Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of...

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Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH

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Page 1: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Layer-Specific Attentional Modulation in Early Visual Areas

Elizabeth A. BuffaloLaboratory of Neuropsychology

National Institute of Mental Health, NIH

Page 2: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Fries, Reynolds, Rorie, and Desimone (Science, 2001)

Attentional Modulation in Area V4

Page 3: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Unattended stimulus

Attended stimulus

V4

v2 v2

pp

V1V4

TETEO

V2

Page 4: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

1°

RF

1°

RF

1°

RF

1°

RF

Resp

on

se/

Rew

ard

0.5-5.0s1.0s

Spatial Attention Task

fix

Page 5: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.
Page 6: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.
Page 7: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Electrode Path

Modified from Gegenfurtner, Kiper, and Levitt (1997)

Page 8: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Superficial Recording Deep Recording

Page 9: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Electrode Path

Modified from Gegenfurtner, Kiper, and Levitt (1997)

Page 10: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Attentional Modulation in Area V2Superficial Layers

Page 11: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Attentional Modulation in Area V2Deep Layers

Page 12: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.
Page 13: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Superficial Layers

Deep Layers

Area V1 Area V2

Page 14: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Superficial Layers Deep Layers

Page 15: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Cortical Circuitry

Page 16: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Feedforward intracortical connections V1 (II/III) to V2 (IV)

Cortical Circuitry

Page 17: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Feedforward intracortical connections V1 (II/III) to V2 (IV)

Feedback intracortical and subcortical connectionsV2 (VI) to V1 (VI)V1 (V) to SC,V1 (VI) to LGN,V2 (V) to SC, Pons, Striatum

Cortical Circuitry

Page 18: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

V1

TE

V2

V4

TEO

pfc

Superficial LayersGamma-frequency synchronization:

Attention

Page 19: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Superior Colliculus, Striatum, Pons, LGN

V1

TE

V2

TEO

pfc

V1

TE

V2

V4

TEO

pfc

Superficial LayersGamma-frequency synchronization:

Attention

Deep LayersBeta-frequency synchronization:

???

Page 20: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Baker, Kilner, Pinches, and Lemon (1999)

Beta-frequency Oscillations

Page 21: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Synchronization correlated with behavioral response

Superficial Layers Deep Layers

Page 22: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Synchronization correlated with behavioral response

Superficial Layers Deep Layers

Page 23: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Superior Colliculus, Striatum, Pons, LGN

V1

TE

V2

TEO

pfc

V1

TE

V2

V4

TEO

pfc

Superficial LayersGamma-frequency synchronization:

Attention

Deep LayersBeta-frequency synchronization:

Motor response inhibition?

Page 24: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Superficial Layers: Coherence Across Time

Page 25: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Deep Layers: Coherence Across Time

Page 26: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Cortical Circuitry

LGN

Higher Cortical Areas

SC

Page 27: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Cortical Circuitry

LGN

Higher Cortical Areas

SC

Inhibitory Interneurons

Page 28: Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.

Collaborators

Robert DesimonePascal FriesTim BuschmanDavid HeisterPartha Mitra


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