- `Part I: General Information

DATE PREPARED: 2-10-10

Name: Lynne Lipton Levitsky

Office Address: Pediatric Endocrine Unit Massachusetts General Hospital55 Fruit StreetBoston, MA 02114

Home Address: 165 Tremont Street, # 1703Boston, MA 02111

E-Mail: Llevitsky@partners.org FAX: 617-726-3044

Place of Birth: Columbia, SC

Education:

1962 B.A., cum laude with honors in biology Bryn Mawr College1966 M.D., cum laude Yale University

School of Medicine

Postdoctoral Training:

1966-67 Intern in Pediatrics Bronx Municipal Hospital Bronx, NY1967-68 Resident in Pediatrics Children's Hospital Philadelphia,

of Philadelphia PA1968-70 Fellow in Pediatric University of Maryland Baltimore,

Endocrinology and School of Medicine MD Metabolism

Licensure and Certification:

1971-2008 California License1989- Massachusetts License1971 Diplomate, American Board of Pediatrics1978 Diplomate, American Board of Pediatrics Sub-Board in Pediatric

Endocrinology

Academic Appointments:

1970-73 Assistant Professor Pediatrics Abraham Lincoln School of Medicine, U. of Illinois

1973-78 Assistant Professor Pediatrics Pritzker School of Medicine,University of Chicago

1978-85 Associate Professor Pediatrics Pritzker School of Medicine,1

University of Chicago1985-89 Professor of Pediatrics Pritzker School of Medicine,

University of Chicago1990- Associate Professor of Pediatrics Harvard Medical School

Hospital or Affiliated Institution Appointments:

1970-73 Pediatric Endocrinologist U. of Illinois Hospitals1973-86 Medical Staff Michael Reese Hospital

and Medical Center1986-90 Medical Staff Wyler Children’s Hospital,

University of Chicago1986-90 Medical Staff La Rabida Children’s

Hospital, University of Chicago1990- Pediatrician Massachusetts General Hospital

Other Professional Positions and Major Visiting Appointments:

1990-2005 Scientific and Medical Staff Shriners Burns Institute, Boston, MA

1990-96 Medical Staff Beverly Hospital, Beverly, MA1996- Consultant Medical Staff Northshore Children’s

Hospital, Salem, MA

2002-2003 Pediatric Endocrinologist Brigham and Women’s Hospital2005- Pediatric Endocrinologist Cambridge Hospital

Hospital and Health Care Organization Service Responsibilities:

1970-73 Pediatric Attending/Pediatric University of Illinois Endocrinologist Hospitals

1973-86 Pediatric Attending/Pediatric Michael Reese Hospital & Endocrinologist Medical Center

1986-89 Member, Section of Endocrinology Pritzker School of MedicineDepartment of Pediatrics University of Chicago

Chicago, IL1990- Pediatric Endocrinologist Massachusetts General Hospital1990-96 Pediatric Endocrinologist Beverly Hospital, Beverly, MA1996- Pediatric Endocrinologist Northshore Children’s

Hospital, Salem, MA

1990- Pediatric Attending Massachusetts General Hospital

Major Administrative Responsibilities:

1973-86 Director, Div. of Endocrinology Michael Reese Hospital & Med. Ctr. & Metabolism Chicago, IL

1973-86 Associate Director Michael Reese Hospital & Med. Ctr.Clinical Research Center Chicago, IL

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1973-76 Director, Pediatric Microchemistry Michael Reese Hospital & Med. Ctr. Laboratory Chicago, IL

1983-86 Vice Chairman, Michael Reese Hospital & Med. Ctr.Department of Pediatrics Chicago, IL

1983-90 Director, Pediatric Model Unit, Pritzker School of MedicineDiabetes Research & Training University of ChicagoCenter

1986-90 Head, Chicago Children's Diabetes La Rabida Children’s Center Hospital, Chicago, IL(Conceptualized, organized and developed this center – the only full service facility for the care of children with diabetes in Illinois)

1990- Chief, Pediatric Endocrine Unit Children’s Service, MassachusettsGeneral Hospital, Boston,

MA(MassGeneral Hospital for Children)

1993-96 Clinical Advisor, Pediatric Massachusetts General Hospital Microchemistry Laboratory

1994-96 Physician Liaison with Massachusetts General Hospital Pilgrim Health Care (Pediatrics)

Major Committee Assignments:

National:

1979 Site Visit Team, Brown University Member NIH/NICHHDSchool of Medicine

1981 Special Review Committee to Member NIH/NIDDK choose participants in Diabetes Control and Complications Trial

1982 Site Visit Team,University of New Member NIH/NIDDK Mexico

1982-85 Medical Science Advisory Board Member Juvenile Diabetes Research Review Committee Foundation

1985 Site Visit Team, Brown Member NIH/NICHHDUniversity School of Medicine

1985 Site Visit Team, University of Member NIH/NICHHD Colorado School of Medicine

1986 Special Review Committee Member NIH/NIDDKDiabetes Control and Complications Trial

1986 Site Visit Team, Special Study Member NIH/NIDDK Section, Houston, TX

1986 Site Visit Team, Michigan DRTC Member NIH/NIDDK1993 Ad Hoc Reviewer Member NIH/NICHHD1996 NIH Site Visit Team, University of Member NIH/NICHHD

Colorado School of Medicine1996 Ad Hoc Reviewer, Initial Review Member NIH/NICHHD

Group1996 Ad Hoc Reviewer Member NIH/NICHHD

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HED-1 Study Section1997, 98 American Academy of Pediatrics RepresentativeNIDDK/CDC

Representative to National Diabetes Education Program Planning Conference Bethesda, MD

1998 Pediatric Endocrine Society Member American Representative to Academy of Academy

Pediatrics Task Force on of PediatricsSubspecialty Representation

1998-2002 Special Grants Review Committee Member NIH/NIDDKSubcommittee B

2001-2003 Chair1999-2000 Endocrinologic and Metabolic Consultant FDA

Drugs Advisory Committee 2001-2004 Member1999- Standing Panel, Accreditation Member Endocrinology

Appeals in Pediatric Endocrinology ACGME EndocrinologyAccreditation

1999, 2003 Biologic Response Modifiers Member FDA/CBERAdvisory Committee Meeting Human Islet Transplant Trials

2002,4 Endocrinology, Metabolism, Nutrition Ad Hoc member NIH/NIDDK& Reproductive Sciences Study SectionZRG1 SSS-T 10/02, 2/2004

2004- Editorial Board, American Academy of Pediatrics, PREP Self-Assessment 2005- Endocrine Metabolic Drugs Advisory Committee, FDA Consultant

2006- NIH/NIDDK special study section to review Ad Hoc member RFA-DK-05-014 The Obese and Diabetic Intrauterine Environment: Long-term Metabolic or Cardiovascular Consequences in the Offspring

2006 NIH/NIDDK Special Emphasis Panel/Scientific Review Group ZDK1 GRB-G to review K23 Ad Hoc member

2006 FDA Endocrine Metabolic Drugs Ad hoc consultantAdvisory Meeting on L-Thyroxin Stability

2007 Special Emphasis Panel/Scientific Review Ad Hoc ChairGroup ZDK1 GRB-4 M2 1, Training Grants

2008- Maintenance of Certification Committee Part IV LWPES American Board of Pediatrics,Quality Initiative, RepresentativeDiabetes

2008- Diabetes Advocacy Consortium LWPESRepresentative

See also committee and leadership activities for the Endocrine Society, the Academy of Pediatrics, and the Lawson Wilkins Pediatric Endocrine Society

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Regional:

1984-89 Research Committee Member American Academy of Pediatrics, Illinois Chapter

1988-89 Executive Committee Member Chicago Pediatric Society

Medical School:

1986-89 Clinical Research Center Member U. ChicagoAdvisory Committee

1988-89 Clinical Policy Committee Member U. Chicago1988-89 Committee on Appointments Member U. Chicago

and Promotions

Affiliated Institutions:

1975-76 & Research Committee Member Michael Reese1979-83 Hospital and1982-83 Chair Med. Ctr.1974-77 Clinical Research Committee Member Michael Reese1976-77 Chair Hospital and

Med. Ctr1983-86 Medical Board Member Michael Reese

Hospital andMed. Ctr

1990- Scientific Advisory Committee Member Massachusetts General Clinical Research Center General Hospital

1990-94 Subcommittee for the Review Member Massachusettsof Research Protocols General Hospital

1994-96 Children's Service Planning Member Pediatrics, Committee Massachusetts

General Hospital1994-96 Children's Service Shared Member Pediatrics,

Management and Network MassachusettsDevelopment Committee General Hospital

1994-96 Ad Hoc Children's Service Member Pediatrics, Research Committee Massachusetts

General Hospital1996- 2003 Junior Promotions Committee Member Pediatrics,

MassachusettsGeneral Hospital

2002-2006 ECOTE (Executive Committee on Elected MassachusettsTeaching and Education) Member General Hospital

2004- Quality Assurance in Diabetes Member PartnersTask Force Health Care

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2007- MGH Representative to Pediatric CTSA/C Harvard Medical School

Professional Societies:

Year Society Role

1972- American Academy of Pediatrics Fellow(Committee Assignments asNoted under National)

1998 Endocrine Section RVU work group Chair,ICD representative

1970- American Diabetes Association Physician Member2001 Speaker on Management of Childhood Diabetes-National Meeting2002 Speaker in Debate on Screening for Celiac Disease –National Meeting2003 Chair of Session on New Treatments for Pediatric Diabetes

1980-93 Midwest Society for Pediatric Research MemberAbstract reviewer, Chair of meeting sessions

1986-93 Central Society for Clinical Research Member1978- Society for Pediatric Research Member

1979-87 Abstract reviewer and chair of meeting sessions1988- American Pediatric Society Member

Abstract reviewer and chair of meeting sessions1978 - Endocrine Society Member

Abstract reviewer, chair of meeting sessions1999-01 Special Programs Committee Member 2000 Symposium –New Developments Chair

in the Management of Diabetes Mellitus in Children

2006-Clinical Guidelines Committee

1978 - Lawson Wilkins Pediatric Endocrine Member Society

1984-87 Diabetes Committee Member 1987 Chair1990-94 Education Committee Member1994 Chair1996-99 Executive Council Director 1997- 2002 American Academy of Liason

Pediatrics Section on Endocrinology and Lawson Wilkins Pediatric Endocrine Society

2001- Professional and Clinical MemberAffairs Committee

2004-2007 Steering Committee, Clinical Research Network2004 President Elect, Lawson Wilkins Pediatric Endocrine Society

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2005 President, Lawson Wilkins Pediatric Endocrine Society2006 Immediate Past President, Lawson Wilkins Pediatric Endocrine Society2007-8 Member, Board of Directors, Lawson Wilkins Pediatric Endocrine

Society2009- Chair, Education Council of the LWPES

Community Service Related to Professional Work:

1973 -85 Medical Advisor Medical Human Growth Advisor Foundation, Illinois

Chapter1978-89 Board of Directors Member American Diabetes

Association, NorthernIllinois Affiliate

1975-89 Speaker Panel, Speaker American Diabetes Parent Child Education Association, Northern

Illinois Affiliate1990- Occasional Speaker Speaker American Diabetes

Family Education Day Association, Mass

Affiliate2002 Keynote Speaker Speaker Prader Willi Association of

New England2006 Turner Syndrome Education Speaker Turner Syndrome Society of

Day New EnglandEditorial Boards:

Year Role Name of Journal(Ad Hoc Reviews go back into the 1970’s, but I have not kept formal records!)

1996- Ad hoc Reviewer Diabetes Care1997,8 Ad hoc Reviewer J. Ped. Gastroenterol and Nutrition1997- Ad hoc Reviewer Am J. Physiol: Endo Metab1997- Ad hoc Reviewer Pediatrics1996,7 Ad hoc Reviewer Pediatric Research1997- Ad hoc Reviewer Metabolism1997- Ad hoc Reviewer J. Clinical Endo Metab1997- Ad hoc Reviewer Am J. Physiol:Regulatory,

Integrative and Comparative Physiology1998- Ad hoc Reviewer Endocrinology2000- Ad hoc Reviewer Diabetes2002- Ad hoc Reviewer New England J. Med2003- Ad hoc Reviewer J Pediatrics2003- Ad hoc Reviewer Pediatric Diabetes

2004- Editorial Board J. Clinical Endo Metab2007- Associate Editor Current Opinion in Endocrinology,

Diabetes, Growth and Development and Obesity, Williams and Wilkins

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2008- Associate Ediotor J. Pediatric Endocrinol Metab

Awards and Honors:

1965 Alpha Omega Alpha, Yale Chapter1985 Mary Jane Kugel Award, Juvenile Diabetes Foundation International (For

service on MSRC)2004 President, Lawson Wilkins Pediatric Endocrine Society

Part II: Research, Teaching, and Clinical Contributions:

A. Narrative Report:

I am a pediatric endocrinologist with a special interest in diabetes and metabolism. My focus has been on provision and improvement of clinical care in diabetes and in training of the next generation of thought leaders in the field. Over the course of my career I have organized and participated in national clinical conferences on Cerebral Edema in Diabetic Ketoacidosis, Management of Childhood Diabetes, Celiac Disease and Diabetes Mellitus, and Metabolic Syndrome and Type 2 Diabetes. I have spoken on these topics and other endocrine topics both nationally and internationally as an invited speaker, and as requested at courses organized by the American Academy of Pediatrics, and Harvard Primed continuing education. I serve as a member of the editorial board of the PREP (Pediatric Review examination group for the Academy of Pediatrics, providing content in Pediatric Endocrinology and contributing to the overview of content in all aspects of pediatrics). Nationally, I have served as President of the Lawson Wilkins Pediatric Endocrine Society and continue leadership roles in this organization. I am now serving as LWPES liason to a multi-organizational group that is attempting to rationalize provision of diabetes care in this country. In addition, I serve on a group that will work on Strategic Planning for this organization for the next 5 years. I also am on the Editorial Board of the Journal of Clinical Endocrinology and Metabolism, the Journal of Pediatric endocrinology and Metabolism and am the Editor of the Pediatric Section of Current Comments in Endocrinology, Metabolism and Diabetes.

I have also had an active research career, working in the basic laboratory on aspects of carbohydrate metabolism in fetal and neonatal life, and now on developing an understanding of the function of the pancreatic beta cell in order to reconstruct it in a cell less likely to sustain autoimmune damage in individuals with type 1 diabetes mellitus. Several recent publications describe this work. I have trained 8 fellows and summer student research associates in the laboratory at Massachusetts General Hospital. My clinical research work presently is related to the development and conduct of the TODAY study, an NIH-funded trial of treatments for type 2 diabetes in children and Adolescents. I am the Associate Director of the study at the Massachusetts General Hospital-Boston site. I devote about 40% of my time to patient care and have developed the Pediatric Diabetes Center at the Massachusetts General Hospital, and clinical care center that is appropriately staffed to care for children with the most difficult of chronic endocrine diseases. I also have a special interest in hypothalamic-pituitary disorders and in growth disorders and focus on these areas in my clinical care. Essentially all of my patient care activities are also used as educational sites by fellows, resident, and medical students. Since arriving at MGH, I have trained 23 fellows in the clinical care of patients with endocrine disorders, and of those that have graduated, 15/18

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remain in academic positions.I look forward to continuing national and international work in diabetes and pediatric endocrinology, as well as continuing research into the treatment of type 1 diabetes, and a continuing career as an educator and clinician on the local level.

B. Funding Information:**All research except as noted (T = teaching, R = Research, C = Clinical) Year Funding Source P.I./Co-P.I. Grant Title

1971 BRSG U. Ill. P.I. Cerebral Ketone Body Utilization in the Baboon Neonate

1974-79 USPHS P.I. Functional Maturation of the Endocrine Pancreas

1975-78 USPHS P.I. Energy Metabolism in the Fetus and Neonate

1977-80 USPHS (Pilot P.I. Pathophysiologic Correlations in Experi- Project, DRTC) mental Autoimmune Diabetes Mellitus

1979-83 USPHS P.I. Metabolism in the Subhuman Primate and Ovine Fetus

1983-90 USPHS P.I. Pediatric Model Unit of DRTC, A. Rubenstein, P.I. for DRTC (T, R, C)

1983-84 Cambridge Quest P.I. The Effect of Altered Nutritional Regimens Foundation upon Glycemic Control in Children

with Insulin-dependent Diabetes Mellitus1984-93 USPHS P.I. Metabolism in the Nonhuman

Primate and Ovine Fetus1985-87 JDRF P.I. Mechanism of Glycogenesis in the Fetus1990-91 Shriners P.I. Burn Stress: Is Interleukin-1 the

trigger for the Neuroendocrine Response?1991-93 Shriners P.I. Regeneration of Adipose Tissue after Severe

Burn Injury: Clinical and Experimental Studies

1993-94 MGH Interim P.I. Metabolism in the Fetal HepatocyteSupport Fund

1995-95 Genentech Fndtn P.I. The Effect of Growth Hormone uponfor Growth & Develop. Human Adipogenesis

1994-95 Genentech Fdtn. Consultant Culturally Sensitive Educational Materials for Growth & Develop. On Growth and Development for the Ethnic

Cambodian Population 1995-96 Genentech Fdtn. P.I. The Effect of Growth Hormone upon

for Growth & Develop. Human Muscle Glucose Transport

1994-96 Genentech, Inc. P.I. Pubertal Changes in Growth Hormone9

Treated Patients1994-96 Genentech Fdtn. Co. I. MIS during Sexual Maturation

for Growth & Develop.1995-97 Genentech Fdtn. P.I. The Effect of Growth Hormone upon

for Growth & Develop. Human Adipocyte Glucose Transport

1995- 97 Novo-Nordisk P.I. Human Muscle Glucose Transport: Effect of GH and IGF-1

1993- Genentech, Inc. P.I. Effect of GH upon Statural Growth and Body Composition in Children with

Prader- Willi Syndrome1996-2001 USPHS P.I. Metabolism in the Fetal Hepatocyte

HD312151997-99 Genentech Fdtn. P.I. Bone Metabolism in Anorexia Nervosa-

Fellowship Dr. Leslie Soyka2000-01 Genentech Center Consultant Obsesive Compulsive Disorder in Turner

for Clinical Research Syndromeand Education

2000-2003 USPHS Co-Invest. Transcriptional Control of CarbohydrateDK54399 Responsive Genes (P.I. David B. Rhoads)

2000-2002 USPHS Harvard - Mentor Bone Metabolism andTraining grant in growth factors in Anorexia Nervosa - Academic Nutrition Fellowship Madhusmita Misra, M.D.

2001-2003 USPHS NIDDK DRC P.I. Islet Function in mice with selective lossPilot Project of HNF1beta in Beta cells

2001-2003 USPHS NIDDKPilot Project P.I. Antecedents of adult insulin resistance in human infants

2002-2008 USPHS NICHD Co-P.I. TODAY study (Treatment trial for Type 2 D. Nathan, P.I. Diabetes in Childhood)

2002-2008 USPHS NICHD, co-invest Effects of Anorexia on Peak Bone Mass A. Klibanski, P.I.2005-2008 Genentech, Inc. P.I. Growth hormone and insulin resistance

in girls with Turner Syndrome or idiopathicshort stature

2005-2008 Pfizer, Inc. P.I. Growth hormone and insulin resistance in children with intrauterine growth restriction

2005-2008 ADA Co-Invest Role of HNF1beta in Beta Cell David B. Rhoads, P.I. Development2009-2011 Harvard P.I. Noninvasive Measurement of Hydration

Catalyst Not funded

C. Report of Current Research Activities:

Project RoleRole of HNF1Beta in Beta Cell Development Co-Investigator

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Effects of Anorexia Nervosa on Peak Bone Mass Co-InvestigatorTODAY study (Treatment Trial for Type 2 DM) Co-Investigator (funded 20%)Growth Hormone and insulin resistance in children PIwith intrauterine growth restriction

Patents:Method of enhancing Native Promoter activity: Provisional Patent Applied for (Huang, Levitsky, Rhoads)

D. Report of Teaching:

1. Local Contributions

a. Continuing Inpatient House Officer and Medical Student Teaching

1970-73 Ward Attending, General Pediatrics (3 mos/yr) and AttendingPediatric Endocrinologist (6 mos/yr), University of Illinois Hospital

1973-86 Ward Attending, General Pediatrics, Michael Reese MedicalCenter (3mos/yr)

1973-86 Attending Pediatric Endocrinologist, Michael Reese Medical Center (6-11 mos/year)

1973-86 Outpatient teaching throughout year in diabetes and endocrinologyclinics at above institutions. Organizer of curriculum forendocrinology at Michael Reese Medical Center

1986-89 Attending Pediatric Endocrinologist, Wyler Children's Hospital (3 mos/yr)

1986-89 Associate Attending in Pediatric Endocrinology, La RabidaChildren's Hospital

1990- Attending in Pediatric Endocrinology, Massachusetts General Hospital (HMS Clerkship PD 507 M.3, 2-4 students/year) – Organizer of course experience. Contact time 10 –20 hr/wk

1994- 2006 Attending in Pediatrics, Massachusetts General Hospital, ½ - 1 mo/yrc. Local Invited Teaching presentations:Presentations at home institution at least 10 times/year since 1970 (1 hour grand rounds or other formal didactic contributions)At Massachusetts General Hospital:1990- Grand Rounds in Pediatrics and approximately every other year1990- 6-10 formal 1 hour presentations in Pediatric Endocrinology didactic or clinical conferences, or Chief of Service Rounds and didactic conferences in Pediatrics yearly on various Endocrine topics.

d. Continuing Medical Education

Each of these talks requires 10 hours or so of preparation

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1970-92 Yearly speaker at Cook County Graduate School Courses inPediatrics, Family Practice, Critical Care and Diabetes Education

1987 Organized Endocrine component of Advances in PediatricsCourse, Cook County Graduate School-20 hours of preparation

1970-89 Approximately 10-12 talks yearly to professional groups in theIndiana and Northern Illinois area on assorted endocrine topics

1990-yearly Regional talks in the greater Boston area1991-yearly Speaker Post Graduate Course in Primary Care Pediatrics,

Massachusetts General Hospital, Harvard Medical School1995,6,2008,9 Speaker Academy of Pediatrics National CME Meetings2001- Speaker at Pediatric Emergency Medicine Conference, Massachusetts

General Hospital, Harvard Medical School 2004, 2006 Speaker at Harvard Primed Conference20042008 Harvard Primed Conference Mexico City, Mexico

e. Advisory and supervisory responsibilities in clinical and laboratory setting:

1990- Precepting residents, fellows as previously described in ambulatory and inpatient setting.

f. Teaching leadership Role in Department/affiliated Institution

1975-86 Director, Pediatric Endocrine Training Program, Michael Reese Hospital and Medical Center

1990- Director, Pediatric Endocrine Training Program, Massachusetts General Hospital

g. Advisor and Supervisory Responsibilities

Fellowship Trainees:

As Director of Pediatric Endocrine Training Program, Michael Reese Medical Center

1975-77 Nives Dumbovic, M.D. - faculty, Rush Medical School,Pediatric Endocrinologist , Chicago, IL

1977-79 Deborah V. Edidin, M.D. - faculty, Northwestern University Medical School, Division of Pediatric Endocrinology

1978-80 Nancy E. Friedman, M.D. - faculty, Duke University School ofMedicine, Division of Pediatric Endocrinology

As Member of Training Program Attending Staff, Wyler Children's Hospital

1986-89 Mary Kreiter, M.D., faculty Rush Medical School, Division of Pediatric Endocrinology

As Director of Pediatric Endocrine Training Program, Massachusetts General Hospital12

1990-91 Lauren Frisch, M.D., Pediatric Endocrinologist, Pittsburgh, PA1991-92 Kristina Rother, M.D., Research Associate, National Institutes

of Health1992-96 David Zangen, M.D.,Chief, Pediatric Endocrinology, Hadassah Hospital,

Jerusalem, Israel1993-96 Nejib Raboudi, M.D., Pediatric Endocrinology, Tunis, Tunisia1994-97 Cecilia Capriles, M.D., Pediatric Endocrinology, Caracas,

Venezuela 1994-98 Karen Loechner, M.D., Ph.D., Faculty,Pediatric Endocrinology,

University of North Carolina1996-99 Andrew Lane, M.D., Faculty, Pediatric Endocrinology, S.U.NY.,

Stonybrook1996-99 Leslie Soyka, M.D., Faculty, Pediatric Endocrinology, U. Mass Medical

Center1998- 2001 Robert Gensure, M.D., Ph.D. Chief, Pediatric Endocrinology, Tulane

University School of Medicine1999- 2002 Madhusmita Misra, M.D. Faculty, Harvard Medical School,

Massachusetts General Hospital2000-2003 Christopher P. Houk, M.D.Faculty, Pediatric Endocrinology, Medical

College of Georgia2001-2004 Elaine C. Moreland, M.D., Faculty, University of Alabama2002-2005 Tandy Aye, M.D. Faculty, Stanford University2003-2004 Angel Guacaneme, M.D., Fellow in Pediatric Endocrinology, St. Jude’s

Memphis TN2004-2006 Clemens Bergwitz, M.D., Faculty, Endocrinology, MGH, Harvard

Medical School2004-2007 Elka Jacobson-Dickman, M.D, faculty, SUNY Downstate Medical

Center, Brooklyn NY2004-2007 Rajani Prabhakaran, M.D., Pediatric Endocrinologist, Austin, Texas2005- Jennifer Sivitz, M.D., Fellow in Pediatric Endocrinology2005- Ximena Lopez, M.D., Fellow in Pediatric Endocrinology2005- Elvira Isganaitis, M.D., MPH. Fellow in Pediatric Endocrinology2006- Melissa Woo, M.D., Fellow in Pediatric Endocrinology2006- Takara Stanley, M.D., Fellow in Pediatric Endocrinology2006-2008 Tamara Wexler, M.D., Fellow in Adult Endocrinology2007- Vi Nguyen, M.D., Fellow in Pediatric Endocrinology2008- Melissa Russell, M.D. Fellow in Pediatric Endocrinology2008- Sharon Straussman, M.D., Fellow in Pediatric Endocrinology2008- Michelle Katz, M.D., Fellow in Pediatric Endocrinology2009- Deborah Mitchell, M.D., Fellow in Pediatric Endocrinology

Eray Savgan-Gurol, M.D., Fellow in Pediatric EndocrinologyAs Director of Pediatric Endocrine Research Laboratory, Massachusetts General Hospital:1990-1997 Qingjun Zheng, M.D. Research Fellow, presently Pediatrician, St.

Vincent’s Medical Center, New York, NYThese students are now all physicians in training or in practice or academic positions:

1993 Tamara Cochran, 1st year Medical Student, Columbia P&S

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Society for Pediatric Research Summer Research Student

1993 Jennifer Lightdale, 3rd Yr Medical Student, Mount Sinai Medical SchoolSociety for Pediatric Research Summer ResearchStudent (Competed fellowship in Pedi GI- Harvard Combined Program)

1995 Savita Mohan 1st Yr Medical Student, New York University School of Medicine, Society for Pediatric Research Summer Research Student

2002 Sarah Unterman 1st yr medical student, LWPES summer student research fellowship

2003 Tal Minor 1st yr Medical Student, Cornell, Soc Pediatric Research Summer Research Student

2003 Ganiu Eddu 1st yr Medical Student, U. Illinois, LWPES summer student research fellowship

2007 Amanda Leonberger Society for Pediatric Research, Summer Research Student, 1st yr Medical Student, Creighton University

2. a. Regional, National or International Contributions

Oct. 1982 Thyroid Disease in Pediatric Patients. 7th AnnualPostgraduate Program, American Thyroid Association

June 1984 Diabetes Mellitus Modern Management. Illinois Academyof Pediatrics

May 1985 Diabetes in Childhood. Schaffran Memorial Lecture, Aurora, ILMarch 1986 Hypoglycemia. Leon Librik Memorial Lecture, University of

Illinois, Peoria, ILJan. 1987 New Aspects of Diabetes Management. Chicago Pediatric SocietyMarch 1987 Diabetes Mellitus in Children and Adolescents. Chicago

Medical Society, Midwest Clinical Conference April 1987 Cerebral Edema in Diabetic Ketoacidosis. Symposium, Lawson

Wilkins Pediatric Endocrine Society, Society for Pediatric Research

May 1989 Diabetic Ketoacidosis. Lawson Wilkins Pediatric EndocrineSociety, Diabetes Symposium, Society for Pediatric Research

Oct. 1989 Evaluation of the Metabolic Effects of Hypoglycemia in HumanInfants and Non-human primates. Ciba Foundation DiscussionGroup on Neonatal Hypoglycemia, London, England

Oct. 1989 Mortality from Diabetic Ketoacidosis. Hospital Saint-Vincentde Paul, Paris

Oct. 1989 Treatment of Diabetic Ketoacidosis. International Study Group ofDiabetes in Children and Adolescents, Bled, Yugoslavia

Apr 1990 Role of the Pediatrician in the Prevention of Complications ofDiabetes, St. Barnabas Medical Center, New Jersey

Jan 1991 Diabetic Ketoacidosis, Yale New Haven Medical CenterJune 1991 Cerebral Metabolism and Hypoglycemia in the Newborn, Progress

in Neonatology. IX International University Children's ClinicSymposium, Vienna, Austria

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June 1992 Neonatal Endocrine Emergencies - Pediatric Endocrine NursesSociety

Aug 1992 Lectures - Review in Pediatrics, National Center for AdvancedMedical Education, Chicago, IL

Sept 1992 Diabetes Update, Chicago Pediatric SocietyNov 1993 Diabetes Ketoacidosis, Mamonides Medical Center, Pediatric

Endocrinology Course, Brooklyn, NYApril 1995 Seminar, Office Management of Diabetes Mellitus, Academy of

Pediatrics Spring Meeting, Phila, PAMay 1995 Prevention of the Complications of Diabetes Mellitus,

Newer Metabolic Aspects of Diabetes Mellitus, Serono SymposiumLawson Wilkins Pediatric Endocrine Society, San Diego, CA

June 1995 Update on Diabetes Management, Cook County Hospital GrandRounds, Chicago, IL

June 1995 Diabetes Update, Beverly Hospital Grand Rounds, Beverly, MAMay 1996 Office Management of Diabetes Mellitus in Children, Northshore

Children's Hospital, Salem, MA October 1996 Seminar, Office Management of Diabetes Mellitus, Academy of

Pediatrics Annual Meeting, Boston, MAApril, 1997 Update on Diabetes Mellitus, Grand Rounds, University of Illinois

Medical CenterNov,1997 Pitfalls in Pediatric Endocrinology, CoChair, U. Athens, Athens,

GreeceJune, 2000 Meet the Professor Session, Diabetic Ketoacidosis in Children,

Endocrine Society, Toronto, CanadaJune, 2001 Meet the Professor Session, Diabetic Ketoacidosis in Children,

Endocrine Society MeetingJune, 2001 Speaker, Session on Management of Childhood Diabetes, American Diabetes

Association.Jan, 2002 Endocrine Grand Rounds, Brown University, Experiences with Childhood

Cushing’s DiseaseMar, 2002 Pediatric Endocrine Rounds, Boston Children’s Hospital, Childhood

Cushing’s DiseaseMar, 2002 Grand Rounds, Holy Family Hospital, Endocrine EmergenciesMay, 2002 Grand Rounds, Newton Wellesley Hospital, Bone Health in Childhood and

AdolescenceMay, 2002 Grand Rounds, Northshore Medical Center, Pituitary Tumors in childhoodJune, 2002 Speaker, Session on Management of Childhood Diabetes:Screening for Celiac

Disease, American Diabetes AssociationSept, 2002 Keynote Speaker, New England Pediatric Endocrine Nurses Organization,

Congenital Adrenal HyperplasiaOct, 2002 Grand Rounds, Holy Family Hospital, Type 2 DiabetesOct, 2002 Speaker, Academy of Pediatrics Annual Meeting, Boston, Type 2 Diabetes

MellitusNov, 2002 Speaker, Department of Pediatrics, Mt. Sinai Hospital and Medical School, New

York, Diabetes Conference, Type 2 DiabetesOct, 2003 Grand Rounds, Northshore Medical Center, Childhood Type 2 diabetesOct, 2003 Alfred S. Traisman Memorial Lecturer, Children’s Memorial Hospital,

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Northwestern U., Chicago, IL, Type 2 Diabetes in ChildhoodNov, 2003 Grand Rounds, Lawrence General Hospital, The Epidemic of Childhood Obesity

and Type 2 DiabetesFeb, 2004 Grand Rounds, Lawrence General Hospital, Diabetic KetoacidosisMay, 2004 Grand Rounds, Newton Wellesley Hospital, Type 2 Diabetes in Children and

AdolescentsOct, 2004 Obesity and Type 2 diabetes in Adolescents, Blue Cross/Blue Shield Panel on

Childhood ObesityOct, 2004 Type 2 Diabetes and Metabolic Syndrome, Chelsea Health CenterOct, 2004 Transcription Factors and MODY Diabetes, Columbia University Pediatric

Endocrine Rounds, New York, NYOct 2004 Type 2 Diabetes, Harvard Primed, BostonNov, 2004 Type 2 Diabetes in Children, Annual Pediatrics Day, Pinnacle Health Systems,

Harrisburg, PAFeb, 2005 Type 2 Diabetes and Metabolic Syndrome, East Boston Neighborhood Health

CenterMar, 2005 Metabolic Syndrome and Type 2 Diabetes, Grand Rounds, Cambridge HospitalApril, 2006 Presidential Address, Lawson Wilkins Pediatric Endocrine SocietyOct, 2006 Metabolic Syndrome and Type 2 Diabetes, Harvard Primed, BostonOcr, 2006 Metabolic Syndrome and Obesity, Endocrine Grand Rounds, Brown UniversityNov 2006 Short Stature, Endocrine Day, Department of Pediatrics, Flushing Hospital

Medical CenterFeb, 2007 Obesity and Type 2 Diabetes: TODAY study Update, Grand Rounds Univeristy

of Massachusetts Medical CenterApril, 2007 Obesity and Type 2 Diabetes: The Big Picture, Grand Rounds Cambridge

Hospital

Yearly Participant in Massachusetts General Hospital Pediatrics Review Course and Pediatric Emergencies Course. Topics: Types 1 and 2 Diabetes, Thyroid disease, Endocrine Emergencies.

b. Professional Leadership Roles Related to Teaching

1987 Preparation & Organization of Course on Complications of Diabetic Ketoacidosis for Lawson Wilkins Pediatric Endocrine Society

1994 Preparation and Organization of Serono Symposium, Molecular Biology for Endocrinologists for Lawson Wilkins Pediatric Endocrine Society

2003 One of the coordinators of a consensus conference on Diabetic Ketoacidosis – a joint project of the LWPES and the European Society of Pediatric Endocrinology

2005As president of the LWPES helped to organize the program for the endocrine component of the PAS meetings.

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2006- Editor, Growth and Development, For Current Opinion in Endocrinology Diabetes, and Obesity, Williams and Wilkins

2009-- Chief, Education Council of the Lawson Wilkins Pediatric Endocrine society—Tasked with providing and coordinating education resources for members and others in the field.

E. Report of Clinical Activities

1. Clinical practice of pediatric endocrinology at Massachusetts General Hospital, Northshore Children’s Hospital, and Cambridge Hospital.

2. Patient Load – Approximately 25 outpatients/week, 2-3 months as inpatient attending

3. Clinical Contributions – Recognized as a consultant pediatric endocrinologist nationally (listed in the appropriate Best Doctor’s, etc for at least 15 yr).

Part III: Bibliography

Original Articles

1. Miller ME, Seals J, Kaye R, Levitsky LL. A familial plasma-associated defect ofphagocytosis: a new cause of recurrent bacterial infections. Lancet 1968; i:60-63.

2. Cornblath M, Levitsky LL, Kling A. Response to intravenous glucose in juvenile macaque monkeys: effect of central nervous system lesions and species differences. Diabetes. 1971; 20:156-161.

3. Beitins I, Bayard F, Levitsky LL, Ances IG, Kowarski A, Migeon CJ. Plasmaaldosterone concentration at delivery and during the newborn period: effectof maternal sodium restriction. J Clin Invest. 1972; 51:386-394.

4. Firor HV, Moore ES, Levitsky LL, Galvez M. Parathyroidectomy in childrenwith chronic renal failure. J Pediatr Surg. 1972; 7:565.

5. Raiti S, Trias E, Levitsky LL, Grossman M. Oxandrolone and human growthhormone: comparison of growth stimulating effect in short children. Am JDis Child. 1973; 126:597-600.

6. Levitsky LL, Speck S, Shulman R. Metabolic response to fasting in experimental intra- uterine growth retardation: a comparison of two models. Biol. Neonate.1976; 30:11-16.

7. Garland JT, Jennings J, Levitsky LL, Buchanan F. Stimulation of DNA synthesisin isolated chondrocytes by somatomedin. II. Validation of the assay for clinical use and comparison with the stimulation of protein synthesis. J Clin Endo Metab. 1976; 43:847.

8. Levitsky LL, Fisher DE, Paton JB, de Lannoy CW. Fasting plasma levels of glucose, acetoacetate, D-§-hydroxybutyrate, glycerol, and lactate in the baboon infant: correlation with cerebral uptake of substrates and oxygen.Pediatr Res. 1977; 11:298-302.

9. Levitsky LL, Kimber A, Marchichow JA, Uehera J. Metabolic response to fastingin experimental intrauterine growth retardation induced by surgical and non-surgical maternal stress. Biol Neonate. 1977; 31:311-315.

10. Levitsky LL, Uehara JA, Marchichow JA, Dumbovic N. Glucagon response to arginine in growth hormone deficient children before and after treatment with growth hormone in children with non-endocrine short stature. Clinical Endocrinology.1978; 8:473-481.

11. Duquesnoy RJ, MacDonald MJ, Mullins T, Hackbarth SA, Traisman HS, 17

Levitsky LL. Increased frequency of HLA-DW3 in North American black patients with juvenile onset diabetes. Tissue Antigens. 1979; 13:369-372.

12. Martin LG, Grossman MS, Connor TB, Levitsky LL, Clark JW, Camitta FO. Effect of androgen on growth hormone secretion and growth in boys with short stature. Acta Endocr. 1979; 91:201-212.

13. Edidin DV, Levitsky LL, Schey W, Dumbovic N, Campos A. Resurgence of nutritional rickets associated with breast feeding and special dietary practices. Pediatrics. 1980; 65:232-235.

14. Levitsky LL, Paton JB, Fisher DE, de Lannoy CW. Arterial blood levels of energy substrates and evidence for renal glucose production in the baboon infant.Pediat Res. 1980; 14:926-931.

15. Jennings J, Buchanan F, Levitsky LL, Garland JT. Growth hormone dependenthuman serum stimulation of thymidine and sulphate incorporation intoembryonic chicken cartilage. Acta Endocr. 1980; 94:480.

16. Levitsky LL, Paton JB, Fisher De, de Lannoy CW. Uptake and release of energysubstrates, oxygen, and carbon dioxide by the hindlimb of the fasting baboon.Biol Neonate. 1981; 39:105-112.

17. MacDonald MJ, Traisman HS, Levitsky LL, Dequesnoy RJ, Mullins P, Hackbarth SA. HLA types in American Black juvenile diabetics: strong associations withDw3 and Dw4. Metab. 1981; 30:533-536.

18. Friedman NE, Levitsky LL, Edidin DV, Vitullo DA, Lacina SJ, ChiemmongkoltipP. Echocardiographic evidence for impaired myocardial performance in childrenwith type I diabetes mellitus. Am J Med. 1982; 73:846-850.

19. Brusilow SW, Danney M, Weber LJ, Batshaw M, Burton B, Levitsky L, Roth K,McKeethren C, Ward J. Treatment of episodic hyperammonemia in childrenwith inborn errors of urea synthesis. N Eng J Med. 1984; 310:1630-1634.

20. Levitsky LL, Paton JB, Fisher DE, de Lannoy CW. Splanchnic uptake and release of energy substrates in the fasting infant baboon. Pediatr Res. 1984; 18:1316-1320.

21. Levitsky LL, Edidin DV, Mennella JA, Spaulding NH, Hseih L-C. The effect of dexamethasone and surgically induced intrauterine growth retardation on renal and hepatic levels of phosphoenolpyruvate carboxykinase in the rat. Biol.Neonate. 1986; 49:36-42.

22. Levitsky LL, Paton JB, Fisher DE, Spaulding NH, Paton AL. Gluconeogenesis from lactate in the chronically catheterized baboon fetus. Biol Neonate.1986; 50:97-106.

23. Baum VC, Levitsky LL, Englander RM. Abnormal cardiac function followingexercise in young insulin dependent diabetics. Diabetes Care. 1987; 10:319-323.

24. Pinsky L, Kaufman M. Levitsky LL. Partial androgen resistance due to a distinctive qualitative defect of the androgen receptor. Am J Med Genetics.1987; 7:459-466.

25. Levitsky LL, Paton JB, Fisher DE. Precursors to glycogen in ovine fetuses.Am J Physiol. 1988; 255:E743-E747.

26. Schoeller DA, Levitsky LL, Bandini LG, Dietz WH, Walczak A. Energy expenditure and body composition in Prader-Willi Syndrome. Metabolism.1988; 37:115-120.

27. Schoeller DA, Bandini LG, Levitsky LL, Dietz WH. Energy requirements of obese children and young adults. Proceedings of the Nutrition Society. 1988; 47:241-246.

28.. Levitsky LL, Schoeller DA, Lambert GH, Edidin DV. The effect of growth hormone therapy in growth hormone deficient children on cytochrome P-450 dependent 3-N-demethylation of caffeine measured by the caffeine 13CO2 breath test. Dev Pharmacol Ther. 1989; 12:90-95.

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29. Paton JB, Levitsky LL, Fisher DE. Placental transfer and fetal effects of maternalsodium beta-Hydroxybutyrate infusion in the baboon. Pediatr Res. 1989; 25:435-439.

30. Cuttler L, Jackson JA, uz-Zafor MS, Levitsky LL, Mellinger RC, Frohman LA.Hypersecretion of growth hormone (GH) and prolactin in McCune-AlbrightSyndrome. J Clin Endocrinol Metab. 1989; 68:1148-1154.

31. Ehrmann DA, Rosenfield RL, Cuttler L, Burstein S, Cara JF, Levitsky LL. A new test of combined pituitary-testicular function using the gonadotropin-releasing hormone agonist nafarelin in the differentiation of gonadotropin deficiency from delayed puberty. Pilot studies. J Clin Endocrinol Metab. 1989; 69:963-967.

32. Rosenfield RL, Burstein S, Cuttler L, Cara JF, Levitsky LL, Barnes RB, Ehrmann D: Use of nafarelin for testing pituitary-ovarian function. J Reprod Med. 1989;34:1044-1050.

33. Kreiter M, Burstein S, Rosenfield RL, Moll G, Cara JF, Yousefzadeh D, Cuttler L, Levitsky LL: Preserving adult height potential in girls with idiopathic trueprecocious puberty. J Pediat. 1990; 117:364-370.

34. Levitsky LL, Scanu AM, Gould SH: Lipoprotein (a) levels in black and white children and adolescents with insulin dependent diabetes mellitus.Diabetes Care 1991; 14:283-287.

35. Zheng Q, Levitsky LL, Fan J, Ciletti N, Mink K: Glycogenesis in the fetal and adult rat hepatocyte is differently regulated by medium glucose. Pediat Res 1992; 32:714-718.

36. Cuttler L, Rosenfield RL, Ehrmann DA, Kreiter M, Burstein S, Care JF, LevitskyLL: Maturation of gonadotropin and sex steroid responses to gonadotropin-releasing hormone agonist in males. J Clin Endocrinol Metab 1993; 76:362-366.

36. Levitsky LL, Stonestreet BS, Mink K, Zheng Q: Glutamine carbon flux and glutamine uptake in the fetus of the fed and fasted ewe. Am J Physiol, 1993; 265:E722-E727.

37. Levitsky LL, Zheng Q, Rhoads DB, Mink K: GLUT-1 and GLUT-2 mRNA and glucose transporter activity in cultured adult and fetal hepatocytes. Am J Physiol 1994; 267:E88-E94.

38. Barnes RB, Rosenfield RL, Ehrmann DA, Cara JF, Cuttler L, Levitsky LL: Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: Evidence for perinatal masculinization of neuroendocrine function in women. J Clin Endocrinol Metab, 1994; 79:1328-1333.

39. Zheng Q, Levitsky LL, Mink K, Rhoads DB: Glucose regulation of glucosetransporters in cultured adult and fetal hepatocytes, Metabolism, 1995; 44:1553-1558.

40. Rhoads DB, Rosenbaum DH, Unsal H, Isselbacher KJ, Levitsky LL: Circadian periodicity of intestinal Na+/Glucose cotransporter 1 mRNA levels is transcriptionally regulated. J Biological Chem, 1998; 273:9510-9516.

41. Soyka LA, Grinspoon S, Levitsky LL, Herzog DB, Klibanski A: The effects of anorexia nervosa on bone metabolism in female adolescents. J. Clin Endocrinol Metab, 1999; 84:4489-4496.

42. Tavakkolizadeh A, Berger UV, Shen KR, Levitsky LL, Zinner MJ, Hediger MA, Ashley SW, Whang EE, Rhoads DB: Diurnal rhythmicity in intestinal SGLT-1 function, V(max) and mRNA expression topography, Am J Gastrointest Liver Physiol 2001; 280:G209-G215.

43. Misra M, Soyka LA, Miller KK, Grinspoon S, Levitsky LL, Klibanski A, Regional body Composition in adolescents with anorexia nervosa and changes with weight recovery, Am J Clin Nutr 2003;77:1361-7

44. Yang, F., T. Agulian, J. E. Sudati, D. B. Rhoads, and L. L. Levitsky. Developmental regulation of galactokinase in suckling mouse liver by the Egr-1 transcription factor.

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Pediatric Research 55: 822-829 (2004)

45. Wang, L., C. Coffinier, M. K. Thomas, L. Gresh, G. Eddu, T. Manor, L. L. Levitsky, M. Yaniv, and D. B. Rhoads. Selective deletion of the HNF1 β (MODY5) gene in β cells leads to altered gene expression and defective insulin release. Endocrinology 145:3941-9

46. Tavakkolizadeh A, Ramsanahie A, Levitsky LL, Zinner MJ, Whang EE, Ashley SW, Rhoads DB. Differential role of vagus nerve in maintaining diurnal gene expression rhythms in the proximal small intestine. J Surg Res. 129:73-8, 2005

46. Misra M, Levitsky LL, Intermittent growth attenuation: is this a sign of craniopharyngioma? J Pediatr Endocrinol Metab 19:1033-8, 2006

47. Huang J, Karakchuk V, Levitsky LL, Rhoads DB, Expression of HNF4 variants in pancreatic islets and Ins-1 cells, Diabetes Metab Res Rev, 2008, 24: 533-543

48. McCormack S, Mitchell DM, Woo M, Levitsky LL, Ross DS, Misra M, Radioactive iodine treatment for hyperthyroidism in children and adolescents: referral rate and response to treatment, Clin Endocrinol (Oxf) 71:884-891, 2009

49. Huang J, Levitsky LL, Rhoads DB, Novel P2 promoter-derived HNF4alpha isoforms with different N-terminus generated by alternate exon insertion, Exp Cell Res, 2009, 315:1200-11.

50. Stanley TL, Levitsky LL, Grinspoon SK, Misra M., Effect of body mass index on peak growth hormone response to provocative testing in children with short stature. J Clin Endocrinol Metab. 2009 4875-81.

51. Huang J, Levitsky L, Rhoads D, Enhancement of native promoters by introducing non-adjacent response-element multimers: Generation of regulated, specific and powerful promoters, submitted to Nucleic Acid Research

Reviews, Chapters and Editorials:

1. Levitsky LL, Cornblath M. Hypoglycemia in childhood. In: Barnett HL, ed.Pediatrics, 15th Edition. New York: Appleton-Century Crofts, 1973:360-367.

2. Levitsky LL, Cornblath M. The infant of the diabetic mother. In: Fajans S.,Sussman K., eds. Diabetes mellitus: diagnosis and treatment. Volume III.New York: Amer Diabetes Assoc Inc., 1971:243-246.

3. Levitsky LL, Edidin DV. Growth disorders in children. ComprehensiveTher. 1980; 6:22.

4. Edidin DV, Levitsky LL. Nutritional rickets in infancy. In: Lifshitz F., ed.Clinical disorders in pediatric nutrition. New York: Marcel Dekker, 1981;146-165.

5. Levitsky LL, Edidin DV. Diabetic ketoacidosis. In: Vidyasagar D., ed. Neonataland pediatric intensive care. Littleton, MA: PSG Publishing Co., 1985;175-188.

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6. Levitsky LL, Growth and pubertal patterns in insulin dependent diabetesmellitus (IDDM). Seminars in Adolescent Medicine. 1987; 3:233-239.

7. Baum VC, Levitsky LL. Echocardiographic evaluation of left ventricular function in asymptomatic adolescent diabetic patients. Practical Cardiology. 1987; 13:42.51.

8. Levitsky LL. Short stature. In: Dershewitz R., ed. Ambulatory pediatric care.Philadelphia: J.B. Lippincott Company, 1988; 334-339.

9. Levitsky LL. Short stature. In: Dershewitz R., ed. Ambulatory Pediatric Care. Philadelphia: J.B. Lippincott Company, 1992, 2nd edition; 334-340.

10. Rother KI, Levitsky LL. Diabetes mellitus during adolescence. Endo Metab Clinics of N. Am, 1993; 22:553-572.

11. Axelrod L, Levitsky LL. Hypoglycemia. In: Kahn CR, Weir GC, eds., Joslin's Diabetes Mellitus, 1994:976-998.

12. Zangen D, Levitsky LL: Diabetes Ketoacidosis. In: Pugliese, Fort and Lifshitz,eds., Pediatric Endocrinology, 3rd edition, 1995.

13. Raboudi N, Levitsky LL: Insulin Dependent Diabetes Mellitus. In: Burg FD,Ingelfinger JR, Wald ER, Polin RA, eds., Current Pediatric Therapy, 15th edition,1995 and 16th ed.,1999

14. Lee MM, Levitsky LL; Tall Stature. In: Burg FD, Ingelfinger JR, Wald ER,Polin RA, eds., Current Pediatric Therapy, 15th edition, 1995

14. Capriles, C, Levitsky LL: Insulin-dependent Diabetes Mellitus. In: Finberg L, ed., Saunders Manual of Pediatric Practice, 1998

16. Loechner K, Levitsky LL: Thyroid Disorders. In Burg FD, Ingelfinger JR, Wald ER, Polin RA, eds., Current Pediatric Therapy, 16th edition, 1999

17. Levitsky LL. Short stature. In: Dershewitz R., ed. Ambulatory Pediatric Care. Philadelphia: J.B. Lippincott Company, 3nd edition;1999.

18. Levitsky LL. Diabetes mellitus. In: Dershewitz R., ed. Ambulatory Pediatric Care.Philadelphia: J.B. Lippincott Company, 3rd edition; 1999

19. Lee MM, Levitsky LL, Disorders of the Adrenal. In Burg FD, Ingelfinger JR, Wald ER,

Polin RA, eds., Current Pediatric Therapy 17th edition., 2002

20. List JF, Levitsky LL, The epidemic of type 2 diabetes in children and adolescents, Endocrinology Rounds 1:issue 7, 2002 (www.endocrinologyrounds.org)

21. Houk CM, Levitsky LL, Ambiguous Genitalia, in Up to Date in Pediatrics, web-based and CD ROM based text, 2003, 2008

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22 Aye, T, Levitsky LL. Diabetes Mellitus in Children and Adolescents, In: Rakel, Robert, Bope, Edward, eds Conn’s Current Therapy 56th Ed. Phildadelphia: Saunders, 2003.

23. Aye T, Levitsky, LL, Type 2 Diabetes: An epidemic disease in childhood, Current Opin Pediatr 15:411-415, 2003

24. Freemark, M., and L. L. Levitsky. Screening for celiac disease in children with Type 1 diabetes: Two views of the controversy. Diabetes Care 2003; 26: 1932-1939.

25. Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, Danne TP, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage MO, Tasker RC, Wolfsdorf JI; European Society for Paediatric Endocrinology; Lawson Wilkins Pediatric Endocrine Society. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics. 2004 Feb;113(2):e133-40.

(Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, Danne TP, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage MO, Tasker RC, Wolfsdorf JI; ESPE; LWPES. ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents. Arch Dis Child. 2004 Feb;89(2):188-94.)

26. Levitsky LL. Childhood immunizations and chronic illness. N Engl J Med. 2004 ;350:1380-2

27. Levitsky LL, Symptomatic cerebral edema in diabetic ketoacidosis: the mechanism is clarified, but still far from clear, J Pediatr. 2004 145:149-150.

28. Prabhakaran R, Levitsky, LL, Diabetic Ketoacidosis, Pediatric Critical Care Medicine, Eds Slonim AD, Pollack MM, Lipincott 2006

29. Jacobson-Dickman E, Levitsky LL, Role of Oral Agents in the Management of Childhood Diabetes, Pediatric Clinics of North America, ed. M Sperling, 52:1689-703, 2005 Clinics of North America, ed. M Sperling

30. Levitsky, LL, Misra M, Associated Autoimmune diseases in children and adolescents with type 1 diabetes mellitus, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008

31. Levitsky, LL, Misra M, Complications and screening in children and adolescents with type 1 diabetes mellitus, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008

32. Levitsky LL, Misra M, Epidemiology, presentation, and diagnosis of type 1 diabetes mellitus in children and adolescents, Up To Date in Pediatrics, web-based and CD ROM based text, 2009

33. Levitsky LL, Misra M, Management of type 1 diabetes mellitus in children and adolescents, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008

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34. Levitsky LL, Misra M, Special situations in children and adolescents with type 1 diabetes mellitus, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008

35. Levitsky LL, Cognitive dysfunction following treatment of Cushing’s syndrome, Nat Clin Pract Endocrinol Metab 2:666-7, 2006.

36. Levitsky LL, Defining the role of IGF-1 therapy for short children, J Clin Endocrinol Metab 92:813-4, 2007.

37. Lopez X, Levitsky LL, Hypoglycemia, Nutrition Handbook, Academy of Pediatrics, R Kleinman, ed, 2008

38. Rhoads D, Levitsky LL, Macronutrient Requirements for Growth: Carbohydrates, in Nutrition in Pediatrics: Basic Science and Clinical Applications, 4 th edition, eds: Walker, Duggan, Watkins, 2008

39. Isganaitis E, Levitsky L, Preventing Childhood Obesity: Can we do it?, Current Opinion in Endocrinology, Diabetes and Obesity, 15:1-8, 2008

40. Rhoads DB, Levitsky L, The function of HNF1 in the pathogenesis of diabetes, Expert Review of Endocrinology and Metabolism 2008, 3: 391-403.

41. Sherry N, Levitsky, L Management of diabetic ketoacidosis in children and adolescents.

.Paediatr Drugs. 2008;10:209-15.

42. Levitsky LL, Misra M, Boepple PA, Hoppin AG, Adolescent obesity and bariatric surgery. Curr

Opin Endocrinol Diabetes Obes. 2009 ;16:37-44.

42. Straussman S, Levitsky L, Neonatal Hypoglycemia, Current Opinion Endo, Diabetes, Obesity 17:20-24, 2010

Books, Monographs, and Text Books:1. Proceedings, Growth hormone and growth factors in endocrinology and metabolism, 23rd International Symposium, eds. Camacho-Hubner C, Levitsky LL, Hughes I, de Zegher F, Gunnarsson R, Acta Pediatrica 86:Suppl 423, 1-217, 1997 Obesity in Childhood, Current Opinion in Endocrinology, Metabolism and Diabetes, ed. Levitsky L, 1 (1): 2008Puberty and its Disorders, Current Opinion in Endocrinology, Metabolism and Diabetes, ed, Levitsky LL, 2009.Fetal and Neonatal Endocrinology, Current Opinion in Endocrinology, Metabolism and Diabetes, ed, Levitsky LL, 2010

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Clinical communications

1. Levitsky LL, Trias E, Grossman M. Spontaneous thyrotoxicosis in infancy. Pediatrics. 1970; 46:627-629.

2. Friedman NE, Levitsky LL, Edidin DV. Choanal atresia and associated multipleanomalies. J Pediatr. 1980; 94:1123.

3. Edidin DV, Levitsky LL. Prepubertal gynecomastia associated with estrogen-containing hair cream. Am J Dis Child. 1982; 136:587-588

4. American Academy of Pediatrics (AAP), Sections on Endocrinology and Ophthalmology, Position Statement. Screening for Retinopathy in the Pediatric Patient with Type 1 Diabetes Mellitus. Pediatrics. 1998; 101:313.

5. Levitsky, L., Section Editor, Hormonal Disorders, Harvard Medical School Family Health Guide, ed.Komaroff, AL, Simon & Schuster, 1999

6. Levitsky, L, and Gensure R,Thyroid Disease, in Review of Pediatrics, eds Burg F, Nelson K, Vaughn V, WB Saunders, 2002 (Multiple choice and patient management questions with annotated discussion for a learning materials program)

7. Misra M, Levitsky LL, Lee MM, Transient hyperthyroidism in an adolescent with hydatidiform mole, J Pediatr 140:362-366, 2002

8. Israel EJ, Levitsky LL, Anupindi SA, Pitman MB, Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-2005. A 14-year-old boy with recent slowing of growth and delayed puberty. N Engl J Med 2005; 352:393-403.

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