Barenys, Axel Mosig, Ellen Fritsche

Joachim Wiest, Kristina Wagner, Roman Kolar, Irmela Ruhdel

Katharina Dach, Susanne Giersiefer, Farina Bendt, Ulrike Huebenthal, Heike Heuer, Ellen Fritsche

Isabel Engelhardt, Irmela Ruhdel, Kristina Wagner

Frank Alexander, Joachim Wiest

Susanna Alloisio, Giovanni Arnaldi, Patrizia Garbati, Paola Gavazzo, Antonio Novellino, Aldo Pagano

Laura Behm, Michael Kirschbaum, Claus Duschl

Tuula Heinonen

Maxi Hofrichter, Julia Tigges, Friederike Schröter, Alexey Epanchintsev, Jean-Marc Egly, james adjaye, Dieter Willbold, Jean Krutmann, Ellen Fritsche

Freia Schmid, Thomas Schwarz, Lena Schober, Moriz Walter, Michael Klos, Wolfgang Schuberthan, Andrea Traube, Andreas Traube, Jan Hansmann, Heike Walles, Florian Groeber

Hanna Vuorenpää, Kirsi Penttinen, Mari Pekkanen-Mattila, Jertta-Riina Sarkanen, Timo Ylikomi, Katriina Aalto-Setälä, Tuula Heinonen

Jo Vinall, Frank Toner, Clive Roper

Youna Coquin, Manon Fournier, Lucie Oger, Hayat Dacq, Françoise Bree, Eva-Anne Subileau, Valery Shevchenko, Christophe Chesne

Nicole Beißner, Michaela Zorn-Kruppa, Stephan Reichl

David Roberts

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015VIII

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Influence of brake wear particle size on the biological impact using a 3D human epithelial tissue barrier model

Cytotoxic and immunological effects of engineered nanomaterials

Mimicking the cyclic mechanical stress of the lung parenchyma in a breathing lung-on-chip

Human lymphoblastoid cell lines as an in vitro tool in preclinical drug evaluation

The HuALN model for testing immune reactivity in vitro

Hydra offers potential as a simple alternative model organism for ecotoxicology and environmental genomics assessment

Ethics review of animal experiments in Europe under Directive 2010/63/EU

Harm-benefit analysis of animal experimentation: a qualitative study of ethics committee practice in six European countries

Community guidelines on animal studies - ALS research as a case-study

A model for predicting human liver toxicity, based on molecular fragments

A Microfluidic Four-Organ-Chip – A Potential Tool for ADME Profiling

Stem cell-derived human dorsal root ganglia-like cells to identify peripheral neurotoxicants

Glutamate and Hypoxia as a Stress Model for the Isolated Perfused Vertebrate Retina

Refinement of orofacial surgical experiments in the Göttingen minipig™: morphometry of the mandibula by 3D-computed tomography

First successful therapy with a new retinal ischemia organ culture model

Non-animal Testing: It’s within REACH

Generation of in vitro skin models using ORS cells

Hana Barosova, Savvina Chortarea, Jana Kukutschova, Martin J.D. Clift, Miroslav Vaculik, Alke Petri-Fink, Barbara Rothen-Rutishauser

Marika Mannerstrom, Jing Zou, Tarja Toimela, Ilmari Pyykkö, Tuula Heinonen

Janick Stucki, Andreas Stucki, Marcel Felder, Sean Hall, Yves Mermoud, Ralph Schmid, Thomas Geiser, Olivier Guenat

Tijana Markovic, David Gurwitz, Maša Vidmar, Helena Podgornik, Irena Mlinaric-Rascan

Christoph Giese, Annika Lubitz

Mohammed Zeeshan, Anbazhagan Murugadas, Panayappurath Ibrahim, Ramasamy Babu Rajendran, Mohammad Akbarsha

Anna Olsson, Sandra S Silva, Jesper Lassen, Peter Sandøe

Anna Olsson, Ana C Castro, Peter Sandøe, Jesper Lassen

Nuno Henrique Franco, Joana G. Fernandes, An-drew J. Furley, Andrew J. Grierson, Anna Olsson

Fabiola Pizzo, Anna Lombardo, Emilio Benfenati

Juliane Hübner, Ilka Maschmeyer, Alexandra K. Lorenz, Anja Ramme, Tobias Hasenberg, Katharina Schimek, Christopher Drewell, Sophie Bauer, Roland Lauster, Uwe Marx

Lisa Hoelting, Stefanie Klima, Christiaan Karreman, Marianna Grinberg, Johannes Meisig, Magrit Henry, Tamara Rotshteyn, Jörg Rahnenführer, Nils Blüthgen, Agapios Sachinidis, Tanja Waldmann, Marcel Leist

Jose Hurst, Sebastian Müller, Martin S. Spitzer, Karl-Ulrich Bartz-Schmid, Sven Schnichels, Kai Januschowski

Giuliano Mario Corte, Johanna Plendl, Hana Hünigen, Stefan M. Niehues

Patricia Klemm, Jose Hurst, Matthias Blak, Maxi-milian Schultheiss, Karl-Ulrich Bartz-Schmidt, Martin S. Spitzer, Sven Schnichels

Gilly Stoddart, Julia Baines

Anna Löwa, Nada Charbaji, Christopher Wolff, Sarah Hedtrich

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 IX

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New tools to assist in the application of the read-across approach

Refinement of welfare through application of a quantitative system for assessment of lifetime experience

Hydra, a Suitable Candidate for Risk Assessment of Nanomaterials

Journal policies on animal use – current landscape and future directions

Influence of CD4+ T Cell Migration into a Filag-grin Deficient Skin Model in Terms of Skin Barrier Proteins and Barrier Function

Barriers to the implementation of refinements in animal laboratories

Refinement strategies in experimental autoimmune encephalomyelitis (EAE) in mice

Non-technical summaries- a review of EU member states efforts so far

The need for proactive rehoming policies in the EU

Impaired Skin Barrier Function of Cutaneous Squamous Cell Carcinoma

EPAA - 10 years of progress and more to do

Enhancing effect of alternating electric fields of different frequencies on biological activity of 5FU, HuIFN-αN3, Royal Jelly and combinations of them on CaCo-2 cells

REACH, the Cosmetics Regulation and upholding the animal testing ban

Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices

Testing of differentiation and cytotoxicity to evaluate the safety of a Chinese herbal medicine extracts used for the treatment of atopic dermatitis

In vitro effects of zinc oxide nanoparticles on human intestinal Caco-2 cells

Toxicological effects of copper oxide nanoparticles on Caco-2 intestinal cells

Decision Algorithm for 3R (Refine, Reduce, Replace) Programs - a case study in vaccines

Alessandra Roncaglioni, Emilio Benfenati, Alberto Manganaro, Giuseppina Gini

Michael Dennis, Tomasz Zarorski, Sally Sharpe, Peter Storey, Anna Rance, Ian Hall, Sarah Wolfensohn

Anbazhagan Murugadas, Mohammed Zeeshan, K Thamaraiselvi, Mohammad Akbarsha

Nuno Henrique Franco

Leonie Wallmeyer, Christopher Wolff, Sarah Hedtrich

Katy Taylor

Kristina Ullmann

Katy Taylor

Katy Taylor

Christopher Wolff, Christian Zoschke, Vivian Kral, Johanna M. Brandner, Monika Schaefer-Korting

Renate Weissenhorn

Bratko Filipič, Lidija Gradisnik, Miloš Đonović, France Pavlovčič, Wadi Zoghbi, Dunja Exel Gregorič, Časlav Daničič, Klemen Rihar

Julia Baines

Helena Obernolte, Detlef Ritter, Jan Knebel, Peter Braubach, Danny Jonigk, Armin Braun, Katherina Sewald

Lu Li, Andrea Haase, Ling Cheng, Clara BS Lau, Chi Chiu Wang, Ping Chung Leung, Horst Spielmann, Monika Schaefer-Korting, Andreas Luch

Francesca Caloni, Paride Mantecca, Aharon Gedanken, Isabella De Angelis, Nicholas Bellitto, Ilana Perelshtein, Cristina Cortinovis

Francesca Caloni, Marco Albonico, Paride Mantecca, Aharon Gedanken, Nicholas Bellitto, Maria Chiara Perego, Ilana Perelshtein, Cristina Cortinovis

Iwona Wilk-Zasadna, Laura Viviani, Benn Reeve, Deborah Novicki, Stephanie Herman

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015X

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Towards the Assessment of Skin Sensitization Potency: Quantitative Estimations by the Direct Peptide Reactivity Assay

Dermal sensitizers - identification and potency ranking using IVSA and epiCS®

The importance of understanding drivers of classification in vivo for selection of chemicals used in the development and evaluation of in vitro serious eye damage/eye irritation assays: Cosmetics Europe analysis

Characterization of 3D Reconstructed Human Airway Models Used for Biomarker and Inflam-matory Response Studies.

NanoSafety research and its challenges!

VPA Read across: Development of predictive biomarkers by using toxicity data of structurally similar compounds.

Directive 2010/63/EU: five years after its adoption

The Future of the QSAR Toolbox: moving to less uncertainty in predictive toxicology

A multi-targeted in vitro approach to predict the potential risks to human health and ecosystems during exposure to mixtures (CER 16 05 06*) from disposal of wastes.

Use of (Q)SARs under REACH - perspective of a regulator

Non-Animal Replacements for Acute Toxicity Testing

Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure

Mechanistic studies on signaling pathways contrib-uting to human neural progenitor cell migration

Depletion of Neural Stem Cells from the Sub-Ventricular Zone of Adult Mouse Brain Using Cytarabine

Identification of transcriptome signatures and bi-omarkers specific for migration-inhibiting potential developmental toxicants in human neural crest cells

CON4EI: Consortium for in vitro Eye Irritation testing strategy

Susanne N Kolle, Britta Wareing, Denis Mulliner, Bennard van Ravenzwaay, Robert Landsiedel

Dirk Weisensee, Oliver Engelking

João Barroso, Nathalie Alepee, Els Adriaens, Magalie Cluzel, Ann De Smedt, Jalila Hibatallah, Martina Klaric, Karsten Mewes, Marion Millet, Uwe Pfannenbecker, Marie Templier, Pauline McNamee

Holger Behrsing, Hans Raabe, Rodger Curren

Peter Wick, Matthias Rösslein, Cordula Hirsch, Tina Buerki

Regina Stöber, Sylvia E. Escher, Jan G. Hengstler

Herman Koeter

Romualdo Benigni, Joop De Knecht

Anna Maria Bassi, Chiara Scanarotti, Stefania Vernazza, Jenia Danailova, Maria Adelaide Pronzato, Susanna Alloisio, Antonio Novellino

Matthias Herzler

Kevin Coll, Richard Clothier, Nathalie Belot, Chris-topher Longmore, Suzanne Avey, Karl Bygrave, Carol Barker-Treasure

Olga Danov, Sylvia E. Escher, Katrin Schröder, David Vorgrimmler, Peter Braubach, Danny Jonigk, Gregor Warnecke, Armin Braun, Katherina Sewald

Christiane Hohensee, Susanne Giersiefer, Ellen Fritsche

Tahereh Esmaeilpour, Amir Ghanbari, Hassan Azari, Soghra Bahmanpour

Giorgia Pallocca, Marianna Grinberg, Tanja Wald-mann, Jörg Rahnenführer, Magrit Henry, Agapios Sachinidis, Marcel Leist

An Van Rompay, Els Adriaens, Nathalie Alepee, Helena Kandarova, Przemyslaw Fochtman, Katarzyna Gruszka, Agnieszka Drzewiecka, Joke Lenoir, Jamin A. Sr. Willoughby, Robert Guest, sandra verstraelen

Lecture

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Poster

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Lecture

Lecture

Lecture

Lecture

Poster

Lecture

Poster

Poster

Poster

Poster

Poster

Poster

Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 XI

ID Title Authors Type

190

191

192

193

194

195

196

197

198

199

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203

Systematic literature review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods

Outlook on currently available non-animal test methods for skin sensitization testing

Cytochrome C assay as a tool for determining ranking for nanomaterials surface reactivity

Application of in chemico and in silico methods to address protein-binding, the molecular initiating event of skin sensitization

Intra- and Interlaboratory validation of LuSens: a reporter gene-cell line to detect keratinocyte activation by skin sensitizers

Assessment of the predictivity of neuronal networks coped to microelectrode arrays for identification of neurotoxicants

Metabolomics in vitro: a new approach for systemic toxicity – first applications for mode of action identification and chemical grouping

Failure and Success: in vitro ocular irritation test methods for agrochemical formulations the Bovine Cornea Opacity and Permeability Test and the EpiOcular™ Eye Irritation Test

A decision-making framework for the grouping and testing of nanomaterials

Training as a tool to Implement of 3R in India

Reconstructed Human Skin Pioneers the Implementation of Diversity into Preclinical Testing in vitro

The Berlin-Brandenburg Research Platform BB3R and Integrated Graduate School

Are Xenobiotic Metabolizing Enzyme Activities in Cells relevant for Skin Sensitization?

Stefan Masjosthusmann, Alm Henrik, Jenny Baumann, Lieve Geerts, Helen Håkansson, Hilda Witters, Ellen Fritsche

Daniel Urbisch, Naveed Honarvar, Susanne N Kolle, Annette Mehling, Tzutzuy Ramirez, Wera Teubner, Bennard van Ravenzwaay, Robert Landsiedel

Muhammad-Adeel Irfan, Wendel Wohlleben, Robert Landsiedel

Daniel Urbisch, Naveed Honarvar, Susanne N Kolle, Annette Mehling, Tzutzuy Ramirez, Wera Teubner, Bennard van Ravenzwaay, Robert Landsiedel

Tzutzuy Ramirez, Alexandra Aumann, Tina Woehrle, Amber Edwards, Kimberly G Norman, Cindy Ryan, Markus Fehr, Florence Burleson, Leslie Foertsch, Xiaohong Wang, Frank Gerberick, Nadine Stein, An-nette Mehling, Bennard van Ravenzwaay, Robert Landsiedel

Tzutzuy Ramirez, Timo Weisschu, Hans-Albrecht Huener, Robert Landsiedel, Bennard van Ravenzwaay

Tzutzuy Ramirez, Alexander Strigun, Werner Mellert, Hennicke Kamp, Tilmann Walk, Bennard van Ravenzwaay

Susanne N Kolle, Maria Cecilia Rey Moreno, Win-fried Mayer, Andrew van Cott, Bennard van Ravenzwaay, Robert Landsiedel

Josje H E Arts, Mackenzi Hadi, Muhammad-Adeel Irfan, Athena M Keene, Reinhard Kreiling, Delina Lyon, Monika Maier, Karin Michel, Thomas Petry, Ursula G. Sauer, David B Warheit, Karin Wiench, Wendel Wohlleben, Robert Landsiedel

Vijay Pal Singh, Kunal Pratap Singh

Monika Schaefer-Korting, Christian Zoschke, Stefan Hönzke, Ulrike Alexiev, Alexander Boreham, Lilian Julia Löwenau, Christian Hausmann, Leonie Wallmeyer, Julia Tigges, Jean Krutmann, Sarah Hedtrich, Ellen Fritsche

Monika Schaefer-Korting, Günther Weindl, Vivian Kral, Johanna Plendl, Christa Thöne-Reineke, Roland Lauster, Axel Pries, Robert Preissner, Marcus Weber, Burkhard Kleuser, Andreas Luch, Gilbert Schönfelder

Daniel Urbisch, Eric Fabian, Daniela Vogel, Tzutzuy Ramirez, Susanne N Kolle, Matthias Becker, Bennard van Ravenzwaay, Robert Landsiedel

Poster

Lecture

Poster

Poster

Poster

Lecture

Lecture

Lecture

Lecture

Lecture

Lecture

Lecture

Poster

Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015XII

ID Title Authors Type

204

205

206

207

208

209

210

211

213

214

215

216

217

218

219

220

221

Cellular human based systems for investigating the toxicity effects of inhalable substances

Assess the bio-barrier function of the human respi-ratory system using an in vitro 3D model of airway epithelial model (MucilAir™)

A dynamic multi-organ-chip as a tool for effect prediction of hepatic metabolism on drug toxicity in vitro

Evaluation of selumetinib and trametinib MEK in-hibitors antitumor efficacy in a preclinical in vitro human lung cancer model

Towards the Replacement of in vivo Repeated Dose Systemic Toxicity: Achievements of the SEURAT-1 Research Initiative

Assessing skin sensitization hazard in mice and men using non-animal test methods

A human ex vivo model to investigate cigarette smoke-induced lung tissue damage

Localization and internal dose of CeO2 nano-particles in an airway epithelium cell model in comparison to A549 lung cells

The activation of macrophages in co-culture ini-tialised by metal oxide nanoparticles

Six organ chip for substance toxicity testing using Homunculus platform

Good In Vitro method practices (GIVIMP) as a basis for the development of harmonised standards for in vitro bio-barrier methods

Assessment of sensitization and photosensitization of benzophenone-3 based on DPRA

Animals are not Materials and Methods: Why it is important to focus on Replacement

A Course in Alternatives: Focus on Replacement and non-animal methods

Intelligent inserts as scaffolds for functional cell co-culture models on a biomimetic scale

Oocyte-Like Cell Differentiation of Mouse Embry-onic Stem Cells by Two-Step cultivation

Human stem-cell based functional neuronal in vitro disease models

Samuel Constant

Samuel Constant, Song Huang, Ludovic Wiszniewski

Natalya Pulkova, Anna Aleksandrova, Nadejda Khaustova, Svetlana Tonevitskaya, Dmitriy Sakharov

Samuel Constant, Christophe Mas

Tilman Gocht, Elisabet Berggren, Michael Schwarz, Maurice Whelan

Daniel Urbisch, Annette Mehling, Katharina Guth, Tzutzuy Ramirez, Naveed Honarvar, Susanne N Kolle, Robert Landsiedel, Joanna Jaworska, Petra Kern, Frank Gerberick, Andreas Natsch, Roger Emter, Takao Ashikaga, Masaaki Miyazawa, Hitoshi Sakaguchi

Sophie Seehase, Karoline I. Gaede, Christian Kugler, Ekkehard Vollmer, Torsten Goldmann

Sergey Tatarenko, Harald Jungnickel, Jutta Tentschert, Peter Laux, Andreas Luch

Tiina Titma

Dmitry Sakharov, Eugene Trushkin, Svetlana Tonevitskaya, Alexander Tonevitsky

Sandra Coecke, Jos Bessems, Ann-Charlotte Bostroem, Varvara Gouliarmou, Pilar Prieto-Peraita, Maurice Whelan, Andrew Worth

Carolina Benevenuto, Lorena Gaspar

Candida Nastrucci

Candida Nastrucci

Silvia Angeloni

Soghra Bahmanpour, Nehleh Zareifard, Tahereh Talaei-Khozani, Tahereh Esmaeilpour

Susanna Narkilahti

Lecture

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Lecture

Lecture

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Poster

Poster

Poster

Poster

Lecture

Lecture

Lecture

Lecture

Lecture

Lecture

Poster

Lecture

Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 XIII

ID Title Authors Type

222

223

224

225

227

229

230

231

232

233

234

235

236

237

238

An in vitro model for hepatocyte-like cell differen-tiation from Wharton’s jelly derived-mesenchymal stem cells by cell-base aggregates

Nanoparticles at the human placental barrier: Advancing in vitro placenta models using co-cultures and mimicking the 3D and/or dynamic microenvironment

An In Vitro Reconstructed Normal Human Corneal Tissue Model for Corneal Drug Delivery Studies of Ophthalmic Formulations

InvertTox presents its new in vivo alternative test-ing strategy for predictive toxicology and efficacy screenings: the NeoMac assays

A novel assay for evaluating wound healing in a full-thickness in vitro human skin model

An In vitro reconstructed psoriasis tissue model for evaluation of drug therapeutics

The Effect Of Fetal Liver Extract And 3D Culture On Hepatogenic Capability Of Human Wharton's Jelly Mesenchymal Stem Cells Co-Culturing With Endothelial Cells

Optimization of an Eye Irritation Assay for Hazard Identification and Labelling of Materials to Address the EU Cosmetic Directive and REACH Legislation

The Danish 3R-Center

Development, Optimization and Standardization of an in vitro Skin Irritation Test for Medical Devices Using the Reconstructed Human Tissue Model EpiDerm

Rat early reactions on the empty and enriched environment

Determination of contact sensitization potential of chemicals using in vitro reconstructed normal human epidermal model EpiDerm: impact of the modality of application

Characterization of the effects of epigallocatechin gallate (EGCG) exposure during neurodevelop-ment within the AOP concept

Avian encephalomyelitis live vaccines - alternative methods for batch virus titration

NanoE-Tox – in-depth database on ecotoxicity of nanomaterials

Tahereh Talaei-Khozani, Maryam Borhan-Haghighi, Maryam Ayatollahi, Zahra Vojdani

Tina Buerki, Carina Muoth, Leonie Aengenheister, Melanie Kucki, Pius Manser, Wolfram Jochum, Peter Wick

Yulia Kaluzhny, Miriam Kinuthia, Laurence d’Argembeau-Thornton, Victor Karetsky, Patrick Hayden, Silvia Letasiova, Mitchell Klausner

Maxime Willems, Els Adriaens, An-Sofie Stevens, Karen Smeets, Jean-Paul Remon

Katarina Sebova, Michael Bachelor, Mitchell Klausner, Patrick Hayden, Jonathan Oldach, Gina Stolper, Max Li

Katarina Sebova, Mitchell Klausner, Seyoum Ayehunie, C. Hedin, Annie Cataldo, M. Spratt, Patrick Hayden

Zahra Vojdani, Zahra Khodabandeh, Tahereh Talaei-Khozani, Soghra Bahmanpour

Yulia Kaluzhny, Helena Kandarova, Laurence d’Argembeau-Thornton, Jane De Luca, Patrick Hayden, Amy Hunter, Thoa Truong, Silvia Leta-siova, Mitchell Klausner

Tom Bengtsen

Helena Kandarova, Jamin A. Sr. Willoughby, Wim H. de Jong, Michael Bachelor, Silvia Letasiova, Tatiana Milasová, Bridget Breyfogle, Liset de la Fonteyne, Kelly, P. Coleman

Györgyi Szabó, Andrea Ferencz, Gamal Eldin Mohamed, Daniella Fehér, Krisztina Juhos, György Wéber

Silvia Letasiova, Valentina Galbiati, Helena Kandarova, Emanuela Corsini, Dagmar Lehmeier, Helge Gehrke

Marta Barenys, Kathrin Gassmann, Christine Baksmeier, Sabrina Heinz, Martin Roland Schmuck, Maria Teresa Colomina, Sivaraj Sundaram, Heike Heuer, Ellen Fritsche

Lena Rimpel, Carmen Jungbäck, Andreas Motitschke

Katre Juganson, Angela Ivask, Irina Blinova, Monika Mortimer, Kaja Kasemets, Anne Kahru

Poster

Poster

Poster

Poster

Poster

Poster

Poster

Lecture

Poster

Lecture

Poster

Poster

Lecture

Lecture

Poster

Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015XIV

ID Title Authors Type

239

240

241

242

243

244

246

247

249

250

255

256

257

258

259

260

261

QsarDB: solution strategy for efficient use of QSAR models

The use of the 'Neurosphere-Assay’ to study specific disturbances on FGF-2 function during neurodevelopment

Improving animal welfare through competence: The EUPRIM-Net education and training programs

In vitro characterization of monoamine oxidases, steroid-5α-reductases, sulfotransferases and glu-tathione S-transferases in excised human skin and reconstructed skin

Biotransformation of 2,4-toluenediamine by human skin and reconstructed tissues

Replacing rodent models for investigating the influence of the microbiota upon innate immune responses and resistance to pathogens.

Using human organotypic glioblastoma tissue slices for therapy improvement

KeratinoSens Skin Sensitisation Test: Adaptation to Animal-Free Culture Conditions

An animal-free batch testing method for alum-adjuvanted veterinary rabies vaccines

Stem-cell based in vitro models to study human CNS pathophysiology

Phenotypic responses of human asthmatic airway epithelial cultures to rhinovirus and poly(I:C)

CERST-NRW: a German state government of North Rhine Westphalia-funded initiative for the development of alternative methods to animal testing

Holistic approach to Risk Assessment of chemicals for REACH purposes

In vitro evaluation of photoprotective efficacy of commercial sunscreens by biological parameters

Beyond Europe: Accelerating Regulatory Uptake and Use of 3R Best Practices Globally

Adressing inflammatory parameters of the intesti-nal mucosa: From the mouse to the test tube

BlueScreenTM AF (Animal-Free) - The First Truly Animal-Free In Vitro Test for Human Genotoxicity

Uko Maran, Sulev Sild, Villu Ruusmann, Geven Piir, Alfonso Garcia-Sosa, Kalev Takkis, Mare Oja, Elmar Laigna, Priit Ahte, Iiris Kahn, Andre Lomaka

Marta Barenys, Ekaterini Kefalakes, Ellen Fritsche

Valeska Marija Stephan, Björg Pauling, Robert Teepe

Lisa Grohmann, Monika Schaefer-Korting, Günther Weindl

Lisa Grohmann, Daniel Becker, Jörg Rademann, Nan Ma, Monika Schaefer-Korting, Günther Weindl

Andrew King, Rachel Lawrence, Imelda McGonnell

Susann Haehnel, Felicitas Merz, Henry Oppermann, Juergen Meixensberger, Frank Gaunitz, Ingo Bechmann

Nathalie Belot, Bushra Sim, Matthew Field, Carol Barker-Treasure

Verena Jakel, Karin Duchow, Beate Krämer, Max Bastian

Zeynab Nayernia

Patrick Hayden, Jianwu Bai, Steven Smock, R. Jackson, Kenzie MacIsaac, Yongsheng Huang, Jonathan Oldach, Brian Roberts, Michael Crackower, Yu-Lu Ma, Joel Klappenbach, Stephen Alves, Helena Kandarova

Ellen Fritsche

Costanza Rovida

Sônia Aparecida Figueiredo, Dayane Moraes, Michelle Andrade, Maria José Vieira Fonseca

Troy Seidle

Benno Weigmann, Maike Windbergs

Nathalie Belot, Bushra Sim, Matthew Field, Matthew Tate, Louise Birrell, Carol Barker-Treasure

Lecture

Lecture

Lecture

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Poster

Poster

Poster

Poster

Poster

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Lecture

Lecture

Poster

Poster

Lecture

Lecture

Poster

Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 XV

ID Title Authors Type

262

263

264

267

268

269

270

271

272

274

275

276

277

279

280

281

A New Tool for In Vitro Sunscreen Quality Control

In vitro models of skin wounds – potential, limitations and perspectives

Functional characterization of reconstructed skin containing in vitro generated Langerhans cells

What happens when the particle has landed? – In vitro models for studying post-deposition events of aerosolized particles

Applying Adverse Outcome Pathways to support Integrated Approaches to Testing and Assessment (IATA)

Pain Management and post-operative Monitoring and Care of Laboratory Rodents in Germany – Lessons learnt and Recommendations to improve Practice

A porcine retina organ culture model to study neuronal degeneration

EU Placentology Network for Chemicals Safety Testing in Pregnancy – EU-PlaNet

Epithelial-endothelal co-cultures to mimic the air-blood-barrier

Microfluidic in-vitro platform for parallel human multi-tissue interaction studies

Implementing the 3Rs: turning words into action

Accomplishments and next steps for the Roundtable on Science and Welfare in Laboratory Animal Use

Skin sensitisation AOP and structured approaches to data integration

Alzheimer's disease research in the 21st century: the shift towards a new paradigm

Evaluation of inflammatory and genotoxic effects of smokeless tobacco using a human organotypic model of oral epithelium

In vitro induction of airway goblet cell hyperplasia by Th2 cytokines, viral exposure or cigarette smoke

Dayane Moraes, Sônia Figueiredo, Michelle Andrade, Maria José Vieira Fonseca

Maike Windbergs

Stephanie Bock, Christian Zoschke, Gerrit Müller, Monika Schaefer-Korting, André Said, Günther Weindl

Marius Hittinger, Stephanie Kletting, Xabi Murgia, Nico Mell, Clemens Tscheka, Henrik Groß, Hanno Huwer, Christiane de Souza Carvalho-Wodarz, Brigitta Loretz, Nicole Schneider-Daum, Claus-Michael Lehr

João Barroso

Kathrin Herrmann, Paul Flecknell

Sandra Kühn, Jose Hurst, Adelina Jashari, Kathrin Ahrens, Marc-Ilan Wunderlich, Burkhard Dick, Sven Schnichels, Stephanie Joachim

Christiane Albrecht, Paul Brownbill, Martina Ceckova, Igor Chernyavsky, Gernot Desoye, Sophie Gil, Stefan Hansson, Lisbeth Knudsen, Lopa Leach, Rohan Lewis, Udo Markert, Line Mathiesen, Jana Pastuschek, Andre Schmidt, Henning Schneider, Christian Wadsack

Brunhilde Blömeke

Jin-Young Kim, David Fluri, Jens Kelm, Andreas Hierlemann, Olivier Frey

Emily McIvor

Lida Anestidou

Silvia Casati

Francesca Pistollato, P. Charukeshi Chandrasekera

Patrick Hayden, Jonathan Oldach, Bridget Breyfolgle, Mitchell Klausner, Michael Bachelor, Silvia Letasiova, Helena Kandarova

Patrick Hayden, R. Jackson, Amy Hunter, Silvia Letasiova, Helena Kandarova

Poster

Lecture

Lecture

Lecture

Lecture

Lecture

Poster

Poster

Lecture

Lecture

Lecture

Poster

Lecture

Lecture

Poster

Poster

Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015XVI

ID Title Authors Type

283

284

285

286

287

289

290

294

295

296

297

299

300

301

302

303

Human induced pluripotent stem cells as tools for studying the etiology of Non Alcoholic Fatty Liver Disease

Phenotypic and biomarker evaluation of zebrafish larvae as alternative model to predict mammalian hepatotoxicity

Teaching alternative methods in Toxicology in Veterinary Science

Development of best practice in nanosafety assess-ment via the QualityNano Research Infrastructure

A microfluidics integrated electronic monitoring system of a 3D in vitro model of the renal tubule

iPS-derived human 3D cardiac microtissues to assess cardiac toxicity

Scientific and animal welfare issues surrounding the new CRISPR/Cas-9 approach to produce transgenic animals and advanced in vitro disease models

Use of ex vivo organotypic lung tissue in translational research of respiratory injury and inflammation diseases

Omics analysis of human liver microtissues grown over 4 weeks: Implications for studies of liver functions

Pro-drug activation in a dynamic microfluidic sys-tems interconnecting liver and tumor microtissues

RTgill-W1 cell line assay for predicting fish acute toxicity: evaluation of a round-robin test

Cost-effective low-serum cell culture media for expression and purification of molecular motor

CRISPR/Cas-induced structural variants

Mechanisms of vasculogenesis in 3D fibrin matri-ces mediated by the interaction of adipose-derived stem cells and endothelial cells

Modeling Parkinson's Disease using Forward and Reverse Genetics in Human iPS Cells

3D biocompatibility test systems mimicking the in vivo situation: evaluation of a hydroxyapatite-nanoparticular paste

Nina Graffmann, Marie-Ann Kawala, Wasco Wruck, James Adjaye

Sandra Verstraelen, Bernard Peers, Walid Maho, Karen Hollanders, Sylvie Remy, Pascale Berckmans, Adrian Covaci, Hilda Witters

Francesca Caloni

Inge Nelissen, Andrea Haase, Anna Salvati

Vincenzo Curto, Miriam Huerta, Marc Ramuz, Jonathan Rivnay, Xenofon Strakosas, Roisin Owens

Jens Kelm, Victor Zamora Rodriguez, Irina Agarkova, Philippe Beauchamp, Christian Zuppinger, Godfrey Smith

Horst Spielmann

Katherina Sewald

Jens Kelm, Simon Messner, Lisa Fredriksson, Claudia Escher, Magdalena Bober, Katrin Roessger, Wolfgang Moritz, Magnus Ingelman-Sundberg

Jens Kelm, David Fluri, Rosemarie Marchan, Kurt Boonen, Seddik Hammad, Bart Landuyt, Jan G. Hengstler, Andreas Hierlemann, Olivier Frey

Melanie Knöbel, Scott E. Belanger, Pascale Berckmans, Mary Jo Bernhard, Ludek Bláha, Scott D. Dyer, Tina Haupt, Joop L.M. Hermens, Maria Therese Hultman, Heike Laue, Adam Lillicrap, Marie Mlnaříková, Andreas Natsch, Jiři Novak, Theo Sinnige, Knut E. Tollefsen, Hilda Witters, Kristin Schirmer

Marko Ušaj, Arnon Henn

Malte Spielmann

Wolfgang Holnthoner, Pablo Hofbauer, Sabrina Rohinger, Susanne Wolbank, Heinz Redl

Saniye Sprenger, Sanam Bashir, Jingzhong Zhang, Anne-Kathrin Dreyer, Ralf Kühn

Veronika Hruschka, Abigail Pinnock, Jie Chen, Aileen Crawford, Christian Gabriel, Cheryl Miller, Heinz Redl, Susanne Wolbank

Lecture

Poster

Lecture

Poster

Lecture

Poster

Lecture

Lecture

Poster

Lecture

Poster

Poster

Lecture

Poster

Lecture

Lecture

Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015 XVII

ID Title Authors Type

304

305

306

307

308

309

311

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314

315

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Integration of in vitro and in silico approaches to characterize endocrine activities of zearalenone and metabolites

In vitro hiPSC-based modeling of late-onset disease using progerin-induced aging

Preventing unnecessary testing by means of read-across: scope, justification and assessment

Pain for Profit. Can monetary reasons justify animal research ethically?

Cryopreserved human hepatocytes and IdMOC system for the evaluation of adverse human drug properties

Different Concepts of Committees in EU Member States, to Support the Competent Authorities Performing the Project Evaluation According to Directive 2010/63/EU

Cryopreserved human hepatocytes and IdMOC experimental system for the evaluation of human drug properties

The Austrian Catalogue of Criteria. A Tool to Objectify the Harm-Benefit Analysis within the Evaluation of Research Proposals Involving the Use of Live Animals

The implementation problem: barriers to and op-portunities for the use of non-animal veterinary vaccine potency tests

Differentiated human skin-derived stem cells as a novel cell source for in vitro screening of drug-induced liver injury (DILI)

Evaluation of an In Vitro Human Dermal Sensitiza-tion Test for Use with Medical Device Extracts

Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long term opportunities?

Metabolomics as a Read Across Tool

The chicken chorioallantoic membrane (CAM) as model for tumour-stroma interaction in human skin cancer can widely replace the mouse in cancer research

Veronika Ehrlich, Luca Dellafiora, Julie Mollergues, Chiara Dall’Asta, Patrick Serrant, Maricel Marin-Kuan, Elena Lo Piparo, Benoit Schilter, Pietro Cozzini

Justine Miller, Yosif Ganat, Robert Bowman, Janmeet Saini, Barbara Corneo, Amber Frye, Philip Manos, Sally Temple, Lorenz Studer

Karel de Raat

Herwig Grimm, Norbert Alzmann, Vera Marshi

Albert Li

Norbert Alzmann, Vera Marashi, Herwig Grimm

Albert Li

Vera Marashi, Norbert Alzmann, Herwig Grimm

Jeffrey Brown, Christopher Faßbender, Amy Clip-pinger, Gilly Stoddart

Vera Rogiers, Tamara Vanhaecke, Joery De Kock, Robim Marcelino Rodrigues

Jamin A. Sr. Willoughby

Natalie Burden

Tzutzuy Ramirez Hernandez, Olga Duerr, Eric Fabian, Frank Faulhammer, Markus Frericks, Michael Herold, Gerhard Krennrich, Ralf Looser, Werner Mellert, Erik Peter, Volker Strauss, Tilmann Walk, Hennicke Kamp, Bennard van Ravenzwaay

Nassim Ghaffari-Tabrizi-Wizsy, Corinna Krump, Ruben Errampalli, Gert Schwach, Angela Schweizer-Trummer, Marie-Therese Frisch, Birgit Reininger-Gutmann, Iris Zalaudek, Becker Jürgen C, Beate Rinner, Anton Sadjak

Poster

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Lecture

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Linz 2015

ALTEX Proceedings 4(2), 2015, Linz 2015XVIII

ID Title Authors Type

320

321

322

323

325

326

327

328

329

330

331

332

333

Reconstructed Human Epidermis Test Methods for Skin Corrosion Endpoint: How Can Changes in Prediction Models Improve Final Predictions?

Modelling the air-blood-barrier in state of disease – challenges and perspectives

Refinement facilitated by the Culture of Care

Replacement - Coming closer to a dream

The role of the animal welfare officer on the 3R´s principle in laboratory animal science in Germany

Small Airway-on-a-Chip: A Novel Human Inflammatory Disease Model

CAAT-Europe and knowledge exchange on the progress of the 3Rs and research methods

Characterization of Transporter Activities in Different Cell Types by Using Fluorescent Substrates

New guidance on information requirements for skin corrosion/irritation and serious eye damage/eye irritation under REACH

Weighted Gene Co-Expression Network Analysis to Characterize Drug Induced Cardiotoxicity

Accessibility of published QSAR models: ecotoxic endpoints

3D cultivation and differentiation of human neural progenitor cells in a biomimetic functionalized hydrogel matrix as a model for developmental neurotoxicity testing

A human in vitro model for studying cholestasis

Bertrand Desprez, João Barroso, Claudius Griesinger, Helena Kandarova, Nathalie Alepee, Horst Fuchs

Marius Hittinger, Brigitta Loretz, Hanno Huwer, Christiane de Souza Carvalho-Wodarz, Nicole Schneider-Daum, Claus-Michael Lehr

Susanna Louhimies

Thomas Hartung

Christa Thöne-Reineke

Kambez Benam, Richard Novak, Janna Nawroth, Remi Villenave, Mariko Hirano-Kobayashi, Carolina Lucchesi, Thomas C. Ferrante, Young-Jae Choe, Rachelle Prantil-Baun, James C. Weaver, Kevin K. Parker, Anthony Bahinski, Donald E. Ingber

Marcel Leist

Jia Jia, Markus Keiser, Dieter Runge, Anett Ullrich

Bohumila Bichlmaier Suchanova, George Cartlidge, Kimmo Louekari, Laura H. Rossi

Jufeng Wang, Huimin Jiang, Zhengming He, Bo Li

Iiris Kahn, Priit Ahte, Sulev Sild, Uko Maran

Christine Hellwig, Jenny Baumann and Ellen Fritsche

Yeda Kaminski, Sebastian Klein, Elmar Heinzle, Fozia Noor

Poster

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Poster