Level of Tumor Protein Indicates Chances Cancer Will Spread AND Malfunctioning Gene Associated

With Lou Gehrig's Disease Leads to Nerve-Cell Death in Mice

Mallory Fernández ZuritaMedicine Student

UPBMedellín-Colombia

FOLDING

FOLDING

INTRODUCTION

New way to discover if a cancer will spread or if it won’t.

Possible treatment that will reduce the nerve-cell death in degenerative diseases.

Level of Tumor Protein Indicates Chances

Cancer Will Spread (Science Daily, Feb. 2-2011)

Level of Tumor Protein Indicates Chances Cancer Will Spread

CPE- delta N is a protein that has been found in high leves in tumors that are removed from the body, when they surely has made metastasis.

The tests they made predicted the spread even when the conventional tecniques suggest that the spread was unlikely.

Level of Tumor Protein Indicates Chances Cancer Will Spread

The tests were made indirectly, by measuring levels of a molecule that assists in manufacturing the protein.

When the level of CPE delta-N RNA in the tumor was more than twice that in the surrounding tissue, the cancer was highly likely to metastasize within two years or to appear again in the same place.

Level of Tumor Protein Indicates Chances Cancer Will Spread

In the cases where cancer appeared again or made metastasis, CPE-delta N RNA levels were greater than 1 million.

In the cases where cancer made no metastasis or appeared again the tumors had less than 250,000 copies.

STUDENT OBSERVATION

This particular protein that has been related with the metastasis of cancer represents a huge improve in the tests that can be made to prevent and be ready for the spread of a tumor.

More studies about this protein and the effects that can produce should be done.

Malfunctioning Gene Associated With Lou

Gehrig's Disease Leads to Nerve-Cell Death in Mice

(Science Daily, Jan. 6-2011)

Malfunctioning Gene Associated With Lou Gehrig's Disease Leads to

Nerve-Cell Death in Mice Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), and

frontotemporal lobar degeneration (FTLD) are characterized by protein clumps in nerve-cells that include an RNA-binding protein called TDP-43.

Malfunctioning Gene Associated With Lou Gehrig's Disease Leads to

Nerve-Cell Death in Mice

In both diseases

neurons die

The clump of protein is toxic to the cell.

Mutated TDP-43 bound up in clumps outside the nucleus depletes the cell of the function of normal TDP-43 protein that regulates gene expression.

Possibly for two

reasons

The loss of function of TDP-43 is important because it regulates gene expression.

Expression of TDP-43 caused neuron loss in forebrain regions; degeneration of part of the spinal cord tract and muscle spasms in the mice used for the experiment.

Malfunctioning Gene Associated With Lou Gehrig's Disease Leads to

Nerve-Cell Death in Mice

STUDENT OBSERVATION

This study is important for the knowledge that we need to have about this two specific diseases.

This knowledge is necessary for the creation of new medications.

Medications to preserve their capacity to life their lives as normal as possible.

More studies about this protein and the effects that can produce should be done.

MEDICAL UTILITY

MEDICAL UTILITY

The CPE-delta N protein will improve the hability of the doctors to predict if a cancer will spread.

MEDICAL UTILITY

By using the test of CPE-delta N protein and the conventional tecniques, we can be more sure about the metastasis of cancer.

MEDICAL UTILITY Studies about the TDP-43

protein will continue to be done so someday the scientist and doctors will have the chance to offer the patients with ALS and FTLD an oppoprtunity to stop or minimize the damage of their neurons.

BIBLIOGRAPHY Malfunctioning Gene Associated With Lou Gehrig's Disease

Leads to Nerve-Cell Death in Mice. Science Daily. January 6, 2011.

Level of Tumor Protein Indicates Chances Cancer Will Spread. Science Daily. February 2, 2011.