LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for...
Transcript of LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for...
![Page 1: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/1.jpg)
LIMOR MAN M.D, M.MED.SC
ASSISTANT PROFESSOR OF RESEARCH IN OBSTETRICS AND GYNECOLOGY
RONALD O. PERELMAN AND CLAUDIA COHEN CENTER FOR REPRODUCTIVE MEDICINE
WEILL CORNELL MEDICINE, NYC, NY, USA
![Page 2: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/2.jpg)
•
•
![Page 3: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/3.jpg)
•
• MINIMIZE ISCHEMIC INJURY TO THE
TRANSPLANT BY REDUCING THE LATENCY
PERIOD BEFORE NEOVASCULARIZATION
IMPROVE SURVIVAL
![Page 4: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/4.jpg)
•
-Baird DT, Campbell B, de Souza C, Telfer E. Long-term ovarian function in sheep after ovariectomy and autotransplantation of cryopreserved cortical strips. Eur J Obstet Gynecol Reprod Biol. 2004 Apr 5;113 Suppl 1:S55-9.
•
-Dolmans MM, Martinez-Madrid B, Gadisseux E, Guiot Y, Yuan WY, Torre A, Camboni A, Van Langendonckt A, Donnez J. Short-term transplantation of isolated human ovarian follicles and
cortical tissue into nude mice. Reproduction. 2007 Aug;134(2):253-62.
0
20
40
60
80
100
InVIVO Postgra ing
%Primordialfollicles
![Page 5: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/5.jpg)
![Page 6: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/6.jpg)
primordial primary preantral antral
AMH AMH
FSH FSH
Metabolic demands
![Page 7: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/7.jpg)
![Page 8: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/8.jpg)
-Gougeon et al. Human Reproduction 1986
In vitro
activation
protocols
? Controlled
Ovarian
Hyperstimulation
(COH)
-Kawamura et al. PNAS. 2013.
![Page 9: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/9.jpg)
![Page 10: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/10.jpg)
•
•
•
•
![Page 11: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/11.jpg)
ROBUST ENRICHMENT OF IGF-1 IN CULTURE
ng
/mL
P<0.001
Vectors-IGF-1
Human Endothelial Cells
0
200
400
600
800
1000
1200
1400
1600
ECs IGF-ECs
IGF-1
![Page 12: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/12.jpg)
EXPERIMENTAL DESIGN
Human Ovarian Tissue
Fibrin clot
CONTROL GROUP STUDY GROUP
END POINT 3 WEEKS n=8 n=6
![Page 13: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/13.jpg)
0
20
40
60
80
PrimordialPrimarySecondary
Blank
IGF
P=0.41 P=0.03 P=0.05
%
![Page 14: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/14.jpg)
0
5
10
15
20
25
30
SecSimple Secpre-antral
Blank
IGF
P=0.22 P<0.001
%
![Page 15: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/15.jpg)
CELL-BASED STRATEGY
![Page 16: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/16.jpg)
-Gougeon et al. Human Reproduction 1986
In Vitro
Activation
Protocols
IGF-1
Co-
Transplantation COH
![Page 17: LIMOR MAN M.D, M.MED - cme-utilities.comcme-utilities.com › mailshotcme › Material for Websites... · TRANSPLANT BY REDUCING THE LATENCY PERIOD BEFORE NEOVASCULARIZATION IMPROVE](https://reader034.fdocuments.in/reader034/viewer/2022042310/5ed7590d10199002b7560e60/html5/thumbnails/17.jpg)
Daylon James
Laura Park
Jovana Lekovich
Glenn Schattman
Zev Rosenwaks
Nikica Zaninovic
Richard Bodine
Michael Ginsberg