Less Until None
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Transcript of Less Until None
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Less Until None:
A Planfor a World
without T1D
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LESS UNTIL NONE
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JDRF’s Vision for the Future
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Therapies CureDelivery of Continuous Therapeutic Improvements
Side-EffectsComplicationsPatient Burden
Glycemic ControlSafety
Normal Physiology Restored
Better Safety, Fewer Side-Effects, Less Exposure to Complications
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JDRF Research Priorities
Regenerating new beta cells
Encapsulation of alternative beta cell sources
Immune therapies
Diagnostic, measurement and imaging tools
Artificial pancreas systems
Novel insulins and other blood sugar control drugs
Diabetic eye disease
Complications prevention
Preventing the autoimmune process from ever starting
Stopping and reversing the autoimmune process early to
maintain insulin independence
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Artificial PancreasAutomated technologies to help maintain better control of blood-glucose levels
Integrated smart technology to automate routine elements of insulin management
FDA released final guidance on pathway for commercialization of devices
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Glucose Responsive Insulin (GRI)
Form of insulin that activated when blood-glucose levels start to rise
Simplifies life for and improves overall blood-glucose controls
JDRF competition underway to accelerate progress on GRI
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EncapsulationEasily implantable Beta cells or islets surrounded by a protective shield/capsule
Able to sense glucose levels and produce insulin as needed
Hidden from the immune system to sustain normal function
Eliminating the need for immunosuppressive drug therapy
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Regeneration
Ability to create new insulin producing cells destroyed by autoimmune attack
Creating abundant supply of Beta cells through stem cells and regeneration
Immune therapy for suspected “triggers” including viruses
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Secondary Prevention
Preserve beta cell function in these newly diagnosed individuals
Approaches include:Reducing inflammationBoosting beta cell survival Suppressing the autoimmune attack
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Primary Prevention
Prevent the autoimmune attack on beta cells before it starts
Approaches include:Viral vaccinesBeta Cell Autoantigen Vaccines
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Funding Scaleand Scope
IndustryInfluence
R&DExpertise
Government Advocacy
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Make a Difference and Get Involved!
Give generously to speed JDRF research to cure, better treat and prevent T1D.
Join a JDRF Walk, Ride, Gala or other fundraising event.
Volunteer at the local JDRF chapter. Participate in clinical research.
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Thank you!