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20

10

1,

6

2,

6

3,

6

4,

6

0,

6

%

20

10

1,

6

2,

6

3,

6

4,

6

0,

6

%

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..

== (+)(+)

((--))

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;;

..

.. ,,

,, ,, DNADNA..

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superoxidesuperoxide radicalradical((OO22--))..

hydrogenhydrogenperoxideperoxide ((HH22OO22),), ..

hydroxyl radicalhydroxyl radical ((OHOH**).). HH22OO22,,

.. nitric oxidenitric oxide ((NONO**) () (JJ..

KarlssonKarlsson, 1997), 1997)..

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22--5%5%

22

..

..

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1.1. ..

2.2. 2,2,

((underperfusionunderperfusion)) ((reperfusion).reperfusion). ..

3.3.

((oxidativeoxidativeburst).burst).4.4.

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((RadakRadak etetal. 1998).al. 1998).

((.... )) ,,

((Reddy etReddy etal. 1998).al. 1998).

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((Reddy et al. 1998).Reddy et al. 1998).

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..

(( ,, ,, ))..

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,,

""""

,, ..

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--

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22 OO22-- + 2+ 2 ++ SODSOD 2222 ++ 22

22 2222 CATCAT 22 22 ++ 22

222 + 22 + 2 GSHGSH GPXGPX GSSGGSSG + 2+ 2 HH22OO

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CC

AA

Q10Q10

(())

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15%15%

vsvs --

--

vsvs

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,,

,,

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-- (())

(())

(())

(( ))

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++ CC

[[FeFe]]

[[FeFe]] ..

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(5(5--10%)10%) (10(10--20%)20%)

(( 25%,25%,

-- 5%)5%)

(( C)C)

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((dede ValkValk && MarxMarx1999).1999).

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..

,,

,, ,,

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,, ..

,, ,, ,,

..

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,, ,, ,, ..

((// ))

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(( 250250 mgmg ).).

..

..

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;;

;;

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FentonFenton HaberHaber--WeissWeiss

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--

Fenton reactionFenton reaction

MtMtnn++ + H2O2+ H2O2 -------- MtMt(n+1)+1(n+1)+1 + HO+ HO.. ++HOHO--

n+n+ ==

(n+1)+1(n+1)+1

== (()) (())

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FentonFenton.. ,, ((222)2)

,, ,, ,, ..

((StadtmanStadtman, 1990), 1990)..

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,,

..,,

FentonFenton ((RadakRadak S. 2000).S. 2000).

,, ,,

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..

70.70.

..

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..

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((FacchiniFacchini & Saylor, 2002; Meyers et& Saylor, 2002; Meyers et

al.2002)al.2002)..

Dr. SullivanDr. Sullivanss

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Dr. SullivanDr. Sullivanss

..

..

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;;

..

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;;

..

ScavengerScavenger PathwayPathway

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ScavengerScavengerPathwayPathway

ScavengerScavenger WBCWBC

LDLLDL

:: ,,

,, ,,,, LDLLDL..

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LDLLDL

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Nikolaidis et al. 2006

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Jamurtas et al. 2006

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Nikolaidis et al. 2006

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Nikolaidis et al. 2006

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Nikolaidis et al. 2006

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Gougoura et al. 2007

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