Lecture - Olfaction Pathway
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Transcript of Lecture - Olfaction Pathway
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OLFACTION
CHRISTOPHER E. CALAQUIAN, MD, DPBO-HNS
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RHINENCEPHALON
• Rostral portion of the brain
• Consists of the (1)olfactory nerves,
(2)olfactory bulbs,
(3)olfactory tracts,
(4)a portion of the anterior perforated substance,
(5)pyriform region of the cortex,
(6)entorhinal cortex of the parahippocampus and
(7)the corticomedial division of the amygdala
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PERIPHERAL OLFACTORY APPARATUS
• Found in a specialized area of the nasal mucosa ------OLFACTORY EPITHELIUM
• Pseudostratified columnar olfactory epithelium on the superior concha, the roof of the nasal chamber, and upper portion of the septum
• Scents or chemicals trigger/stimulate receptors in the epithelium via voltage channels or ligand-receptor mediated 2nd messenger system
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LATERAL MEDIAL
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PATTERN OF PERIPHERAL APPARATUS
olfactory epithelium
olfactory nerves
cribriform plate of -------------------------
ethmoid
olfactory bulb
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OLFACTORY BULBS AND PATHWAYS
• OLFACTORY BULB - contains layers of different neuron cell types (laminar)
Mitral cells - receive direct synaptic input from olfactory nerve fibers and send out their axons to the lateral olfactory tract
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CROSSING OVER
• Occurs in the anterior olfactory nucleus
• Located in the olfactory stalk
• contains cells coming from the olfactory portion of the anterior commissure
• sends fibers from IPSILATERAL bulb to CONTRALATERAL bulb
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Crossing over
(Olfactory trigone)
Anterior OlfactoryNucleus
Lateral OlfactoryNucleus
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OLFACTORY TRACT
• Has two stria - a medial and a lateral striae
MEDIAL STRIAE ANTERIOR
OLFACTORY NUCLEUS
LATERAL STRIAE LATERAL OLFACTORY NUCLEUS
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LATERAL OLFACTORY TRACT
• Mitral cells that skirts the lateral margin
anterior perforated substance
pyriform cortex (primary olfactory cortex)
entorhinal cortex (secondary olfactory cortex)
amygdala
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Entorhinal
Primary olfactory
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PRIMARY OLFACTORY CORTEX
• THREE layered paleocortex, older than the neocortex of the visual, auditory and somatosensory systems
• The olfactory cortex connects with the neocortex via :
(1) projections directly to the orbitofrontal cortex
(2) projections to the thalamus* which connects to the orbitofrontal cortex
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OrbitofrontalCortex
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OLFACTORY DISCRIMINATION
• Subserved by the connection of the olfactory cortex to the orbitofrontal cortex
• When severed in experimental animals, they cannot discriminate or identify differences in odor (although they can only distinguish the presence or absence of the odor)
• May also be possible via connections with the temporal lobe
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AMYGDALA
• Regulation of the chemosensory control of social behaviors
sexual
aggressive
maternal responses
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ENTORHINAL AREA, AMYGDALA & HIPPOCAMPUS
• Integration of olfactory information with visual, auditory and somatosensory information
• Learned emotional response
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Amygdala
Parahippocampus
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NERVES AFFECTING OLFACTION
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Trigeminal(Pterygopalatine)
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