LECTURE 8C 6 March 2015 MINERALS MINOR MINERALS IN HEALTH AND DISEASE.
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Transcript of LECTURE 8C 6 March 2015 MINERALS MINOR MINERALS IN HEALTH AND DISEASE.
IDATME
INGESTION-oral, tube feeding, IV
DIGESTION- none
ABSORPTION- active, facilitated and occasionally simple
TRANSPORT-FREE – rare- e.g. iodine
-BOUND - very common- -mostly protein e.g. iodine, iron
IDATME continued
METABOLISM-minerals in = minerals out -participate as co-factors for various enzymes
EXCRETION – definitely in urine, faeces, sweat, saliva is questionable
MINERAL SUPPLEMENTS
REQUIRED IF:
A) inadequate dietary supply of minor minerals relative to need
B) in disease in general, a monitoring of minor minerals shows requirement
MINOR MINERALS IN HEALTH AND DISEASE
ATHEROSCLEROSIS
SELENIUM- part of an antioxidant protein
antioxidant protein reduces free radicals and oxidant damage due to free
radicals
R-COO.
MINOR MINERALS IN HEALTH AND DISEASE CONTINUED
fluoride prevents tooth decay but too
much fluoride
gives mottled
teeth
MINOR MINERALS IN HEALTH AND DISEASE CONTINUED
COELIAC DISEASE
malabsorption
lack of iron-get anemia
MINOR MINERALS IN HEALTH AND
DISEASE CONTINUED
Alcoholism- low zinc due to increased
urinary output and
malabsorption of zinc
- malabsorption due to poor
fat breakdown due to
poor liver function.
MINOR MINERALS IN HEALTH AND
DISEASE CONTINUED
BURNS- loss of zinc with albumin
(zinc is bound to albumin) is a
possible explanation for zinc
loss
MINOR MINERALS IN HEALTH AND
DISEASE CONTINUED
Diabetes
chromium deficient persons supplement with chromium and get better
glucose transport
MINOR MINERALS IN HEALTH
AND DISEASE CONTINUED
Rheumatoid arthritis
low dietary intakes of zinc and selenium
WHAT IS NEW IN MINOR MINERAL RESEARCH ?
Björkblom B, Adilbayeva A, Maple-Grødem J, Piston D, Ökvist M, Xu XM, Brede C, Larsen JP, Møller SG.
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.
J Biol Chem. 2013 Aug 2;288(31):22809-20. doi: 10.1074/jbc.M113.482091. Epub 2013 Jun 21.
Protein in brain called DJ-1 binds copper to reduce early onset Parkinson’s disease- this effect is lost with certain mutations