LEVERAGING MINNESOTA’S ASSETS TO BECOME THE DIABETES LABORATORY

FOR THE WORLD

Minnesota Senate Finance CommitteeMay, 2013

• TextThe Decade of Discovery (DoDD) was launched by Mayo Clinic and the University of Minnesota to conquer a disease with devastating physical, economic and social impacts: diabetes.

Decade of Discovery aligns and integrates the significant resources and strengths of Mayo Clinic and the University through a disciplined, goal-directed approach to prevent, optimally treat and ultimately cure Type 1 and Type 2 diabetes.

Decade of Discovery in Diabetes

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Management Team

Oversight Committee

Susan Crockett, Ph.D. — General Mills

Michael Gorman, M.B.A, J.D. — Split Rock Partners

Chris Schaeffer — American Diabetes Association, Minnesota Chapter

Eric J. Jolly, Ph.D. — Science Museum of Minnesota

David M. Kendall, M.D. — Eli Lilly

Cindy Kent — Medtronic, Inc.

Dale Wahlstrom, M.S. — LifeScience Alley and the BioBusiness Alliance of Minnesota

David D. Etzwiler, J.D., M.P.P. – Executive DirectorFormer Vice President of Community Affairs and Executive Director of the Medtronic Foundation

Steven Smith, M.D. – Program LeadMedical Director for Patient Education, Mayo Clinic, past Chair of Diabetes Core Group: Division of Endocrinology, Diabetes, Nutrition, and Metabolism

Maura Donovan, Ph.D. – Chief Technology Officer Former Vice President, Therapy R&D for Medtronic Corporate Ventures and New Therapies

Elizabeth Seaquist, M.D. – Program LeadPresident-Elect, American Diabetes Association, professor, Department of Medicine in Division of Endocrinology and Diabetes at the University of MN

Kathleen Blatz, M.S., J.D. — Co-chair; former Chief Justice of the Minnesota Supreme Court

Vance Opperman, J.D. — Co-chair; Key Investment, Inc., MSP Communications

Ann Albright, Ph.D., R.D. — Centers for Disease Control and Prevention

Richard M. Bergenstal, M.D. —International Diabetes Center, American Diabetes Association (former President)

Jackie Casey —Juvenile Diabetes Research Foundation International (JDRF), Minnesota Chapter

Frank B. Cerra, M.D. — University of MN

Leadership

• Text• More than 25 million Americans have diabetes; 79 million have prediabetes • By 2020, estimates are that 52% of Americans will have diabetes or

prediabetes

DIABETES COSTS• $3.1 billion annually in MN• Estimated to grow to $6.4 billion

by 2025• $200 billion in 2010 in U.S.• Estimated to be more than $500

billion in 2020

Diabetes Impacts: Health and Costs

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IN MINNESOTA- Diabetes doubled among adults since

1995- 290,000 adults with diabetes in MN- 1.4 million adults with prediabetes

- Every year 20,000 Minnesotans diagnosed

- 6th leading cause of death- Risk of heart disease and stroke is 2-4

times higher than for those without- Leading complication among mothers

giving birth

• Text Strong, goal-directed research with a focus on “fast translation” to a cure, employing team science that incorporates the best of academia and industry working together toward a common, transformative goal

A “mission-driven” commitment to large-scale care delivery and prevention work with an understanding of system needs and the required alliances to impact those needs

Rigorous governance and program management across scientific and clinical themes with clearly defined milestones and metrics

The Vision: a “Moonshot”Combining academic research with the best of industry

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Research

Community Prevention

Governance

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Discovery and TranslationFocus on Areas of Highest Promise

Drug discovery: identify targets for intervention based on key metabolic

and autoimmune processes and

physiological mechanisms that underpin type 1 and

type 2 diabetes

Cell-biology based therapies: replace/sustain beta cell function through

regeneration, reprogramming and

replacement including beta cell biology,

regenerative medicine, gene therapy, and

transplantation

Devices: accelerate technologies by

combining biological, mathematical and

engineering knowledge to develop novel ways

to treat and deliver cures for diabetes

Rigorous RFP Process to Identify Lead Programs

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Discovery and TranslationPortfolio Approach

Discovery

Pre-clinical(in vivo / animal

studies)

Phase 1(1st human dose to 1st

patient dose)

Phase 2(1st patient dose to 1st

pivotal dose)

Phase 3(1st pivotal

dose to reg. submission)

Regulatory Submission

Probability of a substance moving to the next phase:

varies varies ~55% ~25% ~70% ~95%

ApprovalApproval

Many ideas will be brought into the program to increase the chance of success

Project plans will include go-no go criteria and well defined milestones

Progress against milestones will be regularly assessed

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Discovery and TranslationLeveraging Minnesota’s Strengths to be a Center of Excellence

#1 in Diabetes &

Endocrinology (2012 report)

Industry and academic partnering is a priority

• # of diabetes patents is decreasing while incidence is escalating• Historically, a majority of the novel pharmaceuticals comes from academia

and biotech

Industry is looking for innovation

Different partnering models are being pursued

All eyes will be on MN as a catalyst for innovation in diabetes therapy development

Prevention StrategyMinnesota Diabetes Collective Impact InitiativeDecade co-leads statewide coalition with mission to become the state with the lowest incidence and the healthiest outcomes for diabetes in the nation.• Prevention Strategy

• Identify, prioritize and scale evidence based interventions with the highest benefit for participants and public/private payers

• National Diabetes Prevention Program• MN poised to be first state in the U.S. to implement NDPP on large scale

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Collective Impact Participants include:American Diabetes Association BCBS of Minnesota Centers for Disease Control & PreventionCourage Center Decade of Discovery Essentia HealthGovernor’s Task Force/Health Care HealthEast HealthPartnersICSI International Diabetes Center The Isuroon ProjectLifeScience Alley Mayo Clinic Health System MedicaMN Community Measurement MN Department of Health MN Health Action GroupMinneapolis Urban League Novo Nordisk Sanford Health SystemSEIU Healthcare Minnesota Stairstep Foundation Stratis HealthSouthside Community Clinic Ucare UnitedHealth GroupUnited Way University of Minnesota West Side Community Health YMCA of the Greater Twin Cities

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Through the Decade of Discovery, Minnesota has the opportunity to play a leadership role in a legacy project that will:

Improve public health by transforming the lives of people with diabetes

Deliver multi-billion dollar savings to the health care system, to employers, government payers and families by reigning in the huge and growing costs associated with diabetes

Stimulate significant economic development – creating new businesses and jobs from our research

The Goal: Improve Health, Save $

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