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Lipids Dr Hadi Ansarihadipour
Transcript of Lipids - dezazma.comdezazma.com/wp-content/uploads/2019/08/Lipids-1.pdf · Important in the...
Lipids
Dr Hadi Ansarihadipour
References:
1. Molecular Cell Biology. Fifth Edition. Harvey Lodish. Copyright
© 2004 by W. H. Freeman & Company
2. Biochemistry. Lehninger. 4th Edition, 2005.
3. Wikipedia
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Cholesterol
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β-sitisterol
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saccharolipid
Structure of the saccharolipid
Kdo2-lipid A (a hexa-acylated
disaccharide of glucosamine
that is glycosylated with two
3-deoxy-D-manno-
octulosonic acid (Kdo)
residues).
Glucosamine residues in
blue, Kdo residues in
red, acyl chains in black
and phosphate groups in
green. dezazma.com
The building block of isoprenoid alcohols dezazma.com
isoprenoid alcohols
H – [ CH2CCH3=CHCH2 ]n – OH
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Important in the acylation of:
1. Proteins
2. Carotenoids
3. fat-soluble vitamins: A, E and K
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Cardiology
1. coronary heart disease:
angina and myocardial infarction
2. congestive heart failure
3. high blood pressure
4. abnormal cholesterol levels
5. deep vein thrombosis and pulmonary
embolism
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Endocrinology
1. diabetes mellitus
2. polycystic ovarian syndrome
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Reproductive medicine
1. menstrual disorders
2. infertility
3. complications during pregnancy
4. birth defects
5. intrauterine fetal death
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Neurology
1. stroke
2. migraines
3. carpal tunnel syndrome
4. meralgia paresthetica
5. dementia
6. idiopathic intracranial hypertension
7. multiple sclerosis
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Psychiatry
1. depression in women
2. social stigmatization
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Rheumatology and Orthopedics
1. Gout
2. poor mobility
3. osteoarthritis
4. low back pain
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Dermatology
1. stretch marks
2. acanthosis nigricans
3. lymphedema
4. cellulitis
5. hirsutism
6. intertrigo
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Gastroenterology
1. gastroesophageal reflux disease
2. fatty liver disease
3. cholelithiasis (gallstones)
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Oncology
1. esophageal
2. colorectal
3. pancreatic
4. gallbladder
5. endometrial
6. kidney
7. Leukemia
8. Hepatocellular carcinoma
9. malignant melanoma
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Respirology
1. obstructive sleep apnea
2. obesity hypoventilation syndrome
3. asthma
4. increased complications during general
anaesthesia
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Urology and Nephrology
1. erectile dysfunction
2. urinary incontinence
3. chronic renal failure
4. hypogonadism
5. buried penis
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