Lisa Grohskopf, MD, MPH Medical Officer Influenza Division Centers for Disease Control and...
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Transcript of Lisa Grohskopf, MD, MPH Medical Officer Influenza Division Centers for Disease Control and...
Lisa Grohskopf, MD, MPHMedical Officer
Influenza DivisionCenters for Disease Control and Prevention
U.S. Influenza Surveillance
National Center for Immunization & Respiratory Diseases
Influenza Division
VRBPAC MeetingFebruary 25, 2011
Characteristics of Recent Influenza Viruses Tested at CDC
Of 644 U.S. viruses antigenically characterized at CDC since October 1, 2010:
85 (13%) Influenza A (H1N1) 85 (100%) A/California/7/2009-like
348 (54%) Influenza A (H3N2) 345 (99%) A/Perth/16/2009-like
211 (33%) Influenza B 199 (94%) Victoria lineage; 198 (99%) B/Brisbane/60/2008-like 12 (6%) Yamagata lineage
High level resistance to adamantanes persists among Influenza A isolates; A(H1N1), A(H3N2) and B virus isolates tested remain susceptible to neuraminidase inhibitors
Percentage of Visits for Influenza-like Illness (ILI) Reported by
the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet), Weekly National Summary,
September 30, 2007 – February 12, 2011
Influenza Positive Tests Reported to CDC by U.S. WHO/NREVSS Collaborating Laboratories, National Summary, 2010-11
Per
cent
Pos
itive
Num
ber
of P
ositi
ve S
peci
men
s
Epidemic Threshold
Seasonal Baseline
Pneumonia and Influenza Mortalityfor 122 U.S. CitiesWeek Ending 02/12/2011
2007 20082006 2009 2010 2011
0
5
10
15
20
25
30
35
402
00
7-4
0
20
07
-46
20
07
-52
20
08
-06
20
08
-12
20
08
-18
20
08
-24
20
08
-30
20
08
-36
20
08
-42
20
08
-48
20
09
-01
20
09
-07
20
09
-13
20
09
-19
20
09
-25
20
09
-31
20
09
-37
20
09
-43
20
09
-49
20
10
-03
20
10
-09
20
10
-15
20
10
-21
20
10
-27
20
10
-33
20
10
-39
20
10
-45
20
10
-51
20
11-0
5
Nu
mb
er
of
de
ath
s
Week of Death
2007-08
Number of Deaths Reported = 88
2008-09
Number of Deaths Reported = 133
2009-10
Number of Deaths Reported = 282
Deaths Reported Current WeekDeaths Reported Previous Week
2010-11
Number of Deaths Reported = 35
Number of Influenza-Associated Pediatric Deaths by Week of Death: 2007-08 season to present
Key Points
Influenza A(H3N2), A(H1N1), and B strains continue to co-circulate in the U.S.
Recently characterized strains appear to be well-matched to the recommended 2010-2011 seasonal vaccine
Recently circulating viruses remain susceptible to neuraminidase inhibitors
In the U.S., influenza activity remains high in recent weeks
Increase in proportion of influenza A viruses identified as A(H1N1) since the beginning of the U.S. season