Lecture VII. CNS Patterning
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Lecture VII. CNS Patterning Bio 3411 Wednesday September 16, 2009
description
Lecture VII. CNS Patterning. Bio 3411 Wednesday September 16, 2009. T. Woolsey 3802 North Building 362-3601 [email protected]. Reading. THE BRAIN ATLAS: p 10. Selected References:. - PowerPoint PPT Presentation
Transcript of Lecture VII. CNS Patterning
Lecture VII. CNS Patterning
Bio 3411 Wednesday
September 16, 2009
• T. Woolsey
• 3802 North Building
• 362-3601
2Lecture VII. CNS PatterningSeptember 16, 2009
Reading
THE BRAIN ATLAS: p 10
3Lecture VII. CNS PatterningSeptember 16, 2009
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Selected References:
† Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R640-642.
Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer.†Hartenstein, V. (1993). Atlas of Drosophila Development.
Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division.
Chapter 52, pp 1019-1040.†Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier.
Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10th ed.). Philadelphia,: Saunders.––––––––––––––
† Posted on web site.
What the last Lecture was about
• General mechanisms for assembling neurons and groups of neurons
• Diffusion vs Contact
• Attraction vs Repulsion
• Examples of impacts of contact
• Examples of impacts of diffusion
• Specification by growth factors
• The chemoaffinity hypothesis
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What this Lecture is about
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• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
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Recap of Early Embryogenesis
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Ranson & Clark (1959)
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Kandel, Schwartz, & Jessell (2000)
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Kandel, Schwartz, & Jessell (2000)
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From Tube to Brain
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Kandel, Schwartz, & Jessell (2000)
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THE BRAIN ATLAS 3rded, p.10
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Hamilton, Boyd, & Mossman (1972)
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Hamilton, Boyd, & Mossman (1972)
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Hamilton, Boyd, & Mossman (1972)
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Hamilton, Boyd, & Mossman (1972)
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Hamilton, Boyd, & Mossman (1972)
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Hamilton, Boyd, & Mossman (1972)
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From Fly Egg to Fly Brain
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Hartenstein (1993)
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Hartenstein (1993)
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Hartenstein (1993)
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Hartenstein (1993)
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Segmentation and Signals
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Kandel, Schwartz, & Jessell (2000)
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Kandel, Schwartz, & Jessell (2000)
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Kandel, Schwartz, & Jessell (2000)
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Kandel, Schwartz, & Jessell (2000)
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Kandel, Schwartz, & Jessell (2000)
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Kandel, Schwartz, & Jessell (2000)
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Ancient Choice?
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Benito-Gutierrez & Arendt, (2009)
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Benito-Gutierrez & Arendt, (2009)
What this Lecture was about
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• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
Reflections
• Early events initiating the nervous system
• Beginning the sculpture – proliferation and death mechanisms
• Signals for functional and connectional specificity – contact, distance, for or against
• The pattern and organization emerges
• Generalizations made but questions unanswered
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Sequential Restrictions (Refinements) are the Bases for Development (and plasticity)
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pluripotent, stem cell
differentiated
genetic
environmental
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http://embryo.soad.umich.edu/
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Finis
