Lecture 10 – Second Messengers IV – Niric Oxide, cGMP , and ROS Signalling
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Transcript of Lecture 10 – Second Messengers IV – Niric Oxide, cGMP , and ROS Signalling
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Lecture 10 – Second Messengers IV – Niric Oxide, cGMP, and ROS Signalling
BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy
Last modified -13F
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CSB Fig 02:01 Cell signalling pathways
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
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Transducers Second Messengers II
1. Nitric Oxide• cyclic GMP Signaling
2. Redox signaling3. ROS signaling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:45 NO and cyclic GMP signalling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:46 NO synthase mechanism
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:47 eNOS activation
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:48 Summary of redox signalling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:49 Reactive oxygen species (ROS)
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:50 Sites of ROS formation
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:51 Plasma membrane ROS formation
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:52 GSH/GSSG couple
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:53 H2O2 metabolism
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:54 Peroxiredoxin catalytic cycles
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:55 Reversible & irreversible ROS oxidations
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:56 ROS formation and action
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:57 Recovery of protein oxidation
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:58 Thimerosal-induced Ca2+ signalling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 2:59 Figure ROS effects on Ca2+ signalling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:60 ROS microdomains
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:61 ROS microdomains