leading the wave · Research and clinical practice, including the International Society for...
Transcript of leading the wave · Research and clinical practice, including the International Society for...
Advanced PERG and VEP
Envoy
leading the wave
E3 console paired with an Envoy monitor, patient chin rest and 32-bit amplifier create a compact system
Intersession StudyUnmatched repeatability: 50
PERG & VEP responses from
10 different test sessions &
multiple Envoy systems
Portable SystemThe desktop Envoy system
can easily be transported
from one office location to
another within minutes
The first advanced monitor system, custom engineered by Diagnosys, that has no luminance artifact enabling precise ISCEV standard compliant PERG and VEP testing
Desktop Envoy™
Handheld ApplicationThe Envoy stimulator disconnects
from its stand enabling ultimate
flexibility for patient testing,
including pediatric
Profile with Envoy features:• Operating Room arm• Patient set up in nearby chair• Fully integrated with the system
32-Bit AmplifierUnprecedented 1 nano Volt
resolution and illuminated
receptacles guide lead insertion
and eletrode contact quality
Monocular monitor: Ultra high luminance and contrast monitor that is only 4"x3" in size
Our fully integrated cart-based systems enable compact funtionality in a mobile system for use throughout your facility
Cart-Based Envoy
Envoy™ Advanced PERG and VEP leading the wave
Macula and Ganglion Cell objective, functional testing
PERG Applications • Detect & monitor dysfunction of retinal ganglion cells
and the macula caused by conditions such as: o Glaucoma o Macular disease and dysfunction o Diabetic maculopathy o Distinguish between maculopathy & optic neuropathy
VEP Applications • Detect & monitor dysfunction of optic nerve & disc function
caused by conditions such as: o Optic nerve atrophy, including glaucomatous o Ischemic optic neuropathy o Papilledema o Optic neuritis o Multiple sclerosis
Features
Advanced performance • Very high luminance • Micro-second class response times • High contrast black and white monitor
Easy to use • Monocular and ultra compact • Setup in minutes & portable • Desktop, extendable arm for cart, handheld
Specifications Display type: OLED SVGA 800x600 pixel array Calibrated luminance: >500 cd/m2 Contrast ratio: >300:1 Monochromatic black and white
Viewing area: approx. 12.5 x 9mm Viewing angle: 24x32 degrees Response time: <1 ms Checks, bars, gratings as standard with 1 pixel resolution Envoy Monitor Weight: <1 lb (0.5 kg) Dimensions: 3.9 x 2.8 x 1.8 inches (98x70x45 mm)
Envoy ordering information Envoy configuration Model number: D352 Configuration: select 1 option per field below
D352 - ___
T Table stand and chinrest
X Extendable arm for carts
B Extendable arm & table stand
A Research animal stand
N No table stand, no arm
Industry leading protocols - Pattern Electroretinography
(PERG), ISCEV standard - Pattern Visual Evoked Potential
(VEP), ISCEV standard - Uniform Field - Custom PERG, including horizontal
bars and larger field size - Custom Pattern VEP, including
multiple contrast levels and larger field size
- Onset VEP
Envoy shown mounted on its table stand
Available on the following systems:• Diagnosys E3 desktop systems (D315)
o Option “T”
• Diagnosys Profile cart systems (D310) o Options “T”, “X”, and “B”
UK: Diagnosys LTD UK ● 5 Trust Court, Vision Park ● Histon, Cambridge, CB24 9PW ● Phone/Fax: +44 (0) 1223 520699 ● Email: [email protected]
The information listed herein is accurate as of the date of printing, however may change at any time without notice. The contents may differ from the current status of approval of the product in your country. Please contact your local Diagnosys representative for more information © 2016 by Diagnosys, LLC. All copyrights reserved.
Doc: #14824 Rev: #B ECN 902 Date: 1/20/2017
US: Diagnosys LLC USA ● 55 Technology Dr, Suite 100 ● Lowell, MA 01851 USA ● Phone: 978.458.1600 ● Fax: 978.458.1755 ● Email: [email protected] www.diagnosysllc.com
Application overview Research and clinical practice, including the International Society for Clinical Electrophysiology of Vision (ISCEV)1-9 have found that PERG and VEP tests may detect early optic nerve and RGC damage, including Glaucoma. Shown below are PERG and VEP results using a Diagnosys system on a range of patients. Description Summary PERG VEP • Normal patient • Well formed PERG and VEP • Large P50 and N95 responses • N95/P50 >1.1 • VEP P100 peak near 100 ms • Case A: normal OD, abnormal OS • Poorly formed PERG • Small N95 response • VEP P100 slightly delayed 111 ms • Case B: abnormal • Poorly formed PERG • Small N95 response • VEP P100 peak small & delayed References on PERG and VEP:
1. ISCEV: A Guide to Procedures; Standards, Recommendations and Guidelines 2. Heckenlively, JR, et al; Principles and Practice of Clinical Electrophysiology of Vision; 2006; MIT Press 3. Holder, G; Pattern Electroretinography and an Integrated Approach to Visual Pathway Diagnosis; Prog in Ret & Eye Res, 2001 Vol. 20 4. Bach M, et al; Pattern Electroretinogram in Glaucoma Suspects: New Findings from a Longitudinal Study; Invest Oph & Vis, June 2011, Vol 52 5. Quigley HA, et al; Chronic glaucoma selectively damages large optic nerve fibers; Invest Ophthalmol Vis Sci 1987; 28:913-920 6. Howe, JW, et al; Simultaneous recording of PERG & VEP in a group of patients with chronic glaucoma; Doc Opth Proc Ser 1984; Vol 40 7. Drum B, Quigley HA, et al; PERG & optic nerve histology in monkeys with unilateral laser induced glaucoma; Inv Ophth Vis Sci 1986; 27 8. Arden, GB, et al; Pattern electroretinograms become abnormal when background diabetic retinopathy deteriorates to a pre-proliferative
stage: possible use as a screening test. Br. J. Ophthalmol; 1986; Vol 70 9. Viswanathan S, Frishman LJ, Robson JG; The uniform field and PERG in macaques with experimental glaucoma: removal of spiking
activity; Invest Ophthalmol Vis Sci. 2000; Vol 41 All Diagnosys systems, including Envoy, meet or exceed ISCEV standards; FDA 510(k) K863956; Diagnosys is ISO 13485 compliant.
US: Diagnosys USA ● 55 Technology Drive, Suite 100 ● Lowell, MA 01851 USA ● Phone: 978.458.1600 ● Fax: 978.458.1755 ● Email: [email protected]: Diagnosys LTD UK ● 5 Trust Court, Vision Park ● Histon, Cambridge, CB24 9PW ● Phone/Fax: +44 (0) 1223 520699 ● Email: [email protected]
Simplify your visual electrophysiology
If you would like more information on Diagnosys products,
please contact us at either our US or UK locations
Doc #: 14824 Rev: B ECN #: 902 Date: 1/20/2017
www.diagnosysllc.com
Espion™ software provides detailed test reports that are concise and easy to interpret (ISCEV standard PERG & VEP tests using the E3 or Profile system).
The industry leader. Decades of experience, thousands of installations.
• Most experienced customer support team in the industry• Hundreds of peer-reviewed papers published using our systems• Extensive world-wide network of leading experts operating Diagnosys systems
Ordering information:Model #: D315 (desktop), D310 (cart), D352 (add-on module) Available on the following systems or as an upgrade to them: • Diagnosys E3 desktop systems • Diagnosys Profile cart-based systems