Ldb Convergenze Parallele_Mantovani_02
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Transcript of Ldb Convergenze Parallele_Mantovani_02
Diego Mantovani, PhD, FBSE
Lab. Biomaterials and Bioengineering
Dept of Min-Met-Materials Eng. Research Center, CHU de Québec
Université Laval
www.lbb.ulaval.ca 2
Outline
Introduction The science behind the project – case study PI: what to do? Absolutely patenting (fiction) Absolutely licensing (fiction) The real case Side knowledge …
The science behind the project
Grafting biomolecules to vascular prostheses by functionnalisation
Pascale Chevallier, Martin Castonguay, Jean-Francois Pageau, Diego Mantovani , Gaétan Laroche
Vascular Prostheses
Research Strategies Interfacial Problem
Blood Flow
Expected Obtained
Plasma RF
Rationale
Modification Surface Functionnalisation
Chemical Functionalities Bio-conjugation
AIM : anchoring specifically bioactive
molecules
Under vacuum
RFGD NH3
NH2
RESULTS
1000 800 600 400 200 0 Binding energy (eV)
Virgin commercial prosthesis
Ammonia plasma
x 4
x 4
x 4
C 1s (32.8%)
F 1s (67.2%) F KLL F 2s
C 1s (55.4%) N 1s (12.2%)
F 1s (28.7%)
O 1s (3.7%) F 2s
F KLL
Ammonia plasma + bioactive molecules
F KLL
F 1s (12.7%) O 1s (16.2%) C 1s (57.7%)
N 1s (6.7%) F 2s
Cl 2p (2.11%)
Results
Commercial prosthesis Treated prosthesis
Platelets
* 5000 * 5000
Gore Tex Treated
Cells
[cells] = 5*103 cells/ml during 7 days
Gore Tex Treated
* 20
* 20
In vivo - dogs
/ *2000
Gore Tex Treated
In vivo (6 mo. dogs)
www.lbb.ulaval.ca 14
PI – what to do?
Patent? License? In site development under ultra conservative confidentiality?
www.lbb.ulaval.ca 15
Absolutely patenting or absolutely licensing
Why? What? Where? How? Whom? For how long? What?
www.lbb.ulaval.ca 16
(partial) Analyses and (some) criteria
Funding: governmental vs risk capital The environment, in term of:
• Risk analysis • Investors
Personal motivation
• Future and prospective consideration • Personal stimuli
The real case …
2 patents on the technology 1 patent on a side technology (anti-fog!?) Spin-off (Materium) was created Licenses are under negotiation
University is happy, especially the TTO Scientists also but ... tired
D. Mantovani, 17 www.lbb.gmn.ulaval.ca