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F 1

C IC2

C 2014

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& F

A

()

)

C /

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H

39 I A

CI

B 3

G ,

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H C

B 6/52

E ,

D , ,

B

I 2 3

2 2

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HL 1990

F (A) C B C

DM, 3

H

B 6

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E

2 2

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D

F , .

L

A

:

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L

50 B7 K

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D ?

F , .

L

A

:

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H&E 40

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H&E 2030

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H&E 400

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Leishmania

Vector-borne diseases

Protozoan parasites of genus Leishmania

>20 species associated with human disease

Multiple clinical manifestations

Cutaneous

Mucocutaneous

Visceral

C

HI

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Cutaneous Leishmania - Geographic distribution

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200,000 400,000

C

0.7 1.3

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Geographic distribution

4

E 88 , 72

:

90%

A, B, I, ,

A

90%

B, B .

90%

B, B, I,

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E C ,

L K, E (200506), , K (2008),

, (2009) ,

,

I 1984 1994 A , . 100 000 300 000

. I , .

I 1997, 400% . . E E.

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E

HI

(L)

HI

I L,

A HI L

100 2320

I E, 70% HI

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Transmitted by the bite of female sandflies

Reservoirs

humans (anthroponotic forms) animals (zoonotic)

(In the New World all the forms are zoonotic,humans being infected only secondarily)

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&

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Leishmanial parasites

The species of genus Leishmaniaare in the familyTrypanosomatidae

They alternate between two hosts: the vertebrate

amastigotes; intracellular forms

the invertebrate

promastigotes

I :

.L. J, .

A H. , .

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C ...

C L

D

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C/

F

E,

C

H

L1999 D

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3 34%

68%

6%

I

I D

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..,

()

D

,

M HI

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M

, , M , M

F H

H

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, ,

D

D

D

.., B, I,

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D H

C L H M & L H M

C CDC L H M

A

A F CDC

I

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C

/(, , , )

, GK ,

G, A

20// / 2028

I A, 3M

I ..

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C A

A B

C, F K

L 1999 B H

D. .. A

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C I

C

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BE EAE I AHEICI B

L

A:

()

M ()

L

L 1999 B H

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L , ,

A ,: DEE 3050%

I

, A/C

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C , H :

&

/HI

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H://..////

A A 346:891

% . C I

D 2005 40:1395

B H

2 1999 11919

M D 21 E 2002

B L

1865 1926

I M

M D G

A M

C D

18631915,

I M

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L C

B

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C L

.

() . A

,

( , ).

:

, ( ),

.

.// /2014

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B

1/2: 57B/6 BALB/

E IF IL2 > 1 ;

A

2 IL4

2002:195;15651573

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F ?A

I A, =209

A 3 : 63/80 (79%)

22/65 (34%)

F

8.5 11.2