LifePak® Nano Workshop North America Leadership Conference March 3, 2006 This material has been...

LifePak® Nano Workshop

North America

Leadership Conference

March 3, 2006

This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

One unique technology teamed with Two proprietary products drive One exclusive sponsoring story

The Opportunity Simplified

Carsten R Smidt, Ph.D., FACN

Vice President,

Global Research & Development

Pharmanex

Huzhou Mfr. PlantShanghai R&D Center

Beijing Clinical Center Provo, Utah Headquarters & Pharmanex Research Institute

over 125 Scientists

Prof. Lester Packer

The Power of Nanotechnology

Nano-Switch

Nanotube Wires

What is Nanotechnology?1. Size: 1 -100 nanometers

– Most molecules are 1 to 100 nm in size

2. Function at the Molecular Level– Nanotechnology achieves new

functionalities by molecular rearrangements

Reasons for Limited Absorption

• Poor intestinal solubility• Requires fat for dissolution (e.g.,

Lipocarotenes)• Aggregation into large particles

– not easily digested and absorbed

The Nanotechnology DifferencePharmanex patent-pending & proprietary process

Small nano-nutrients are easily dispersed and absorbed

+

nano-carbohydrateshellCoenzyme Q10

nano-CoQ10

=

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

NanoCoQ10™

CoQ10 Absorption by Human Intestinal Cells

0.0

50.0

100.0

150.0

200.0

250.0

300.0

A B C D

pm

ol/m

g p

rote

in

NanoCoQ10

5-fold increase in absorption!

The Nanotechnology Difference

Intestinal Lumen Mucosa Cell(Intestinal Wall Cell)

Cel

l Mem

bra

ne

nano-CoQ10

Nano-Carbohydrate Shell

CoQ10

Nano-CoQ10

Carotenoids?

Nano-Carotenoids

lifepak® nano Study

15000

20000

25000

30000

35000

40000

0 2 4 6 8 10Time (weeks)

An

tio

xid

ant

Sco

re

Placebo

lifepak nano

?

60+ Antioxidants

Ongoing placebo-controlled clinical study

Nano-Carotenoids

Nano-CoQ10

Red WinePolyphenols

NewVitamin E

Highly Effective

Minerals

lifepak nano: 8 Formulas in 1

>

Complete, Balanced and Convenient

MultiVitaminMineral

Anti-oxidantFormula

GlucoseMetabolismFormula

ImmuneNutrientFormula

BoneFormula

Cardio-VascularFormula

AntiAging

Formula

The New Dimension!

• For All Adults (age 18-121)

• Proprietary Science• Broadest Health

Benefits

www.lifepaknano.com

Angela Mastaloudis, PhDAssociate Senior ScientistR&D, Pharmanex

• Ph.D. Exercise Physiology Oregon State University

• M.S. Nutrition Science Oregon State University

• Society for Free Radical Biology and Medicine – Young Investigator Award

• Lester Packer – Young Investigator Award

• Linus Pauling Institute– Graduate Fellowship

• New, broader-spectrum nano-carotenoid formula:– alpha-carotene– beta-carotene– lycopene– lutein– zeaxanthin (new): Eye health benefits*– astaxanthin (new): Inflammatory balance*

• as found in 5-10 fruits & vegetables per day


lifepak nano

Pharmanex Nanotechnology

• To increase intestinal uptake of poorly absorbed fat-soluble nutrients:– Carotenoids (lycopene, alpha+beta-carotenes,

zeaxanthin, astaxanthin)

– Coenzyme Q10

= Better Bioavailability*

= Increased Scanner Scores*


Purpose• How much more and how much faster

does lifepak nano increase scanner scores than a placebo?

ORORPLACEBOPLACEBO

Study Design ISupplementation• 52 Subjects were recruited and randomly assigned

to groups• Twice a day, with breakfast and with dinner,

subjects took:– lifepak nano

or– Placebo

• Study length: 18 weeks

Study Design II

BioPhotonic Scanner • Subjects were scanned a total of 15 times!

Diet• We encouraged to continue with their typical diet

for the entire study

Results• 42 out of 52 subjects completed the 18 week study

0

2,500

5,000

7,500

10,000

12,500

15,000

17,500

20,000

0 1 2 3 4 6 8 10 13 15 18

Weeks

Sca

nn

er

Sco

re In

cre

ase

(C

ou

nts

)

*

**

*

*

**

**

Scanner Scores Increase with lifepak nano

*p<0.05 between groups

45% Increase!

41% Increase!

37% Increase!

30% Increase!

19% Increase!


*p<0.05 compared to wk 0 #p<0.05 compared to placebo

#, *#, *

#, *

#, *#, *

#, *#, *#, *#, *

10,000

15,000

20,000

25,000

30,000

35,000

40,000

45,000

0 1 2 3 4 6 8 10 13 15 18

Weeks

Sca

nn

er

Sco

re (

Co

un

ts)

LifePak Nano Placebo

NSE NSE GlobalGlobal

ConventionConvention


*p<0.05 compared to wk 0 #p<0.05 compared to placebo

#, *#, *

#, *

#, *#, *

#, *#, *#, *#, *

10,000

15,000

20,000

25,000

30,000

35,000

40,000

45,000

0 1 2 3 4 6 8 10 13 15 18

Weeks

Sca

nn

er

Sco

re (

Co

un

ts)

LifePak Nano Placebo

Summary• Lifepak nano increased scanner scores as

fast as two weeks

• Scanner scores increased in all 20 subjects taking lifepak nano

• Lifepak nano increased scanner scores 18,000 units more than placebo in 18 weeks

• Even after 18 weeks scanner scores were still increasing in the lifepak nano group

Better Bioavailability*

Faster and Higher Increases in Scanner Scores*

=


The Power of Nanotechnology

Visit our PRODUCT SHOWCASE!

Key Business Takeaways• Nanotechnology increases absorption of poorly absorbed nutrients*

• First in industry to apply nanotechnology to a multivitamin supplement*

• Proprietary and patent-pending

• Guaranteed to increase SCS* • Clinically proven ~ 18,000 increase

• Do You NANO?


www.lifepaknano.com

More InformationPresentations

www.pharmanexusa.com

Leadership Conference link

My Office Marketing Tools

Product Resources

www.pharmanexusa.com

www.pharmanexscanner.com

www.lifepaknano.com

Product Support

E-Mail: [email protected]

Phone: 1-800-487-1000

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